Researchers found diverse genomic changes in single neurons from Alzheimer's patients, showing that over 90% of sporadic Alzheimer's disease brains display highly significant DNA increases. Neurons from patients with sporadic Alzheimer's disease were four times as likely to contain more than two copies of the Alzheimer's-linked gene APP.
Researchers at Cleveland Clinic have linked trimethylamine N-oxide (TMAO) to chronic kidney disease, finding higher levels in patients with the condition associated with greater mortality risk. Elevated TMAO levels are also linked to cardiovascular disease and kidney disease progression.
Researchers found improvement in movement and motor skills in people with Huntington's after one month of triheptanoin therapy. The study showed that the synthetic oil could improve brain metabolism in early stages of the disease.
A saliva test for gum disease has been recognized by the National Institute of Health Research (NIHR) and may be made available 'over-the-counter'. The test aims to predict future damage caused by periodontitis, a common inflammatory oral disease linked to diabetes and heart disease.
A study found that decreased blood levels of Klotho increase the risk of heart disease in mice with chronic kidney disease, suggesting potential treatment strategy to protect kidney disease patients' heart health. If confirmed in humans, increasing Klotho levels may help protect the hearts of patients with chronic kidney disease.
A large cohort study found that women with celiac disease do not report fertility problems more often than women without the condition. However, rates of infertility were slightly higher among women diagnosed with celiac disease at a younger age, likely due to increased concern prompting earlier consultations.
Medical experts call for radical improvements in UK liver disease treatment and detection, citing a 'postcode lottery' for patients. The commission recommends increasing specialist centers and improving primary care services to address excessive alcohol use and obesity.
A new vaccine is being developed to prevent canine gum disease, a common condition that affects most dogs by three years of age. The vaccine targets the most common types of bacteria causing periodontal disease in dogs.
Research found that people with asthma had a 27% higher incidence of Crohn's disease, while those with COPD had a 55% higher incidence compared to the general population. The study highlights the importance of early detection and treatment of bowel diseases in airway patients.
Researchers found that blocking the ALS mutation in the brain slowed disease onset and progression, suggesting that early dysfunction of brain motor neurons may contribute to later disease development. The study used rats with ALS, showing delayed disease onset and extended survival when suppressing the mutation in the brain.
Researchers have identified key components in oats that trigger an immune response in some people with coeliac disease, potentially leading to better tests and new treatments.
A study of 699 African American adults found that those with severe periodontal disease developed chronic kidney disease at a rate 4 times higher than those without. Targeting periodontal disease may be an important path towards reducing disparities in chronic and end-stage kidney disease.
A recent study has discovered a genotype variant that speeds up the progression of amyotrophic lateral sclerosis (ALS) in mice, leading to faster disease progression and shorter life spans. The research aims to better understand the molecular pathway of this accelerated model to develop more successful drug trials for all ALS patients.
Two cholesterol management guidelines agree that nearly all patients with chronic kidney disease should receive statins, but 50% of those recommended are not taking them. The study found the Pooled Cohort risk equations to be accurate among people with CKD, indicating a valid tool for estimating heart disease risk.
Researchers created a cellular model of Parkinson's disease using human stem cells from identical twins with the disease. The study found that dopamine-producing neurons had reduced activity and higher levels of α-synuclein protein, which can be targeted for therapy.
Scientists discover that people with celiac disease also react to non-gluten wheat proteins, which could lead to improved understanding and treatments of the disease. The study identifies five groups of non-gluten proteins causing immune reactions in patients, suggesting a broader range of potential triggers.
Researchers found high rates of individuals testing positive for Chagas disease and related heart disease in Texas, with rates 50 times higher than CDC estimates. The study aims to increase awareness and diagnosis of this emerging infectious disease in the southern United States.
Researchers have identified chemical changes in DNA that could screen people for Crohn's disease and reveal possible targets for new treatments. These genetic changes can be detected in blood samples, opening the door to a simple test for the condition.
Researchers found that calcium build-up in coronary artery walls is a more useful indicator of heart disease risk in patients with CKD than traditional measures of atherosclerosis. The study suggests that this finding could help safeguard the heart health of millions of people globally who have chronic kidney disease.
A new study finds that calcium buildup in coronary arteries is a strong indicator of heart disease risk in individuals with chronic kidney disease. This measure outperforms other commonly used tests in predicting cardiovascular disease among CKD patients, who are at high risk for heart disease.
