Articles tagged with Gene Editing
CHOP and Penn Medicine researchers have developed a proof-of-concept model for delivering gene editing tools directly into diseased blood cells within the body. This approach aims to reduce costs and increase access to gene therapies for blood disorders, which currently require chemotherapy and stem cell transplants.
Researchers at Cornell University have discovered a mutation in the MdLAZY1A gene responsible for the 'weeping' growth pattern in apple trees. This finding could lead to more productive and labor-saving orchards by allowing branches to grow downwards, thereby increasing resource allocation towards reproductive growth.
Gang Bao's lab receives a 4-year, $2.6 million grant from the National Institutes of Health to investigate the safety and efficacy of using gene editing treatments like CRISPR-Cas9 to treat sickle cell disease. The team aims to understand the mechanisms behind large gene modifications and their biological consequences.
Researchers at North Carolina State University used CRISPR gene-editing to breed poplar trees with reduced lignin levels, while improving their wood properties. This breakthrough could make fiber production for paper, diapers, and other products more sustainable, efficient, and cost-effective.
Hematopoietic stem cell culture technology improves genome editing in HSCs by increasing successful correction rates to 100%, eliminating genetic mutations, and enhancing cell transplantation outcomes. This breakthrough enhances the efficiency and safety of gene editing in treating genetic diseases.
A new study by researchers at NYU and the New York Genome Center combines deep learning with CRISPR screens to control human gene expression. The model predicts on- and off-target activity of RNA-targeting CRISPRs, enabling precise gene controls for developing new therapies.
Duke researchers discovered a new approach to CRISPR RNA variants that can specifically target challenging areas of DNA for editing. This improvement enables the repair of mutations associated with more diseases, leading to safer and more effective gene editing therapy.
A new study from Aarhus University has found that applying AI predictions of protein structures enhances the CRISPR technology, making the cuts in a patient's DNA more precise. This discovery may lead to better treatments for patients with genetic disorders and potentially develop cures for various genetic diseases.
Researchers have uncovered a new RNA-guided DNA-cutting enzyme called Fanzor in eukaryotes, which has the potential to edit the human genome with precision. The system was found to be more easily delivered to cells and tissues than CRISPR/Cas systems, making it a valuable new technology for human genome editing.
A new study reveals a consistent difference in favorability ratings between gene editing and genetically modified organisms (GMOs) in social and traditional media. Gene editing consistently receives higher favorability ratings, with close to 100% achieved in numerous monthly values, indicating a positive shift in public sentiment.
Researchers have discovered that gene editing technologies may introduce unintended mutations and damage to DNA in early human embryos. The study found that most cells repair breaks in the DNA using non-homologous end joining, which can lead to additional genetic abnormalities.
A new gene editing tool exploits a bacterial immune system to target and eliminate antibiotic-resistant genes. The tool has shown early promise in laboratory experiments by protecting host cells from developing resistance and reversing it in resistant hosts.
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
Researchers have developed chicken eggs without the protein that causes egg white allergies, confirming their safety profile. The modified eggs, called OVM-knockout, were tested and found to be free from ovomucoid proteins, making them a potential solution for individuals with egg allergies.
Researchers at KAIST have developed a new sRNA tool that can effectively inhibit target genes in various bacteria, including both Gram-negative and Gram-positive bacteria. The BHR-sRNA system was shown to suppress pathogenicity in antibiotic-resistant pathogens and improve industrial strains for high-value-added chemical production.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new approach, STING-seq, combines genetic association studies, gene editing, and single-cell sequencing to identify causal variants and genetic mechanisms for blood cell traits. This method can help scientists identify drug targets for diseases with a genetic basis.
Researchers at Temple University and the University of Nebraska Medical Center developed a novel dual gene-editing approach that can effectively eliminate HIV infection. The therapy targets both HIV-1, the virus responsible for AIDS, and CCR5, a co-receptor that facilitates viral entry into cells.
Researchers developed a new approach to genetic engineering of cells, promising improvements in speed and efficiency over current methods. The technique uses special cell-penetrating peptides to deliver CRISPR-Cas molecules into cells with up to 100% efficiency and low toxicity.
The MBL's 36th year Logan Science Journalism Program provides immersive research training for twelve fellows from prominent news organizations. They will participate in Biomedical and Environmental Hands-On Research Courses, exploring cutting-edge technologies and scientific innovations.
