Articles tagged with Randomization
A randomized clinical trial compared flu vaccine reactions in older adults, finding that injection-site pain was a common side effect. The study also revealed differences in reaction rates among various flu vaccine types.
A three-arm randomized controlled trial showed that participants had the most satisfaction and subjective understanding with the trust-enhanced e-consent after six months. Interactive consent forms beyond federal regulations can enhance patient-informed consent and trust in research.
A multi-center US trial shows that exoskeleton training is safe, feasible, and effective in improving mobility in individuals with spinal cord injury. The study found that most participants mastered the ability to ambulate effectively with the assistance of an exoskeleton after 12-36 sessions.
A randomized trial found fluvoxamine significantly reduces the risk of worsening symptoms like pneumonia and oxygen desaturation in adult outpatients with mild COVID-19. The study also suggests fluvoxamine's potential as a treatment for COVID-19, offering hope for improved patient outcomes.
A randomized clinical trial found that e-cigarette use combined with individual counseling significantly increased quit rates compared to counseling alone. The study concluded that e-cigarette assistance can be an effective complement to traditional counseling services for smokers trying to quit.
Researchers found that tocilizumab, an anti-inflammatory drug, reduced mortality by 30 percent in critically ill COVID-19 patients when administered early in ICU care. The study analyzed data from over 4,000 patients with COVID-19 and found consistent benefits across age, sex, and illness severity.
Researchers compared tocilizumab with standard care to prevent clinical worsening in patients hospitalized with COVID-19 pneumonia. Early administration of tocilizumab was found to be effective in reducing the risk of worsening in these patients.
A randomized trial found that durable polymer drug-eluting stents are non-inferior to biodegradable polymers in patients with acute coronary syndrome, with a higher risk of device-oriented composite endpoint. The study suggests improved outcomes for patients with significant coronary stenosis and eligible for stent implantation.
The TARGET FFR trial found that a physiology-guided incremental optimization strategy (PIOS) reduced the proportion of patients with a final post-PCI FFR ?0.80, while also improving mean Coronary Flow Reserve. The study's results suggest potential benefits for PCI outcomes.
The REFLECT II trial evaluated the safety and effectiveness of TriGuard 3, a self-stabilizing cerebral embolic deflection filter, in patients undergoing TAVR. The device met the primary safety endpoint, but did not demonstrate superiority for reducing ischemic stroke or larger lesions.
A randomized clinical trial found that different fitness strategies were effective for distinct subgroups of participants based on their personality and behavioral characteristics. These subgroups included extroverted and motivated individuals, less active and less social participants, and those who were less motivated and at-risk.
The National Institutes of Health COVID-19 Treatment Guidelines Panel has expressed uncertainty about the efficacy and safety of convalescent plasma for treating COVID-19. The panel's analysis, published in Annals of Internal Medicine, highlights the need for more data before making recommendations on the treatment.
A large randomized trial found that post-operative radiotherapy (PORT) does not significantly improve disease-free survival in completely resected non-small-cell lung cancer (NSCLC) patients. The study included 501 patients and showed no significant difference in overall survival between the PORT group and the control group.
A phase 3 global clinical trial showed a new drug boosts bone growth in children born with achondroplasia by blocking the activity of FGFR3 protein, potentially returning growth rates to normal. The experimental drug vosoritide was safe and effective in increasing bone growth over one year.
A randomized clinical trial in France evaluated the effect of low-dose hydrocortisone on ICU patients with COVID-19-related acute respiratory failure. The study found that hydrocortisone treatment reduced mortality and decreased the need for respiratory support among critically ill COVID-19 patients.
A new randomized control trial found that gamifying mobile mental health intervention content improved resilience and reduced attrition. The study showed significant benefits in both resilience and anxiety measurements after five weeks, with the game group retaining 21% more participants than other groups.
Changing healthcare payment for one insurer can impact patients covered by others, a nationwide randomized trial suggests. The study found lower hospital readmissions and care intensity among TM patients and those with private insurance through Medicare Advantage.
A new randomized trial published in Annals of Internal Medicine found that hydroxychloroquine showed no benefit in reducing symptom severity or duration in outpatients with early, mild COVID-19. The study suggests that the treatment may not be effective in populations at higher risk for severe COVID-19.
A large randomized trial has found that endometrial scratch is not beneficial in women having their first cycle of IVF. The study involved over 1000 women under 37 years old and showed no significant difference in live birth rates between those who received endometrial scratch and those who did not.
