A European study found that long-acting monoclonal antibody immunisation effectively prevented hospitalisation due to RSV infection among children under two years old. The overall immunisation effectiveness was 79%, with a decline in protection over time, highlighting the need for ongoing monitoring.
LD-110, a potent LSD1 PROTAC degrader, induces ER stress and apoptosis in cancer cells by degrading LSD1 and increasing H3K4me2 levels. This study reports the discovery of LD-110 as a highly effective therapeutic agent with potential synergistic effects when combined with GSPT1 degraders.
A new study found that while parents are willing to accept AI-generated images in children's stories with certain conditions, they raise concerns about errors in illustrations that might encourage unsafe behavior or lack real-world accuracy. Parents prefer clear notification on the cover of the story if AI was used to create images.
A groundbreaking study reveals that domestic dogs exhibited significant variation in size and shape at least 11,000 years ago. The research analyzed 643 modern and archaeological canid skulls spanning the last 50,000 years, tracing the emergence of distinct dog forms deep into prehistory.
A study reconstructed key genomic adaptations in animal lineages transitioning to land, revealing convergent molecular responses to similar ecological challenges. The research found that many adaptive functions evolved independently and repeatedly, with gene losses playing a crucial role in the transition to life outside water.
The COP30 climate summit in Brazil has seen countries favoring land-based carbon removal initiatives over emission cuts. However, a new report by the University of Melbourne warns that these efforts may be unrealistic due to global commitments to halt deforestation and forest degradation. The report highlights two essential flaws in na...
A new study by Sightsavers and GLIDE has found that using worn socks with yeast-generated CO2 is as effective as traditional methods for catching blackflies that spread river blindness. The research could provide an alternative to 'human bait' and reduce the risk of disease transmission, offering communities long-term protection.
Researchers have made breakthroughs in overcoming immune reactions behind human rejection of transplanted pig kidneys, paving the way for more successful clinical trials. The study reveals three major immune responses against the pig kidney and identifies potential biomarkers as early-warning systems for rejection.
Research found that deep-sea pelagic fish exhibit a wider range of body types, while benthic species tend towards elongated, tapered shapes. The study suggests that ocean depth and environmental conditions drive evolutionary changes in fish body shape.
The smart bamboo glass exhibits record tensile strength, flexibility, and impact toughness while retaining high visible-light transmission. Annual HVAC savings range from 1.6% to 5.58%, reducing global-warming potential by 35% and human-toxicity indicators by 40-60%.
The degree integration course provides a master's course in basic medicine, Medical Education, and nursing for healthcare professionals in developing countries. Currently, 27 students are being trained, with the goal of creating a virtuous cycle of research, education, and practice in their home countries.
Researchers at UCSF used AI to analyze clinical notes from multiple providers to improve HRS diagnosis accuracy. The technology offers a unified summary of the care team's consensus, aligning care decisions and expediting treatment plans.
Leading experts urge universal hepatitis B vaccination for all newborns in the US, citing a 95% decline in infant infections since 1991. The policy has prevented an estimated one million hospitalizations and 90,000 deaths.
Researchers at University of Illinois Chicago have developed a microfluidic device that can isolate pancreatic cancer cells from blood samples with high accuracy. The lidocaine infusion method has shown promise in reducing the aggressiveness of circulating tumor cells and may help lower the risk of metastasis.
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
A new study shows that while digital access improves daily life activities and sustainability outcomes, it cannot fully replace physical services. The research team developed an innovative evaluation framework to quantify the quality of life in smart cities, highlighting the need for a balance between real-world community support and d...
A genomic study shows that diverse Eurasian cultures kept and spread genetically distinct dog populations over the last 10,000 years. The research highlights the deeply rooted cultural importance of dogs, with a tight link between human and dog genetics showing they were an integral part of society.
A groundbreaking framework for predicting drug safety in liver injury (DILI) has been published by Cellularity in Nature Communications. The ToxPredictor model demonstrates high sensitivity and specificity in identifying phase 3 clinical safety failures, offering improved clarity on hepatotoxic pathways.
A multidisciplinary team of researchers used genomic technology to decode the DNA of non-flowering seed plants, including gymnosperms, to identify genes involved in seed development. The study, published in Nature Communications, may aid scientists in improving crop production and conserving these ancient endangered seed plants.
A new study has analyzed a rare flooding event in the Maldives in July 2022 and found it could become a far more common occurrence in the future. By 2050, predicted rises in sea levels, coupled with increased extreme weather events, may result in such flooding happening every two to three years.
