Researchers at Columbia University have engineered tumor-colonizing bacteria to produce synthetic targets that direct CAR-T cells to destroy cancer cells. The probiotic-guided CAR-T cell platform has shown safety and effectiveness in multiple models of human and mouse cancers.
Researchers at Columbia University are using focused ultrasound to non-invasively open the blood-brain barrier, enabling delivery of gene-editing vectors to treat Alzheimer's and Parkinson's. The technology has shown promising results in reducing beta amyloid and tau loads, as well as improving memory deficits.
Researchers at Columbia University have developed a novel technique for isolating isotopes, which are crucial for energy, medicine, and scientific research. The new method is more effective, cheaper, and easier to scale than current state-of-the-art techniques.
Columbia University researchers have created a novel, fully organic bioelectronic device that can acquire and transmit neurophysiologic brain signals while providing power to the implanted device. The device features a tiny transistor and has demonstrated high electrical performance, long-term stability, and biocompatibility.
Researchers develop predictive model to control gene expression with high accuracy, enabling precise modulation of gene dosage. The AI-powered tool uses deep learning to predict on- and off-target activity of RNA-targeting CRISPRs, holding promise for treating viral infections and developing new therapies.
Researchers at Columbia University develop an energy-efficient method for transferring larger quantities of data over fiber-optic cables by using wavelength-division multiplexing and Kerr frequency combs. The new technology improves on previous attempts to transmit multiple signals simultaneously, enabling systems to transfer exponenti...
A new study finds that electricity market design plays a crucial role in trade-offs between more affordable energy and lower carbon emissions. Researchers discovered that participating in day-ahead markets reduces carbon emissions, while real-time markets reduce costs.
Researchers have developed a fully photostable and photoswitchable nanoparticle that can be controlled indefinitely using near-infrared light. This breakthrough has the potential to revolutionize fields such as optical memory, super-resolution microscopy, and bioimaging.
Researchers create an AI-based approach to predict precipitation intensity and variability, addressing the missing piece of cloud organization in traditional climate models. The new algorithm improves precipitation predictions, including extreme events, and enables better projections of future changes in the water cycle.
A new study shows that the Montreal Protocol is delaying the occurrence of the first ice-free Arctic summer by as much as 15 years. The treaty's implementation has postponed the melting of Arctic sea ice at this very moment, yielding measurable results within a few decades of its implementation.
Researchers engineered bacteria to visually record environment using swarm patterns and deep learning. The system can detect pollutants and toxic compounds in the environment, enabling a low-cost detection and recording system.
Scientists at Columbia University create a new class of integrated photonic devices that can convert light from an optical waveguide to an arbitrary optical pattern in free space. The devices simultaneously control all four optical degrees of freedom, paving the way for applications in quantum optics, optogenetics, and holographic disp...
The National Science Foundation has awarded Columbia University a $20 million grant to establish the AI Institute for Artificial and Natural Intelligence (ARNI), an interdisciplinary center focused on connecting AI systems to brain research. ARNI will bring together top researchers from across the U.S. to advance neuroscience, cognitiv...
Researchers at Columbia University have created a highly dexterous robot hand that combines advanced sensing technology with motor learning algorithms to achieve high dexterity. The hand can perform complex tasks such as rotating an unevenly shaped object without visual feedback, and even operates in dark environments.
Researchers create a 3D-printing system to construct cheesecake from edible food inks, enabling customizable foods with improved nutrient content. The technology could address issues with low-nutrient processed foods, making it appealing for individuals with dietary restrictions and those requiring personalized nutrition.
Researchers at Columbia University are developing algorithms that enable robots to understand object permanence and learn from 3D information. This allows robots to track objects and humans as they move around, improving their perception capabilities in indoor environments.
Researchers at Columbia University have developed a new 'camera' that can see atomic structures in real-time, revealing the dynamic disorder of materials. This breakthrough enables better understanding of thermoelectric devices and waste heat conversion, leading to more efficient sustainable energy applications.
