A BUSM in vitro study discovered a potent combination therapy for breast cancer, including triple-negative and hormone-refractory cases. The treatment re-expressed imprinted tumor suppressor genes, inhibiting cancer cell growth and promoting death.
A new analysis found that physical activity may reduce breast cancer risk by 30% in women, with moderate activity providing the greatest benefit. Exercise before or after menopause also shows promise in reducing breast cancer risk, particularly for hormone receptor-positive tumors.
Research finds that physical activity, regardless of intensity, may reduce breast cancer risk in women. Exercise before or after menopause can lower the risk, especially for hormone receptor-positive tumors.
Researchers uncovered surprises in genes previously thought uninvolved in breast cancer, revealing the complex drivers of this leading cause of cancer death. The study found novel fusion gene MAGI1-AKT3, which acts as an oncogene and offers new therapy targets.
Researchers discovered that NOG enables breast cancer cells to invade bone and establish tumors by increasing osteoclast activity and keeping cells in a stem-cell-like state. This gene plays a key role in the complex process of metastasis, increasing breast cancer's potential for spreading to the bone environment.
Researchers have identified androgen receptors as a key target for treating breast cancer, leading to the development of enzalutamide as a potential new therapy. The study suggests that blocking these receptors can inhibit cancer growth, offering new hope for patients with hormone-dependent breast cancers.
Researchers identify nine new genes that drive breast cancer development, highlighting the genetic diversity of the disease. The study provides insights into the consequences of this diversity and its implications for treatment.
A multicenter study found that the Breast Imaging and Reporting Data Systems (BI-RADS) terminology used by radiologists is useful in predicting malignancy in breast lesions detected with MRI. Features such as irregular shape, spiculated margins, and marked enhancement are most predictive of cancer.
A new study reveals that automated breast ultrasound can detect additional clinically significant breast cancers missed by mammography, in just three minutes of physician time. This technology is a game-changer for women with dense breasts, who are at higher risk of missing cancer diagnoses.
A Moffitt researcher has received a $100,000 grant from General Electric to develop a genetic tool that can identify an individual's predisposition to developing or resisting breast cancer metastasis. The study aims to evaluate inherited changes in DNA predictive of and identify risk for developing or resisting breast cancer metastasis.
Researchers discover Perp, a protein involved in cellular 'glue', plays dual role in preventing breast cancer. Abnormal levels of Perp linked to enhanced inflammatory response and tumor development.
Researchers at Mayo Clinic have discovered a new class of molecular mutation in various forms of breast cancer, which may shed light on the development and growth of different types of breast tumors. Fusion transcripts, the mutated forms of RNA, could provide a way to identify tumor subtypes and offer new strategies for treatment.
A new study has found a link between injectable contraceptives and increased breast cancer risk in young women, particularly those who have recently used the birth control method. Recent DMPA use for over a year was associated with a 2.2-fold increased risk of invasive breast cancer, which dissipates after discontinuation.
A large-scale genetic study reveals that triple negative breast cancer tumours exhibit a continuum of different types, making them difficult to treat. The discovery highlights the importance of tailoring cancer drug treatment to individual tumour profiles.
African American women are more likely to have estrogen receptor (ER) negative breast cancer due to genetic variations in the vitamin D receptor. Vitamin D deficiency is also common among these women, but those with specific genetic variations may have reduced risk.
A study found that combining annual mammography with screening ultrasound in women at high risk for breast cancer and dense breasts resulted in a higher detection rate of incident breast cancers. Supplemental MRI further increased cancer detection, adding 14.7 cases per 1,000 women.
Breast imaging tests have been shown to be ineffective in improving patient outcomes and healthcare quality for women with breast pain. The study analyzed over 900 cases, revealing that these tests did not provide significant reassurance or diagnostic value.
A recent study published in Radiology found that mammography-detected breast cancers in women between the ages of 40 and 49 have a significantly better prognosis compared to non-mammography detected cases. This is attributed to earlier detection and treatment, resulting in lower recurrence rates and mortality.
A study published in American Journal of Pathology reveals that trefoil factor 3 (TFF3) protein, which protects the epithelial surface in normal breast tissue, also promotes tumor invasion and metastasis in breast cancer. Higher TFF3 expression is associated with a more aggressive phenotype.
Researchers at UCLA's Jonsson Comprehensive Cancer Center found that radiation treatment converts normal breast cancer cells into treatment-resistant stem cells. These induced breast cancer stem cells have a 30-fold increased ability to form tumors, undermining the effectiveness of radiation therapy.