Death rates from heart disease and stroke are declining overall in Europe, but at differing rates. Cardiovascular disease remains the leading cause of death among Europeans, accounting for close to half of all deaths. However, cancer is now causing more deaths than heart disease in some countries, particularly among men.
Researchers have made significant breakthroughs in understanding the relationship between genetic changes and disease causation using next-generation sequencing technology. Subtle gene changes are now being associated with unique disease presentations, even in previously undiagnosed forms of disease.
Researchers have identified the mechanism by which Kennedy's disease causes muscle weakness and reduced fertility, impairing autophagy pathway function. The study suggests that targeting the bad androgen receptor protein could prevent the disease and other neurological disorders from progressing.
Researchers at UTHealth Medical School have found misfolded prion proteins in the urine of 13 out of 14 patients with variant Creutzfeldt-Jakob disease, providing a new potential diagnostic tool. This breakthrough could lead to the development of non-invasive tests for diagnosis and monitoring.
A Canadian national survey found that most women lack knowledge of heart disease symptoms and risk factors. Women surveyed were often unaware of their own risk status and had a low understanding of the major symptoms of heart disease.
Scientists have identified a novel mechanism of memory loss in Alzheimer's disease and propose new therapeutic targets, including the production and release mechanisms of GABA in reactive astrocytes. A MAO-B inhibitor showed promise in treating Alzheimer's disease model mice for a short time.
A team of researchers from the University of Pennsylvania and four other American universities will analyze genetic data from 6,000 individuals with Alzheimer's disease and 5,000 older individuals without the disease. The goal is to identify rare genetic variants that may protect against or contribute to the disease risk.
Researchers have identified genetic markers that can predict the development of celiac disease in infants. The study found a significantly higher risk for celiac disease among Swedish children compared to their European counterparts.
Two studies using different mouse models confirm that comorbid Alzheimer's disease and cerebrovascular disease significantly worsen learning and memory outcomes in mice. Researchers say the findings have potential implications for patients with both disorders, who account for approximately 40% of Alzheimer's cases.
A recent NIH-funded study found that children with two copies of a high-risk variant in specific genes have a 26% chance of developing early signs of celiac disease by age 5. The study also revealed higher rates of celiac disease in Sweden compared to the US and other European countries.
A study found that non-surgical gum disease treatment significantly reduced carotid artery thickening, a risk factor for heart disease. The treatment's systemic impact may help reduce cardiovascular disease risk, particularly in high-risk populations like Indigenous Australians.
A recent EULAR study found that obese patients with rheumatoid arthritis (RA) have higher disease activity scores than non-obese patients, irrespective of their disease stage. This suggests that treatment to target protocols may result in obese patients being treated more aggressively than non-obese patients.
A new study suggests revising the definition of kidney disease progression used in clinical trials could shorten trial length and encourage more trials. This revised definition, based on a decline in estimated kidney function, carries higher risks for end-stage renal disease and mortality but is common enough to facilitate testing.
A University of Florida study reveals that gum disease bacteria increase risk factors for atherosclerotic heart disease in mice, potentially changing how physicians diagnose and treat heart disease patients. The study's findings support a causal link between oral disease and increased heart disease risk.
Studies by Penn neurologists investigate the potential of statin use and estrogen to delay Parkinson's onset, with promising findings. Telemedicine is also shown to improve access to specialty care for patients with Parkinson's disease.
A study has identified two subsets of Lyme disease in patients with acute infection, characterized by varying levels of immune system molecules. Patients with high mediator levels experience more severe symptoms and are at higher risk of developing post-treatment Lyme disease syndrome. The findings may help doctors predict which patien...
A new study by LA BioMed Research found that a calcium score can predict heart disease risk among adults with minimal or no known risk factors. Adults with low to moderate calcium scores were more likely to die from heart disease than those with no calcified plaque buildup.
A new study found that ovarian cancer patients' disease-free survival rates significantly improved over time, particularly among those with poorer initial prognoses. The research suggests that considering the time elapsed since remission may provide a more accurate prognosis and inform better follow-up care decisions.
A study found that poor quality of life in African Americans with chronic kidney disease is associated with increased risks of disease progression and heart problems. The research suggests that improving quality of life may help protect patients' health, highlighting the need for better management of kidney disease-related health issues.
People with celiac disease may have a near two-fold increased risk of coronary artery disease compared to the general population. Researchers found that systemic inflammation and autoimmune processes might influence cardiovascular disease development.
