Articles tagged with Randomization
A multicenter randomized trial showed a paclitaxel-coated balloon to be superior to an uncoated balloon in preventing target lesion failure in patients with coronary in-stent restenosis. The study included 600 patients and demonstrated the effectiveness of paclitaxel-coated balloons as a treatment option.
A randomized clinical trial found that linkage case management intervention did not improve 12-month mortality outcomes for hospitalized people with HIV. The study involved 500 participants and sheds light on the potential role of this intervention among hospitalized individuals with HIV.
The latest American Psychiatric Association journals feature new treatments across the lifespan for anxiety, depression, and substance use disorder. The March issue of The American Journal of Psychiatry highlights several studies with these findings.
After 7 to 12 years of follow-up, bariatric surgery outperformed medical/lifestyle intervention in achieving superior glycemic control with reduced medication use and higher rates of diabetes remission. Individuals who underwent bariatric surgery had better long-term management of their type 2 diabetes.
A randomized clinical trial found acupuncture to be clinically efficacious and favorably affect PTSD symptoms in combat veterans. The study suggests that further research is needed to explore the efficacy and mechanisms of acupuncture for PTSD treatment.
In a phase 2 clinical trial, zilebesiran significantly reduced 24-hour mean ambulatory systolic blood pressure in adults with mild to moderate hypertension. The treatment was administered subcutaneously at varying doses and intervals, demonstrating its potential as an RNA interference therapeutic for managing hypertension.
A randomized clinical trial of 1,680 patients with acute ischemic stroke due to large-vessel occlusion found no significant improvement in disability with adjunctive methylprednisolone. The study suggests that methylprednisolone may not be effective as an adjunct therapy after endovascular thrombectomy for this patient population.
A randomized clinical trial of 336 patients with extensive ischemic stroke found that endovascular thrombectomy improved clinical outcomes across a range of infarct volumes. However, the treatment's effectiveness was limited by low enrollment rates among patients with minimal penumbra volume.
Intravenous thrombolysis (IVT) plus thrombectomy demonstrates significant benefits over thrombectomy alone when administered within a short timeframe after symptom onset. This study, based on individual participant data from six randomized clinical trials, found IVT before thrombectomy to be time-dependent and statistically significant.
A randomized clinical trial of 1,015 participants found that apixaban did not significantly reduce recurrent stroke risk compared to aspirin in patients with cryptogenic stroke and atrial cardiopathy. The study suggests that alternative treatments may be more effective for preventing stroke recurrence in these patients.
A study of over 1,700 adult patients found that gastric bypass and sleeve surgeries have few short-term complications and are equivalent in terms of risk. The results suggest that patients and doctors can choose between the two procedures without worrying about short-term surgical risks.
A randomized clinical trial compared the outcomes of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass in 1,735 patients. The study found no clinically significant differences between the two procedures in terms of perioperative risk.
In a randomized clinical trial of 1,068 smokers, electronic cigarettes were shown to be as effective as varenicline in aiding smoking cessation, while being more effective than nicotine chewing gum. The study suggests that e-cigarettes may offer a viable alternative for quitting smoking with minimal behavioral support.
A groundbreaking new book in Chinese bridges the knowledge gap on Mendelian randomization, elevating study quality and enabling local researchers to benefit from its contents. The translation promises to facilitate high-quality studies, equip researchers with reliable results, and advance medical research.
A study published in PAIN found that exposure-based CBT and traditional CBT are equally effective in reducing symptoms of fibromyalgia. The study involved 274 participants with fibromyalgia and showed significant reductions in symptoms and functional impairment after 10-week treatment.
A large randomized study investigated the effect of preoperative, low-dose oral administration of midazolam in older patients on patient satisfaction and safety. No significant difference was found between midazolam and placebo groups regarding patient safety.
A multicenter randomized clinical vignette survey study found that AI models, when systematically biased, reduced diagnostic accuracy. The study involved hospitalist physicians, nurse practitioners, and physician assistants from 13 states.
A systematic review and meta-analysis of 15 clinical trials found daily tooth brushing may reduce hospital-acquired pneumonia rates by up to 50% in high-risk patients. This study suggests that widespread toothbrushing policies could save lives and reduce healthcare costs.
Using metformin plus insulin to treat preexisting type 2 or gestational diabetes diagnosed early in pregnancy did not show a reduction in composite neonatal adverse outcomes. The study suggests that the effect of reducing large-for-gestational-age infant risk after adding metformin to insulin warrants further investigation.
A study published in the Journal of Nursing Administration found that Transcendental Meditation significantly reduced PTSD, anxiety, and burnout in frontline nurses during the COVID-19 pandemic. The technique improved flourishing by 15% and decreased symptoms by more than half over a 3-month period.