The systematic two-stent approach significantly improved clinical outcomes compared to provisional stenting in patients with complex coronary bifurcation lesions. TVMI and TLR rates were lower in the two-stent group, while cardiac death rates were similar.
Researchers found that a digital media literacy intervention increased discernment between mainstream and false news in the US and India. However, the benefits were short-lived, highlighting the need for consistent reinforcement of lessons from the intervention.
A randomized trial found that rituximab reduces the risk of relapse by 64% compared to azathioprine, with fewer severe adverse events. The study suggests that rituximab may be a superior treatment option for patients with ANCA-associated vasculitis, particularly those with history of relapses.
A comprehensive workplace wellness program, iThrive, was found to have no significant effect on employee health measures or medical use. However, it did improve self-reported health beliefs and the proportion of employees reporting having a primary care physician.
A large randomized study found that patients undergoing cardiac catheterization can eat prior to the procedure without increasing complications or costs. The study challenges traditional fasting protocols and could lead to more patient-centered care.
A randomized controlled trial found that intra-articular hypertonic dextrose injections significantly reduced knee pain in patients with moderate to severe osteoarthritis. The study, conducted at the Chinese University of Hong Kong, involved 76 patients who received either the hypertonic dextrose or normal saline injection therapy.
A recent trial demonstrated that an intensified antithrombotic regimen comprising rivaroxaban and aspirin reduces major adverse limb events by 46% compared to aspirin alone. The review highlights the need for better evidence on antithrombotic treatment in peripheral vascular interventions.
A study of randomized controlled trials found that consuming green tea led to a significant decline in body weight and body mass index. However, the analysis did not reveal any notable changes in waist circumference after supplementation.
A George Mason study found that alternate light source detects bruises 5 times better than white light on diverse skin tones, addressing the disparity in bruise detection for people of color. The research aims to improve medical and legal outcomes for victims of violence.
A new study from Aarhus University shows that a motivational interview with a GP can have a preventative effect on cardiovascular disease. The study found a 13% reduction in cardiovascular disease risk among patients without diabetes who talked to a GP trained in motivational interviewing.
This observational study of older adults reveals racial and ethnic differences in depression severity and care. The findings suggest that these disparities exist even among those participating in a cancer and cardiovascular disease prevention clinical trial.
A randomized controlled trial found that tailored messages addressing HPV vaccine concerns improved intent to vaccinate, while a bundled approach was less effective. The study suggests that personalized messaging may be essential for increasing HPV vaccination uptake among hesitant parents.
A study of 217 adults found no difference in the effectiveness of morning versus evening warfarin dosing. The researchers concluded that patients should take warfarin at a time when compliance is easiest, regardless of day or night.
A randomized controlled trial shows that lay health coaching can significantly improve inhaler use among low-income COPD patients, with 40% of health-coached patients demonstrating effective use of their inhalers. The intervention also improved inhaler technique, contributing to long-term COPD outcomes.
A randomized crossover study found that eating non-fried potatoes instead of refined grains improved diet quality and was associated with lower cardiometabolic risk factors. Participants who ate potatoes had higher potassium and fiber intake, as well as a healthier index score.
A randomized clinical trial found that outpatient palliative care was associated with better patient and caregiver outcomes for patients with Parkinson disease. The study included 210 patients and 175 caregivers and examined the effects of palliative care on quality of life, mood, and sleep.
A community health worker program in Philadelphia reduced hospital admissions by 38% and saved Medicaid $1.4 million annually, resulting in a $2.47 return on investment for every $1 spent. The program's success was demonstrated through a randomized controlled trial, improving quality of care and patient outcomes.
A multi-site randomized experiment is being conducted to test a structured investigation protocol for robbery cases in Rochester, NY, and Seattle, WA police departments. The goal is to improve clearance rates and enhance victim satisfaction through standardized investigative actions by trained patrol officers.
A guided self-help approach was safe and effective in reducing psychological distress and improving functioning among female South Sudanese refugee women living in Uganda. The intervention resulted in meaningful improvements in symptoms of depression, PTSD, and explosive anger, with benefits seen across different trauma histories and l...
A randomized controlled trial found that the ACE method was as effective as a specialist stop smoking service in quitting smoking. The study's results suggest that ACE may offer a viable cost-effective alternative for public-funded healthcare settings.
A new randomized controlled trial found that the guided self-help intervention SH+ significantly reduced psychological distress and improved functioning, depression, and wellbeing among South Sudanese female refugees. The intervention was highly acceptable to participants, with 80% attending all five sessions.
