Articles tagged with Randomization
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
A randomized clinical trial found that peer health coaching improved mental health-related quality of life in veterans with cardiovascular disease risks. The study suggests a peer-support model integrated into primary care can lead to well-being improvements beyond blood pressure control.
A supervised hospital walking program has been shown to reduce nursing facility admissions for older adults by lowering the proportion of patients discharged to skilled nursing facilities from 13% to 8%. However, low participation rates and limited impact on length of stay or inpatient falls were noted.
A randomized clinical trial suggests that low-dose atropine may provide a treatment option for childhood myopia progression. The study observed a significant reduction in myopia progression over 3 years.
A Canadian study found that eliminating out-of-pocket medication expenses for patients with cost-related nonadherence results in lower healthcare spending over three years. The analysis suggests that reducing medication costs could lead to significant savings in the overall healthcare system.
A new study published in the European Heart Journal found that plant-based diets can play a significant role in reducing blocked arteries and lowering the risk of heart and blood vessel diseases. The analysis of 30 randomised trials with over 2,300 participants showed a 14% reduction in artery-clogging lipoproteins.
The TWILIGHT trial found ticagrelor monotherapy after PCI to have a similar risk of repeat revascularization and MACCE compared to dual antiplatelet therapy. Ticagrelor monotherapy was also associated with lower NACE and clinically-driven revascularization risk.
A phase IIb trial found brepocitinib superior to placebo in reducing signs and symptoms of psoriatic arthritis after 16 weeks. Response rates were maintained or improved through week 52, with mostly mild or moderate side effects.
A new commentary from infectious disease experts emphasizes the importance of continued masking in healthcare settings due to low evidence of efficacy and high transmission risks. Despite recent conflicting views, the authors argue that mask-wearing remains a crucial strategy for infection prevention.
A recent clinical trial, PLATO, demonstrated that lowering the dose and duration of radiotherapy treatments for anal cancer reduces side effects without compromising cancer cure rates. The treatment involves intensity modulated radiotherapy (IMRT), which allows for personalized doses to be applied to visible tumors.
A study by UMC Utrecht shows that corona patients can measure their blood oxygen levels at home using a pulse oximeter, feeling safe and experiencing more control. This method does not increase GP visits or hospitalization but contributes to relieving caregivers and keeping healthcare affordable.
A randomized controlled experiment involving 26,911 students at 22 diverse U.S. universities found that a low-cost online social-belonging intervention increased the rate of students completing their first year as full-time students, particularly among historically underrepresented groups. The study demonstrates the efficacy of this in...
A randomized clinical trial found that community health workers in early childhood well-child care teams improved receipt of preventive care services compared to usual care. The intervention resulted in better outcomes for Medicaid-insured children, highlighting the potential benefits of team-based approaches to healthcare.
A study comparing physician and AI chatbot responses found chatbots excelled in both quality and empathy, while physicians were preferred for their nuanced understanding. The findings suggest that integrating chatbots into clinical settings could improve response quality and reduce clinician burnout.
The NVX-CoV2373 vaccine demonstrated strong safety and immunogenicity profiles in a clinical trial of over 2,200 adolescents. The study found the vaccine to be efficacious in preventing COVID-19, including the Delta variant.
A growing number of states have implemented policies to cover outpatient hemodialysis for undocumented immigrants with kidney failure. This expansion may be due to increased awareness of poor outcomes with emergency hemodialysis and advocacy efforts. The move towards covering dialysis in all 50 states is called for by experts, who also...
Researchers found that removing ovaries during a benign hysterectomy increases the risk of hospitalization for cardiovascular disease in premenopausal women, but not necessarily for cancer. The study supports current recommendations to conserve ovaries in premenopausal patients at low risk for ovarian cancer.
A randomized clinical trial found that using smartphone apps for home monitoring after oncologic surgery leads to improved quality of recovery and equal patient satisfaction. The study compared this approach with conventional in-person follow-up, revealing no significant differences in these outcomes.
A study of over 43,000 adults found that parathyroidectomy has no estimated effect on long-term kidney function in older adults. However, early treatment may preserve kidney function in patients younger than 60 years old.
