Research identifies novel FAK splicing variants in small cell lung cancer that promote proliferation, migration, and invasion. These variants confer resistance to chemotherapy and radiation, highlighting a new therapeutic vulnerability. Targeted therapy with FAK inhibitors shows promise.
Researchers have identified a promising strategy to improve the effectiveness of targeted therapies in advanced prostate cancer. By combining ADCs with a drug that blocks BCL-XL, they triggered greater cancer cell death and slowed tumor growth. The approach could offer a new strategy for improving antibody-drug conjugates against metas...
Researchers found that tumor cells use DDB1 to ubiquitinate PD-L1, allowing it to enter the nucleus and drive immune suppression. A new compound, thalidomide, disrupts this process, restoring sensitivity to immunotherapy in preclinical breast cancer models.
A randomized clinical trial found video laryngoscopy with a Macintosh blade (VLM) and hyperangulated blade (VLH) to have significantly higher first-pass success rates compared to direct laryngoscopy (DL). The study supports the use of video laryngoscopy as a new standard for routine airway management in adult patients.
A study published in Horticulture Research found that red-stemmed plants of Astragalus membranaceus var. mongholicus accumulate higher levels of isoflavones and volatile organic compounds associated with medicinal quality, while their stems are enriched with cyanidin-based anthocyanins that explain the red coloration.
Researchers recreated melodies from brain activity of people imagining song continuations using electrocorticography. Brain signals revealed pitches of notes in imagined musical melodies, enabling pitch prediction and structure analysis.
A new study from the Centre for Genomic Regulation found that cells use nearly unchanged signals to switch genes on, while varying dramatically to switch genes off in different species. The research provides insights into how genomes evolved and could have implications for medical research.
New research suggests that Agulhas Leakage does not directly regulate the AMOC through salt transport, challenging a long-held textbook concept. Instead, changes in ocean temperature and thermocline structure play a crucial role in shaping the climate system.
A Mayo Clinic study highlights the benefits of animal-assisted treatment in stroke rehabilitation, showing increased patient engagement and improved rehabilitation outcomes. Therapy animals support patients with limited motivation, reduced energy and lack of companionship.
Researchers have identified genetic relationships among all known Hawaiian honeycreeper species, providing insights into biodiversity loss and conservation priorities. The study reveals that most species originated during a rapid diversification event around 2.5-3.5 million years ago.
Researchers found that polyethylene microplastics modify as they age in soil, but these changes have little effect on how they interact with various organic contaminants. The study suggests the soil itself, not the plastic, remains the main factor influencing the environmental fate of these chemicals.
Researchers at Sungkyunkwan University have identified a new principle that controls charge separation in molecular aggregates, crucial for efficient energy devices like organic solar cells and artificial photosynthesis systems. The discovery reveals a fundamental mechanism of charge transfer governed by the surrounding solvent environ...
Scientists created thresholdless corner vortex solitons that unify topological corner states and vortex light, enabling stable high-speed data transmission. The new solitons resist signal damage and maintain performance across a broad input power window.
Researchers found specific song themes tied to specific parts of a dive, revealing insights into how singing affects energy use, oxygen management and vulnerability. The study's findings offer practical applications for tracking whale populations and establishing a clearer baseline for normal humpback behavior.
A new study found that S100–RAGE signaling is a key driver of early drug resistance in tumors, making it a promising target for treatment. Analyzing 47 patients and 109 pretreatment metastatic lesions treated with trastuzumab deruxtecan, researchers identified this pathway as a crucial factor in tumor resistance.
New research reveals that NICE referral criteria for breast cancer risk assessment miss up to 95% of women under 50 who go on to develop the disease within 10 years. A full risk assessment tool, BOADICEA, identifies eight times more women in this age group at higher risk.
Researchers at the University of Jyväskylä found that sauna steam significantly impacts thermoregulatory responses, including increased heart rates and core temperatures. High relative humidity reduces sweat evaporation, forcing the cardiovascular system to work harder.
Researchers at La Jolla Institute for Immunology discovered that immune cells in lung tissue express genes associated with autoimmune disease risk. These tissue-resident immune cells may actively drive the development of autoimmune diseases, particularly in women.
A new study documents how an Indonesian Indigenous community adapted their sacred Cidaku initiation ceremony to protect the endangered salmon-crested cockatoo. The ceremony now uses naturally moulted feathers collected from wildlife rescue centres, preserving spiritual integrity and ensuring species survival.
A research team uses machine learning to regulate environmental processes, achieving precise and predictable remediation of polluted soil. This approach allows for the creation of high-performance charcoal-like substances from farm and forestry waste and polluted soil.