A large-scale survey of 3.5 million Americans found that married people have a significantly lower risk of heart disease than singles, divorced, or widowed individuals. The study also revealed age-related differences in cardiovascular disease risk among married couples.
Research shows that vitamin D deficiency is associated with higher prevalence and severity of coronary artery disease. Patients with low vitamin D levels are at a higher risk of developing severe heart disease, and the study suggests that vitamin D may be beneficial in preventing heart disease.
A study of male military personnel found that those with a medical history of resolved childhood glomerular disease were more likely to develop hypertension as adults. The researchers suggest that glomerular disease during childhood may initiate kidney injury that manifests in adulthood.
Research suggests that shortening the time from symptoms to diagnosis has no bearing on survival or disease stage for most children with unilateral retinoblastoma. However, a longer lag-time between symptom onset and diagnosis is associated with a more advanced stage and worse survival in bilateral cases.
Researchers have identified specific bacteria that are abnormally increased or decreased when Crohn's disease develops, suggesting potential targets for treatment. The study used biopsies from over 1,700 patients to uncover how microbes contribute to the inflammatory cascade of Crohn's disease.
Researchers used ultra-high-field MRI to identify abnormalities in the substantia nigra, a key region affected by Parkinson's disease. The study showed promising results for early detection and classification of the condition, with high sensitivity and specificity rates.
A new study suggests that Alzheimer's disease contributes to nearly as many deaths in the United States as heart disease or cancer. Researchers analyzed data from 2,566 participants aged 65 and older, finding a significant association between dementia diagnosis and increased mortality.
A study found that people with both parents having Alzheimer's disease showed more severe brain abnormalities, including increased brain plaques and reduced brain volume. The research suggests a possible genetic link to the development of Alzheimer's disease.
The American Heart Association's annual statistical update reveals that heart disease and stroke remain major public health concerns in the US, claiming over 787,000 lives annually. Cardiovascular diseases account for more deaths than all forms of cancer combined, with nearly half of African-American adults affected.
A new study has found that heart disease is associated with an increased risk of cognitive decline and dementia in older postmenopausal women. Researchers analyzed data from nearly 6,500 U.S. women ages 65-79 and found that those with heart disease or vascular disease were 29% more likely to experience cognitive decline over time.
A study found that First Nations adults with diabetes are more than double the risk of developing end-stage kidney disease. The high rates of kidney disease among First Nations people are attributed to younger onset of diabetes, leading to increased survival time and likelihood of progression to end-stage renal disease.
Supplementation with multivitamins plus selenium reduced HIV disease progression, immune decline, and illness risk in antiretroviral therapy-naive adults in Botswana. The supplement delayed time to HIV disease progression and improved markers of immune function.
A large study identifies genetic variants that contribute to the progression of chronic kidney disease in African Americans. APOL1 risk variants were found to be associated with higher rates of end-stage renal disease and progression of chronic kidney disease among black patients compared to white patients, regardless of diabetes status.
African-American patients with chronic kidney disease have a faster decline in kidney function due to genetic variations, particularly the APOL1 gene variant. The study suggests that reducing the effect of this gene could lead to a significant decrease in progressive kidney and end-stage kidney disease in blacks.
A new study by Johns Hopkins Medicine found that young and middle-aged women with type 2 diabetes are at a significantly increased risk of coronary artery disease, comparable to men's risk. The study analyzed data from over 10,000 participants and suggests distinct genetic and hormonal factors may contribute to the higher risk.
Researchers say Chagas disease remains a leading cause of heart disease in impoverished North American communities, with inadequate healthcare and limited treatment options available. The editorial calls for increased medical awareness, scientific cooperation, and public-private partnerships to develop new tools and treatments.
A global collaboration of researchers has identified 11 new genetic areas of interest contributing to late onset Alzheimer's Disease. The study expands the scope of disease understanding to include new areas such as the immune system, where a genetic overlap with other neurodegenerative diseases was found.
Patients with moderate to severe psoriasis are at increased risk of developing chronic kidney disease, particularly those with severe disease. Closer monitoring and careful consideration of medications are recommended for this patient population.
Researchers identified 13 metabolites that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls. Twelve of the metabolites are linked to mitochondrial function, suggesting suppressed mitochondria as a fundamental characteristic of diabetic kidney disease.
Two studies published in BMJ Group found a significant association between aircraft noise exposure and cardiovascular disease hospital admissions. The research suggests that even low levels of daytime and night-time aircraft noise can increase the risk of heart disease, particularly among vulnerable populations.