Joanna Kreitinger, a University of Montana graduate student, has been awarded a prestigious immunology fellowship to study immune cell development and contribute to understanding lung diseases. Under Professor David Shepherd's leadership, her research aims to develop new drugs to treat diseases of the immune system.
Incorporating laboratory mice that are old and obese into immunotherapy treatments for cancer can hasten therapeutic breakthroughs. The use of young, healthy mice is often preferred, but this approach may not accurately reflect the human immune system's response to treatment.
The George Washington University School of Medicine and Health Sciences is conducting a phase 1 clinical trial to test a hookworm vaccine in an endemic area of Brazil. The trial aims to determine the safety and efficacy of combining two existing vaccines, with potential implications for global health.
Lomonosov Moscow State University scientists have developed a new method to extract DNA from various organisms. This breakthrough could lead to the creation of preventive vaccines against infectious diseases, allergies, and cancers.
Researchers identified key signal TBK1 drives Tfh cell maturation, promoting precise immune response. ICOS regulates B cell activation and specificity through TBK1 association.
Researchers at Cardiff University discovered a signaling molecule that can alleviate asthma symptoms such as mucus production and airway constriction. The study found that blocking this molecule can help regulate the allergic immune response, potentially leading to improved treatment options for asthma sufferers worldwide.
Researchers at the University of Minnesota have created a new model to study the human immune system, using 'dirty mice' that mimic the exposure to microbes found in humans. This new model has shown to improve the accuracy of potential therapeutics and vaccines.
A Massachusetts General Hospital study confirms the safety of allergy immunotherapy with no evidence of infections related to administration. The study analyzed 10 years of data from over 135,000 patients and found no soft-tissue or systemic infections attributed to AIT.
A study reveals Sharpin's role in regulating survival of immunosuppressive T cells, essential for preventing autoimmune disease and cancer. Sharpin-deficient mice develop severe skin lesions and inflammation due to reduced Treg counts.
A new study published in Science suggests that food tolerance emerges over time in normal individuals due to specific populations of T cells. The research found that consumption of a normal diet stimulates gut cells that suppress rejection of food by the immune system, making children more susceptible to food allergies.
A study published in Nature Immunology identified Trabid, a protein regulator, as a key component in regulating interleukin genes and promoting autoimmune inflammation in multiple sclerosis patients. This finding suggests that Trabid may be a potential therapeutic target for treating inflammatory diseases such as MS.
A study published in The Journal of Allergy and Clinical Immunology found that preventative treatment with omalizumab reduces fall exacerbations in a high-risk group of allergic asthma subjects. Increasing inhaled steroid treatment levels offered little to no additional benefit.
The La Jolla Institute will characterize immune responses to dengue virus and Mycobacterium tuberculosis with the HIPC grant. The research aims to identify effective gene signatures for vaccines against these diseases, which are major global health challenges.
Researchers at La Jolla Institute for Allergy and Immunology identified the matchmaker that brings critical calcium channel components together, allowing calcium to rush into cytosol. This finding provides a potential target for developing drugs to modulate T cell activation status.
A new study by the American College of Allergy, Asthma and Immunology found that 53% of siblings of children with food allergies had a sensitivity to a food, while only 13% had an actual food allergy. The study suggests that food allergy testing should be limited in these cases.
A recent study by the American College of Allergy, Asthma, and Immunology found that 34% of patients with cardiovascular disease were incorrectly labeled as having an aspirin allergy due to gastrointestinal symptoms. In reality, only 2.5% of patients had a true aspirin hypersensitivity.
A study by American College of Allergy, Asthma, and Immunology (ACAAI) found that patients who were told they had a penicillin allergy but tested negative could safely take the drug. Researchers examined records of 15 patients who received intravenous penicillin without adverse reactions.
Researchers have developed methods to overcome technical limitations in studying the immune system, allowing for investigation of interdependent components and their impact on functions at the systems level. The new book provides valuable insights into team science and the application of computational tools to model immunity.
Researchers discovered that macrophages and monocytes actively participate in multiple sclerosis progression, exacerbating disease severity through stress signals. The study highlights the significance of the crosstalk between the peripheral immune system and brain, opening new avenues for potential therapies.
Researchers found that patrolling monocytes play a key role in blocking lung metastasis by recognizing and scavenging tumor cells. This discovery could lead to new treatments for lung cancer by augmenting existing immunotherapy approaches.
A new review based on latest evidence interprets how to guide physicians and families regarding food introduction and allergy prevention. Introducing peanut between 4-11 months is now recommended for high-risk infants, contradicting previous avoidance diets.
