Researchers identified protein patterns in bones that change with age, suggesting potential biomarkers for determining age in human remains. The study's findings have implications for forensic science and may help reconstruct ancient species relationships.
A new study found that DNA testing has a modest impact on sexual assault arrest rates, with most arrests occurring before laboratory results are available. In 7.6% of cases, DNA matches were made to suspects in the FBI's Combined DNA Index System database.
Glicksberg's study found that specimen pH, temperature and chemical structure had a significant influence on drug stability. Her research may help predict the stability of future synthetic cathinones.
A new analysis reveals that people with indigenous backgrounds are less likely to be identified after death due to inadequate family involvement and trust issues with government institutions. Non-governmental organizations can serve as bridges between families and authorities to improve identification rates.
Researchers from Australian National University have found that parturition scars on skeletal remains are not a reliable indicator of childbirth. The technique has been used in police investigations to narrow down identities, but it could lead to complications or delays if incorrectly applied.
Dr. Michael A Gimbrone, Jr has made significant contributions to the field of vascular biology through his research on endothelial cells and the development of methods for culturing these cells. His work has led to a paradigm shift in our understanding of vascular diseases and has paved the way for countless studies and discoveries.
Dr. Katerina A. Politi has made significant contributions to the understanding and treatment of EGFR mutant lung cancer. Her research has led to a paradigm-shift in the diagnosis and treatment of lung cancer, including the early adoption of molecular profiling.
Dr. Xiao-Ming Yin's pioneering research has significantly impacted our understanding of cellular degradation pathways, leading to novel cancer treatment approaches and potential therapeutic strategies for non-alcoholic fatty liver disease.
A systematic review of 15 studies found that most vulnerable nursing home residents are at risk of becoming victims, while legal examinations are often infrequent due to administration complexities. The report also highlights the underreporting of sexual assaults in nursing homes, with only 1% of staff-to-resident incidents reported.
A new study found that firearm threats by male partners are a significant predictor of post-traumatic stress disorder symptom severity in women. The study suggests that validated measures to assess firearm-related threat could be valuable predictive tools for identifying at-risk women.
Researchers have developed a new scientific technique that can analyze human hair to provide clues about a person's lifestyle. The technique uses liquid chromatography in conjunction with isotope ratio mass spectrometry (LC-IRMS) to identify 15 isotope ratio measurements that potentially yield crucial information about certain lifestyl...
A demo version of a new Pathology Atlas will be presented on April 2-5 at AACR17, offering information on human gene expression levels and their relationship with cancer patients' clinical outcomes. The atlas provides analysis on nearly 8,000 cancer patients across various major cancers.
Researchers at Brigham and Women's Hospital have discovered a new genetic variant linked to Tau pathology in Alzheimer's disease. The study, published in Molecular Psychiatry, highlights the potential for targeting the protein tyrosine phosphatase receptor-type delta (PTPRD) gene as a therapeutic strategy.
A new gene variant has been identified in the PTPRD gene that is associated with the accumulation of neurofibrillary tangles (NFTs) in the brain. The study found that this variant affects more than one mechanism of tangle accumulation and may be a key target for developing therapies targeting Tau pathology.
The Association for Molecular Pathology published consensus recommendations to validate next-generation sequencing (NGS)-based oncology panels. The guidelines address NGS test development, optimization and familiarization, and best practices for establishing test performance characteristics.
A study published in PLOS Medicine found that six unsaturated fatty acids are associated with Alzheimer's disease cognitive symptoms and neuropathology. The researchers analyzed brain tissue samples from older individuals with healthy brains, those with tau or amyloid proteins but no memory problems, and those with Alzheimer's disease.
A new study found that a diabetes drug called amylin improved learning and memory function in AD patients and reduced AD pathology in their brains. The findings suggest a potential blood test for AD using pramlintide.
Scientists at the University of Alberta have developed synthetic DNA motors that can be used for improved disease detection and drug delivery. The nanomachines demonstrate the potential for early diagnosis and targeted release of drugs within patients, resulting in fewer side effects.
Researchers at the University of Pittsburgh School of Medicine have identified a novel genetic mechanism and marker that may predict response to a class of drugs in many cancer types. Elevated levels of IGF2BP3 protein were found in both thyroid and other common cancers, suggesting its potential as a biomarker for treatment response.
A new approach to surgical pathology in brain tumor patients uses stimulated Raman histology, improving speed and diagnostic efficiency. The method, tested in an operating room, produces accurate results faster than conventional methods.