Researchers developed a new technique to analyze frozen tumor specimens, enabling the study of rare cancers and unique patient histories. This breakthrough increases the number and variety of tumor samples available for scientific analysis.
Columbia Engineering neuroscientists identified a specific neural mechanism in the human brain that enhances memory for emotional events. High-frequency brain waves in the amygdala and hippocampus are critical to this process, and disruptions can impair memory specifically for emotional stimuli.
The Center for Ubiquitous Connectivity (CUbiC) aims to flatten the computation-communication gap by delivering seamless Edge-to-Cloud connectivity with transformational reductions in energy consumption. Led by Columbia Engineering Professor Keren Bergman, CUbiC will create new ultra-energy efficient technologies and system architectures.
Researchers at Columbia Engineering's Lipson Nanophotonics Group create tunable and narrow-linewidth chip-scale lasers emitting light of different colors, including green, blue, and violet. These inexpensive lasers have the smallest footprint and shortest wavelength of any tunable and narrow-linewidth integrated laser emitting visible ...
Researchers at Columbia University School of Engineering and Applied Science have developed a preclinical evaluation pipeline for characterization of bacterial therapies in lung cancer models. They combined bacterial therapies with other modalities of treatment to improve treatment efficacy without any additional toxicity.
Researchers developed a new method to target and treat visceral adiposity using positively charged P-G3 nanomaterials, which inhibit unhealthy lipid storage in enlarged fat cells. This approach also rejuvenates healthy fat cells, promoting metabolically healthy fat cell formation.
Researchers at Columbia Engineering created a compostable bioleather with superior flame-retardance and low environmental impact. The microbial nanocellulose (MC) bioleather has a significantly smaller carbon footprint than synthetic leather or cotton, making it an attractive alternative to traditional leather.
Researchers at Columbia University have invented a flat lens that exclusively focuses light of a selected color, appearing transparent until illuminated with the correct wavelength. The device overcomes challenges in conventional AR glasses, enabling unattenuated and undistorted vision of both real-world scenes and contextual information.
A team led by neuroengineer Paul Sajda aims to develop a comprehensive understanding of human decision making, using a multidisciplinary and multimodal approach. The research will focus on rapid decisions made under stress, fatigue, and time constraints.
Researchers developed a new method for converting light frequencies using atomically thin layers of molybdenum disulfide, enabling smaller lasers and potential applications in optical communications. The breakthrough could lead to compact phase-matched nonlinear optics and waveguide devices.
The NSF ERC grant will support the development of streetscape applications to forge livable, safe, and inclusive communities. The project aims to transform urban areas by harnessing data from smart streetscapes to address critical needs in road safety, traffic efficiency, and environmental sensing.
A new AI program identified four variables for a swinging double-pendulum, but the remaining two variables remain a mystery. The AI successfully predicted physical phenomena in other systems, such as air dancers and lava lamps, with varying numbers of variables.
Researchers at Columbia University and Rover Diagnostics have developed a low-cost, portable platform that provides RT-PCR results in 23 minutes, matching laboratory-based tests. The system uses plasmonic nanoparticles to achieve real-time and multiplexed RT-qPCR on clinical specimens.
Researchers at Columbia University have developed a new verification technology for the Arm Confidential Compute Architecture, demonstrating the first formal verification of a prototype. This breakthrough enables the creation of confidential computing architectures that can protect sensitive user data.
A Columbia University team created a robot that can learn and understand its own body, planning motion and avoiding obstacles without human assistance. The robot's self-model was accurate to about 1% of its workspace, paving the way for more self-reliant autonomous systems.
Columbia researchers built a 2.6nm-long single molecule wire that exhibits an unusual increase in conductance as the wire length increases and has quasi-metallic properties. The breakthrough overcomes the exponential-decay rule, enabling electronic devices to become even tinier.