Research found parabens in breast tissue of all study participants, regardless of underarm product use, indicating alternative sources. The study detected five common paraben esters in 60% of samples and high levels of n-propylparaben near the armpit.
Breast cancer mortality is higher in Hispanic women compared to non-Hispanic white women, with a 20% increased risk of death. The ethnic disparity may be attributed to tumor phenotypes less responsive to chemotherapy, which affects long-term survival rates.
Research found that diabetes increases breast cancer risk by 37% in women diagnosed within four years of cancer development. Obesity after age 60 also significantly increases the risk, with a 55% increase in breast cancer cases compared to the general population. High and low blood lipids were also associated with different risks.
A meta-analysis of 123 randomised trials involving 100,000 women with breast cancer shows that modern chemotherapy regimens reduce breast cancer mortality by around one-third compared to no chemotherapy. The findings suggest that standard 1980s chemotherapy regimens could produce a reduction of almost a quarter in breast cancer mortality.
Research found a significant link between women with lobular breast cancer and fathers with prostate cancer, with the risk of lobular cancer almost doubling when considering family history. The connection was independent of hormone receptor status.
The new guidelines recommend no routine mammography screening for women aged 40-49, and extend the screening interval to every 2-3 years for women aged 50-74. The task force also advises against routine clinical breast exams and breast self-exams in asymptomatic women.
A recent study found that women taking combination estrogen and progestin menopausal hormone therapy are at a greater risk of developing breast cancer if they experience new onset breast tenderness. In contrast, women on estrogen alone without breast tenderness did not have an increased risk of breast cancer.
A large study found that 53% of male breast cancer patients experience tamoxifen-related side effects, leading to early discontinuation. The study suggests that these patients may be at increased risk of cancer recurrence.
A new study from Washington University School of Medicine finds that adolescent girls with a family history of breast disease have a higher risk of developing benign breast disease as young women, and this risk rises with increasing alcohol consumption. The researchers suggest limiting alcohol intake to lower risk or avoid increasing it.
A new study found a significant association between adolescent alcohol consumption and increased risk of benign breast disease among girls with a family history of breast cancer. Consuming more alcohol was linked to a higher risk, particularly in those with rapid height growth spurts.
Researchers at Johns Hopkins Medicine have developed a new breast cancer therapy that delivers anticancer drugs directly into the breast ducts via the nipple. The treatment has shown no major side effects in human patients and has been effective in animal models, with some drugs even preventing tumors from forming.
A new study finds that both dense and non-dense fat tissue are independently associated with an increased risk of breast cancer. The research used sophisticated computer software to analyze mammograms of postmenopausal women with breast cancer, comparing them to controls without cancer.
A new study finds that women who undergo advanced post-mastectomy breast reconstruction experience significant gains in psychological, social, and sexual wellbeing just three weeks after surgery. However, physical wellbeing at the abdominal location may not improve until later.
A new model estimates that the probability of a woman with screen-detected breast cancer surviving is likely below 10%, contradicting previous claims. The study's findings suggest that the benefit of screening mammography may be lower than previously thought.
Researchers at Huntsman Cancer Institute have discovered a new way to model human breast cancer that could lead to predicting which breast cancers will spread. The model was created using tumor tissue grafted into mouse mammary glands and found that it accurately predicted the behavior of human breast cancers.
Post-menopausal women with high hormone levels, including estrogen and testosterone, have a higher risk of breast cancer. Researchers found that each additional elevated hormone level increases risk by 16%. The study suggests that models assessing breast cancer risk could be improved by considering multiple hormone levels.
A large study of over 10,000 breast cancer patients found that radiotherapy significantly reduces the risk of cancer recurrence and mortality. The study found that radiotherapy almost halves the 10-year-risk of recurrence and reduces the 15-year-risk of mortality by a sixth
A recent study published in Nutrición Hospitalaria found that obese women, particularly those with morbid obesity, develop breast cancer at a significantly earlier age. The researchers discovered that the age at first menstruation is a key factor in determining the development and diagnosis of breast cancer.
Researchers discovered a gene has opposite effects in prostate and breast cancers, promoting growth when 'on' or 'off'. This finding suggests treating prostate and breast cancers requires distinct strategies, with blocking AR effective for prostate cancer but supporting AR production for breast cancer.
Post-menopausal women experiencing new onset breast tenderness after starting combination hormone therapy may have an increased risk of breast cancer compared to those without breast tenderness. Higher breast density is associated with a higher risk of breast cancer, with extremely dense breasts posing a four to six times higher risk.
