A study published in Acta Neuropathologica found that APOE ε4 is associated with widespread TDP-43 pathological subtype in sporadic ALS. This discovery suggests a new perspective on why ALS pathology spreads differently among patients.
The University of Texas at San Antonio's three nominated researchers, Lyle Hood, Amina Qutub, and David L. Roberts, have made significant contributions to various fields, including medical devices, AI in healthcare, and mental health services.
Dr. Michele Carbone received the 2026 Szent-Görgyi Prize for his groundbreaking discovery that mesothelioma can be transmitted through families in a Mendelian fashion, driven by inherited mutations in the BAP1 gene. His research has transformed how the disease is understood, diagnosed, treated and prevented worldwide.
The National Comprehensive Cancer Network has launched a new version of its Distress Thermometer and Problem List in over 70 languages to screen patients for mental, physical, social, or spiritual distress. The tool aims to enhance cancer care by identifying psychological distress and providing support.
Dr. Byron L. Cryer brings extensive experience to the AGA presidency, with expertise in gastroprotection and upper gastrointestinal pharmacology. He has authored over 150 peer-reviewed publications and served on various academic leadership roles.
A phase 2 clinical trial found that burosumab safely restored normal phosphate levels and improved physical function in patients with severe fibrous dysplasia. Key findings include reduced pain, fatigue, and mobility impairment, as well as significant improvements in children's mobility and independence.
A new study reveals that humans in Sri Lankan tropical rainforests were consistently consuming plants and animal resources, with a gradual shift toward greater plant consumption over time. This trend begins in the Late Pleistocene and continues into the Holocene, far earlier than the first confirmed evidence for domesticated crops.
A new approach enables computers and machines to capture images at higher resolution and faster speed, making it impervious to reflective surfaces. The technology uses a virtual screen created by repurposing the surroundings of specular objects.
Research found that Western honey bees and myrtle rust fungus have formed an invasional mutualism, where the fungus is nutritious for bees. The fungus remains viable in beehives for over a week, potentially spreading human-assisted to other areas.
Researchers at the Francis Crick Institute have developed a new method to enhance anti-cancer immunity by redirecting non-specialized immune cells to present a broader range of tumor antigens. This approach, leveraging understanding of dendritic cell biology, has shown promise in reducing tumour growth and amplifying responses in mice.
Researchers estimate blue buttons can survive for several years drifting on the ocean surface, much longer than previously estimated. The float that keeps them afloat grows new rings from its outermost layer, expanding over time.
A meta-analysis of 10-year data from 4 randomized trials found no significant difference in all-cause mortality between DES PCI and CABG. Long-term follow-up supports considering both approaches for suitable patients.
The ARTICA meta-analysis investigated the safety and effectiveness of coronary revascularisation in patients undergoing TAVI, providing comprehensive insights into the optimal role of PCI. The findings suggest a potential benefit of selective, physiology-informed PCI in patients with severe aortic stenosis and CAD undergoing TAVI.
A subgroup analysis of the CHAMPION-AF trial reveals that left atrial appendage closure (LAAC) efficacy and safety are not affected by age, suggesting it can be considered for suitable candidates regardless of age. The choice between LAAC and DOAC should be made on an individualized basis in a shared decision-making process with patients.
A study found that universal free school meals can decrease out-of-school suspensions by 10% in elementary schools and 6% in middle and high schools. This impact was more pronounced in schools with fewer eligible students before implementing the policies.
Older patients with accessible advance directives in electronic health records had 25% less potentially burdensome end-of-life care and 31% fewer hospital deaths compared to those without these directives. The associations were attenuated among patients with dementia and Black patients, highlighting the need for targeted research.
Researchers found that aerobic exercise counteracted oxidative stress and inflammation caused by nanoplastics in female zebrafish. Exercise also improved neuroendocrine health by altering gut microbe balances.
Researchers have used fungal light-producing enzymes to track processes like tumor progression and inflammatory responses. The study reveals the role of caffeylpyruvate hydrolase (CPH) in breaking down oxyluciferin, allowing for sustainable bioluminescence.
Roxana Mehran is recognized for her impactful work on improving outcomes for patients undergoing interventional procedures. She has contributed to major trials, including the TWILIGHT trial, and advocates for women in medicine through initiatives like Women As One.
Researchers found medaka in semi-natural conditions ovulated 3.5 hours earlier than those in laboratory settings due to environmental differences in light and water temperature fluctuations. This study highlights the need to consider these factors when interpreting model organism research.
