Researchers at Tokyo Medical and Dental University identified a microRNA molecule that can silence specific cancer-promoting genes, overcoming resistance to certain drugs. The study found that the miRNA target multiple genes and pathways simultaneously, making its impact potent.
Researchers found that miR-513b-5p attenuates autophagy and tumor growth in liver cancer cells by targeting PIK3R3. The study suggests miR-513b-5p as a promising therapeutic target for hepatocellular carcinoma.
A new study reveals that four miRNAs can effectively inhibit SARS-CoV-2 replication, with lower levels in elderly and diabetic individuals. Exercise boosts the level of these miRNAs, providing better protection against COVID-19.
A new genetic engineering platform has been established in methylotrophic yeast Pichia pastoris, enhancing homologous recombination rates and genome editing efficiency. This breakthrough can enable the stable loading of over 100 exogenous genes and precise regulating of gene expression.
A recent study has identified specific miRNA signatures associated with EGFRI-induced skin rash, suggesting potential treatment-dependent biomarkers for this common side effect. The research found that miR-21 and miR-520e serum concentrations were negatively correlated with the severity of skin rash.
A study has identified a microRNA-like small RNA encoded by SARS-CoV-2 as a reliable biomarker for stratifying severe COVID-19 patients from mild/moderate ones. This biomarker enables early detection of high-risk individuals, allowing for optimized treatment and improved treatment outcomes.
Researchers at the Hefei Institutes of Physical Science have developed high-power Er3+-doped mid-infrared lasers with peak powers over 0.33 MW and repetition rates up to 150 Hz. The lasers achieved quasi-continuous signals, making them promising candidates for dental ablation surgery and optical parametric oscillator applications.
A study by Kyushu University researchers found that deficiencies in key genes lead to an imbalance in neural stem cells, resulting in fewer neurons and more astrocytes. This imbalance disrupts brain function and leads to Rett syndrome symptoms.
Researchers at Jiangnan University developed a sensing platform to detect microRNA-205, a potential biomarker for radiation-resistant nasopharyngeal carcinoma. The method shows high sensitivity and excellent selectivity, enabling detection of miR-205 with a limit of detection of 4.78 nM.
The study reveals that 1B3, a novel synthetic miR-193a-3p mimic, consistently suppresses several pro-tumorigenic phenotypes in vitro, including reduced cell proliferation, viability, and induced apoptosis. The pleiotropic mechanism of 1B3 action supports its development as a novel therapeutic agent for cancer treatment.
Researchers at CNIC have discovered a specific blood marker for myocarditis, allowing clinicians to distinguish the disease from other cardiomyopathies. The biomarker, miR-721, was validated in numerous hospitals and has high sensitivity and specificity (>90%) for myocarditis diagnosis.
A Spanish research team has developed a low-cost, easy-to-use biosensor to detect breast cancer in its earliest stages. The biosensor provides results in under an hour and can help address limitations of current diagnostic methods.
Researchers at Newcastle University discovered that tiny pieces of genetic material, miR-424-5p, increase in early stages of heart disease in type 1 diabetes patients. This biomarker has the potential to define additional therapeutic options to help patients with type 1 diabetes.
Researchers developed an exosome-based therapeutic strategy to target and treat late-stage colorectal cancer by disrupting immunosuppressive factors. In preclinical models, this approach proved effective in enhancing the anti-tumor immune response and controlling tumor growth.
Scientists identified microRNA-29 as a powerful controller of brain maturation, which was found to be depleted in mice with autism-like symptoms. The study suggests that boosting levels of miR-29 could lead to therapeutic strategies for neurodevelopmental disorders like autism.
A team of scientists at the National Institutes of Natural Sciences has successfully developed a broadband mid-infrared (MIR) source with high beam quality, enabling simplified environmental monitoring systems. The MIR source facilitates industrial and medical applications, including gas detection and breath analysis.
Researchers at the University of Plymouth have discovered a biomarker, Fibulin-2 (FBLN2), that can distinguish between grade I and II meningioma tumours. This breakthrough could spare surgery for up to 85% of patients with lower-grade tumours, reducing the need for high-risk treatments.
Researchers discovered microRNA-4287 inhibits prostate cancer's progression and metastasis, leading to increased cell cycle arrest. The study found miR-4287 specifically targets SLUG and CD44, suggesting a potential diagnostic and therapeutic tool against advanced prostate cancer.
Researchers found that impaired microRNAs, particularly miR-30c, are responsible for the ineffective function of stem cells in diabetic hearts. Increasing miR-30c levels in the heart improves stem cell survival and growth, offering a novel therapy for treating type-2 diabetic heart disease
A study found associations between urinary miRNAs and cardiorenal outcomes, including blood pressure and eGFR levels, in Mexican children. The researchers identified several miRNAs associated with kidney function, blood pressure, and electrolyte biomarkers.