A randomized clinical trial found that a telephone-based program encouraging increased vegetable consumption did not decrease the risk of prostate cancer progression over two years. The study suggested that the intervention may have been underpowered to identify a clinically important difference in cancer progression.
A new study by MIT economists found that a hotspotting program has virtually no impact on patient health care use, contradicting previous claims of a significant reduction in rehospitalizations. The study evaluated 800 patients and found similar outcomes between those enrolled in the program and those not.
A study found that advance care planning is associated with improved survival among terminally ill patients, particularly those with diseases other than cancer. This approach enables adults to discuss their wishes and priorities for end-of-life care.
Researchers aim to provide evidence for micro-fragmented adipose tissue as a viable alternative to surgery for treating meniscal tears. The one-year study will monitor changes in meniscal tissue, pain levels, and functional activity.
In a randomized clinical trial, adults with moderate to severe migraines took either ubrogepant or a placebo. After two hours, participants reported a significant reduction in pain and associated symptoms. The study provides encouraging results for the treatment of migraine pain.
A randomized clinical trial evaluated mailed HPV self-sampling test kits versus standard care reminders for detecting and treating cervical precancers. The study found that the self-sampling kit increased detection rates without a significant impact on treatment outcomes.
A randomized controlled trial found that young adults with unhealthy diets showed significant improvements in mood and reduced symptoms of depression after eating a healthy diet for three weeks. The study provides preliminary evidence that small, simple diet adjustments can improve depression symptoms.
Emerging norms in engaged translational genomics research raise substantial ethical concerns. Simplified Spanish-language consent materials require cultural congruence, while participant benefits in HIV prevention research highlight potential direct and indirect benefits for stigmatized populations.
A major Canadian-led study has found that most adults can continue to eat red and processed meat without significant impacts on heart disease, diabetes, or cancer. The researchers concluded that a small reduction in risk was associated with reducing meat consumption by three servings per week.
A major meta-analysis found daily omega-3 supplementation reduced risks of heart attack and CVD events by 8%, with higher doses providing greater risk reduction. The study included over 120,000 adults in 13 randomized trials worldwide.
The study implemented randomized quality improvement projects across NYU Langone Health, finding that changing prompts for tobacco cessation counseling increased medication prescription rates. Post-discharge phone calls were largely ineffective in improving patient satisfaction or hospital readmissions.
Researchers conducted a randomized controlled trial in New Haven, Connecticut, where police officers made community policing visits to residents' homes. The study found that positive interactions improved public trust and cooperation with police, especially among black individuals and those with strong negative views towards the police.
The Lancet published several studies on cardiovascular disease, including a new risk chart for 21 global regions and a trial on percutaneous coronary intervention versus coronary artery bypass grafting. Additionally, the journal presented findings on sirolimus-eluting stents versus durable polymer everolimus-eluting stents in patients ...
A new study finds that excess body fat increases the risk of depression, with a 17% higher probability for every ten kilograms of extra weight. The study suggests that psychological consequences of being overweight or obese drive this increased risk, rather than biological effects.
Researchers at Boston University School of Public Health found that patients who start long-term buprenorphine treatment before discharge from a short-term inpatient program are less likely to relapse and more likely to keep up treatment. This approach reduces the risk of overdose and improves outcomes for opioid users.
The study analyzed combined patient-level data from two randomized clinical trials to examine the effectiveness of dual antiplatelet therapy in patients who experienced a minor stroke or transient ischemic attack. The results indicate that treatment with clopidogrel and aspirin can improve outcomes for these patients.
A randomized trial of 120 hospital patients found that virtual reality (VR) sessions significantly reduced severe pain scores compared to a relaxation program on TV. Patients who used VR reported higher satisfaction with the experience and no difference in opioid prescribing.
A Finnish study has found that bowel preparation before colon surgery does not reduce surgical site infections or complications. The study of 400 patients showed no benefits to the procedure, suggesting it may be unnecessary.
This systematic review and meta-analysis found parent-based interventions associated with improved condom use and parent-child sexual communication in adolescents. The findings were generally modest, but there was a significant association across studies.
A randomized clinical trial and meta-analysis found intensive blood pressure control to be more effective than standard control in reducing stroke recurrence risk. Patients who received intensive blood pressure control had a lower risk of stroke compared to those on standard control, suggesting potential benefits for stroke prevention.