A new report in The American Journal of Pathology reveals that potent cytotoxins produced by group A streptococcus (GAS) contribute to the severity of 'flesh-eating disease'. Production of both NADase and streptolysin O is necessary for full virulence, and infections can be controlled better with toxin-deficient bacteria.
Researchers have identified a new virus as the cause of congenital tremors in newborn piglets, a potentially life-threatening disease. The discovery represents a significant diagnostic breakthrough, enabling detection through molecular methods and highlighting the risk of sexual transmission.
A scoring system, known as Dr. Logan's triage tool, can help law enforcement identify high-risk individuals who may pose a threat to criminal justice officials. The tool assesses danger-related factors such as rule breaking, violence at a young age, and substance abuse to predict attacks against police, judges, and other officials.
The Association for Molecular Pathology (AMP) has published a joint guideline to standardize the interpretation and reporting of sequence variants in cancer. The guidelines aim to improve patient care by establishing standardized classification, annotation, interpretation, and reporting conventions for somatic sequence variants.
Research at McGill University has identified a link between decreased X chromosome gene PPP2R3B expression and tumor progression in melanoma. The findings suggest that genetic specificity of the X chromosome plays a role in gender differences observed in melanoma prognosis.
A new study published in The American Journal of Pathology found that over 90% of bladder cancers lack the enzyme argininosuccinate synthetase 1, making them susceptible to arginine-degrading therapy. This approach has shown promising results in treating bladder cancer with low ASS1 expression.
A study by the University of Warwick found that around 50% of participants believed they had experienced fictitious events, such as taking a childhood hot air balloon ride. The findings have significant implications for fields like forensic investigations, therapy treatments, and courtrooms, where memories are used to inform decisions.
The study highlights the lack of research on bite-mark identification and its low validity. Forensic dentists' claims of unique dental signatures are unfounded, leading to wrongful convictions. Recent DNA exonerations support the rejection of bite-mark identifications as reliable evidence.
A new method for identifying illicit drugs has been developed, offering high sensitivity and fast results. This technique uses multi-dimensional chromatography combined with a micro-extraction method, allowing for rapid analysis in under 20 minutes.
Researchers developed an improved animal model of Alzheimer's disease using tau protein isolated from patient brains. The model replicates the formation and spread of brain fibrils associated with AD, offering new opportunities for investigating therapies to stop or slow their progression.
The black blow fly genome sequencing project provides a major resource for researchers studying unusual or dangerous insects. The study may benefit human health by advancing wound care and estimating postmortem interval, while also improving pest management through better understanding of insecticide sensitivity and resistance.
A novel technique using Direct Sample Analysis Time-of-Flight Mass Spectrometry (TOFMS) can identify NBOMe compounds on blotter paper in under 15 seconds. This method will help forensic laboratories efficiently analyze growing caseloads of designer drugs, potentially reducing the risk of fatalities and severe injuries.
Researchers identify direct link between brain inflammation and CTE, with longer football careers predicting increased inflammation and disease progression. The study suggests that treating inflammation could prevent or lessen CTE development, offering potential biomarkers for early identification.
Researchers developed a new method using atomic force microscopy to quantify the mechanical properties of hair, documents, fingerprints, and explosives. This can help improve the accuracy and reliability of forensic practices.
The Association for Molecular Pathology released a new report highlighting the potential of MALDI-TOF-MS in identifying invasive infectious diseases. The technology has been shown to accurately identify filamentous fungi and mycobacteria, but more testing is needed before its use can be recommended.
Researchers at Kansas State University have designed a soybean variety that protects against nematode parasites, which are the No. 1 soybean disease in the nation. The new variety could potentially save the soybean industry millions of dollars per year by controlling nematodes and their reproduction cycles.
Researchers at TGen and NAU used deep DNA sequencing to recreate the anthrax genome from Sverdlovsk, Russia victims, providing a precise examination of the anthrax strain used in Soviet biological weapons development. The study's findings put the strain into a global context, enabling forensic tracking and identification.
Researchers have identified a unique set of protein markers in human hair that could be used to distinguish individuals. The findings demonstrate the robustness of these proteins and estimate that they would be sufficient to provide a unique pattern for an individual among a population of one million.
A widely used brain cancer cell line, U87MG, has been found to be of unknown origin and different from the original patient tumor. Researchers used forensic and mitochondrial DNA profiling to trace the cell line's origin, revealing a potential mix-up or cross-contamination.