A new study from the University of Kansas reveals that everyday people often focus on punishment as a solution to gender-based violence rather than examining its causes. Commenters regularly called for imprisonment and stripping perpetrators of power and resources, with some even advocating for poverty as a form of punishment.
Researchers have discovered a new way to channel light waves using naturally hyperbolic van der Waals material without the need for conventional nanofabricated waveguides. This phenomenon, known as plasmon canalization, can be tuned by adjusting the excitation wavelength.
Researchers at KAIST have developed a technology converting CO2 dissolved in seawater into calcium carbonate, enabling permanent storage and helping the ocean absorb more carbon dioxide. The system reduced electricity consumption by up to 54% and produced high-purity hydrogen and magnesium hydroxide.
A recent study on orphaned grizzly bears found a high mortality rate of 83%, largely due to human-bear conflicts, illegal killings, and intraspecific killing. The study also highlights the risk of habituation to humans, which can lead to serious conflicts, particularly when combined with oversized size from excessive growth during reha...
A new project supported by DARPA will study AI systems to determine how to train them to withstand failures, attacks, and unexpected situations. The goal is to develop self-improving AI for safety, enabling AI systems to recognize weaknesses in their reasoning and improve behavior over time.
Artificial intelligence can exacerbate or mitigate inequities in correctional health systems. Designing AI for access, inclusion, and trust is crucial for ensuring health equity among incarcerated populations. The study outlines policy and implementation considerations necessary to address these concerns.
During REM sleep, the brain processes internal bodily signals more strongly than external auditory stimuli. By calculating an audio-cardio index, researchers found that the brain turns its listening inward, reorganizing sensory information processing as it shifts from wakefulness to sleep.
Drug spending has become increasingly focused on highly novel drugs in the last decade, driven by increased prescribing of innovative medicines. The shift is attributed to changes in market forces and government policies that better reward pharmaceutical innovation.
Researchers created a planning framework that assesses long-term investment strategies for improved resilience in the power grid. The framework maps weather events to grid impacts and quantifies cost-benefit trade-offs of possible solutions.
The Office of Naval Research (ONR) has been instrumental in shaping the U.S. Navy and Marine Corps' technological advancements for 80 years. Key initiatives include the newly released 2026 Science and Technology Strategy and the CNR Fellows program, which fosters collaboration between academia and industry.
An international team of scientists describes seven new species of Madagascar's elusive diamond frogs, revealing a more diverse group than previously thought. The research provides an important foundation for future conservation efforts in Madagascar's rapidly disappearing forests.
A comparative review identifies how EU and US surface water monitoring architectures can strengthen surface water protection in China. The analysis suggests combining routine assessment with rapid diagnosis and long-term ecological observation to support precise and adaptive water governance.
A new meta-analysis of 114,000+ participants found that low-dose omega-3 supplementation is not associated with an increased risk of atrial fibrillation, even among individuals at elevated cardiovascular risk. In contrast, high-dose prescription therapies may modestly increase AF risk in these patients.
Scientists at Colorado State University have successfully created an ultracold neutral plasma, cooling electrons to near absolute zero. This breakthrough will aid in the development of better computer models for fusion energy systems and help understand white dwarf stars and extreme environments in the universe.
A team of researchers at Flinders University has discovered a novel method to manipulate tiny nanoscale 'bubble' domains within ferroelectric crystals using near-visible light. The study reveals that these structures rapidly expand after the light is switched off, triggering a temporary change in their electronic state.
A team from North Carolina State University developed techniques that can enhance day-ahead solar forecasts, outperforming individual models in some cases. The approach emphasizes regional variables and combined forecasts from multiple models for improved accuracy.
Research from University of Georgia suggests that focusing on personal benefits can encourage people to participate in environmental cleanup efforts. Exercise and physical activity were found to be key motivators for many participants, who saw picking up litter as a way to improve their health and well-being.
A new study reveals that early snakes experimented with multiple habitats and sensory strategies before evolving into modern species. The research describes the discovery of a well-preserved fossil snake skeleton from the Late Cretaceous period, which provides insights into the early neuroanatomy and ecological diversity of snakes.
Researchers developed a wearable optoelectronic clip that turns exhaled breath into a clear optical switching signal, enabling touch-free interaction and respiratory health monitoring. The device showed high accuracy in multi-user tests, suggesting its potential for practical applications.
A team at Pusan National University created a stretchable organic electrochemical transistor that can be easily reprogrammed to perform different functions. The device combines logic, memory, and a visible color readout without complex circuitry.
