A new study shows that pancreatic cancer cells' ability to detect the extracellular matrix determines their growth rate and response to chemotherapy. The researchers found that cells detecting ECM have low autophagy levels and high growth rates, while those farther away from ECM have high autophagy levels and can survive chemotherapy.
A new study found that a key protein HOXD13 drives melanoma tumor cells' ability to grow with oxygen and nutrients. The researchers also discovered that HOXD13 suppresses the activity of cytotoxic T cells, which recognize cancer cells as abnormal and kill them.
A new study found that patients with Long COVID have a larger choroid plexus, which tracks with Alzheimer's disease markers and greater dementia risk. The research also suggests that CP alterations may predict long-term cognitive issues in some individuals.
A new study by NYU Langone Health researchers identified the high-level visual cortex as the brain region responsible for one-shot perceptual learning, a type of fast flashes of insight. The team developed an AI model that replicated human-like perception using stored priors and achieved one-shot learning capability.
An AI tool developed by researchers at NYU Langone Health can accurately predict which patients will require skilled nursing facilities after leaving the hospital, enabling faster and more effective discharge planning. The tool uses short summaries of doctor notes to identify key risk factors and predicts patient needs with 88% accuracy.
A new strategy for studying Hirschsprung disease in mice has revealed the interactions between multiple genes that control the condition. Researchers found that combining weaker mutations in genes RET and EDNRB creates a more realistic model of the disease, with key similarities to human HSCR.
A new NYU study found that supporting parents with infants during pediatric check-ups leads to better academic skills in elementary school, particularly for families in poverty. The Smart Beginnings model combines play and reading activities to foster cognitive development.
A new study found that aerobic exercise can increase dopamine release and improve motor performance in middle-aged mice, suggesting a potential link to improved mobility and reduced symptoms of Parkinson's disease. The research team plans to repeat the study in genetically engineered mice models for neurodegenerative disorders.
A new study finds that reducing arsenic levels in drinking water can decrease death rates from chronic diseases such as heart disease and cancer. Over a 20-year period, efforts to lower arsenic levels resulted in a 70% decrease in chemical levels, halving arsenic levels in urine among study participants.
Researchers have made breakthroughs in overcoming immune reactions behind human rejection of transplanted pig kidneys, paving the way for more successful clinical trials. The study reveals three major immune responses against the pig kidney and identifies potential biomarkers as early-warning systems for rejection.
Researchers developed an AI tool to detect bone loss using CT scans originally taken for other purposes, revealing trends in bone loss across a diverse patient population. The study found that young women had higher bone density than men of the same age, with steeper declines among postmenopausal women.
A new study estimates that about 14% of adults worldwide have chronic kidney disease, with 1.5 million deaths in 2023. Early detection and treatment are crucial to prevent severe interventions like dialysis and transplantation.
A new study reveals that a large gap between two common kidney function tests may indicate future disease, particularly among older adults. The research found that over a third of hospitalized participants had a significant difference in their creatinine and cystatin C readings, which can predict serious health problems.
Researchers from NYU Langone presented practice-changing studies on inflammation, heart attack management, and kidney function in heart failure care. The findings highlight the importance of personalized treatment strategies and balancing effective care with monitoring of kidney health.
Researchers discovered that blocking a specific protein called ferroptosis suppressor protein 1 (FSP1) reduces tumor growth by up to 80% in mice with lung adenocarcinoma. This study provides hope for developing novel clinical therapies for cancer patients.
Genome-wide association studies and burden tests identify different genes, with major implications for drug development. The study proposes two key features for ideal gene prioritization: importance and trait specificity.
Researchers from NYU Langone Health have made a significant discovery about how the brain forms and recalls memories. The study shows that activity in signaling pathways connecting two brain regions, the entorhinal cortex and the CA3 region of the hippocampus, help mice encode in brain circuitry maps of places.
Researchers develop a compound that reduces cell death, inflammation, and organ damage in diabetes. The drug candidate, RAGE406R, prevents the interaction between two proteins that enable heart and kidney injury, and accelerates wound closure.
Researchers found distinct brain features in football players, including shallower left superior frontal sulci and wider left occipitotemporal sulci, which may indicate increased risk of chronic traumatic encephalopathy (CTE). The study's findings could lead to the development of early detection tests and therapies.
Researchers found a drug that blocks harmful immune proteins, preventing congenital heart block in newborns. A multicenter trial is planned to assess the effectiveness of the drug in preventing congenital heart block.
A new study led by NYU Langone Health researchers shows that almost 70% of focal epilepsy patients, considered treatment resistant, experience a reduction in their average monthly seizure frequency over three years. The study found that even those who respond poorly to initial therapies may eventually see improvement.
Dr. Peiro brings extensive expertise in performing delicate, life-saving surgery on babies before and immediately after birth. The center combines expertise in maternal-fetal medicine, genetics, and diagnostics with multidisciplinary pediatric teams to ensure seamless care.
Researchers at NYU Langone Health found that pembrolizumab therapy results in a trend toward improvement in survival rates for patients with Merkel cell carcinoma. After two years, 73% of patients taking pembrolizumab showed no signs of cancer recurrence.
Dr. Kathryn Colby, NYU Langone Health's chair of ophthalmology, has received the prestigious Castroviejo Medal for her pioneering work on Fuchs endothelial corneal dystrophy. Her research explores a new surgical procedure to stimulate corneal regeneration.
A new study found that a smartphone app for muscle relaxation significantly reduced migraine-related disability in patients visiting the emergency department. The percentage of patients with at least a five-point improvement in disability nearly doubled for those who used the app.
A new study found that 80% of participants who reported a change in their smelling ability after COVID-19 scored low on a clinical scent-detection test two years later. Those with a history of COVID-19 may be especially at risk for hyposmia, an issue underrecognized among the general population.
