Researchers at UCSF have discovered that a mother's immune response prevents fetal acceptance of transplanted blood stem cells, but their own stem cells can be used to overcome this issue. The study suggests that using maternal stem cells could lead to successful treatment of genetic diseases before birth.
U-M researchers found that breast cancer stem cells are regulated by mesenchymal stem cells from the bone marrow, creating a 'niche' for the cancer cells to replicate. By blocking signals from this niche, researchers hope to target and kill breast cancer stem cells using existing medications.
Researchers developed a gene therapy strategy using parthenogenetic embryonic stem cells, which can differentiate into multiple tissue types and potentially reduce rejection problems. The approach shows promise for treating autosomal dominant diseases like Beta Thalassemia, tuberous sclerosis, or Huntington's disease
Researchers at UC Santa Cruz identified a crucial molecule for blood stem cells' niche in the bone marrow, potentially improving transplant safety and efficiency. The study's findings may lead to safer and more effective treatment options for cancers like lymphoma and leukemia.
Researchers found that male pattern balding may arise from a problem with stem-cell activation rather than the numbers of stem cells in follicles. The team discovered that bald areas had the same number of stem cells as normal scalp, but were depleted in progenitor cells.
Scientists at King's College London have made a critical discovery about the role of beta-catenin in leukemia stem cells. By suppressing this protein, they were able to reverse leukaemic stem cells to a pre-leukaemic stage and 're-sensitize' resistant cells to treatment.
Researchers at the University of Rochester Medical Center have created a way to isolate pure preparations of neural stem cells directly from human brain tissue. This breakthrough technique saves months of time and labor in the laboratory, allowing scientists to study stem cells in unprecedented detail. The findings suggest that human n...
Studies reveal that stem cell transplantation is safe and effective in treating various hematologic malignancies, with no significant increase in overall cancer risk. Researchers found a promising new treatment to prevent chronic graft-versus-host disease, a serious complication of stem cell transplantation.
Researchers discovered a protein necessary for normal cell division in blood-forming stem cells, which resulted in abnormal numbers of chromosomes and high rates of cell death. This finding highlights the metabolic differences between stem cells and other blood-forming cells.
A study has revealed a relationship between blood cells and their stem cell 'parents', influencing gene expression and behavior. The discovery opens up new research avenues into diseases caused by stem cell disorders.
UC San Diego undergraduate bioengineers develop a new microenvironment that provides all three types of cues necessary for stem cell growth and differentiation. The system uses a gelatin-like hydrogel bathed in an electrolyte solution, mimicking the natural environment to steer stem cells towards specific cell types.
Researchers at Duke University Medical Center discovered a novel feedback mechanism controlled by the Zif protein that regulates the balance of brain stem cells. This discovery has implications for understanding neural stem cell self-renewal and may lead to new therapies against brain tumors and diseases.
A recent study published in Stem Cells journal has awarded human cord-blood research with a $10,000 prize for its potential to cure acute kidney injury. The research revealed the regenerative potentials of human cord-blood stem cells as a future cell therapy.
Stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. Upon re-feeding, insulin-like peptide expression and stem cell numbers recover quickly.
Researchers found that nerve cell activity regulates balance between stem cells and mature nerve cells in the developing brain. The study suggests that abnormal brain activity may have long-lasting effects on brain development and could lead to new therapies for neurodegenerative diseases.
Researchers tested three MRI contrast agents on different stem cell populations and found changes in stem cell proliferation depending on the agent used. The study revealed varying labeling efficiencies with each agent, but no significant alterations in cell phenotypes or differentiation.
University of Pittsburgh researchers have developed a 3D system to mimic colon cancer stem cell growth patterns. They found that some cancer stem cells produce differentiated cells, while others produce self-renewing cells, paving the way for testing new therapies.
A team of researchers has generated 100 new lines of human induced pluripotent stem cells (iPSCs) from individuals with lung diseases, including cystic fibrosis and emphysema. The new stem cell lines could lead to new treatments for these debilitating diseases.
A team of Singaporean scientists has made a major breakthrough by discovering the most important genes in human embryonic stem cells, which are crucial for treating debilitating conditions. The researchers identified a particular gene called PRDM14 that makes it easier to turn adult cells into pluripotent stem cells.
Researchers at Rockefeller University identified a gene called Sept4 that regulates programmed cell death in precursor cells, which can increase the risk of developing cancer. The study found that mice lacking the Sept4 gene had twice as many hematopoietic stem cells and were more susceptible to tumors.