A recent study published in Nature Genetics found that depression beginning before age 25 has a stronger hereditary component and is associated with a higher risk of suicide attempts. The research identified 12 genetic regions linked to early-onset depression, highlighting the potential for precision medicine in psychiatry.
New research reveals that oceanic upwelling systems amplify acidification, posing existential threats to fisheries and coastal economies. The study used historic coral samples and regional ocean models to predict future changes.
The American Psychological Association's new health advisory emphasizes that generative AI chatbots and wellness applications lack scientific evidence to ensure user safety. Despite their low cost and accessibility, these tools are not a substitute for systemic solutions to the mental health crisis.
Eric Nestler receives the UNIGE Synapsy Prize 2025 for his pioneering work in linking fundamental neuroscience research to clinical advances in mental health. His career has shown how stress and addictive substances alter gene expression, affecting neural circuits involved in reward and mood.
Keck Hospital of USC and USC Verdugo Hills Hospital earned a Fall 2025 'A' Hospital Safety Grade from The Leapfrog Group, recognizing their rigorous commitment to patient safety. This is the first time Keck Medicine has received two 'A's simultaneously.
A 7-week randomized controlled trial found that a train fare subsidy program significantly increased daily walking steps among prime-aged adults by 711.43 steps/day for those subsidized with 1000 points. However, middle-aged and older adults did not experience significant increases in step count.
Researchers have developed phytochemical-engineered vesicles that combine Ginsenoside Rg1 priming with nanoscale engineering, offering a scalable and innovative strategy for mitigating myocardial ischemia/reperfusion injury. These nanovesicles demonstrated dual efficacy in scavenging mitochondrial reactive oxygen species and repairing ...
A new synthesis method allows for the scalable direct synthesis of short-wavelength infrared PbS quantum dot inks, yielding over 10 grams of QD solids per batch. The results achieve a power conversion efficiency of nearly 9% in solar cells fabricated using the inks.
Researchers have developed a compact device that can detect light intensity, wavelength, and polarization, addressing a critical bottleneck in optoelectronics. The perovskite-based photodetector enables precise control over polarization states through pulsed-voltage-driven ion migration.
Researchers examined single event effects in carbon nanotube devices and found they exhibited outstanding radiation tolerance, outperforming silicon-based devices. The study suggests that CNTs can serve as an excellent radiation-hard technology for future electronic applications.
Researchers develop a technology to boost natural photosynthesis efficiency by combining Ru-Oxo clusters with g-C3N4 nanosheets, leading to improved crop yields. The system promotes plant growth by up to 36% and improves sunlight utilization, paving the way for sustainable agricultural technologies.
Researchers developed a Mo-MXene/MoO2-N/Ce composite system to regulate dielectric polarization response. The system achieves precise regulation of dielectric loss, with optimal reflection loss reaching -57.46 dB at 13.43 GHz and 4.685 mm thickness.
Researchers have developed a new class of ultrafast nanomotors powered by near-infrared (NIR) light, capable of reaching velocities up to 100 body lengths per second. The hybrid nanomotors operate through a simple photothermal mechanism and demonstrate precise nanoscale transport without the need for chemical fuels.
Researchers developed a new oral taste-masking agent using mesoporous molecular sieves, which successfully masked the bitter taste of cetirizine and achieved high drug loading rates. The agent showed significant shielding effects and is expected to become a high-efficiency taste masking agent for improved oral administration.
The newly released expert consensus systematically reviews epidemiological characteristics, laboratory diagnostic methods, and optimized treatment pathways for managing ESBL-E infections. It provides individualized, evidence-based antimicrobial therapy based on infection severity, pathogen characteristics, and pharmacokinetic–pharmacod...
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
High-resolution label-free imaging reveals stable organelle dynamics and spatial organization, overcoming phototoxicity and halo artifacts. ExAPC microscopy captures biomolecular condensate-like structures and cellular responses to drugs.
The University of Osaka and NEC have demonstrated a wide-area distributed campus AI processing platform, enabling on-demand use of GPUs from compute servers via an optical network. This platform leverages NEC's ExpEther technology to connect and disconnect devices across campus, improving efficiency and optimizing GPU utilization.
A decade-long study by Chinese Academy of Sciences researchers found that soil microbial communities reorganize to form more stable networks, reducing carbon emissions. Microbial thermal adjustment and efficient microorganisms mitigate the effects of climate warming.
Headache disorders affect nearly one in every three people, causing significant disability and health loss. Migraine and medication overuse drive most of the global burden, emphasizing the need for improved prevention, management, and access to care.
The 2025 Global Carbon Budget projects a record high of 38.1 billion tonnes of fossil CO2 emissions, with decarbonisation efforts not enough to offset growing energy demand. Climate change is weakening the land and ocean carbon sinks, reducing the remaining carbon budget to limit global warming to 1.5°C.
