Barts Charity has awarded £6.5 million to Queen Mary University of London to transform its Charterhouse Square campus, featuring new labs, offices, and biorepositories for world-leading research in medicine and dentistry. The funding will support the expansion of research capacity and enhance collaboration among teams.
Researchers developed a method to measure 71 elements in water, beverages, and biological fluids simultaneously, providing a distinct 'fingerprint' to differentiate substances. This advancement has implications for fields like nutrition, ecology, climate science, and environmental health.
A new study from Western University identified the gene Panx1 as a key regulator of fat accumulation in mice. The research found that mice lacking Panx1 accumulated more fat and developed insulin resistance, increasing their risk for Type 2 Diabetes. Further studies are underway to explore the link between Panx1 and human obesity.
Researchers at UCLA will use a new liquid biopsy tool to test individuals at risk of lung cancer, with the goal of detecting the disease earlier. The technology aims to differentiate between cancerous and benign lung lesions, reducing unnecessary procedures and improving patient outcomes.
A study found that female-specific genetic mutation ATRX increases susceptibility to pancreatitis and pancreatic cancer. The research team discovered that deleting the gene in females led to increased progression to cancer, while males with the mutation experienced reduced risk of injury and progression to cancer.
Researchers at NYU Langone Health successfully guided the regrowth of missing bone in lab animals using chemically coated ceramic implants. The implants, made from beta tricalcium phosphate and dipyridamole, were naturally absorbed by the test animals' bodies as new bone gradually replaced the devices.
Cynthia Pine, a renowned researcher at Queen Mary University of London, has received the IADR E.W. Borrow Memorial Award for her groundbreaking work on preventing childhood dental caries. Her research focuses on promoting oral health in disadvantaged communities and developing interventions to improve parents' key dental health behaviors.
Researchers found that the PGC-1α gene controls the equilibrium of bone and fat in bone marrow and affects how stem cells differentiate into bone or fat cells. Increasing PGC-1α expression may slow down bone loss and decrease bone marrow fat, suggesting a protective role in maintaining the bone-to-fat balance.
Scientists have developed a biodegradable patch that sticks to the inside of the mouth, administering steroids directly to oral ulcers while creating a protective barrier. The novel plaster, called Rivelin, is effective in treating conditions such as oral lichen planus and recurrent aphthous stomatitis.
A definitive list of never events has been established in dentistry to ensure excellent patient care globally. The consensus includes routine assessments, surgery, and equipment sterilization errors.
The University of Louisville will receive a five-year, $11.2 million federal grant to establish an interdisciplinary research program focused on the microbiome, inflammation, and disease development. Researchers will study various diseases, including inflammatory bowel disease, periodontitis, and neurological disorders.
A NYU Dentistry study found that a comprehensive cavity prevention program with primary and secondary prevention strategies significantly lowers the rate of new and untreated cavities compared to traditional molar sealant programs. Both school-based programs reduced the risk of untreated decay over time.
Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities. The new technology restores mineral structure found in native tooth enamel, enabling daily use as part of preventive dental care routine.
A survey of 502 individuals found that patients are more willing to undergo non-invasive dental procedures such as teeth cleaning and whitening performed by a robot. The promise of half-price dentistry increased participants' willingness to accept robotic dentistry, with only 32% opposed at full price.
Barts and The London School of Medicine and Dentistry has been allocated additional 32 new places for local medical students, providing opportunities for students from diverse backgrounds. This expansion aims to increase the number of primary care staff in the area following graduation.
A study at the University of Minnesota School of Dentistry found a significant decrease in opioid prescriptions after implementing an opioid prescribing protocol. The analysis showed a 47.1% reduction in total opioid prescriptions and tablets per prescription written.
Researchers analyzed preschool-age children's supragingival microbiomes to understand early childhood caries (ECC) development. Notable differences in bacterial species abundance were found among caries-free, restored disease, and untreated disease groups, suggesting that restorative care alone may not reverse ECC-associated dysbiosis.
The symposium reviewed current developments and challenges in 3D printing and bioprinting for regenerating complex dental, craniofacial, and oral tissues. Researchers showcased their work on guided self-assembly, 3D-printed constructs, and geometric controls of periodontal tissue regeneration.
J. Bernard Machen, a renowned educator and researcher, has been awarded the AADR Honorary Membership for his dedication to public health and dental research. The American Association for Dental Research (AADR) recognized Machen's innovative leadership in dental education and unwavering support for research and discovery science.