Researchers at Karolinska Institutet have discovered how stem cells and other cells repair damaged spinal cord tissue in mice. The study identified ependymal cells as a key player in this process, which is crucial for developing therapies for spinal cord injury.
Research in the Journal of Tissue Engineering reveals that stem cells detect surface features with mechanosensors, which modulate gene expression through biochemical signaling cascades. This understanding opens doors to develop improved clinical prostheses with topographies that directly modulate stem cell fate.
A team of researchers has found a way to increase the number of blood-forming stem cells by using a unique stretchy surface. This breakthrough could revolutionize stem cell transplants by generating up to three times more stem cells than current methods.
The annual Stem Cells Young Investigator Award is presented to a young scientist who published an important paper in the journal. The award recognizes innovative young investigators making significant contributions to stem cell biology and applications.
A new study reveals that mesenchymal stromal cells from wisdom teeth can be reprogrammed into stem cells, offering a potential source of treatment for patients. The cells displayed varying degrees of robustness and proliferated up to 100 times more efficiently than typical skin-cell-derived iPS cells.
A study published in Cell Stem Cell reveals that NURF, an enzyme that regulates DNA packaging, allows specific genes to be turned on and off in stem cells. This dynamic structure enables stem cells to maintain their potency and prevent differentiation into other cell types.
Researchers have discovered unique metabolic properties of bone-marrow stem cells that allow them to survive and replicate in low-oxygen environments. This finding may lead to new strategies for enriching stem cells by selecting those with specific metabolic characteristics.
A research team at the University of Georgia has discovered a critical role for the cancer-causing gene Myc in stem cell biology, which could revolutionize medicine by enabling patient-specific stem cells. The study found that Myc sustains pluripotency by repressing a master regulator gene, and its absence triggers differentiation.
For the first time, researchers have identified and isolated adult mammary stem cells in mice using a genetically modified mouse model. The tagged stem cells exhibit bright green fluorescence under a microscope, representing a new alternative to induced pluripotent stem cells for various medical applications.
The University of South Florida researchers warn that the growing number of stem cell journals may compromise the quality of research in the field. They recommend authors to follow Good Publications Practices when choosing a publication outlet.
A UCSF-led team discovered a key reason why blood stem cells are prone to developing genetic mutations that can lead to adult leukemia. They found that quiescent blood stem cells use an error-prone DNA repair mechanism, which can result in chromosomal instability and contribute to hematopoietic abnormalities.
A study by Dr. Paul Frenette reveals a unique 'partnership' between bone marrow stem cells, which could lead to advances in regenerative medicine. The partnership involves hematopoietic stem cells (HSCs) and mesenchymal stem cells, with the latter playing crucial roles in maintaining HSCs and facilitating regeneration.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have found that adult stem cells vital for lung repair are associated with a poor prognosis in patients who develop cancer. These cells may mutate into cancer-causing stem cells, making them a potential target for prevention strategies and new targeted therapies.
A team led by Drs. Michael A. Matthay and Jae W. Lee found that bone marrow stem cells secreted a protein that restored the lung barrier, preventing fluid and other elements from entering the lungs. The study suggests that this therapy may be a viable option for preventing respiratory failure in critically ill patients.
Researchers at UCSF have successfully purified one type of human embryonic stem cell using a novel, high-throughput strategy that avoids genetic engineering. The technique links two existing technologies and enables the separation of pure stem cells from teratoma-forming cells at a rate of about 25,000 cells per second.
Researchers found that human embryonic stem cells and reprogrammed cells exhibit very few differences in gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers. This study suggests that reprogrammed cells may indeed hold clinical promise ascribed to them earlier.
Stem cell differentiation is a crucial process that can be accelerated using a novel type of matrix, adjusting its stiffness without altering its chemical composition. By analyzing traction forces and cellular behavior, researchers predict stem cell differentiation as early as Day 1.
Researchers are developing a method to identify and purify stem cells from patients themselves that can give rise to beating heart cells. This approach aims to create an ideal product for transplant to repair heart damage caused by heart attack or cardiomyopathy.
A new technique developed by Professor Fiona Watt's team allows for the examination of individual stem cells to learn about their biology and screen new drugs. This approach has demonstrated its potential to encourage stem cells to repair damaged tissues.
Researchers at UC San Diego identify new signaling pathway critical for embryonic stem cells' self-propagation, finding that inhibiting this pathway reduces teratoma formation. This breakthrough enables a potential solution to the major obstacle in developing human embryonic stem cell therapies.
Researchers identify a protein released by neural stem cells that induces signaling in glioblastoma cells, causing them to differentiate. This discovery could lead to new therapy concepts targeting tumor stem cells and potentially destroying the aggressive brain tumors.