Researchers have developed a new approach to create large-scale uniform porous SiO2 monolayer coatings for high-reflection and anti-reflection optics. The coatings demonstrate excellent laser damage resistance, surpassing that of fused silica substrates.
A recent study by Nagoya University researchers found that orexin neurons play a crucial role in regulating motivated behavior. Using novel rat models, they discovered that activity in orexin neurons increases with effort, helping drive motivated behavior.
A team at University Akron used AUC to study molecular clusters and their interactions with biomolecules, revealing key findings on hydration shells and intermolecular distances. The technique offers a powerful tool for characterizing complex solution systems, overcoming limitations of traditional methods.
A cost analysis of the 2025 New Mexico measles outbreak found it carried an estimated societal cost of $5.4 million, with vaccination-related activities accounting for about $2.1 million. The findings underscore the importance of maintaining strong vaccination coverage to prevent future outbreaks.
A Swansea University PhD researcher has received funding to attend the Psychonomic Society Annual Meeting to share her findings on how neurodivergent people process visual symbols. Her research reveals that neurodivergent participants respond more quickly and accurately to these symbols, highlighting important differences in cognitive ...
A new type of conductive hydrogel has been developed using gelatin to stabilize liquid metal particles, enabling high sensitivity in motion sensing and real-time handwriting recognition. The material also harvests solar energy via photothermal conversion.
Researchers discovered lupus-associated inflammatory signals reprogram white blood cells to produce less effective antibacterial response. Hydroxychloroquine and anifrolumab therapies restore neutrophil function in killing bacteria.
Researchers developed a method to modify vehicle sounds using auditory augmented reality, which can draw pedestrian attention without loud warnings. By artificially increasing the frequency of approaching vehicle sounds, participants judged the vehicle as moving faster and closer.
A team of researchers at North Carolina State University has created a novel approach to optimize vaccine distribution by combining machine learning with column generation. This method accelerates run-time for the optimization model by 79.1% while maintaining high-quality solutions.
A team identified GABPA as the missing link recruiting Integrator complex to target specific genes. Biochemical and structural analyses confirmed direct interaction between GABPA and Integrator's endonuclease module.
Researchers identify subtropical lakes as natural laboratories for tracking biodiversity, water quality, and ecosystem resilience in a rapidly changing world. The study highlights the global scientific importance of these largely overlooked lakes, which can serve as 'sentinel ecosystems' revealing early signs of environmental change.
Researchers have developed an ultrafine ruthenium nanocluster catalyst that selectively converts lignin-derived compounds into 1,4-cyclohexanediol using only pure water. The process achieves a 96.7% yield, exceeding current industrial benchmarks and commercial noble metal catalysts.
A blood test that detects circulating tumor DNA can predict whether patients with advanced non-small cell lung cancer are benefiting from immunotherapy. The test was found to be accurate in predicting therapy response and can provide clinically meaningful information weeks before conventional imaging.
Researchers discovered a protein called TRAILshort that suppresses T-cell activity and reduces the effectiveness of CAR-T cell therapy in cancer patients. Elevated levels of TRAILshort were found in various cancers, infectious diseases, and autoimmune disorders.
A study by Drexel University found that people form a stronger bond with an expressive humanoid robot, but this trust can quickly dissipate when the robot makes errors. The researchers measured brain activity, hormones, and self-reported attitudes to understand how humans build and lose trust through collaboration with robots.
Current Engineering Letters and Reviews is an international, interdisciplinary journal publishing high-quality research and reviews in engineering sciences. It aims to foster collaboration and publish groundbreaking work on technological innovation and sustainable development.
Seoul National University researchers have developed an off-stochiometric anode material that enables safe, ultra-fast charging of lithium-ion batteries. The new design strategy overcomes kinetic limitations and preserves the NASICON structure against irreversible damage.
A new study finds that neither injection molding nor 3D printing is universally superior for polypropylene parts. Injection molding outperforms 3D printing in terms of mechanical strength and softening temperature, but the latter is more cost-effective for low-volume production and rapid prototyping.
Researchers found a variant in the thymic stromal lymphopoietin (TSLP) gene associated with EGPA susceptibility in both Japanese and European populations. Additionally, the HLA-DRB1*07:01 allele was linked to EGPA in Japanese individuals, but not in Europeans.
Researchers developed a new dielectric elastomer that amplifies its own motion through resonance, eliminating the need for rigid supporting structures. The material generates asymmetric electric fields through space-charge accumulation, producing self-induced bending and resonant motion.