Researchers at Cold Spring Harbor Laboratory have identified molecular signals that can convert tumor-promoting fibroblasts into beneficial ones in pancreatic tumors. By manipulating these signals, they aim to recruit tumor-restricting cells into the anticancer fight and develop a combination therapy approach.
A new study by Cold Spring Harbor Laboratory has identified new regulators of nitrogen use in plants, which may lead to the development of crops better suited to thrive under different environmental conditions. The researchers found that eliminating certain genes can stunt plant growth and distort roots when nitrogen is scarce.
Researchers at Cold Spring Harbor Laboratory have developed a new approach called Density Estimation using Field Theory (DEFT) to analyze small datasets, inspired by theoretical physics. The method fixes shortcomings of common statistical methods, providing more certainty in conclusions.
Researchers at Cold Spring Harbor Laboratory found that sustained lung inflammation can awaken dormant breast and prostate cancer cells, leading to metastasis. A new antibody approach may block this signaling pathway, preventing cancer recurrence.
Splicing errors can lead to faulty proteins, increasing disease risk. Researchers analyzed 32,000 DNA sequences to understand the rules guiding RNA processing and improve predictions of genetic mutations' impact on disease risk.
Scientists at Cold Spring Harbor Laboratory have published a detailed map of structural variations in breast cancer cells, revealing 20,000 genetic errors that disrupt cell growth and cause cancer's hallmark. The study sheds light on how cancer cells rapidly evolve and provides valuable insights for future research and clinical practice.
A new compound, DPM-1001, has shown promise in reducing copper levels in cells and improving symptoms of Wilson's disease. The study confirmed that the compound is orally available and specifically targets copper, reducing unwanted side effects.
Researchers have discovered a new type of small-cell lung cancer (SCLC) with distinct biological signatures, paving the way for developing personalized treatments. The discovery involves a novel transcription factor called POU2F3, which is expressed in a specific subset of SCLC tumors and may be targeted by specific drugs.
A new technology improves on retrograde viral tracing, enabling neuroscientists to study the connectivity of specific neurons and their functions. The 'receptor complementation' strategy eliminates tropism, a common problem in retrograde tracing, allowing for more accurate results.
Researchers developed a precision-medicine approach using patient-derived organoids to predict treatment responses in pancreatic cancer. The method identified specific gene signatures that can guide the selection of chemotherapy regimens, offering hope for improved survival rates and quality of life.
Researchers at Cold Spring Harbor Laboratory have identified a neural circuit in the amygdala that generates anxiety. The critical role of dynorphin was revealed, which could serve as a cellular target for treating anxiety-related disorders.
A team led by CSHL Professor Douglas Fearon found that dormant cancer cells are already in the liver before surgery, expressing MHC1 and CK19 markers. In a post-operative stress-induced state, these cells re-express markers and begin to divide, forming seeds of metastatic lesions.
Biologists at Cold Spring Harbor Laboratory have uncovered a structural variation in the NMDA receptor that enables it to function in low pH environments, such as those encountered during stroke or epileptic seizures. This adaptation could lead to new therapeutic strategies for treating neurodegenerative diseases.
Researchers have identified a therapeutic RNA molecule that corrects the genetic processing error causing familial dysautonomia by enabling human and mouse cells to produce normal levels of IKAP protein. The discovery provides proof of concept for potentially treating this rare disorder.
Researchers at Cold Spring Harbor Laboratory have discovered a genetic mutation associated with intellectual disability, developmental delays, autism spectrum disorder, and congenital cardiac anomalies. The mutation, in the NAA15 gene, is linked to Ogden syndrome, a more severe condition also caused by a mutation in the NAA10 gene.
Researchers at Cold Spring Harbor Laboratory discovered that cancer cells lacking tumor-suppressor protein PTEN are vulnerable to mitochondrial inhibitors, which induce them to consume glucose and quickly run out of energy. This finding suggests that such drugs could eliminate cancer cells while leaving healthy cells intact.