A randomized clinical trial found that anakinra did not prevent mechanical ventilation or reduce mortality risk in hospitalized patients with severe COVID-19 pneumonia. Future research is needed to assess anakinra in less severe cases.
Enoblituzumab, a monoclonal antibody, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body. The drug targets B7-H3 protein overexpressed on prostate cancer cells, blocking immune system inhibition and triggering tumor cell destruction by activating immune cells.
A group led by Virginia Tech's Audrey Ruple developed the PetSORT guidelines to standardize reporting in clinical trials involving dogs and cats. The guidelines address methodological features often missing from reported trials, which can affect meta-analysis results.
Researchers found that using monoclonal antibodies within two days of a COVID-19 diagnosis reduced the risk of hospitalization or death by 39% compared to those who did not receive treatment. This finding suggests that early treatment with monoclonal antibodies significantly reduced the severity of COVID-19.
A randomized clinical trial found that a video-based decision support tool increased patient knowledge, but not assent, to ICD implantation among Black patients. The study also highlighted the complexity of aversion to cardiac procedures in Black communities, emphasizing the need for further research on social determinants of health.
A multi-site randomized controlled trial found Health TAPESTRY to have widespread reach and adoption, but no significant clinical benefits on hospitalizations and physical activity. The study tested implementation and reproducibility of the program across diverse primary care practices.
A WVU researcher is working on a biopsychosocial intervention to help people with chronic hip pain move and regain mobility. The intervention, called HIPS, combines mindfulness techniques like self-compassion and progressive relaxation with goal-setting and diaphragmatic breathing to reduce pain and increase physical activity.
A secondary analysis of a randomized trial found that even a small reduction in sleep time per night can significantly affect health-related quality of life in children. The study suggests ensuring sufficient good-quality sleep is crucial for child health.
A systematic review of 33 randomized controlled trials found that yoga improved gait speed and lower extremity strength in inactive older people. However, it did not offer a benefit for frailty markers compared to exercise or tai chi.
A study by the University of Missouri found that older adults who completed an eight-week resistance training program maintained long-term exercise habits and increased their physical energy despite COVID-19 restrictions. The Stay Strong, Stay Healthy program improved participants' sleep, balance, flexibility, and self-confidence in da...
A virtual care team consisting of physicians and pharmacists improved the adoption of life-saving therapies in patients with heart failure, leading to increased use of evidence-based treatments and better patient outcomes. The strategy was safe and effective, with comparable length of stay and safety events between the groups.
High-dose anticoagulation reduces intubations and deaths by 30% in hospitalized COVID-19 patients, especially those with ARDS. The study found a significant reduction in mortality and need for ICU care among patients treated with therapeutic anticoagulation.
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
Researchers at Sandia National Laboratories and Purdue University have developed a technique called moving target defense to protect against hackers taking control of military jets. This approach involves shuffling network addresses to make it difficult for attackers to access critical systems.
Researchers found that an immersive virtual reality (IVR) intervention significantly improved pain and anxiety in pediatric patients undergoing a blood draw. The IVR group showed better outcomes compared to the control group.
A randomized controlled trial found that calorie restriction slowed the pace of biological aging in healthy adults by 2-3%, measured using the DunedinPACE algorithm, which translates to a 10-15% reduction in mortality risk. The intervention had no effects on other epigenetic clocks.
Researchers found that AI significantly improved the detection of lung nodules on chest X-rays, detecting actionable nodules at a rate of 0.59% compared to 0.25% without AI assistance. The study suggests that AI may work consistently across different populations.
An updated Cochrane review found no effect of vitamin D supplements on reducing the risk of asthma attacks or improving control of asthma symptoms in children and adults. The review analyzed data from 20 randomized controlled trials involving over 2,200 people with mild to moderate asthma.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
A new study found a significant weight loss of 8.8% among participants after six months, with improvements in health and vitality. The approach addresses biological antecedents of food intake and develops intrinsic motivation for behavior changes.
A Dartmouth-led study found that team-based coaching significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions. The Collaborative with Surveillance intervention reduced the odds of AKI by 46 percent, making it a promising approach to address this prevalent adverse event.