Researchers create new prediction model combining age, sex, genetic risk, and brain amyloid levels to calculate lifetime risk of developing memory problems. The study, published in The Lancet Neurology, found women have a higher lifetime risk than men, with the common APOE ε4 variant increasing risk.
A new study reveals that 16% of the Arctic Ocean's dissolved organic carbon comes from land, primarily from thawing permafrost and coastal erosion. This finding has significant implications for understanding how terrestrial organic matter affects Arctic marine ecosystems and the ocean's ability to store CO2.
A novel methylation analysis method, called UMBS-seq, achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection. The method outperforms existing methods for 5-methylcytosine detection with low input DNA, preserving DNA integrity.
Researchers discovered a cellular protein, FGD3, that enhances the effectiveness of breast cancer chemotherapy and immunotherapies. FGD3 weakens cancer cells when attacked by drugs like ErSO or doxorubicin, causing them to rupture and alert the immune system.
A study from the University of Victoria suggests that humans can smell testosterone and associate it with dominance. The research found that participants rated men with higher testosterone levels as more dominant than those with lower levels, indicating a link between body odour and perceptions of social status.
In a study by Michelle Miner at UC Riverside, bumble bees were found to avoid foraging near ant colonies due to the risk of being bitten. However, aggressive bees who fought back were victorious in individual fights but may ultimately harm their colony by wasting energy.
Researchers developed a reconfigurable bioinspired vision sensor using GaN/AlN quantum-disk-in-nanowires, emulating the human retina's dual-cell system. The QD-NW platform enables real-time, low-power high-accuracy visual perception and opens pathways for neuromorphic vision systems.
A Cochrane review found that low-dose colchicine reduced heart attacks and strokes in people with a history of heart disease or stroke. The study involved nearly 23,000 participants and showed that taking colchicine could prevent about two of each heart attack and stroke among those with cardiovascular disease.
SourceCochrane·JournalCochrane Database of Systematic Reviews·TypeSystematic review·DateNov 12, 2025
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
SourcePATH·JournalThe Lancet Global Health·TypeRandomized controlled/clinical trial·DateNov 12, 2025
Experts argue that e-cigarette regulation should prioritize children's best interests, citing the WHO Framework Convention on Tobacco Control and the UN Convention on the Rights of the Child. The authors recommend strict measures to reduce e-cigarette appeal, availability, and affordability among children.
Researchers developed a bioinspired dual-mechanism iontronic pressure sensor (FIPS) that mimics human skin structure, achieving high sensitivity and full-range linearity for real-time musculoskeletal load monitoring. The FIPS platform opens new avenues for wearable biomechanics, sports medicine, and rehabilitation robotics.
Researchers developed a biochar-based material that dramatically improves nitrate removal from agricultural soils and water, maximizing both nitrate adsorption and ammonium retention. The optimized composite achieved nitrate reduction rates as high as 71 percent and increased ammonium retention by 53 percent compared to biochar alone.
The prevalence of high blood pressure among children and adolescents increased from 3.2% to 6.2% between 2000 and 2020, with obesity identified as a substantial driver. Early detection and prevention efforts are crucial to control high blood pressure in children and reduce the risks of future health complications.
A newly discovered carnivorous lizard, Tainrakuasuchus bellator, lived 240 million years ago and resembled a dinosaur due to its armour-plated body. The species was among the top predators of its time in Brazil during the Triassic Period.
Researchers have presented a comprehensive review on synergistic ferroptosis–immunotherapy nanoplatforms to overcome TME resistance and enhance antitumor immunity. The work offers a systematic roadmap for integrating ferroptosis induction with immunotherapy.
A new report from the Higher Education Policy Institute calls for a fundamental rethink of NHS clinical placement provision. The paper proposes practical interventions to make placements more effective and sustainable, including greater use of simulation and digital learning, new supervision frameworks, and community-based models.
A US study found that extending anti-clotting treatment beyond 90 days reduces recurrent VTE rates by 81% and death rates by 26%, while increasing major bleeding risk. The overall 'net clinical benefit' persists even after three years of treatment.
A systematic review examines the current landscape in data processing flow, multimodal fusion strategy, and model architecture for affective computing. Deep learning methods are shown to extract feature representations with high consistency across public datasets and self-collected data.
Scientists successfully measured electric potential in plasmas using a non-contact diagnostic technique, enabling the detection of temporal transitions in internal plasma potential distribution. The method allows for improved predictive models of plasma behavior and confinement frameworks in fusion research.