A commonly used cell line, U87MG, was found to have a different DNA profile than the original tumour it was established from. Genetic analysis revealed that the cell line likely originated from a human glioma tumour, highlighting the need for proper identification of cultured cells.
Researchers at Temple University Health System will investigate the combined impact of tobacco smoke and opiates on HIV-induced tissue damage in brain, lungs, and other organs. The study aims to better understand the pathology of HIV infection and develop new treatments for affected individuals.
A study led by a Michigan State University criminologist reveals that female forensic scientists face higher stress levels than males, with 78% reporting mid to high levels of job stress. Despite overall job satisfaction, scientists who testified more often in court and worked longer hours were happier with their jobs.
The Association for Molecular Pathology has developed a new framework for defining the clinical utility of molecular diagnostics, emphasizing the importance of context in interpreting test results. This approach aims to improve patient care by providing clinically useful and appropriate testing based on realistic evidence levels.
A University of Colorado Cancer Center study found that only 4.6% of cases had discrepancies between initial and final evaluations, with most being due to process errors or interpretation errors. The study aimed to reduce discrepancy rates by identifying trends and implementing changes.
Researchers at Purdue University have developed a new technique called RetroScope, which can recover multiple previous screens of an Android app from the phone's memory image. The technique uses the device's graphical rendering code to obtain and bring up several previous screens shown by an app.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
A survey of 628 US physicians reveals that shaken baby syndrome and abusive head trauma are widely accepted diagnoses among medical professionals. The study found that 88% of respondents acknowledged the validity of shaken baby syndrome, while 93% affirmed abusive head trauma as a diagnosis.
Forensic geneticists confirm that the blood found on the scene in 1934 is indeed that of King Albert I, contradicting conspiracy theories about his death. The study used DNA comparison with two distant relatives to verify the king's identity, providing historical importance and closure.
A research team found that a fungus, Pneumocystis carinii, plays a more important role in pneumonia than previously thought. The fungus was detected in piglets of all ages and appeared to proliferate before bacterial pathogens, suggesting it may be a 'door opener' for secondary infections.
Researchers aim to detect insider threats before they occur by analyzing digital forensic traces and identifying abnormal patterns in employee behavior. The new technology has the potential to prevent corporate espionage and widespread breaches like those committed by Chelsea Manning and Edward Snowden.
The NIST Ballistics Toolmark Research Database provides a statistical foundation for reliably linking bullets to the guns that fired them. The database uses 3D topographic surface maps to analyze bullet markings, allowing researchers to quantify uncertainty and develop more accurate bullet-matching algorithms.
The College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology announced a revised evidence-based guideline for molecular testing in lung cancer patients. The guidelines aim to improve patient selection and targeted therapies.
Researchers at Allina Health have developed an algorithm to simplify the complex pathology classification process for pituitary adenomas. The new system helps pathologists make a more accurate diagnosis with fewer tests, saving time and reducing costs.
Researchers found that blocking acetylcholine in genetically modified mice caused Alzheimer's-like pathology, highlighting the importance of this neurotransmitter for brain health. The study suggests that targeting one of the affected messenger RNA pathways may lead to a reversal of dementia progression.
Researchers found long-term damage to the blood-spinal cord barrier after ischemic stroke, leading to a 'toxic environment' in the spinal cord. This damage can cause further disability and exacerbate disease pathology, including motor neuron deterioration and motor dysfunction.
A new study finds that mental health professionals overestimate their ability to identify mentally ill patients who may engage in firearm violence. The researchers conclude that mental health professionals need more training on firearms issues to prevent firearm trauma by the mentally ill, with a focus on firearm suicides.
Research published in Frontiers in Psychology found that people who witnessed a crime can identify criminals through their distinctive scent. Human nose-witnesses were able to correctly identify perpetrators in almost 70% of cases, showing promise for forensic applications.
A new study published in Violence and Gender journal found that nearly 2 of every 5 bisexual female college students were victims of sexual assault. Greek life was identified as a strong factor linked to higher prevalence of sexual assault for most student groups.
Researchers at Cummings School of Veterinary Medicine found different injury patterns in abused animals and those hit by cars, with abused animals showing more head injuries and rib fractures. The study aims to help uncover animal abuse and provide a tool for forensic veterinarians.
New research from North Carolina State University finds cribra orbitalia, a condition with porous bone inside the eye sockets, is common in both North America and South Africa, affecting 12.35% of modern North Americans and 16.8% of modern South Africans. The high rates may be linked to iron-poor diet and intestinal parasites.