Researchers at Gladstone Institutes have made a groundbreaking discovery about how neurons consume and metabolize glucose, a process crucial for maintaining normal energy levels. The study found that neurons rely on glycolysis to break down glucose, and its disruption can lead to severe learning and memory problems in mice.
Researchers developed an optimized genome-editing method that vastly reduces mutations, enabling more effective treatment of genetic diseases. The new technique uses a 'safeguard gRNA' to control DNA cleavage, reducing off-target effects and cytotoxicity.
Researchers at the University of Tokyo have discovered the 3D structure of TnpB, a protein involved in genome editing and a probable precursor to the CRISPR-Cas12 enzyme. The study reveals how TnpB recognizes and cuts DNA using a unique pseudoknot shape similar to that found in guide RNAs of Cas12 enzymes.
Researchers have developed a new method for downregulating gene translation in plants using upstream open reading frames (uORFs). The study, published in Nature Biotechnology, demonstrates the potential for precise and incremental regulation of gene expression.
A new study led by OHSU researchers reveals that gene editing technology in human embryos can lead to unintended changes in the genome and may not accurately reflect gene edits. The study highlights the need for caution when using genetically edited embryos to establish pregnancies.
Researchers developed a machine learning algorithm to predict the chances of successful prime editing gene edits, assessing thousands of DNA sequences and identifying key factors such as sequence length and DNA repair mechanisms. The tool promises to speed up efforts to bring prime editing into the clinic.
Researchers from Rice University have developed a new approach to control gene expression using proteolysis targeting chimeras (PROTACs). By reengineering the PROTAC molecular infrastructure, they demonstrated the ability to achieve chemically induced dimerization (CID), allowing for precise control over gene activation in specific loc...
The CABBI team successfully demonstrated precision gene editing in miscanthus, a promising perennial crop for sustainable bioenergy production. The results will accelerate efforts to tap the huge potential of this highly productive but genetically complex grass as a source for biofuels, renewable bioproducts, and carbon sequestration.
Researchers at UW-Madison developed silica nanocapsules that can carry CRISPR tools across the blood-brain barrier, enabling brain-wide gene editing for disorders like Alzheimer's and Parkinson's. The technology has potential for non-invasive delivery of gene therapies.
Researchers developed a flexible genetic hacking system to convert split gene drives into full gene drives, enabling safe testing and potential real-world applications. The new system revealed surprising fitness costs of full drive systems, with slower-than-predicted spread rates in cage experiments.
A new approach to gene therapy for inherited blindness uses lipid nanoparticles to deliver mRNA inside the eye, targeting light-sensitive cells and creating proteins that edit vision-harming gene mutations. The technology has shown promising results in animal studies, including mice and nonhuman primates.
Hiroshima University researchers have generated a high-quality genome assembly of red perilla, allowing scientists to harness its abundance of potentially useful bioactive chemicals. The study enables targeted gene editing for enhanced phytochemical production, paving the way for new medical applications.
A new breeding strategy enables rapid production of tomatoes with various fruit colors, including red, yellow, pink, and green, using CRISPR/Cas9-mediated multiplex gene editing. This method requires less time and produces transgene-free plants with desirable traits, offering a promising approach for improving multigene-controlled traits.
A WSU-led survey found that US consumers value grape taste more than gene editing, with appearance and pesticide concerns ranking second and third respectively. Most participants were indifferent to the use of CRISPR technology in table grapes.
Researchers discovered a new CRISPR protein that can degrade single-stranded RNA, DNA, and double-stranded DNA, enabling the development of inexpensive and highly sensitive diagnostic tests for various infectious diseases. The test could combine high sensitivity and accuracy with rapid at-home diagnostic features.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.
Researchers at Cornell University discover how to modulate the affinity of Cas proteins, enabling precise gene editing and reducing off-target effects. By modifying guide RNAs, they can tune Cas removal, contributing to future CRISPR applications.
A new microfluidic multiplexed chip uses CRISPR technology to detect SARS-CoV-2 and monitor antibiotic levels, offering a rapid and sensitive solution for managing COVID-19 patients. The test omits nucleic acid amplification and can be easily adapted to new virus mutations.
The new PASTE tool combines precise targeting of CRISPR-Cas9 with integrases to insert large chunks of DNA into the genome without inducing double-stranded breaks. This approach holds promise for treating diseases with multiple mutations, such as cystic fibrosis, with high efficiency and minimal unwanted effects.