A review of hundreds of studies found a link between childhood plastic exposure and long-term health concerns like heart disease, obesity, and asthma. Parents can take simple steps to limit their children's plastic exposure, such as replacing plastic containers with glass or stainless steel.
Researchers identified 27 species of bacteria and fungi that collectively increase the risk of pancreatic cancer by 3.5 times. The study analyzed saliva samples from 122,000 healthy individuals and found that boosting the mouth's microbiome may protect against cancer.
A new study reveals that most epilepsy patients with focal epilepsy will still experience seizures for at least a year after starting treatment. The study suggests that neurologists should rethink their initial approach to antiseizure therapy, as many patients may not respond well to the first medication or regimen prescribed.
Researchers at NYU Langone Health discovered that restricted blood flow can accelerate breast cancer growth by aging the immune system. This effect is caused by impaired blood flow triggering a shift towards immune cell populations that cannot efficiently fight infections and cancer.
A new minimally invasive procedure, genicular artery embolization, has been shown to relieve chronic knee pain caused by osteoarthritis in over 60% of patients. The procedure reduces inflammation and blood flow to joints, providing significant improvements in knee pain and stiffness.
A new study suggests that subtly adjusting the angle of the foot during walking can reduce knee pain caused by osteoarthritis and slow its progression. By tailoring each patient's foot angle to their unique walking pattern, experts believe an easy and fairly inexpensive way to address early-stage osteoarthritis may be found.
Researchers at NYU Langone Health have developed a new technique using focused sound waves and holograms to activate brain circuits in living animals. The study shows that ultrasound waves can temporarily activate neurons, which can lead to widespread effects on neural networks.
A recent biochemical discovery has led to a potential treatment for HPDL deficiency, a rare disease that causes paralysis. Researchers treated an 8-year-old boy with an experimental compound that partially reversed his rapid decline, allowing him to walk long distances again and even run.
A new study reveals an AI-assisted technique that can measure and track aging cells, which are known to play a key role in wound repair and aging-related diseases. The tool uses nuclear morphometrics to analyze cell characteristics and distinguish between healthy and senescent cells.
Researchers have developed a novel treatment approach for autoimmune diseases by engineering a protein that holds closely together two signaling complexes on T cells, shutting down those T cells in a limited way. This approach shows promise for treating conditions such as Type-1 diabetes and multiple sclerosis.
Researchers at NYU Langone Health discovered that a specific biological pathway explains why many patients with deadly melanoma do not respond to latest cancer treatments. The study found therapeutic targets that could limit melanoma growth in patients with NF1 mutations, suggesting a novel approach for treatment.
Researchers found a specific genetic mutation, MT haplogroup T, in patients who did not respond to immune checkpoint inhibitors. The study showed that these patients had more underdeveloped T cells and increased resilience to reactive oxygen species, stunting their attack on cancer cells.
A study published in Nature reveals that cysteine depletion disrupts metabolic pathways, forcing cells to rapidly burn fat stores. The research also highlights the role of coenzyme A (CoA) in shaping metabolism and provides insights into potential future obesity solutions.
A new study reveals that synthetic opioid-involved fatal overdoses among youth aged 15-24 in the US were predominantly caused by fentanyl alone. The rates of overdose deaths involving only fentanyl increased significantly across age, sex, and race/ethnicity, with the highest rates found among males and young adults.
A new study found that providing hearing aids and advice on their use can help preserve social connections in older adults, reducing loneliness. The study showed that those treated for hearing loss retained one additional social connection over a three-year period compared to those who received no treatment.
A new study by NYU Langone Health researchers has revealed the precise mechanisms behind LINE-1 insertion, a genetic element that makes up a large part of the human genome. The findings suggest that LINE-1 can bind to DNA during brief periods when cell nuclei break open, allowing it to replicate and drive genome evolution.
A new study finds that AI tools can significantly improve the readability of online patient education materials, making them more accessible for patients. The researchers used three large language models to optimize the readability of materials without compromising accuracy, resulting in improved scores and reduced word counts.
A new analysis of population surveys estimates that exposure to di-2-ethylhexyl phthalate (DEHP) contributed to 356,238 global heart disease deaths in 2018, accounting for 13% of all global mortality. The study also found higher death risks in the Middle East, South Asia, East Asia, and Pacific regions.
A new NYU Langone Health study found that lung immune cell type nerve and airway-associated interstitial macrophages (NAMs) play a critical role in regulating inflammation during SARS-CoV-2 infection. NAMs promote disease tolerance by restraining the immune response, leading to better survival rates among infected mice.
A new study found that a gene-based blood test can accurately predict skin cancer recurrence in stage III melanoma patients. The test measures circulating tumor DNA levels to identify those most likely to respond well to therapy.
A new study reveals that a special group of cells in the intestines, called tolerogenic dendritic cells, play a key role in preventing food allergies. These cells help to suppress immune responses to food proteins, enabling them to pass through the body without triggering an allergic reaction.
A new study led by NYU Langone Health scientists sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors. Intact BRCA2 functions as a molecular shield, preventing PARP1 from disrupting DNA repair complexes, and its activity dictates PARP inhi...
A new study found that parakeet brains generate patterns seen in humans as they speak, suggesting a similar connection between higher brain activity and sound production. This discovery may help develop new treatments for speech disorders affecting millions of Americans.
Researchers found that lower doses (20mg) and higher doses (100mg) of doxycycline were equally effective in treating lymphocytic scarring alopecia, a rare skin condition causing permanent hair loss. The low-dose regimen resulted in fewer side effects and no compromise on efficacy or anti-inflammatory benefit.