Yogalakshmi Rajendran, an Assistant Professor at the University of California, San Francisco, received the fellowship for her clinical application of autologous blood products in regenerative dentistry and NIH-funded study on oral cavity microflora.
Teresa Dolan, a renowned researcher and clinician, was recognized by the American Association for Dental Research (AADR) with the 2018 AADR Jack Hein Public Service Award. The award honors her exemplary service promoting oral health research to a wide constituency.
A new blood test developed by University of Alberta physician Peter Hwang promises to eliminate the guesswork in diagnosing apparent heart attacks. By analyzing fragmented troponin levels, clinicians can better determine the extent of cardiac damage and make informed decisions about treatment options.
A recent study found that thousands of children with oral pain in London are being taken to pharmacies and non-dental health services, resulting in unnecessary use of NHS resources. The study highlights the need for integrated systems and better referral processes to ensure children receive dental treatment as soon as possible.
Researchers at NYU Dentistry have adapted an HIV test to create a rapid diagnostic test for Zika virus using saliva. The new test can detect both nucleic acids and antibodies of the virus in a fraction of the time of current commercial tests, producing results in minutes instead of hours or days.
A $5-million gift will help develop a new CASA Research Chair in Child and Adolescent Mental Health at the University of Alberta. This initiative aims to improve front-line care for children and youth with mental health and addictions issues, and will focus on community-focused research and evidence-based findings.
A scientifically based CAMBRA model, including risk assessment and aggressive preventive measures, dramatically reduces tooth decay in community dental practices. The study's findings support earlier research and have potential to transform dental care for high-risk patients at lower costs.
A new study published in Scientific Reports found that monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in bone loss responses to parathyroid hormone (PTH) in hyperparathyroidism. Elevated MCP-1 levels have been correlated with elevated serum PTH levels, and its presence may serve as a marker for PTH's effects in humans.
A new study found that elevated oral pathogens and decreased bacterial diversity are associated with precancerous stomach cancer lesions. The researchers suggest that treating chronic periodontal disease and controlling pathogen infections may help prevent stomach cancer.
Researchers discuss conventional versus newly introduced treatment modalities for managing orthodontic pain, highlighting the importance of individualized assessment and case-by-case decision-making.
Galla Chinensis has been identified as a strong potential agent in preventing dental caries due to its antibacterial capacity and tooth mineralization benefit. The main active ingredient of Galla Chinensis is unknown, but medium molecular weight gallotannins have been shown to be most effective.
UTHealth researchers identified a key factor in mid-life cell aging that can predict Alzheimer's disease decades before symptoms appear. The study found that mice lacking IL33 gene experienced dementia at age 68, highlighting the potential of this protein as a biomarker for early detection.
A 5-year NYU Dentistry-funded study will compare two cavity-prevention techniques in six rural New Hampshire counties, aiming to reduce oral health disparities. The research will assess the effectiveness of simple and complex treatments.
A team of researchers has developed an injectable antimicrobial gel that could improve root canal treatment outcomes by providing sustained antimicrobial properties. The gel, which has been shown to have extended residual antibacterial properties, is biocompatible and has minimal toxic effects on stem cells.
Researchers at UCLA School of Dentistry used nanodiamonds embedded with biomaterials to protect disinfected root canals, resulting in improved tissue healing and no infection in three patients. The study confirms the immense promise of using nanodiamonds for overcoming barriers in various medical procedures.
A study of over 1,000 Chinese individuals found a direct correlation between health and the microbes in their intestine. The researchers discovered that the overall microbiota composition of the healthy elderly group was similar to that of people decades younger.
A multi-center study funded by the NIH will test silver diamine fluoride's effectiveness in stopping cavities in young children. The trial aims to provide data for a cavity arrest drug claim and expand access to a simple, non-invasive treatment.
Researchers develop heat-treated magnesium alloy that outperforms titanium in implant applications, promoting bone growth and stability while avoiding complications like infection and corrosion. The T-5 alloy shows superior mechanical properties, lower degradation rates, and limited risks of rejection or infection.
Researchers develop microneedle technology to increase topical anesthesia penetration, reducing patient discomfort during dental procedures. The method has shown promising results in preliminary tests, with patients tolerating deeper injections.
Dr. Yu Zhang received nearly $3.7 million from the NIH's NIDCR to develop strong yet natural-looking materials for restorative dentistry. His research aims to create aesthetic, strong, and abrasion-resistant materials by developing new zirconia-based ceramics.
Researchers at NYU Dentistry have identified two proteins that regulate the formation of pearls, a process that could lead to the development of fracture-resistant materials. These materials could be used in dental implants, aerospace applications, or energy transmission.