Columbia Engineers propose using a time lens to control individual photons, resolving them with picosecond resolution. This breakthrough enables the manipulation of photon spectra and spectral bandwidths, essential for building quantum information networks.
Elham Azizi, a computational biologist at Columbia University, has received a $500,030 NSF CAREER Award to develop new computational methods for analyzing the interactions between immune cells and breast cancer. Her goal is to improve personalized cancer treatments by understanding how aggressive tumors evade the body's immune defenses.
Assistant professor David Knowles at Columbia University wins a $500,000 NSF CAREER Award to develop a new framework and tools for analyzing alternative splicing in diseases such as ALS and cancer. The project aims to create more accurate algorithms for single-cell and long-read RNA-seq analysis.
José McFaline-Figueroa, a genomicist at Columbia University, has received a three-year NSF CAREER Award to investigate how cancer cells respond to anti-cancer therapy. His research aims to understand the molecular changes induced in aggressive cancer cells after exposure to treatment and how these changes alter response to treatment.
James Anderson, assistant professor of electrical engineering at Columbia University, has received a National Science Foundation (NSF) CAREER award for his work on developing randomized algorithms for the analysis and control of large-scale cyber-physical systems. His goal is to provide robust, reliable, and secure autonomy to large-sc...
Researchers from Columbia University have developed a plug-and-play multi-organ chip, customized to the patient, consisting of engineered human heart, bone, liver, and skin linked by vascular flow. The model allows for long-term studies and can be optimized for personalized therapy optimization in cancer and systemic diseases.
Researchers at Columbia University have developed an algorithm that generates whisper-quiet sounds to block smart devices from spying on users. The system works by predicting the characteristics of spoken language and generating a signal that can disrupt automatic speech recognition models.
Researchers at Columbia Engineering and Brookhaven National Laboratory have developed a new high-resolution x-ray imaging technique to reveal the inner structure of novel nanomaterials. The tool, which provides 7nm resolution, has enabled them to study complex 3D architectures with unprecedented detail.
Researchers at Columbia University have developed a way to use the body's ions to transmit data at megahertz rates for implantable bioelectronics. This technique, dubbed ionic communication, leverages electrical potential energy stored in living tissues to exchange data with external devices.
A new technology called MediSCAPE has been developed by Columbia Engineers that can capture real-time cellular detail in living tissues. This allows doctors to make informed decisions about tumor removal without needing to remove tissue and wait for pathology results.
Assistant Professor Henry Yuen at Columbia University will receive a $675,000 grant to develop verification protocols for entanglement theory and explore broader mathematical applications. His work aims to solve fundamental problems in computer science, mathematics, and physics using quantum entanglement.
Columbia University researchers have engineered a microbial encapsulation system that temporarily hides therapeutic bacteria from immune systems, allowing them to deliver drugs to tumors and kill cancer cells in mice. The system, called iCAP, controls the bacteria's surface by manipulating gene circuits.
Researchers discovered that combining polymerase and exonuclease inhibitors reduces SARS-CoV-2 replication by 10 times more than single polymerase inhibitors. This combination approach has great potential to stop the spread of COVID-19 and other coronavirus diseases.
Researchers have developed a low-cost system called SIFTER that uses advanced algorithms and models to continuously screen for fever in multiple people without requiring human interaction. The system can take temperature readings up to three meters away, producing accurate predictions with minimal disruption to normal activities.
Boyce's research aims to develop MRI techniques to characterize the interior of flow systems in 3D, leading to revolutionized technologies in sustainable mining and hydrogen-powered vehicles. He plans to use visualizations to inspire middle- and high-school students from Harlem and the Bronx to pursue STEM studies.
Cidon's new software framework, XRP, aims to speed up cloud computing by offloading storage functions to the operating system. The project expects to more than halve computation and energy needed for common storage operations on fast storage devices.
A new computational method has been developed to accurately predict oxide reactions at high temperatures, even without experimental data. This approach combines quantum mechanics with machine learning to design clean carbon-neutral processes for steel production and metal recycling.