A new brain-mapping technology has revealed that neurons in the primary visual cortex communicate with higher visual areas of the cortex more broadly than previously believed, following specific patterns. This discovery could provide a means of linking visual information across the brain to form complex percepts.
A team of plant geneticists at Cold Spring Harbor Laboratory identified a protein receptor on stem cells that issues different instructions depending on the peptide fragment activating it. This multi-functional receptor has important implications for boosting crop yields, particularly in crops like corn and rice.
Scientists at Cold Spring Harbor Laboratory have discovered a way to rein in an overactive protein that drives some aggressive leukemias. The team's CRISPR-based system identifies two enzymes, LKB1 and salt-inducible kinase, as critical for the survival of certain AML cells.
Researchers have developed a method to identify splicing-based biomarkers for hepatocellular carcinoma (HCC), the most common form of liver cancer. These biomarkers may help predict disease progression and are associated with poor patient survival.
Researchers at Cold Spring Harbor Laboratory find a genetic mutation that increases grains in sorghum by tripling each plant's yield. By reducing hormone levels, they generate more flowers and seeds.
Researchers at Cold Spring Harbor Laboratory have discovered that a widely-studied cancer gene called MELK does not play a crucial role in cancer cell growth. The team's findings suggest that inherent flaws in scientific techniques used to link MELK to cancer led to the error.
A new study reveals that genetic factors causing autism spectrum disorders diminish brain cognitive functions, leading to lower non-verbal IQ. Motor skills also correlate with de novo mutations in ASD, making them a sensitive indicator of damage.
Researchers have sequenced the genomes of 13 wild and domesticated rice species, revealing valuable genetic information for developing new, efficient, and sustainable rice varieties. The newly created genetic resource provides insights into disease resistance genes, which could help reduce pesticide use and ensure reliable rice harvests.
A genome-wide analysis reveals that variations in gene enhancers and promoters contribute to species differences, with larger enhancer ensembles linked to stable expression levels. The study provides insights into evolutionary conservation and the impact of genetic regulation on behavior and morphology.
A multidisciplinary team has developed software called Scikit-Ribo to more accurately determine when cells translate RNA into protein. This method uses advanced statistical modeling techniques and can filter out noise from previous data, providing a clearer picture of translation dynamics.
A team of geneticists has discovered a mechanism that enables plants to count their chromosomes, solving a century-old problem. They found that small RNA molecules, called miR845, trigger the synthesis of secondary RNAs that silence key genes, preventing viable seeds from forming.
Researchers at Cold Spring Harbor Laboratory have developed a method to selectively disable the MYB protein, which enables cancer cells to proliferate. In tests in mice, this approach resulted in an 80% reduction in size of aggressive leukemia without harming normal cells.
A new method using single-cell genomics can help identify potentially lethal prostate tumors before surgery, improving risk assessment and treatment decisions. The approach analyzes genomic patterns in biopsy cores, assigning a score based on clonality and genetic aberrations.
Researchers at Cold Spring Harbor Laboratory have elucidated the mechanism by which newborn neurons migrate to their target destinations in the olfactory bulb. This process is crucial for maintaining proper neural function and may hold promise for treating brain disorders.
Research in mice reveals that the central amygdala, not the lateral portion, is crucial for aversive learning and associating sensory stimuli with threat. This finding has implications for treating disorders like anxiety and PTSD by modifying fear memories.
Researchers have gained insight into how the double helix unwinds in the earliest stages of DNA replication. The new cryo-EM images show that the twin helicase enzymes load head to head, forming a complex that positions one strand for extrusion and another as the leading strand.
A comprehensive study mapped specific cell types in mouse brains, revealing three major inhibitory cell types vary across cortical areas, and female brains have more modulatory neurons in certain subcortical regions. The study provides insights into brain function and has potential applications for understanding psychiatric disorders.
