Researchers have discovered evidence of genetic material from high-risk bacterial groups in wastewater treatment plant effluent, highlighting the potential for antibiotic resistance to spread through ecosystems. This finding emphasizes the need for upgrading WWTPs with advanced technologies to protect public health and waterways.
The €30 million ASCEND project aims to accelerate catalyst discovery using Digital Catalysis and thin-film technologies. By combining AI with physical synthesis and stress testing, the project seeks to unlock performance breakthroughs for commercially viable large-scale deployment of green hydrogen and sustainable chemicals.
A study published in Cell Chemical Biology reveals that an impaired transport protein and ceramide buildup can trigger replicative senescence, a state where cells remain alive but no longer divide. Ceramides accumulate inside the endoplasmic reticulum, triggering stress signals that lead to cellular limbo.
Countries are taking different approaches to regulating polygenic embryo testing, which raises new ethical and legal concerns. The technology has expanded from screening for monogenic diseases to assessing complex traits like intelligence and disease risk, but its clinical value is uncertain due to environmental influences.
This study developed a new predictive model to assess chemical risks in cetaceans by considering the freely dissolved concentration of pollutants. The results show that mixed exposure to POPs at current environmental levels poses a low risk of reducing cell viability or inducing apoptosis.
A new microscopy method can distinguish lipid species in living cells using mid-infrared illumination and optoacoustic detection, producing a unique spectral fingerprint. This approach eliminates the need for chemical labels, reducing stress on cells and enabling real-time lipid mapping.
A longitudinal analysis of 42,000 participants found higher bone lead levels associated with significantly increased cardiovascular disease mortality risk. The study highlights the urgent need for strengthened surveillance, regulation, and remediation to reduce the lead-attributable burden worldwide.
A new study uses drone-based hyperspectral imaging to monitor changes in grassland ecosystems under different grazing pressures. The researchers found that biomass declines with increasing grazing intensity, while certain nutrient-related traits increase, suggesting a shift toward more stress-tolerant plant strategies.
A new study led by Krista Varady found that intermittent fasting reduces testosterone levels and improves female hormone levels in women with PCOS. The study tested time-restricted eating and calorie counting methods, showing that intermittent fasting had additional benefits over calorie counting.
The Joule Hive Thermal Battery system can generate and store heat up to 1,800 degrees Celsius using renewable energy sources like solar or wind. The system's thermal energy storage capabilities make it possible for industrial sites to rely on renewable energy sources flexibly.
A new study by researchers at the University of California, Davis found that breathing in common disinfectant chemicals known as QACs can be far more harmful than swallowing them. The study suggests higher health risks for respiratory diseases such as asthma and COPD from airborne exposure to disinfectant sprays and cleaning products.
Research finds that building gypsum powder reduces soil strength when exposed to water, but augments it at low concentrations of sodium sulfate. The study also reveals the impact of dry-wet cycles on soil pores, structure, and resistance.
A collaboration between Karolinska Institutet and Karolinska University Hospital has integrated whole genome sequencing into routine diagnostic investigations for rare diseases. This approach has enabled the diagnosis of a genetic cause in 23% of patients, with diagnoses involving variants in over 1,500 different genes.
Researchers identified NOX-1 as a key molecular target to prolong ketamine's therapeutic benefits. Combining ketamine with NOX-1 inhibitors significantly extended its antidepressant-like effects. K-4, a novel AMPAR modulator, also showed rapid antidepressant effects that persisted for at least 2 weeks.
Researchers found that early pregnancy probiotics containing Clostridium butyricum significantly reduced the recurrence rate of spontaneous preterm delivery, a major cause of neonatal illness and death. The study suggests that probiotic therapy may offer a simple strategy to prevent premature births in women at high risk.
A new framework proposes a Confucius-inspired approach to reimagining higher education, focusing on relational, contextualized, inward-calling, and unified practices. The study revisits foundational philosophy to address societal needs and challenges, highlighting the importance of self-cultivation and social order.
HeapGrasp uses RGB images to analyze object silhouettes and estimate its 3D shape, reducing the need for depth information. The approach achieves high accuracy while minimizing camera movement and execution time.
Researchers identify DNASE1L2 intron retention as a biomarker for TB progression and reveal its role in regulating inflammation. The study shows that upregulation of DNASE1L2-IR promotes host clearance of pathogen DNA, while downregulation weakens this antibacterial defense mechanism.
Researchers have discovered a new biomarker for immunoglobulin A (IgA) nephropathy, which is an autoimmune disease that can lead to kidney failure. Complement pathway proteins, including CFHR1, were found to be overexpressed in patients with IgA nephropathy, suggesting a potential treatment target and diagnostic marker.
The American College of Lifestyle Medicine launches Project Remission, a national digital series highlighting evidence-based strategies to achieve type 2 diabetes remission through lifestyle interventions. The series showcases clinicians, health systems, and patients who demonstrate the potential of lifestyle medicine in treating chron...