Continued treatment with tirzepatide maintained and augmented initial weight reduction in adults with obesity. Withdrawing tirzepatide led to substantial regain of lost weight in a randomized clinical trial involving 670 participants.
A randomized clinical trial found that Mindfulness-Oriented Recovery Enhancement (MORE) plus usual care significantly decreased drug use, pain, and depression in individuals with opioid use disorder and chronic pain. Participants who received MORE also showed increased methadone treatment retention and adherence.
A new study published in the American Journal of Clinical Nutrition suggests that taking cocoa extract supplements containing 500 mg of flavanols daily may improve cognitive function in older adults with lower habitual diet quality. In contrast, participants with healthy dietary patterns showed no cognitive benefits.
Researchers aim to determine optimal duration and intensity of behavioral interventions for childhood obesity among rural and minority children. The five-year study, funded by the Patient-Centered Outcomes Research Institute, will enroll 900 parent-child pairs and compare different 'dosing' combinations of face-to-face intervention time.
A randomized clinical trial found that excluding aspirin from the antithrombotic regimen in LVAD patients improved adverse event rates by a significant reduction in non-surgical bleeding. The study results suggest that an aspirin-free regimen is safe and may improve longevity, morbidity, and quality of life for these patients.
A randomized clinical trial of 31,000 individuals found that direct-mail human papillomavirus (HPV) self-sampling increased cervical cancer screening by more than 14%. The study suggests that systems implementing HPV self-sampling should prioritize direct-mail outreach for under-screened individuals to increase screening adherence.
Researchers found that acoustic stimulation improved postconcussive symptoms in individuals with mild traumatic brain injury, although the benefits were largely sustained. The study's results suggest that listening to acoustic stimulation based on brain electrical activity may not improve symptoms more than randomly generated sound sti...
A systematic review of 13 randomized clinical trials found that app-based interventions are effective in treating moderate to severe depression. The study's findings support the use of mobile apps as a practical tool for clinical practice.
A comprehensive meta-analysis led by Dr. Micheal Sandbank reveals that many low-quality studies are driving intervention recommendations and patient outcomes in early childhood autism care. The study highlights the need for more rigorous research to understand the positive and negative effects of various interventions.
A randomized clinical trial of 1,175 participants found that treatment with higher-dose fluvoxamine did not improve time to sustained recovery in outpatients with mild to moderate COVID-19. The study compared fluvoxamine 100 mg twice daily for 13 days to placebo.
A randomized clinical trial of 2,858 patients with new-onset and worsening chronic heart failure shows that torsemide and furosemide have no significant difference in clinical or patient-reported outcomes at 12 months. Torsemide is associated with better outcomes for patients with de novo heart failure.
A single dose of zilebesiran safely and effectively lowered systolic blood pressure in people with mild-to-moderate high blood pressure for up to six months. The study found significant reductions in daytime and nighttime systolic blood pressure, as well as low rates of adverse events.
A randomized controlled trial suggests that a more liberal approach to red blood cell transfusions for heart attack patients with anemia may benefit outcomes without significant risk. The study found no statistically significant difference between two transfusion strategies, but results suggest a possible benefit of liberal transfusions.
Patients with heart failure treated with dapagliflozin experienced frequent initial estimated glomerular filtration rate declines, but without increased cardiovascular or kidney event risks. The study suggests that sodium-glucose cotransporter-2 inhibitors can be safely continued in patients experiencing eGFR decline.
A natural language processing model was validated to identify heart failure hospitalizations in a multicenter clinical trial, demonstrating its potential to improve the efficiency of future trials. The study suggests that natural language processing can be used at scale to identify clinical events, but further research is needed.
A randomized clinical trial found that self-monitoring and physician-guided titration of antihypertensive medications reduced postpartum blood pressure compared to usual care. The study involved 220 participants in the UK and showed promising results for long-term blood pressure control.
A randomized clinical trial found that avoiding aspirin as part of an antithrombotic regimen reduces bleeding events without increasing thromboembolism risk in patients with advanced heart failure treated with left ventricular assist devices. The study suggests that aspirin avoidance may be a viable option for these patients.
Patients with HER2-positive breast cancer that has spread to other parts of the body survive for longer if treated with pyrotinib. The new drug targets proteins involved in HER2-positive breast cancer and shows a 22% reduction in risk of death compared to lapatinib.
A recent study in JAMA Cardiology analyzed data from 15,000 patients and found that enteric coating on aspirin does not change its effectiveness or safety for secondary prevention of cardiovascular events. The study suggests that patients can choose the aspirin formulation that suits them best.
