Articles tagged with Randomization
A study by the University of Missouri found that older adults who completed an eight-week resistance training program maintained long-term exercise habits and increased their physical energy despite COVID-19 restrictions. The Stay Strong, Stay Healthy program improved participants' sleep, balance, flexibility, and self-confidence in da...
A virtual care team consisting of physicians and pharmacists improved the adoption of life-saving therapies in patients with heart failure, leading to increased use of evidence-based treatments and better patient outcomes. The strategy was safe and effective, with comparable length of stay and safety events between the groups.
High-dose anticoagulation reduces intubations and deaths by 30% in hospitalized COVID-19 patients, especially those with ARDS. The study found a significant reduction in mortality and need for ICU care among patients treated with therapeutic anticoagulation.
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
Researchers at Sandia National Laboratories and Purdue University have developed a technique called moving target defense to protect against hackers taking control of military jets. This approach involves shuffling network addresses to make it difficult for attackers to access critical systems.
Researchers found that an immersive virtual reality (IVR) intervention significantly improved pain and anxiety in pediatric patients undergoing a blood draw. The IVR group showed better outcomes compared to the control group.
A randomized controlled trial found that calorie restriction slowed the pace of biological aging in healthy adults by 2-3%, measured using the DunedinPACE algorithm, which translates to a 10-15% reduction in mortality risk. The intervention had no effects on other epigenetic clocks.
Researchers found that AI significantly improved the detection of lung nodules on chest X-rays, detecting actionable nodules at a rate of 0.59% compared to 0.25% without AI assistance. The study suggests that AI may work consistently across different populations.
An updated Cochrane review found no effect of vitamin D supplements on reducing the risk of asthma attacks or improving control of asthma symptoms in children and adults. The review analyzed data from 20 randomized controlled trials involving over 2,200 people with mild to moderate asthma.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
A new study found a significant weight loss of 8.8% among participants after six months, with improvements in health and vitality. The approach addresses biological antecedents of food intake and develops intrinsic motivation for behavior changes.
A Dartmouth-led study found that team-based coaching significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions. The Collaborative with Surveillance intervention reduced the odds of AKI by 46 percent, making it a promising approach to address this prevalent adverse event.
Laboratory experiments show rapid antibiotic switches can prevent resistance, with collateral-sensitive drug pairs suitable for therapy. However, environmental conditions in patients differ from labs, and natural degradation affects treatment.
A randomized clinical trial of 1,288 adults with mild to moderate COVID-19 found that fluvoxamine treatment did not reduce time to sustained recovery compared to placebo. The study suggests that fluvoxamine at a dose and duration tested may not be beneficial in patients with mild to moderate COVID-19.
A school-based gardening, nutrition, and cooking intervention improved glucose control and reduced low-density lipoprotein cholesterol in high-risk youth. Elementary schools can incorporate garden-based interventions to improve metabolic parameters in children.
Internet-delivered parent-child interaction therapy shows promise in expanding care for underserved children with developmental delay. The study found significant improvements in child behavior that were maintained across follow-up visits.
A randomized clinical trial found that climate impact menu labels can effectively reduce red meat selections and encourage more environmentally sustainable restaurant food choices. The study suggests that negatively framed labels highlighting high-climate impact items were particularly effective in promoting eco-friendly options.
Researchers found that plasma GH levels are a potential biomarker for predicting treatment outcomes in patients with advanced HCC treated with Atezo/Bev. The study showed significantly superior overall survival and non-significant trend in favor of GH-low patients compared to GH-high patients.
A randomized trial shows that patients undergoing partial knee arthroplasty (UKA) experience faster functional recovery in walking speed and mobility tests compared to those who had total knee arthroplasty (TKA). UKA also resulted in shorter operative times, reduced blood loss, and improved functional outcomes.
A randomized controlled trial found that a low-carbohydrate, high-fat diet helped patients with type 2 diabetes achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. However, changes were not sustained 3 months after the intervention.
A web-based multicomponent intervention has been shown to improve blood pressure control and lower blood pressure levels in patients with hypertension. The study included 4,100 patients and found that such an intervention can provide a new, effective way to treat hypertension in the community.
A study of over one million Medicaid beneficiaries found that more than half experienced significant lapses in coverage, with only 25% continuously enrolled throughout the period. The authors recommend increasing investments to improve long-term health outcomes.
