Articles tagged with Randomization
A study analyzing 105 glaucoma trials reveals significant racial and ethnic disparities in clinical trial participation. Minority groups are underrepresented in these trials, which could impact the development of effective treatments for diverse populations.
A randomized survey experiment found heightened awareness of immigration detention fosters beliefs that the US immigration system lacks procedural and outcome fairness. Individuals' intentions to migrate were not influenced by heightened awareness of immigration detention or nonjudicial removals.
A randomized double-blind controlled trial of convalescent plasma for adults hospitalized with severe COVID-19 found mortality at 28 days in the treatment arm was half the rate seen in the control arm. However, treatment was not associated with other improvements in clinical status among patients.
A study presented at ACC.21 found that low- and high-dose aspirin achieved similar health benefits for those with cardiovascular disease, including reduced death and hospitalization rates. However, the higher dose group was more likely to switch doses and discontinue use due to tolerability concerns.
A study from Bocconi University found that negative campaigning with electoral attacks on opponents backfires, but has positive spillover effects on third candidates in multicandidate races. In a three-candidate race, the 'idle candidate' benefits from negative smearing.
A large analysis of patient data suggests that delayed antibiotic prescribing is a safe and effective strategy for most patients, including those in higher risk subgroups. The study found no significant difference in symptom severity or duration between delayed and immediate antibiotics, but a slight benefit in reducing re-consultation...
A pilot trial found that the 'Sit Less, Interact, Move More' intervention decreased sedentary time, increased stepping time, and boosted step counts in patients with moderate-to-advanced CKD. However, these benefits were not sustained over 20 weeks. The study suggests that additional interventions may be needed to sustain long-term eff...
A randomized controlled study found that a Mediterranean diet combined with small portions of lean beef helped lower LDL cholesterol and non-HDL cholesterol levels. The study suggests that healthy diets can include a wide variety of foods, including red meat, while still being heart-friendly.
A new study led by VCU researchers found that e-cigarettes delivering a high amount of nicotine are effective in reducing smoking and exposure to NNAL, a major pulmonary carcinogen. The study suggests that when e-cigarettes deliver nicotine effectively, smokers have greater success in quitting or reducing their smoking habit.
A large randomized controlled trial found that low-dose IV contrast-enhanced 2-millisievert CT is comparable to conventional-dose CT for diagnosing right colonic diverticulitis. The study included 3,074 patients and demonstrated similar diagnostic performance between the two groups.
School-based interventions, particularly peer-assisted instruction and small-group teaching, have positive effects on reading and mathematics for students with academic difficulties. These targeted interventions can substantially boost skills in these students.
A randomized controlled experiment found that a 30-minute empathy exercise for probation and parole officers reduced their belief that individuals on probation are likely to reoffend. The intervention also led to a 13% decrease in recidivism rates among those supervised.
Professor David Matchar and his team received the Stroke Rehabilitation Award from the American Stroke Association for their project investigating incentives to improve outpatient rehabilitation services among stroke patients. The study found that providing incentives significantly increased the uptake of these services, highlighting a...
A recent study published in JAMA Surgery found that patients have a more difficult time understanding and building trust with their surgeons when they cannot see the surgeon's entire face due to masking requirements. Patients reported improved communication and higher ratings for surgeons who wore clear masks.
A randomized clinical trial found that American Indian and Alaska Native adults with alcohol dependence responded positively to incentives for abstinence. The study examined the effectiveness of incentives offered for laboratory-confirmed abstinence from alcohol among participants diagnosed with alcohol dependence.
Researchers assessed COVID-19 trial recruitment and results reporting within the first 100 days of the pandemic. The study found challenges in recruiting participants and accurately reporting trial results, which can impact the validity of clinical trials.
A simulated online supermarket study found that suggesting healthy food swaps could lower the calories customers buy. The research also explored how social norms and messaging impact the adoption of these swaps.
A randomized controlled trial found that Congressional offices with targeted support reported increased value of scientific evidence for understanding legislative issues. The intervention group introduced around 23% more bills using research evidence language and reported a 7% greater value of using research evidence compared to controls.
A sequential approach to treating comorbid PTSD and major depressive disorder has shown promising results in a randomized control trial. The study found that combining Cognitive Processing Therapy (CPT) and Behavioral Activation Therapy (BA) led to meaningful reductions in PTSD and depression severity.
A new study published in Clinical Trials proposes staging cluster randomized trials to clarify uncertainties around school reopening policies. The trial design would create a rigorous evidence base for policymakers to make informed decisions, considering factors such as community transmission and health system capacity.