A novel multicomponent intervention aimed at improving patient access to kidney transplants did not significantly increase the rate of completed steps in a randomized clinical trial involving 20,375 patients. The study highlights the need for sustained efforts to address barriers to transplantation globally.
A randomized clinical trial involving 126 patients found that landiolol did not prevent organ failure in those with established septic shock. The study concluded that this beta-blocker is not a suitable treatment option for managing tachycardia in these patients.
A randomized clinical trial of 524 trauma patients found that adding sigh breaths to mechanical ventilation did not increase ventilator-free days. However, prespecified secondary data suggest that sighs are well-tolerated and may improve clinical outcomes in this patient population.
Researchers found no significant improvement in primary composite outcomes, including organ support-free days and hospital survival, among hospitalized patients with COVID-19 who received intravenous vitamin C. The study suggests that vitamin C treatment may not be effective in improving patient outcomes for this population.
Tongxinluo significantly improved 30-day and 1-year clinical outcomes in STEMI patients, according to a randomized clinical trial. Further research is needed to understand its mechanism of action.
A phase III pivotal trial evaluating cabozantinib in advanced neuroendocrine tumors demonstrated significant improvements in median progression-free survival (PFS) compared to placebo. The study met its primary objective for both cohorts of patients, providing encouraging news for those with progressive disease.
A randomized clinical trial found that high-frequency electrical stimulation device reduced opioid use and prescribed opioids after cesarean delivery, suggesting a potential adjunct to decrease opioid use without compromising pain control.
A randomized clinical trial found that cefepime increased neurological dysfunction in adults hospitalized with acute infection, while piperacillin-tazobactam did not. The study involved 2,511 participants and suggested that cefepime may be associated with adverse outcomes.
Researchers conducted a randomized trial in Canadian ICUs, finding that switching to small-volume blood collection tubes lowered red blood cell transfusion rates. The study suggests this change may improve patient outcomes and reduce the need for transfusions.
A Phase IIIb study published in the New England Journal of Medicine found that esketamine nasal spray achieved higher remission rates (27.1%) compared to quetiapine extended-release (17.6%) in patients with treatment-resistant depression, indicating its potential as a targeted therapy for this population.
A recent human study found that grape consumption improved key markers of eye health in older adults, including increased Macular Pigment Optical Density (MPOD) and reduced AGEs. Regular grape intake was also shown to increase plasma antioxidant capacity and total phenolic content.
A post hoc analysis of 10,678 participants with atherosclerotic cardiovascular disease found no significant difference in heart attack, stroke, or death risk between enteric-coated and uncoated aspirin. Enteric-coated aspirin may offer reduced bleeding risk, but more research is needed to confirm its benefits.
A randomized clinical trial found that early metformin treatment did not improve insulin initiation or fasting glucose levels in pregnant women with gestational diabetes. Further investigation into larger trials is warranted based on prespecified secondary outcome data.
In a randomized clinical trial, weekly tirzepatide showed greater reductions in HbA1c levels and body weight compared to prandial insulin as an additional treatment in people with inadequately controlled type 2 diabetes. The study also found less hypoglycemia with tirzepatide.
Men with metastatic prostate cancer in Sweden experienced an average survival rate increase of six months after dual treatment was introduced from 2016 onwards. This improvement coincides with the gradual rollout of 'dual treatment', combining standard hormone therapy and chemotherapy or androgen receptor blockers.
A phase III trial suggests that fewer and higher doses of radiation therapy delivered over five sessions are as effective as lower doses delivered over several weeks for patients with locally advanced disease. The treatment achieved a 96% five-year disease control rate, comparable to 95% for conventional radiation.
A Michigan Medicine-led report found that adding a mobile health application to wearable devices did not significantly improve physical activity levels in patients enrolled in cardiac rehabilitation. However, some short-term outcomes showed an increase in walking distance over six minutes for Fitbit users.
A randomized clinical trial shows cognitive-behavioral therapy (CBT) reduces fibromyalgia pain and improves daily living. CBT alters brain connectivity to reduce catastrophizing, a key contributor to fibromyalgia symptoms.
A dose-response meta-analysis of nine randomized trials found gefapixant to improve cough frequency, severity, and quality of life. However, it also led to increased taste-related adverse events compared to placebo.
A study of nearly 500,000 participants found that smoking shortens telomere length in white blood cells, a indicator of aging and cell regeneration. The more cigarettes smoked, the stronger the shortening effect, suggesting a link between smoking and accelerated aging.
In a randomized clinical trial, lorundrostat effectively lowered blood pressure in individuals with uncontrolled hypertension compared to placebo. The study included 200 participants and will require further confirmation.