Researchers at the University of York have discovered a protein that allows the African trypanosome parasite to evade detection by destroying specific parts of its genetic instructions. This breakthrough provides new vulnerabilities for future treatments and could revolutionize our understanding of infection.
A new study from Okinawa Institute of Science and Technology (OIST) identifies the 'long fuse' that led to the diversification of modern squid and cuttlefish. The research suggests that these animals originated in the deep ocean around 100 million years ago, sparking rapid evolution after a mass extinction event.
A new study proposes that biological differences, including genetic factors, contribute to autism's strong sex bias. Research suggests that females may be biologically buffered against developing autism due to their X chromosome.
A study analyzing over 15,000 Latin American individuals identifies 35 genes significantly associated with autism, showing extensive overlap with previously identified genes in European-ancestry cohorts. The findings support the universal biological foundations of autism and highlight the need for diverse populations to be represented ...
The study identified a previously unknown recessive neurodevelopmental disorder caused by changes in the RNU2-2 gene, affecting thousands of individuals in the US. Symptoms vary widely, including developmental delays, limited speech, and seizures, and may be more common than previously thought.
A new study found that some Arctic regions regain their 'greenness' within a decade of a sudden permafrost collapse, while others can take centuries or more to recover. The difference is directly related to each site's gross primary productivity, allowing scientists to predict how long it will take a specific site to recover after a pe...
Researchers at OHSU have discovered a previously unknown system of internal 'trade winds' that help cells rapidly move essential proteins to the front of the cell. This breakthrough reveals that cells don't rely on random diffusion but instead create targeted streams of fluid to push proteins forward.
Researchers at the University of Rochester have developed a squeezed phonon laser that precisely controls individual particles of vibration or sound, allowing for accurate measurements of gravity and other forces. This technology has the potential to create more accurate, 'unjammable' navigation systems without relying on satellites.
Dr. Roxana Mehran was appointed President of the American College of Cardiology, focusing on innovation, equity, and global collaboration to advance cardiovascular care. She aims to improve heart health for all through partnerships with major organizations.
Research shows that targeted interventions highlighting personal impact on others can alter behavior among partisans. Both Republican and Democratic voters reduced risk-taking when presented with a simple message asking to choose the safer option for themselves and others.
A study by ISGlobal found that areas with high conflict intensity recorded a higher disease burden, including higher TB case rates and mortality. The research highlights the need for control strategies adapted to each territory, incorporating conflict-sensitive approaches into surveillance, prevention, and healthcare systems.
Research by University of Leeds researchers found that thawing permafrost makes it 25-100 times more permeable, releasing large amounts of greenhouse gases. This could lead to a self-reinforcing process, exacerbating climate change.
In 2025, MDPI saw a 12% increase in manuscript submissions while growing its journal portfolio to 500 titles. The publisher invested in new staff members globally, focusing on research integrity and technology, resulting in comprehensive indexing in leading databases. This reflects sustained researcher confidence and MDPI's commitment ...
Canada's health system would bear the burden of medical care in major armed conflicts, and lacks a coordinated command structure and surge capacity. A national framework with three pillars – sustained clinical readiness, dual-use capacity, and formal coordination – is proposed to address this vulnerability.
The new brain–heart clinical practice guideline provides a holistic approach to managing chronic diseases by integrating neurologic and mental health evidence with cardiovascular guidance. The guideline aims to improve the management of patients with concurrent brain and heart diseases, which often co-occur and share similar risk factors.
Researchers identify a three-way link between mechanical stress, integrin signaling, and endocytosis in osteoarthritis. Integrin trafficking may help explain why the same pathways have different effects across disease stages and tissue contexts.
Scientists discover arachidonic acid (AA) mediates oxidative stress-induced intestinal injury. AA treatment inhibits organoid activity and stem cell differentiation, leading to reduced goblet and endocrine cells. Inhibiting AA production with a specific inhibitor improves organoid vitality.
Researchers developed PCA-iSIM, a novel super-resolution microscopy system that enables high-resolution imaging of subcellular dynamics in living cells. The approach integrates PCA to extract dominant signal components and enhance robustness and precision in parameter estimation.
Researchers at the University of Reading developed a new method to produce whey protein with improved texture characteristics, reducing bitter and peppery notes. The findings suggest that manufacturing changes can improve the taste and texture of protein drinks, making them more appealing to those relying on them.
A novel minimally invasive method for determining fatty deposits in coronary arteries restricting blood flow has produced similar outcomes to conventional FFR, according to a European randomized trial. The technique, called vessel FFR, uses computer analysis of three-dimensional images to calculate blood-flow restriction severity.