A NYU College of Dentistry team will compare the effectiveness of two cavity-prevention techniques in elementary schools in the Bronx, with a focus on improving oral health equity. The five-year study aims to determine the most effective school-based prevention methods and their impact on quality of life and student achievement.
Researchers at NYU Langone Health's main hospital during Superstorm Sandy found that communication and social support were critical in connecting nurses with others during the crisis. The study also calls for more education and planning for future disasters, including training on power loss and 'all hazards' approaches.
Researchers at NYU Bluestone Center found that dopamine produced by melanocytes contributes to differences in skin responsiveness to heat and mechanical stimuli. This discovery may lead to more targeted and personalized pain treatment, as skin pigmentation affects sensitivity to temperature and pressure.
HIV-associated neurocognitive disorders (HAND) affect approximately one in four people living with HIV, causing symptoms such as memory loss and cognitive decline. Researchers have found elevated levels of microRNAs affecting brain development, providing a potential biomarker for diagnosis and monitoring disease progression.
Researchers at NYU College of Dentistry have identified succinate as a promising target to prevent bone fractures in people with type 2 diabetes. The study found that hyperglycemic mice had significantly higher levels of succinate, leading to more fragile bones and increased risk of fractures.
Researchers at NYU Dentistry aim to understand how immune cells contribute to sex differences in oral cancer pain. The study will determine if neutrophil infiltration affects pain levels in patients and explore a potential mechanism for improving pain management.
Researchers at OHSU developed a process to engineer new blood vessels in teeth, creating better long-term outcomes for patients. This innovation eliminates the need for synthetic biomaterials and restores biological response, potentially leading to improved tooth survival rates.
Researchers from NYU Dentistry studied a sea urchin protein that forms hydrogels, capturing mineral nanoparticles and organizing them into crystalline bricks. The protein, rSpSM50, induces fracture resistance and enables the creation of tunable fracture-resistant materials.
Researchers at the University of Illinois Chicago have discovered a natural compound in grape seed extract that can strengthen dentin and increase the life of resin fillings. The study found that the extract can make composite-resin fillings stronger, allowing them to last longer.
The research team will test a combination of new technologies that release antibacterial agents in response to acid presence, promising longer service life and improved dental applications. The novel materials aim to inhibit oral biofilm formation and have excellent physical and mechanical properties.
A new approach using a combination of silver, titanium oxide and hydroxyapatite nanocoatings successfully inhibited bacterial growth on dental implants by 97.5%, reducing the risk of peri-implantitis. The findings have great potential for increased patient comfort and satisfaction, as well as reduced costs.
A team of USC researchers has identified the intraflagellar transport 88 (IFT88) gene as a potential cause of human cleft lip and palate. The study found that three siblings born with the condition shared a common gene mutation, which was also present in mouse models.
Tom Hobman's lab has been awarded $500,000 to investigate how the Zika virus changes host cells during infection and develop antiviral therapies. The team aims to understand the virus's persistence in the body and potentially block it to prevent transmission.
Researchers at UCLA have discovered that targeting cancer stem cells and killing tumor mass with chemotherapy drugs results in better outcomes for patients with head and neck squamous cell carcinoma. The study also found that cancer stem cells cause cervical lymph node metastasis.
Scientists from Plymouth University Peninsula Schools of Medicine and Dentistry are investigating a potential new drug therapy for dementia diseases. They aim to understand how impaired autophagy, or cellular recycling, contributes to neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease.
A UAlberta study found that AC253 improves memory and learning in mice with Alzheimer's-like symptoms, reducing amyloid levels and inflammation in the brain. Further studies are needed to optimize dosage and effectiveness.
Researchers at UM SOM and SOD published 22 articles on infectious agents, vaccines, and immune system activation. Studies focused on Ebola, Clostridium difficile, biofilms, and other topics, advancing knowledge in infection and immunity research.
Researchers at NYU Dentistry are studying calcium control in dental enamel to develop improved strategies for preventing and treating dental caries. The goal is to understand how changes in calcium levels affect enamel mineralization and develop clinical techniques to replicate these processes.
New York University College of Dentistry has received a grant to investigate potential new compounds for treating osteoporosis. The researchers aim to understand the molecular mechanisms of parathyroid hormone-a related protein and its analogs to develop better-tolerated treatments.
The NYU Department of Pediatric Dentistry has received a $1.3M HRSA grant to develop a diverse and qualified cohort of pediatric dental faculty. The Growing Success program aims to improve oral health care for underserved populations through community-based rotations and mentorship.