A randomized clinical trial compared flu vaccine reactions in older adults, finding that injection-site pain was a common side effect. The study also revealed differences in reaction rates among various flu vaccine types.
A three-arm randomized controlled trial showed that participants had the most satisfaction and subjective understanding with the trust-enhanced e-consent after six months. Interactive consent forms beyond federal regulations can enhance patient-informed consent and trust in research.
A multi-center US trial shows that exoskeleton training is safe, feasible, and effective in improving mobility in individuals with spinal cord injury. The study found that most participants mastered the ability to ambulate effectively with the assistance of an exoskeleton after 12-36 sessions.
A randomized trial found fluvoxamine significantly reduces the risk of worsening symptoms like pneumonia and oxygen desaturation in adult outpatients with mild COVID-19. The study also suggests fluvoxamine's potential as a treatment for COVID-19, offering hope for improved patient outcomes.
A randomized clinical trial found that e-cigarette use combined with individual counseling significantly increased quit rates compared to counseling alone. The study concluded that e-cigarette assistance can be an effective complement to traditional counseling services for smokers trying to quit.
Researchers found that tocilizumab, an anti-inflammatory drug, reduced mortality by 30 percent in critically ill COVID-19 patients when administered early in ICU care. The study analyzed data from over 4,000 patients with COVID-19 and found consistent benefits across age, sex, and illness severity.
Researchers compared tocilizumab with standard care to prevent clinical worsening in patients hospitalized with COVID-19 pneumonia. Early administration of tocilizumab was found to be effective in reducing the risk of worsening in these patients.
A randomized trial found that durable polymer drug-eluting stents are non-inferior to biodegradable polymers in patients with acute coronary syndrome, with a higher risk of device-oriented composite endpoint. The study suggests improved outcomes for patients with significant coronary stenosis and eligible for stent implantation.
The TARGET FFR trial found that a physiology-guided incremental optimization strategy (PIOS) reduced the proportion of patients with a final post-PCI FFR ?0.80, while also improving mean Coronary Flow Reserve. The study's results suggest potential benefits for PCI outcomes.
The REFLECT II trial evaluated the safety and effectiveness of TriGuard 3, a self-stabilizing cerebral embolic deflection filter, in patients undergoing TAVR. The device met the primary safety endpoint, but did not demonstrate superiority for reducing ischemic stroke or larger lesions.
A randomized clinical trial found that different fitness strategies were effective for distinct subgroups of participants based on their personality and behavioral characteristics. These subgroups included extroverted and motivated individuals, less active and less social participants, and those who were less motivated and at-risk.
The National Institutes of Health COVID-19 Treatment Guidelines Panel has expressed uncertainty about the efficacy and safety of convalescent plasma for treating COVID-19. The panel's analysis, published in Annals of Internal Medicine, highlights the need for more data before making recommendations on the treatment.
A large randomized trial found that post-operative radiotherapy (PORT) does not significantly improve disease-free survival in completely resected non-small-cell lung cancer (NSCLC) patients. The study included 501 patients and showed no significant difference in overall survival between the PORT group and the control group.
A phase 3 global clinical trial showed a new drug boosts bone growth in children born with achondroplasia by blocking the activity of FGFR3 protein, potentially returning growth rates to normal. The experimental drug vosoritide was safe and effective in increasing bone growth over one year.
A randomized clinical trial in France evaluated the effect of low-dose hydrocortisone on ICU patients with COVID-19-related acute respiratory failure. The study found that hydrocortisone treatment reduced mortality and decreased the need for respiratory support among critically ill COVID-19 patients.
A new randomized control trial found that gamifying mobile mental health intervention content improved resilience and reduced attrition. The study showed significant benefits in both resilience and anxiety measurements after five weeks, with the game group retaining 21% more participants than other groups.
Changing healthcare payment for one insurer can impact patients covered by others, a nationwide randomized trial suggests. The study found lower hospital readmissions and care intensity among TM patients and those with private insurance through Medicare Advantage.
A new randomized trial published in Annals of Internal Medicine found that hydroxychloroquine showed no benefit in reducing symptom severity or duration in outpatients with early, mild COVID-19. The study suggests that the treatment may not be effective in populations at higher risk for severe COVID-19.
A large randomized trial has found that endometrial scratch is not beneficial in women having their first cycle of IVF. The study involved over 1000 women under 37 years old and showed no significant difference in live birth rates between those who received endometrial scratch and those who did not.