A study by Okayama University researchers found that neuromedin U (NMU) is involved in metabolic processes but its 'anti-hunger' function may not be crucial for rats. Unlike mice, NMU expression is restricted in the rat brain and does not suppress feeding behavior.
Researchers discover chemical inhibitor TIS108 significantly lowers Striga infestation without affecting plant growth or grain yield. The study shows canonical strigolactones contribute to seed germination in root parasitic weeds and play a major role in stimulating invasion by Striga.
Researchers have successfully treated six children with relapsed and treatment-resistant B-ALL using CRISPR-edited T cells, achieving deep remission in four patients. The treatment has shown promise as a viable alternative to currently available treatments.
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
Researchers at Rice University have developed a procedure to quantify unintended changes that accompany on-target CRISPR-Cas9 gene editing, potentially threatening the efficacy and safety of therapies. The new method uses single-molecule sequencing with unique molecular identifiers to detect large deletions, insertions, and chromosomal...
Researchers at Northwestern University developed a new CRISPR-based therapy platform that can deliver cargo to a broader range of tissue and cell types, increasing its potential for treating various diseases. The platform achieves this by transforming the Cas-9 protein into a spherical nucleic acid and loading it with critical components.
The event will cover various topics including microbiota dysbiosis, oral and vaginal microbiota, and their impact on diseases like depression, cancer, and respiratory infections. The meeting aims to accelerate Microbiota medicine applications through strategic discussions.
Researchers at UCI have made significant progress in precision genome editing for treating inherited retinal diseases, enabling precise gene correction and disease rescue. The study highlights the potential of this technology to revolutionize treatment of genetic disorders of vision, with over 270 causative genes identified.
Researchers developed an engineered Cas13 system that detects SARS-CoV-2 in biological samples with high sensitivity and speed. The new platform outperforms traditional PCR testing, finding 10 out of 11 positives and no false positives in clinical samples.
Researchers are exploring ways to target and manipulate the human microbiome, with potential applications in treating diseases such as depression, obesity, and retinal disorders. The conference will feature presentations on innovative strategies and recent findings in modulating microbiota and microbial components.
Researchers at Gladstone Institutes and UCSF have developed a new approach to introduce long DNA sequences into cells with remarkable efficiency. The technology, which uses single-stranded DNA templates, overcomes the limitations of traditional viral vectors and has the potential to make cell therapies faster, better, and less expensive.
A team of researchers from Princeton University and the Broad Institute created a fast, accurate, and equipment-free diagnostic test for COVID-19. The test uses CRISPR technology to detect SARS-CoV-2 variants and can be performed at home without special equipment, improving sensitivity and specificity compared to existing tests.
Researchers at IRB Barcelona have found that CRISPR/Cas9 gene editing can trigger cell toxicity and genomic instability, particularly in regions near the tumour suppressor protein p53. The study identified 3,300 targeted spots with strong toxic effects, highlighting the need for safer CRISPR reagents.
A team of researchers, backed by a £30m grant from the British Heart Foundation, aims to develop the first cures for inherited heart muscle diseases using ultra-precise gene therapy technologies. They plan to deploy CRISPR technology to correct or silence faulty genes, potentially delivering an injectable cure within years.
Scientists have identified a key gene that can improve wheat grain yield by increasing the number of spikelets per spike. The discovery provides a promising solution to address the food security crisis and could lead to significant improvements in wheat yields.
Researchers generated simple kidney-like structures called organoids and used them to identify potential drugs for adult-onset polycystic kidney disease. They found nine compounds that inhibited cyst growth without stunting overall growth.
Experimental study finds large DNA insertions caused by retrotransposition can increase cancer risk in human cells edited with CRISPR/Cas9. In contrast, base editing and prime editing show much lower rates of retrotransposition.
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
A UVA researcher is using a harmless amoeba to develop an innovative treatment for deadly C. difficile infections in young children. The approach has the potential to deliver specific antibodies directly to the gut, reducing the need for antibiotics and addressing a growing public health threat.
Researchers have developed a novel CRISPR-Cas9 method for gene editing in cockroaches, achieving efficiency rates of up to 22% and over 50% in the red flour beetle. The technique, named DIPA-CRISPR, allows for efficient and accessible gene editing without requiring expensive equipment or skilled laboratory personnel.