A study published in Tobacco Control found that alternatives to menthol cigarettes pose significant addiction and health risks. Mentholated pipe tobacco and tubes were the most appealing and addictive options, suggesting they should be included in the proposed ban.
The American Psychiatric Association's December journal issues explore new therapeutic approaches involving psychopharmacology, digital technology, and fMRI neurofeedback. The APA also highlights its vision to ensure access to quality psychiatric diagnosis and treatment.
A randomized clinical trial of 8,800 school-age children with high vitamin D deficiency showed no impact on growth or pubertal development after 3 years of weekly oral vitamin D administration. Vitamin D deficiency is associated with stunting and obesity in children.
Black and Hispanic men are underrepresented in prostate cancer clinical trials compared to their incidence rate. The representation of Black patients has remained consistently low over the past two decades.
Outreach messages via electronic health record patient portals increased well child care visit scheduling and COVID-19 vaccine receipt in a randomized clinical trial of 945 patients. This tool may help restore delayed well child care in populations affected by the pandemic.
Studies found that sotrovimab reduced the risk of severe covid-19 outcomes by 46% compared to molnupiravir. However, no benefit was found for common heart drugs like ARBs in a randomised controlled trial.
A new study has shown that total ankle replacement and ankle fusion surgeries equally improve quality of life for patients with advanced ankle osteoarthritis. However, a fixed bearing joint replacement showed significant improvement over ankle fusion in clinical scores.
A randomized controlled trial found that oral ENT-01 significantly improves constipation and possibly neurological symptoms in persons with Parkinson disease. The treatment is safe for up to 25 days, with a dose-dependent effect that persists beyond the treatment period.
A clinical trial found that early use of ECMO devices did not improve outcomes for adults with rapidly deteriorating or severe cardiogenic shock. Participants who received immediate ECMO therapy showed similar clinical outcomes as those receiving early conservative therapy, including treatment with inotropes and vasopressors.
A new study found that long-term treatment with intravenous iron improved symptoms and reduced recurrent hospitalizations among people with heart failure and iron deficiency. The treatment was associated with a significant benefit on reducing the risk of heart failure hospitalization and cardiovascular death.
A randomized study compared the effects of torsemide and furosemide in people with heart failure. The study found that both loop diuretics were effective in reducing death and hospitalization rates, with no significant clinical difference between the two medications.
A computational study found that adding more than two stratification factors to a phase 2 trial can significantly reduce its statistical power, making it harder to detect a positive result. For modestly sized trials with 84 participants, using four or six stratification factors resulted in power decreases of 13% and 25%, respectively.
A Mayo Clinic study found that clinicians who were high adopters of an AI-enabled clinical decision support tool were twice as likely to diagnose low left ventricular ejection fraction as those who were low adopters. The tool's accuracy was critical in detecting serious health conditions before symptoms appeared.
A 6-month randomized clinical trial found that a low-carbohydrate diet intervention resulted in larger reductions in hemoglobin A1c (HbA1c) levels compared to usual diet among adults with elevated untreated HbA1c. The study suggests that this dietary approach may be useful for preventing and treating type 2 diabetes.
A new study from the University of South Australia found that severe vitamin D deficiency is associated with a higher risk of mortality. The research evaluated 307,601 records from the UK Biobank and found that individuals with low vitamin D levels had a significantly decreased risk of death over a 14-year follow-up period.
A meta-analysis by Goethe University Frankfurt found that individualized treatment combined with cognitive behavioral therapy (CBT) led to a significant increase in pain relief. The study showed an 84% higher success rate compared to standard exercise therapies, making this approach the most effective.
A landmark study published in The Lancet found that chlorhexidine gluconate and povidone-iodine aqueous solutions are equally effective in preventing surgical site infections in patients with open fractures. This finding has significant implications for healthcare practitioners and may reduce costs associated with accessing these antis...
A randomized clinical trial found that adding sugar warnings and prohibitions on front-of-package claims reduced parents' purchases of high-sugar beverages. However, percentage juice disclosures had no effect on behavior.
A secondary analysis of a randomized clinical trial found that positive patient beliefs about antibiotic effectiveness for appendicitis are linked to lower risk of surgery and faster symptom resolution. This association remains unclear, with further research needed to understand its underlying mechanisms.