Researchers identify patterns of cell-to-cell communication as the core feature that makes possible rigorous distinctions among neuron types. The study points to 'core genetic recipe' for constructing diverse nerve cells, resolving long-standing debates about neuronal classification.
Plant geneticists have developed a new application of CRISPR technology to rapidly generate variants of crops that display improved traits. By mutating regulatory regions, the scientists can achieve subtle changes in yield traits, providing flexibility for improving crop yields. This method has the potential to break yield barriers and...
A recent study by Cold Spring Harbor Laboratory reveals the intricate interactions between chandelier cells and pyramidal neurons in the cerebral cortex. The research shows that these inhibitory cells can receive information from hundreds of excitatory cells, influencing their firing patterns and local circuit activity.
A team of scientists has made a groundbreaking discovery about the RNA interference (RNAi) machinery, revealing that it can multiply its effect on repressing gene expression. This process is essential for cell survival and regulation of genetic activity.
Researchers at Cold Spring Harbor Laboratory have discovered an epigenetic factor, FOXA1, that reprograms gene enhancers in cancer cells, allowing them to 'remember' an earlier developmental state and become metastatic. This mechanism is a major breakthrough in understanding the spread of pancreatic cancer.
A new library of CRISPR targeting sequences enhances precision and efficacy, reducing off-target effects. The tool facilitates multiplexing and combinatorial targeting, improving gene editing outcomes.
Researchers at Cold Spring Harbor Laboratory have identified the specific hormone receptors and brain regions responsible for masculinization in mice. The study found that estrogen receptor alpha is essential in inhibitory neurons for male sexual and aggressive behaviors to emerge, while deleting it had no impact on excitatory neurons.
Research sheds light on how conserved mechanism regulates development and cancer; implications for new cancer therapies. TUTase enzymes interact with let-7, a small RNA molecule important in development and cancer.
A team from Cold Spring Harbor Laboratory has discovered small RNA fragments that protect the genome from retrotransposons during epigenetic reprogramming in preimplantation embryos. These fragments, consisting of 18 and 22 nucleotides, are perfect complements of sequences within retrotransposons.
A new mathematical method identifies ancient genetic variations contributing to autism spectrum disorder, suggesting a small effect of each variant. The approach uses discordant siblings to find a clear signal of these shared variants, which are common among individuals with autism in both affected and unaffected populations.
Researchers identified natural genomic variation in Cryptococcus neoformans, influencing prevalence and disease severity. The study found specific variants associated with clinical isolates linked to known virulence factors.
The new maize genome provides unprecedented detail on gene regulation and variation, enabling scientists to understand how the plant adapts to changing conditions. This knowledge has huge implications for breeding and expanding maize's growing range as climate change intensifies.
Researchers identified BPTF as a protein essential for mammary stem cell maintenance and found that removing or inhibiting it causes stem cells to differentiate and die. This discovery provides hope for developing a drug that targets BPTF in breast cancer cells, potentially leading to the differentiation and death of these cells.
Researchers at Cold Spring Harbor Laboratory discover that adding beneficial traits can have negative consequences due to epistasis. They find a case of negative epistasis in a tomato plant and show how to exploit this knowledge to unlock untapped yield potential by adjusting the dosage of genes responsible for different traits.
Researchers discovered mutations in gene promoters that affect cell adhesion and axon guidance pathways in pancreatic cancer, providing new insights into its development and progression. These findings could lead to the identification of novel molecular targets for treatment.
A study led by Raffaella Sordella proposes a novel theory on how cancers circumvent targeted therapy killing power. The research suggests that genetic diversity in tumor cells, caused by non-genetic mechanisms, can help them survive and eventually relapse.
The study found extensive variation among Burkholderia cenocepacia isolates from cystic fibrosis patients, with changes in clinically relevant bacterial phenotypes. Genetic determinants of motility and biofilm formation may be promising targets for anti-virulence drugs.