A novel software-based method combines AI to evaluate plaque restriction in coronary arteries, producing similar clinical outcomes as the gold standard wire-based procedure. The FFRangio technique eliminated additional procedural steps and was faster to perform.
A newly developed AI tool called EvORanker analyzes genetic patterns across over 1,000 species to identify the cause of rare diseases. In clinical testing, it successfully identified the disease-causing gene in nearly 70% of cases, offering new hope for treatment and closure.
The SPIRIT-HF trial found that spironolactone did not improve outcomes in patients with heart failure with preserved ejection fraction (HFpEF) and mildly reduced ejection fraction (HFmrEF). The study also raised safety concerns about the use of spironolactone in older patients with heart failure.
A Phase 2 trial found significant benefits for patients with poor prognosis and limited options, including improved six-minute walking distance and right heart function, and a lower rate of clinical worsening events. Sotatercept reduced pulmonary vascular resistance and showed a favorable safety profile.
Parties to the Convention on Migratory Species agree to list 40 additional species on Appendices I and II, including iconic species like cheetahs, hyenas, and great hammerhead sharks. The agreement also includes multi-species conservation plans for key regions like the Amazon.
A new study led by NYU Langone Health finds that combining advanced imaging tests can identify the underlying cause of heart attacks in most patients without blocked arteries. The research used coronary optical coherence tomography (OCT) and cardiac magnetic resonance imaging (MRI) to reveal a likely cause in 79 percent of patients.
The ORBITA-CTO trial found that angioplasty reduced angina episodes and improved quality-of-life scores in patients with chronic total occlusion. Patients who received CTO angioplasty were four times more likely to experience improved angina scores, with a significant reduction in angina-free days.
A minimally invasive procedure using a clip to repair the valve significantly reduced heart failure hospitalizations by 40% in patients with severe tricuspid regurgitation. The study, presented at the American College of Cardiology's Annual Scientific Session, showed improved long-term outcomes without crossover between treatment groups.
Researchers developed a new technology combining ver. 3 of the STAR architecture with molecular model optimization, significantly reducing computational resource requirements for chemical material design calculations. This breakthrough enables realistic energy calculations using early-FTQC quantum computers within a practical timeframe.
Researchers developed a strategy to overcome lattice-mismatch limitations in Ga2O3 heteroepitaxy by inserting a precisely engineered gallium oxynitride layer with a close atomic structure match. High-quality β-Ga₂O₃ films were grown, demonstrating outstanding performance metrics for ultraviolet photodetectors.
The Emboliner device performed comparably to the Sentinel device in protecting against stroke and death in patients undergoing TAVR. The study found that both devices captured similar amounts of debris particles, with the Emboliner capturing three times as many larger particles.
A small study found mavacamten significantly improved left ventricular outflow tract gradient and symptoms in adolescents with obstructive HCM. The treatment may also reverse some heart damage and favorably remodel the heart, suggesting potential benefits for children diagnosed with the disease.
Patients who received temporary heart pump had almost double the risk of dying from a cardiovascular event compared to those receiving standard care. The study found no evidence that the device protected the heart during the angioplasty procedure.
A new metahydrogel platform integrated with AI-driven signal processing suppresses motion noise, delivering clinical-grade accuracy in tracking fatigue levels with 92% accuracy. The system also enables broader neurophysiological and mental health monitoring with diverse biosignal types.
Dr. Lisa G. Roth, MD has joined Hassenfeld Children’s Hospital at NYU Langone and Perlmutter Cancer Center as director of the Division of Pediatric Hematology-Oncology. She will oversee clinical care, research, and education programs while expanding access to advanced therapies and clinical trials.
A minimally invasive procedure to insert a new valve showed lower one-year event rates for death or disabling stroke compared to traditional repeat mitral valve replacement surgery. The study found that transcatheter mitral valve-in-valve (mVIV) reduced in-hospital deaths, acute kidney injury, and life-threatening bleeding complications.
A new aquaculture facility is being built in Namie Town, Fukushima Prefecture, to support Benizake salmon farming using 'The Third Water'. The facility will have a capacity over eight times larger than the existing tank and aims to raise fish from eggs and ship them two years later.
The PRO-TAVI study found that older, high-risk patients can safely defer percutaneous coronary intervention (PCI) until after transcatheter aortic valve replacement (TAVR), with comparable outcomes between the two groups. Omitting PCI before TAVR did not increase the risk of death, heart attack, stroke, or moderate to severe bleeding.
Insilico Medicine and Eli Lilly partner to accelerate discovery of novel therapeutics using AI engine, focusing on preclinical development for certain indications. The collaboration aims to deliver transformative therapies for diseases with high unmet need.
Researchers at Murdoch University have developed a forensic tool that uses facial similarity analysis to identify potential connections between victims of sexually motivated crime. The tool, called Face Similarity Linkage (FSL), analyzes 21 key facial landmarks and can flag potential links between victims even with imperfect photos.