A new study from the University of Eastern Finland has identified two potential biomarkers, miR-9a-3p and miR-136-3p, which could serve as diagnostic biomarkers for mild traumatic brain injury. These microRNAs were found to be elevated in both animal models and human patients, suggesting their potential use in diagnosing the condition....
Researchers discovered pancreatic beta cells secrete miR-29 family members to promote insulin resistance and enhance hepatic glucose output. This finding reveals a new mechanism linking obesity-induced insulin resistance in type 2 diabetes's pathogenesis.
Sanjeev Bhalla, MD, has been recognized as the 2021 ARRS Distinguished Educator for his proven record of improving radiological education. He is a dedicated teacher and innovator in medical imaging.
A new imaging test can reliably distinguish breast cancer patients who are unlikely to benefit from hormone therapy. The test measures estrogen receptor functionality, and a PET scan detects increased progesterone receptors in response to estrogen stimulation.
Atrial fibrillation death rates in Europe are highest in wealthier countries, with women more likely to die than men. Lifestyle factors such as obesity and alcohol consumption in wealthier nations contribute to these disparities.
Researchers identified pancreatic β cell-derived exosomal miR-29 family as a new mechanism that regulates glucose homeostasis through liver. Exosomal miR-29s negatively regulate insulin signalling pathway via targeting p85 α, attenuating the suppression of insulin on glucose output.
Australian researchers have discovered a new mechanism by which prostate cancer cells can adapt and evolve into more aggressive forms, making them resistant to treatment. The study highlights the importance of targeting microRNA-194 to slow down and inhibit the growth of prostate cancer models with neuroendocrine features.
Researchers found a ubiquitin ligase complex that degrades miR-7 and other miRNAs in cells. This discovery sheds light on how cells dispose of genetic molecules regulating protein production.
Scientists have discovered a new RNA-centric mechanism that regulates the creation of a crucial cancer microRNA. The findings reveal that environmental stimuli can activate a 'hidden' layer of regulation, enhancing the efficiency of miR-21 processing and potentially leading to disease.
The study finds that high miR-708 expression is associated with survival rates in lung squamous cell carcinoma patients. Additionally, miR-708 decreases proliferation, survival, and migration of lung cancer cells by inhibiting PGE2 signaling.
Researchers found that miR-133b levels were significantly lower in FAP-associated Desmoid tumors than in sporadic Desmoid tumors, while SIRT1 mRNA levels were up-regulated. A negative correlation between miR-133b and SIRT1 was observed, suggesting a novel mechanism underlying progression of FAP-associated Desmoid tumor.
This study reveals that hypoxic exosomes promote sphere formation and stem-like phenotype in EWS cells by delivering enriched miR-210. The knockdown of HIF-1α led to decreased exosomal miR-210 levels, while inhibition of miR-210 attenuated sphere formation.
Researchers found that diabetes increases autophagy initially, but then decreases it due to the activation of tumor suppressor p53 and microRNA miR-214, leading to hypertrophy, scarring, and inflammation in the kidneys. This discovery offers a potential target for preventing or slowing kidney failure.
Hyeon K. Park, a renowned plasma physicist, has made seminal contributions to fusion plasma diagnostics through his original works in ECEI and MIR. His research enhanced the synergies with numerical modeling and theories, leading to rich discoveries of novel plasma physics phenomena.
Researchers at Washington University School of Medicine have developed an experimental imaging agent called Galuminox that detects inflammation via positron-emission tomography (PET) scans. The agent has shown promise in imaging inflammation in the lungs of mice with acute lung injury, and its potential uses include cancer treatment an...
Researchers at HSE University have discovered microRNA molecules that can bind to coronavirus genomes, slowing down their replication and potentially allowing the virus to delay an active immune response. The study found four families of human miRNAs with binding sites for all seven types of human coronaviruses, including SARS-CoV-2.
Researchers studied sleep patterns of astronauts before, during and after spaceflight to find that they slept an average of only 5.7 hours in space, with a 17.7% reduction in sleep efficiency. Sleep architecture also changed, with decreases in non-REM and REM sleep.
Researchers at Scripps Research have identified a new class of compounds that can restart cellular production of VEGF-A, a key factor in rebuilding blood vessels and muscle in damaged heart tissue. The discovery has the potential to revolutionize the treatment of heart failure and other cardiovascular diseases.
A first-in-human study found that MRG-110 significantly reduced miR-92a levels in healthy humans after a single intravenous dose. This inhibition has shown beneficial effects in animal models, including improved vascularization after myocardial infarction and accelerated wound healing.
A team of researchers at North Carolina State University has identified a microRNA, miR-218-5p, that enhances the molecular pathway responsible for promoting hair follicle growth. The study found that increasing miR-218-5p promoted hair regrowth in mice treated with 3D cultured dermal papilla cells.