A University of Waterloo study uses mathematical modelling to explore how Vitamin C affects digestion-related cancer risk. The research suggests that consuming Vitamin C-rich foods like leafy greens may decrease cancer risk, while taking supplements after meals could have a moderate positive effect.
A new study found that handwriting speed and stroke organization can be indicative of cognitive decline in older adults. The research used digital tools to record writing speed and number of strokes in complex tasks, and found that participants with cognitive impairment showed distinct patterns in their handwriting movements.
A team of material scientists has developed a new catalyst that boosts electrocatalytic nitrite reduction to ammonia, overcoming two major bottlenecks in the process. The catalyst features Ni2+-Bi0 dual active sites, achieving high activity and selectivity for ammonia synthesis.
Archaeological studies of Roman-Byzantine villages in Syria reveal advanced construction techniques and domestic layouts that can inform future restoration projects. The findings offer an extensive analysis of building materials used in the construction of a village called Ba'ude.
A Princeton study projects persistent shortfalls in critical EV battery materials if domestic production expansion, demand-side strategies, and international sourcing are not aligned. Domestic expansion can meet projected demand for some key materials, but significant uncertainties remain.
A new study suggests that an earlier first sexual intercourse may be associated with a less favorable multidimensional aging profile, including shorter longevity and higher frailty. The researchers found that genetic differences in early sexual debut were linked to poorer health outcomes later in life.
Researchers created a multifunctional material platform by integrating 2D MXene nanosheets with liquid metal, enabling both high conductivity and electrochemical activity. The MXene-assembled liquid metal hybrid microparticles (MLHMs) demonstrated excellent interfacial adhesion and stability, making them suitable for real-world dynamic...
A breakthrough solution has been unveiled for decarbonizing the transportation sector, particularly heavy-duty marine shipping. The Ammonia Thermal Atmosphere Compression Ignition (TACI) combustion mode achieves highly efficient, stable and clean ammonia diffusion combustion under mild operating conditions.
Researchers develop bond-centric framework to selectively activate C-H and C-C bonds in biomass and plastics for sustainable valorization. The review proposes a roadmap for industrialization, focusing on precise bond discrimination, high solar-to-chemical energy conversion efficiencies, and hybrid systems.
Researchers develop silver-single-crystal silicon nanodisk antenna to overcome the picosecond tail in ultrafast optics. By extracting energy before lattice heating, they achieve modulation in the tens-of-femtoseconds range.
A University of the Sunshine Coast study identifies two psychological patterns that predict men's intention to engage in 'stealthing', a form of sexual violence. Men with a strong sense of entitlement and those who exhibit punitiveness are more likely to commit the crime, while those with greater confidence in condom use are less likely.
A new study led by Murdoch University found that children of parents with severe mental illness are more likely to experience cognitive difficulties. The study analysed data from over 1.5 million people and found that offspring tended to perform lower across several cognitive domains, particularly where a parent had schizophrenia or bi...
A new study found that fexaramine, a gut-targeted drug, improved both metabolic and reproductive problems in PCOS model mice. The treatment restored disrupted menstrual cycles, reduced ovarian follicles, and lowered testosterone levels, suggesting a potential new approach to treating PCOS.
A new UC San Diego study reveals that women are more vulnerable to dementia risk factors affecting cognition, with some risk factors having stronger impacts on women than men. The findings suggest a greater need for targeted interventions, such as managing depression and improving cardiovascular health.
Tiny forelimbs in meat-eating dinosaurs, including T. rex, were linked to strong skulls and jaws used for attacking large prey. The study found a correlation between reduced forelimb size and skull robustness, suggesting that tiny arms evolved as a byproduct of powerful heads.
A new study found that urbanization-related changes in the song of European songbirds can have important consequences for birds living in noisy cities. While some species exhibit a broader dominant frequency range in their songs, others do not adapt to urban environments.
Researchers from Harrington Discovery Institute provide a new understanding of cancer processes and identify promising targets for treatments. They uncover a class of therapeutic targets that may complement existing therapies.
Adults should aim for 560-610 minutes of moderate to vigorous exercise a week to achieve significant cardiovascular risk reduction. Current guidelines are too low, and individuals with lower fitness levels need more exercise to achieve equivalent benefits.
The University of Utah is launching a groundbreaking testbed, SMART, to accelerate the development of breakthrough technologies in rare earth elements. The initiative aims to strengthen domestic supply chains and address the nation's growing need for critical minerals.
Researchers found that restricting menthol in cigarettes reduced cigarette purchases, while flavor restrictions in e-cigarettes increased nicotine replacement product sales. Tax policies also showed promise, with the highest-tax approach leading to significant reductions in spending.