A new article from the American College of Allergy, Asthma and Immunology recommends using epinephrine for all severe allergic reactions, regardless of symptom certainty. Experts stress that delays can have severe consequences, making epinephrine the most effective tool in combatting anaphylaxis.
A team of researchers at the La Jolla Institute for Immunology has identified LEF-1 and TCF-1 as master regulators that control the fate of T follicular helper cells. These transcription factors pre-program CD4+ T cells to respond to TFH induction signals, making them crucial for inducing a strong and lasting antibody response.
A Temple-led research team has discovered that bacterial biofilms found in the gut can provoke the onset of systemic lupus erythematosus (SLE) in lupus-prone mice. The researchers found that curli amyloid and DNA complexes in biofilms lead to inflammation, self-attacking antibodies, and autoimmune disease symptoms.
Dr. Steven Douglas has made significant contributions to the understanding of HIV infection through his work on immune cells and mechanisms of infection. His research has led to the identification of potential targets for treating HIV, including a pathway involving substance P and a cell receptor.
Researchers have discovered a way to stop lupus without suppressing the immune system by focusing on the TACI receptor. Deleting this receptor eliminates lupus in high BAFF levels, leaving natural immunity intact.
The journal Regenerative Medicine has published a special focus issue on methods to avoid immune rejection in regenerative medicine. The field is immature, but research continues to address the importance of immunity in progress and development.
Dr. Carl June is being recognized for his contributions to cancer immunology, particularly his development of chimeric antigen receptor (CAR) T-cell therapy. His work has enhanced the promise of cancer immunotherapy and led to significant breakthroughs in treating leukemia.
James P. Allison is being acknowledged for his discovery that blocking CTLA-4 signaling improves antitumor immune responses, leading to the development of ipilimumab, a cancer immunotherapeutic. His research has transformed the lives of patients with melanoma and offers hope for other forms of cancer.
James Allison, a renowned immunologist, has been recognized for his pioneering discovery that blocking CTLA-4 improves antitumor immune responses. His work led to the development of ipilimumab, an immune checkpoint inhibitor that transformed melanoma treatment.
Recent studies in Cancer Cell and Trends in Immunology review the intricate relationship between the immune system and cancer. Research has shown that harnessing anti-tumor immunity can be a promising approach to treating various cancers.
Researchers at Massachusetts General Hospital identified a protein called TREML4 that amplifies the cellular response to TLR7 receptor activation, leading to lupus symptoms. Suppressing this pathway may offer new hope for treating autoimmune disorders.
Dr. Elizabeth Jaffee receives the AACR-Joseph H. Burchenal Award for her pioneering contributions to immunotherapies for breast and pancreatic cancers, leading to improved treatments and patient outcomes. Her work also focuses on establishing biomarkers of tumor microenvironment reprogramming.
Researchers at the La Jolla Institute for Allergy and Immunology report that Nuclear Factor of Activated T cells (NFAT) plays a key role in CD8 T cell exhaustion, leading to impaired immune responses. The study identifies NFAT as a molecular hub that orchestrates T cell activation and exhaustion.
Researchers found evidence of prior exposure to Ebola virus among patients with Lassa fever in Sierra Leone between 2011-2014. The discovery suggests that the deadly disease may have been circulating in the area for years before the 2014 outbreak, sparking hope for prevention and control strategies.
A study published in the Journal of Immunology found that infusing memory cells can produce and repeatedly replenish all of the T-effector cells needed to fight CMV infection. This approach may improve on current therapeutic options for controlling CMV infection, which affects up to 80% of adults in the US.
A new UTMB study found that most patients using epinephrine autoinjectors incorrectly, with only 16% using the device properly. Inhaler users also made significant mistakes, with 63% missing three or more steps. Improving patient training is crucial to maximize medication effectiveness.
A two-year study by the Stand Up To Cancer - Cancer Research Institute Immunology Translational Research Dream Team found that pembrolizumab removes PD-1, freeing up immune cells to kill cancer cells. The study validated a pathway to determine patient responsiveness and anticipated better drug combinations for more patients with melanoma.
A new study by the American College of Allergy, Asthma and Immunology found that stocking emergency epinephrine in Chicago Public Schools saved the lives of 38 children and adults experiencing severe anaphylactic reactions. The majority of reactions occurred in elementary schools, primarily due to peanuts and fin fish triggers.
A study presented at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting found that spring pollen counts in Ontario, Canada were down considerably, with levels of certain tree pollens being four to five times lower than usual. This challenges predictions of a harsh 'pollen vortex' affecting allergy sufferers.