A team from the University of California San Diego has developed a new system of algorithms that enables four-legged robots to walk and run on challenging terrain while avoiding obstacles. The system combines vision with proprioception, allowing the robot to move efficiently and smoothly in various environments.
A randomized clinical trial and meta-analysis found that antibiotic eye drops significantly shortened symptoms of conjunctivitis in children. The study's results suggest a promising treatment option for this common childhood condition.
A clinical trial of email alerts from pharmacists to doctors and other practitioners found no reduction in risky opioid prescribing, highlighting the need for rigorous testing of policies aimed at making opioid prescribing safer. The study tested behavioral science techniques to encourage safer prescribing practices.
A study published in JAMA Pediatrics found that gender-affirming top surgery significantly improved chest dysphoria and gender congruence among transmasculine and nonbinary individuals designated female at birth. The procedure was also associated with enhanced body image, with minimal surgical complications reported.
A randomized trial found that a 12-week online yoga program improved knee function in participants, but did not significantly reduce knee pain during walking. The study suggests that unsupervised online yoga programs can be feasible and improve physical function, but more research is needed to sustain the effectiveness.
A randomized clinical trial found that rituximab significantly improved disease control in patients with new-onset myasthenia gravis, reducing the need for cortisone treatments and hospitalizations. The study's results offer hope for a more effective treatment strategy, but larger studies are needed to assess long-term effects.
A randomized controlled trial found that both BVLR and surgery lead to significant improvements in lung function, breathlessness, and exercise capacity. The study suggests that less invasive BVLR may be a good therapeutic option for suitable patients, offering a similar outcome to traditional surgery.
Recent evidence suggests hormone therapy at menopause does not significantly increase the risk of invasive breast cancer. However, estrogen combined with progesterone increases breast cancer risk for women with an intact uterus. Menopause experts offer reassurance to women and their healthcare providers about the safety of hormone ther...
A large, randomized trial found that metformin reduced serious COVID-19 outcomes by more than half in high-risk patients when started early. The study compared three medications and provided valuable insights into their effects on COVID-19.
A pooled data analysis of 21 international clinical trials involving nearly 30,000 people found that salt substitutes lowered blood pressure and reduced the risk of heart attack, stroke, and early death. The benefits were consistent across different geography, age, sex, and health conditions.
A new study led by MIT economist Amy Finkelstein found that for every nine adults who gained access to Medicaid in Oregon, one previously eligible child was added to the Medicaid rolls. The effect is modest but economically meaningful, with children costing four times less to cover than adults.
TCT 2022 will feature late-breaking clinical science presenting the safety and effectiveness of minimally invasive techniques, pharmaceuticals, technologies, and devices for treating or preventing cardiovascular disease. The event takes place September 16-19 in Boston at the Boston Convention and Exhibition Center.
A systematic review and meta-analysis found no significant differences in treatment success between nonoperative and operative management for acute uncomplicated appendicitis. However, the nonoperative group experienced significantly longer hospital stays and higher recurrence rates.
A new study published in the Journal of the American Heart Association found that walking for exercise at a pace that induces leg pain or discomfort improves walking ability among people with peripheral artery disease. The study involved 264 participants who walked at home at either a comfortable pace or a pace that induced leg symptom...
A new study from Tel Aviv University found a promising treatment for long-term COVID-19 symptoms using Hyperbaric Oxygen Therapy (HBOT). Patients treated with HBOT showed significant improvement in cognitive function, attention, and executive functions.
A randomized controlled trial found that establishing specialized help desks for women in local police stations in Madhya Pradesh, India led to increased registration of cases of gender-based violence. The presence of female officers was particularly effective in making the police more responsive to women's security needs.
Outpatient antibiotic management of selected patients with appendicitis is safe, allowing many to avoid surgery and hospitalization. This treatment approach is associated with fewer serious adverse effects compared to hospitalization.
A large multicenter trial found no difference in intubation requirement between awake prone positioning and standard positioning for COVID-19 patients. The study included 400 patients who required oxygen therapy, but the prone positioning strategy did not significantly reduce the risk of intubation or mortality.
A prospective randomized study found that an AI support platform reduced chest CT interpretation times by 22.1%, saving approximately one hour per day for radiologists. The platform provided automated analysis of cardiac, pulmonary, and musculoskeletal findings, resulting in shorter interpretation times.