Scientists have documented humpback whales travelling over 14,000km between their breeding grounds in eastern Australia and Brazil, setting new records for the greatest distances ever confirmed. The findings highlight the value of citizen science and suggest climate-driven changes may be making such crossings more likely.
Patients with breast cancer and low vitamin D levels experienced moderate to severe postoperative pain, while those with sufficient vitamin D levels reported less pain. Vitamin D deficiency was also associated with increased opioid consumption and nausea.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
The Critical Infrastructure Security Institute (CISI) at Texas Tech University will advance research, innovation and collaboration in national security and critical infrastructure protection. The new site expands capacity for cutting-edge solutions to emerging security challenges.
The total cost of emergency admissions for mental health among children and young people in England rose from £22.5 million to £87.3 million between 2012/13 and 2021/22, driven by increases in admission rates and lengths of stay. Eating disorders and self-harm were the two most costly conditions, with over 80% of total mental health co...
A new study suggests that the specific sedatives used during critical illness in early childhood may have long-term implications for a child's neurocognitive development. The research found that treatment with dexmedetomidine, rather than opioids and benzodiazepines alone, was associated with better neurocognitive outcomes.
Scientists confirm decades-long prediction by measuring the color-changing effect of light in chiral carbon nanotubes. The material converts light at a rate two to three orders of magnitude greater than conventional materials.
A new open-source trajectory-planning system, MIGHTY, has been developed by researchers at MIT and the University of Pennsylvania. The system enables robots to generate smooth flight paths while reacting to obstacles in real-time, making it suitable for applications such as search-and-rescue, last-mile delivery, and industrial inspection.
A recent study found significant increases in amputation rates among both opioid- and non-opioid-related hospitalizations between 2016 and 2022. Opioid-related amputations were more common at higher anatomical levels, highlighting the need for earlier intervention to prevent severe harm.
A low-cost game that can identify patients with depression in just three minutes has been developed by NYU Langone Health researchers. The game uses neurobiological studies to measure how patients' decisional reference points respond to changes in their environment, providing clues about what is happening in their brains.
A new study by the University of Portsmouth and Marine Conservation Society reveals widespread presence of toxic PFAS in the Solent's waters, wildlife, and seabed. Levels of PFOS exceeded safety limits, and most species sampled exceeded health benchmarks when considering combined effects.
A recent study by UC Berkeley researchers found that rates of violence against women have remained largely unchanged in California, with Black and multiracial women facing the highest risks. The study analyzed 763,000 assault injuries in California from 2005-2022 and found persistent racial disparities.
The American Ornithological Society recognizes Devon DeRaad and Fengyi Guo for their outstanding work in ornithology, while Olivia M. Smith receives the Ned K. Johnson Award. The award winners will present their research at the AOS annual meeting in Amherst, Massachusetts.
A centuries-old genetic mutation has been discovered in French-Canadian populations, revealing a significant association with an increased risk of pancreatic cancer. The 'jumping gene' causes DNA repair disruptions, leading to a 10-fold higher incidence in pancreatic cases compared to unaffected individuals.
A new study from UC San Diego suggests that advanced large language models (LLMs) can exhibit human-like tone, humor, and fallibility in conversations, making it increasingly difficult for humans to distinguish between them and actual humans. This has major implications for how we think of AI, as the Turing test is no longer just about...
Neutrophils have been found to manufacture a protein called C4A, which has been linked to schizophrenia. This discovery ties together various observations about the disorder and could lead to better treatments and diagnostics.
ISSCR 2027 will bring together scientists, industry leaders, and students to discuss breakthroughs in development, regeneration, AI, and bioengineering. The meeting emphasizes scientific exchange and career development through networking events and mentoring opportunities.
Researchers at Duke University developed a new approach to deliver GLP-1 medications orally that maintains efficacy without requiring fasting. The technique uses an elastin-like polypeptide-based delivery system that protects the peptide from stomach acid and releases it in the intestines, bypassing the stomach's destructive acids.
A study published in Nature Communications identified over 50 previously unknown genes that affect lipid composition in the human body. These findings may provide a better understanding of aging processes and pathological conditions such as Alzheimer's disease, diabetes, and cardiovascular dysfunctions.
Alan G Hinnebusch's pioneering work established the paradigm and mechanism of translational control underlying the Integrated Stress Response. His discovery of key regulators and their conserved role in humans has led to a greater understanding of stress responses and potential therapies.