The American Cancer Society reports a decline in breast cancer death rates among women in affluent areas, shifting the burden to poor women who have lower screening rates. The study highlights disparities in access to prevention and treatment services.
Researchers have found a rise in male breast cancer cases over the past two decades, despite low awareness. The study highlights the need for better information, treatment, and emotional support for men affected by the disease.
Dr. Giuliano was awarded the Brinker Award for Scientific Distinction for his pioneering findings on lymph node removal and his contributions to less invasive breast surgery. His research has led to improved quality of life for women with breast cancer and reduced side effects from breast surgery.
A phase III clinical trial has shown that combining everolimus and exemestane significantly improves progression-free survival for women with advanced breast cancer resistant to hormonal therapy. The combination treatment resulted in an improved survival of nearly seven months compared to women treated with only exemestane.
A University of Melbourne study found that women with a strong family history of breast cancer but no genetic link are not consistently utilizing breast cancer services. They often struggle to interpret their risk and manage it effectively, leading to inadequate access to screenings and interventions.
A multi-institute team led by TGen will study triple-negative breast cancer, a highly aggressive form of the disease that disproportionately affects African-Americans. The research aims to uncover new ways of treating this aggressive form of breast cancer by understanding molecular makeup of breast cancer stem cells.
Researchers identified the cellular origin of a rare form of breast cancer, metaplastic carcinomas, which originate from basal epithelial cell types. The study used mouse models and cancer-causing genes introduced into healthy breast cells to understand the cellular beginnings of cancer.
Black women are more likely to develop a second breast cancer, even if they were not previously diagnosed with the disease. The average age for this development is significantly lower in black women compared to white women.
A protein discovered by Dr. Suresh Alahari's laboratory can inhibit breast cancer cell growth and reduce tumor progression. The research found that Nischarin, a novel protein regulating breast cancer cell migration, acts as a tumor suppressor in breast cancer.
The Translational Genomics Research Institute (TGen) has been awarded $50,000 by the Inflammatory Breast Cancer Research Foundation to discover the genetic origins of Inflammatory Breast Cancer (IBC), a rare and aggressive form of breast cancer that rapidly progresses without warning.
A University of Maryland study found that young women with early-stage breast cancer who undergo lumpectomy and radiation have similar survival rates as those who undergo mastectomy. The analysis of nearly 15,000 patients showed no difference in overall or breast cancer-specific survival between the two groups.
Researchers have identified new genetic markers for patients at high risk for bone metastasis, which may provide additional targets for preventing and treating the disease. A novel vaccine for HER2+ breast cancer is also being developed to address a particularly aggressive form of the disease.
Research presented at the Era of Hope conference explores genes that contribute to breast cancer risk in African Americans and the possibility of mitigating it through vitamin D intake. Additionally, studies examine how daughters of BRCA mutation carriers manage their own risk of breast cancer.
Researchers present novel approaches to breast cancer treatment, including reconstituted cholesterol as a drug delivery model and heat-activated peptide therapy. These methods aim to improve patient outcomes by reducing side effects and increasing targeted treatments.
Tamoxifen therapy for 5 years improves survival by about a third in women with hormone-sensitive breast cancer, according to an analysis of over 20,000 patients. The treatment reduces the risk of breast cancer recurrence and death in ER-positive disease, regardless of chemotherapy use.
A study found that women with dense breasts are at higher risk of certain breast cancers and their tumors are more likely to be aggressive. Breast density was also linked to specific tumor characteristics, including ductal carcinoma in situ (DCIS) and estrogen receptor-negative tumors.
A randomized trial found that manual breast milk expression was more effective in improving breastfeeding rates than using a breast pump, especially in the first two months. Manual expression also led to higher comfort levels and more frequent breastfeeding among mothers.
A recent study shows that regular breast screening with mammography significantly reduces the number of deaths from breast cancer. Over 130,000 women were monitored for nearly three decades, and results indicate that 30% fewer women in the screening group died of breast cancer.
A large-scale Swedish trial shows that regular mammography screening reduces breast cancer mortality by 30% over seven years. The study's findings confirm the long-term benefits of mammography screening and provide new insights into its impact on breast cancer deaths.
A team of researchers has identified a new breast cancer tumor suppressor called Runx3, which regulates gene expression and targets the estrogen receptor alpha. The study found that Runx3 suppressed breast cancer cell growth and inhibited tumor formation in mice, offering potential benefits for early detection and treatment.