A new method detects MIR images using Si cameras through non-degenerate two-photon absorption, enabling simple and efficient imaging. The approach avoids alignment artifacts and utilizes the nonlinear optical properties of the Si chip itself to trigger photo-induced charge carriers.
Researchers propose a novel vdW heterostructure for MIR light-emission applications using BP and TMDC materials. The BP-WSe2 heterostructure shows a type-I band alignment, enhancing MIR photoluminescence by ~200%. In contrast, the BP-MoS2 heterostructure forms a type-II band alignment, enabling efficient MIR electroluminescence.
Research found that miR-133b levels were significantly lower in FAP-associated Desmoid tumors than in sporadic Desmoid tumors. SIRT1 mRNA levels were up-regulated in FAP-associated Desmoid tumor, suggesting a novel mechanism underlying progression.
Scientists have identified a microRNA in obese mouse mothers that increases the odds of liver cancer in their offspring and throughout future generations. The study found that maternal obesity causes susceptibility to liver cancer in offspring, with the severity increasing over generations.
miR-151a regulates endothelial cell motility and angiogenesis, with Slug expression required for these functions, providing new insights into the processes in the lung niche environment. The study highlights the potential of miR-151a as a therapeutic target against lung cancer.
Researchers discovered a microRNA named miR-126-5p that protects endothelial cells from damage and reduces atherosclerosis risk. By inhibiting caspase-3 activity, miR-126-5p maintains vascular integrity and prevents the development of atherosclerotic lesions.
A study published in Oncotarget found that physical activity can modulate miRNAs involved in breast cancer progression, leading to reduced cancer cell viability. The researchers identified two specific miRNAs, miR-206 and anti-miR-30c, which showed promising results as non-invasive biomarkers for breast cancer prevention.
Researchers at Karolinska Institutet have discovered a new mechanism by which microRNAs regulate protein production, potentially leading to new cancer treatments. The study focused on miR-34a, a microRNA that plays a key role in cancer by regulating the activity of the p53 protein.
Glioblastoma cells acquire radiation resistance by dumping exosomal microRNA miR-603, leading to increased protein production and insensitivity to radiation. This study reveals a new therapeutic strategy for overcoming cancer cell resistance.
The number of stroke evaluations at US hospitals has dropped by nearly 40% during the pandemic, suggesting many people are delaying medical care. This delay can lead to reduced access to life-saving treatments and increased risk of death and disability.
Researchers at Moffitt Cancer Center identified potential therapeutic targets for cutaneous squamous cell carcinoma by studying the activity of protein TAp63 and microRNAs. The study found that miR-30c-2* and miR-497, which are normally expressed in normal skin, are underexpressed in cuSCC tumors and inhibit growth when reintroduced.
Scientists from Japan's University of Tsukuba discovered a regulatory pathway governing the first quiescence period in Drosophila germline cells. This break is crucial for pole cell migration and gamete development. The study confirmed that the two rest periods are essential for Drosophila germline development.
A recent study published in Oncotarget found that microRNA (miR) dysregulation is associated with immune cell activation, gastric inflammation, and carcinogenesis. Specifically, miR-155 upregulation is considered a key marker of chronic gastric inflammation and predisposes patients to gastric carcinogenesis.
Researchers found that both strands of microRNA coordinate to act on the same cancer pathways, driving aggressiveness and growth. MicroRNAs miR-30a and miR-145 were identified as key players in keeping cancers in check, impacting patient survival.
Researchers at UCLA have identified a method to track the treatment of intestinal failure-associated liver disease (IFALD) in children by measuring the levels of micro-RNA 122. This non-invasive marker may be used to diagnose and monitor the disease without biopsies.
Scientists at St. Jude Children's Research Hospital have identified two critical microRNAs driving ventricular enlargement in models of schizophrenia. Reduced expression of these microRNAs leads to increased motile cilia movement and brain ventricle enlargement, highlighting a potential target for future treatments.
A recent study found that one in three children affected by the outbreak are yet to receive treatment, highlighting the need for urgent government intervention. The average age of children affected is just 3 years old, and most cases were transmitted through reused needles and contaminated blood products.
Researchers found luteolin suppresses both early stage prostate carcinogenesis and CRPC by inducing apoptosis. MicroRNA-8080 (miR-8080) recruited by luteolin down-regulates AR-V7, inhibiting tumorigenesis and enzalutamide resistance in CRPC.
A team of investigators from Brigham and Women's Hospital has identified a specific microRNA, miR-30d, that increases during peak disease in MS patients. Orally administering a synthetic version of the microRNA prevented disease in a preclinical mouse model.
Research reveals that adolescent binge drinking can lead to altered gene expression, increasing susceptibility to anxiety and alcohol use disorders in adulthood. Targeting specific microRNAs may be a new approach to undoing the damage of early-life alcohol exposure.