Cancer stem cells have been identified in a model of human lung cancer, but their uniqueness varies between tumors depending on the tumor's genetic signature. The study suggests that targeting specific cancer cell populations based on the tumor genotype may lead to personalized and effective treatments.
Researchers discovered a key regulator of spermatogonial stem cell self-renewal by manipulating the STAT3 protein. This process may be linked to degenerative diseases in humans, highlighting the importance of understanding stem-cell activity in disease prevention and treatment.
Researchers at the University of Michigan have developed a new synthetic stem cell growth matrix that overcomes major challenges in human embryonic stem cell research. The new coating, made from a water-soluble gel, has been shown to support long-term growth and maintenance of pluripotency in human embryonic stem cells.
A UCI study identifies the body's immune system as a key player in navigating transplanted stem cells to injured areas in the central nervous system. Adult neural stem cells were shown to be guided by CXCR-4 receptors and chemokine proteins to specific sites, where they differentiated into oligodendrocytes to repair damaged tissue.
Researchers at Karolinska Institutet have successfully cultured human embryonic stem cells under chemically controlled conditions without the use of animal substances. This breakthrough enables large quantities of human embryonic stem cells to be produced in a completely defined environment, paving the way for future clinical uses.
Rensselaer Polytechnic Institute has been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program to create an upstate center of excellence for basic stem cell research. The grant will be used to build sophisticated laboratories with high-throughput culture and imaging equipment, enhancing stem cell research...
Embryonic stem cells can switch between different cell types, indicating a potential for pluripotency. Researchers hope to understand this process to create specific cell types in the lab.
Researchers at Linköping University discovered a new function that regulates stem cell production of different types of cells in various parts of the nervous system. The study found that Hox genes, similar to a GPS system, guide stem cells to produce specific nerve cells in certain regions.
A new study compares induced pluripotent stem (iPS) cells and embryonic stem cells in modeling fragile X syndrome, a genetic disorder. The research reveals that the two cell types behave differently in the disease model, with iPS cells not fully replicating the gene silencing process.
Researchers successfully transplanted endometrial stem cells into the brains of mice with a Parkinson-like condition, restoring partially dopamine levels. This finding raises the possibility of women serving as their own stem cell donors and banks being established for men and women with Parkinson's disease.
Researchers at PMH discovered that progesterone alters breast stem cells, a finding with significant implications for breast cancer risk. The study shows how hormones affect breast stem cells during the reproductive cycle, providing a new pathway to understanding cell growth leading to breast cancer.
UCI scientists Marian Waterman and Aileen Anderson receive grants totaling $2.6 million to study human stem cells for therapeutic use and biomedical innovation. The research will further understanding of how stem cells survive and remain pluripotent, potentially leading to breakthroughs in induced pluripotent stem cell therapies.
Einstein will increase research space and recruit new stem cell scientists with the new facility expansion, focusing on four broad themes: stem cell biology, genetics, cancer stem cells, and translational stem cell research. The renovation is expected to create 150 new jobs and drive scientific innovation for multiple diseases.
A new strategy for reprogramming human adult cells into induced pluripotent stem (iPS) cells has been successfully developed, eliminating the need for oncogenes. This innovation offers improved safety and efficiency for producing patient-specific stem cells for therapeutic applications.
The Rutgers Stem Cell Research Center has derived new human embryonic stem cell lines, addressing concerns of contamination in previously approved lines. The center also offers a training course for stem cell scientists, with over 100 trained researchers to date.
Researchers solve the decade-old mystery of fragile human embryonic stem cells by discovering two novel synthetic small molecule drugs that promote cell survival. The team also unravels the mechanisms behind e-cadherin's role in cell signaling, providing a new understanding of stem cell biology and paving the way for potential therapies.
Researchers at UTHealth are developing new strategies to derive hematopoietic stem cells from pluripotent stem cells, which could potentially treat blood diseases. Additionally, they are exploring gene-corrected induced pluripotent stem cells for treating two pediatric lung diseases, Surfactant Protein B Deficiency and Cystic Fibrosis.
Researchers at Cedars-Sinai Heart Institute have developed a method to guide cardiac stem cells using micro-size iron particles and a magnet, increasing retention in the injured area and enhancing heart function. This innovative technique shows great promise for improving the effectiveness of stem cell therapies for heart disease.
Researchers discover a commercially available supplement stimulates production of hematopoietic stem cells, repairing the body. The supplement increases levels of these cells in the blood over a two-week period, showing potential for treating conditions associated with low cell counts.