A recent study by the American College of Allergy, Asthma and Immunology (ACAAI) found that teenagers with asthma have higher health literacy levels than their caregivers. Additionally, a study on YouTube videos for asthma control revealed that most popular videos provide low-quality information, while videos from healthcare providers ...
Grad students require 'street smarts' for success in academia, with techniques like self-marketing and networking crucial for career advancement. The proportion of PhDs securing tenured positions has declined, emphasizing the need for efficient use of training time and professional connections.
The International Union of Immunology Societies is urging urgent funding and implementation of Ebola vaccine trials. Several promising vaccine candidates, including Cad3 Ebola and rVSV-ΔG-ZEBOV, are being tested in phase 1 clinical trials, showing safe and efficient results in non-human primates.
Researchers at NYU Langone Medical Center are working on a five-year contract to discover fundamental immunology, microbial genetics, and protein structure of Staphylococcus aureus. The goal is to identify Sa antigens that are crucial for effective immune defenses.
The San Antonio Life Sciences Institute has awarded over $750,000 in grants to researchers studying the intersection of immunity, microorganisms, and cancer. These collaborations aim to address public health issues and diseases with global impact, such as diabetes and cancer.
Dr. Surendra Sharma, a research scientist and professor at Women & Infants Hospital of Rhode Island, has received the Distinguished Service Award for advancing reproductive immunology research. His laboratory focuses on understanding premature birth and pregnancy complications.
A study by La Jolla Institute for Immunology identifies new genetic neighborhoods active in diseased cells, highlighting 33 genes that could be targeted with drug treatments. The research uses a novel approach to find specific genes associated with asthma, which may lead to more effective treatments.
Researchers at UT Southwestern Medical Center have discovered that type I interferons can block the development of T helper 2 cells, which drive asthma and allergies. This finding offers new hope for treating allergic asthma patients by targeting this pathway.
Researchers show that proliferation unlocks expression of Interleukin-10 in NK cells, a protein that moderates the immune system. This helps prevent hyperactivation of CD8 T cells, which can cause damage. The study provides another important role for lymphocyte proliferation and may help design vaccines.
A new study published in the Journal of Allergy and Clinical Immunology found that infants exposed to a diverse range of bacterial species in house dust during the first year of life are less likely to develop asthma in early childhood. The study, led by UCSF researchers, suggests that immune responses may be shaped by exposures during...
A team of scientists has identified a previously unknown form of lymphocyte that protects against intracellular infection, providing important insights into the human immune system. The discovery of these 'precursor cells' could lead to the development of new vaccination strategies to prevent intracellular infections.
Researchers discovered that a subset of immune cells called Th22 acts as a tumor helper, supporting colon cancer cells in renewing and developing stem cell properties. The study suggests targeting the pathway involving epigenetic factor DOT1L to potentially treat colon cancer.
Immunology is the study of the human immune system, which seeks out and destroys dangerous bacteria, viruses, and fungi. It also explores how its activity connects with other body systems, influencing metabolism, hormone levels, and overall well-being.
Researchers have discovered a new vulnerable site on the HIV virus that can be attacked by human antibodies, neutralizing its infectivity across various strains. This finding is crucial in developing an effective vaccine against HIV.
Researchers at Tufts University have discovered a mechanism linked to the development of severe schistosomiasis, a disease caused by parasitic worms. The innate cell receptor CD209a controls the magnitude of disease, with mice expressing high levels of CD209a developing severe inflammation.
The study found that HPV disrupts host-cell genes and chromosomes at sites of viral insertion, leading to overexpression or disruption of cancer-causing genes. This damage promotes the development of cancer by increasing the expression of viral E6 and E7 proteins.
Researchers at La Jolla Institute for Immunology have identified a novel interaction between Protein Kinase C-η and CTLA-4, a key immune checkpoint receptor. This finding may lead to new tumor immunotherapy strategies targeting CTLA-4.
Physician Emil J Freireich and scientist Jim Allison have been elected as fellows of the American Association for Cancer Research Academy, known for their contributions to cancer treatment and immunotherapy. Their work has driven significant innovation and progress against cancer, leading to improved survival rates for patients.
Researchers at Case Western Reserve University have found a novel population of neutrophils that produce Interleukin 17 (IL-17) and exhibit enhanced microbial killing activity. These cells may contribute to both controlling infection and causing tissue damage, highlighting the need for further regulation.
Immunologists have developed an improved mass spectrometric method for proteomic analyses, allowing for the identification and quantification of more proteins. The new technique, called ISOQuant, eliminates the need for labeling samples, enabling direct analysis of patient samples and specific immune cells.