The systematic two-stent approach significantly improved clinical outcomes compared to provisional stenting in patients with complex coronary bifurcation lesions. TVMI and TLR rates were lower in the two-stent group, while cardiac death rates were similar.
Researchers found that a digital media literacy intervention increased discernment between mainstream and false news in the US and India. However, the benefits were short-lived, highlighting the need for consistent reinforcement of lessons from the intervention.
A randomized trial found that rituximab reduces the risk of relapse by 64% compared to azathioprine, with fewer severe adverse events. The study suggests that rituximab may be a superior treatment option for patients with ANCA-associated vasculitis, particularly those with history of relapses.
A comprehensive workplace wellness program, iThrive, was found to have no significant effect on employee health measures or medical use. However, it did improve self-reported health beliefs and the proportion of employees reporting having a primary care physician.
A large randomized study found that patients undergoing cardiac catheterization can eat prior to the procedure without increasing complications or costs. The study challenges traditional fasting protocols and could lead to more patient-centered care.
A randomized controlled trial found that intra-articular hypertonic dextrose injections significantly reduced knee pain in patients with moderate to severe osteoarthritis. The study, conducted at the Chinese University of Hong Kong, involved 76 patients who received either the hypertonic dextrose or normal saline injection therapy.
A study of randomized controlled trials found that consuming green tea led to a significant decline in body weight and body mass index. However, the analysis did not reveal any notable changes in waist circumference after supplementation.
A recent trial demonstrated that an intensified antithrombotic regimen comprising rivaroxaban and aspirin reduces major adverse limb events by 46% compared to aspirin alone. The review highlights the need for better evidence on antithrombotic treatment in peripheral vascular interventions.
A George Mason study found that alternate light source detects bruises 5 times better than white light on diverse skin tones, addressing the disparity in bruise detection for people of color. The research aims to improve medical and legal outcomes for victims of violence.
A new study from Aarhus University shows that a motivational interview with a GP can have a preventative effect on cardiovascular disease. The study found a 13% reduction in cardiovascular disease risk among patients without diabetes who talked to a GP trained in motivational interviewing.
This observational study of older adults reveals racial and ethnic differences in depression severity and care. The findings suggest that these disparities exist even among those participating in a cancer and cardiovascular disease prevention clinical trial.
A randomized controlled trial found that tailored messages addressing HPV vaccine concerns improved intent to vaccinate, while a bundled approach was less effective. The study suggests that personalized messaging may be essential for increasing HPV vaccination uptake among hesitant parents.
A randomized controlled trial shows that lay health coaching can significantly improve inhaler use among low-income COPD patients, with 40% of health-coached patients demonstrating effective use of their inhalers. The intervention also improved inhaler technique, contributing to long-term COPD outcomes.
A study of 217 adults found no difference in the effectiveness of morning versus evening warfarin dosing. The researchers concluded that patients should take warfarin at a time when compliance is easiest, regardless of day or night.
A randomized crossover study found that eating non-fried potatoes instead of refined grains improved diet quality and was associated with lower cardiometabolic risk factors. Participants who ate potatoes had higher potassium and fiber intake, as well as a healthier index score.
A randomized clinical trial found that outpatient palliative care was associated with better patient and caregiver outcomes for patients with Parkinson disease. The study included 210 patients and 175 caregivers and examined the effects of palliative care on quality of life, mood, and sleep.
A community health worker program in Philadelphia reduced hospital admissions by 38% and saved Medicaid $1.4 million annually, resulting in a $2.47 return on investment for every $1 spent. The program's success was demonstrated through a randomized controlled trial, improving quality of care and patient outcomes.
A multi-site randomized experiment is being conducted to test a structured investigation protocol for robbery cases in Rochester, NY, and Seattle, WA police departments. The goal is to improve clearance rates and enhance victim satisfaction through standardized investigative actions by trained patrol officers.
A guided self-help approach was safe and effective in reducing psychological distress and improving functioning among female South Sudanese refugee women living in Uganda. The intervention resulted in meaningful improvements in symptoms of depression, PTSD, and explosive anger, with benefits seen across different trauma histories and l...
A randomized controlled trial found that the ACE method was as effective as a specialist stop smoking service in quitting smoking. The study's results suggest that ACE may offer a viable cost-effective alternative for public-funded healthcare settings.
A new randomized controlled trial found that the guided self-help intervention SH+ significantly reduced psychological distress and improved functioning, depression, and wellbeing among South Sudanese female refugees. The intervention was highly acceptable to participants, with 80% attending all five sessions.