Laboratory experiments show rapid antibiotic switches can prevent resistance, with collateral-sensitive drug pairs suitable for therapy. However, environmental conditions in patients differ from labs, and natural degradation affects treatment.
A randomized clinical trial of 1,288 adults with mild to moderate COVID-19 found that fluvoxamine treatment did not reduce time to sustained recovery compared to placebo. The study suggests that fluvoxamine at a dose and duration tested may not be beneficial in patients with mild to moderate COVID-19.
A school-based gardening, nutrition, and cooking intervention improved glucose control and reduced low-density lipoprotein cholesterol in high-risk youth. Elementary schools can incorporate garden-based interventions to improve metabolic parameters in children.
Internet-delivered parent-child interaction therapy shows promise in expanding care for underserved children with developmental delay. The study found significant improvements in child behavior that were maintained across follow-up visits.
A randomized clinical trial found that climate impact menu labels can effectively reduce red meat selections and encourage more environmentally sustainable restaurant food choices. The study suggests that negatively framed labels highlighting high-climate impact items were particularly effective in promoting eco-friendly options.
Researchers found that plasma GH levels are a potential biomarker for predicting treatment outcomes in patients with advanced HCC treated with Atezo/Bev. The study showed significantly superior overall survival and non-significant trend in favor of GH-low patients compared to GH-high patients.
A randomized trial shows that patients undergoing partial knee arthroplasty (UKA) experience faster functional recovery in walking speed and mobility tests compared to those who had total knee arthroplasty (TKA). UKA also resulted in shorter operative times, reduced blood loss, and improved functional outcomes.
A randomized controlled trial found that a low-carbohydrate, high-fat diet helped patients with type 2 diabetes achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. However, changes were not sustained 3 months after the intervention.
A web-based multicomponent intervention has been shown to improve blood pressure control and lower blood pressure levels in patients with hypertension. The study included 4,100 patients and found that such an intervention can provide a new, effective way to treat hypertension in the community.
A study published in Tobacco Control found that alternatives to menthol cigarettes pose significant addiction and health risks. Mentholated pipe tobacco and tubes were the most appealing and addictive options, suggesting they should be included in the proposed ban.
A study of over one million Medicaid beneficiaries found that more than half experienced significant lapses in coverage, with only 25% continuously enrolled throughout the period. The authors recommend increasing investments to improve long-term health outcomes.
The American Psychiatric Association's December journal issues explore new therapeutic approaches involving psychopharmacology, digital technology, and fMRI neurofeedback. The APA also highlights its vision to ensure access to quality psychiatric diagnosis and treatment.
A randomized clinical trial of 8,800 school-age children with high vitamin D deficiency showed no impact on growth or pubertal development after 3 years of weekly oral vitamin D administration. Vitamin D deficiency is associated with stunting and obesity in children.
Black and Hispanic men are underrepresented in prostate cancer clinical trials compared to their incidence rate. The representation of Black patients has remained consistently low over the past two decades.
Outreach messages via electronic health record patient portals increased well child care visit scheduling and COVID-19 vaccine receipt in a randomized clinical trial of 945 patients. This tool may help restore delayed well child care in populations affected by the pandemic.
Studies found that sotrovimab reduced the risk of severe covid-19 outcomes by 46% compared to molnupiravir. However, no benefit was found for common heart drugs like ARBs in a randomised controlled trial.
A new study has shown that total ankle replacement and ankle fusion surgeries equally improve quality of life for patients with advanced ankle osteoarthritis. However, a fixed bearing joint replacement showed significant improvement over ankle fusion in clinical scores.
A randomized controlled trial found that oral ENT-01 significantly improves constipation and possibly neurological symptoms in persons with Parkinson disease. The treatment is safe for up to 25 days, with a dose-dependent effect that persists beyond the treatment period.
A randomized study compared the effects of torsemide and furosemide in people with heart failure. The study found that both loop diuretics were effective in reducing death and hospitalization rates, with no significant clinical difference between the two medications.
A clinical trial found that early use of ECMO devices did not improve outcomes for adults with rapidly deteriorating or severe cardiogenic shock. Participants who received immediate ECMO therapy showed similar clinical outcomes as those receiving early conservative therapy, including treatment with inotropes and vasopressors.