Articles tagged with Gene Editing
Hiroshima University researchers have generated a high-quality genome assembly of red perilla, allowing scientists to harness its abundance of potentially useful bioactive chemicals. The study enables targeted gene editing for enhanced phytochemical production, paving the way for new medical applications.
A WSU-led survey found that US consumers value grape taste more than gene editing, with appearance and pesticide concerns ranking second and third respectively. Most participants were indifferent to the use of CRISPR technology in table grapes.
Researchers discovered a new CRISPR protein that can degrade single-stranded RNA, DNA, and double-stranded DNA, enabling the development of inexpensive and highly sensitive diagnostic tests for various infectious diseases. The test could combine high sensitivity and accuracy with rapid at-home diagnostic features.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.
Researchers at Cornell University discover how to modulate the affinity of Cas proteins, enabling precise gene editing and reducing off-target effects. By modifying guide RNAs, they can tune Cas removal, contributing to future CRISPR applications.
The new PASTE tool combines precise targeting of CRISPR-Cas9 with integrases to insert large chunks of DNA into the genome without inducing double-stranded breaks. This approach holds promise for treating diseases with multiple mutations, such as cystic fibrosis, with high efficiency and minimal unwanted effects.
A new microfluidic multiplexed chip uses CRISPR technology to detect SARS-CoV-2 and monitor antibiotic levels, offering a rapid and sensitive solution for managing COVID-19 patients. The test omits nucleic acid amplification and can be easily adapted to new virus mutations.
A study by Okayama University researchers found that neuromedin U (NMU) is involved in metabolic processes but its 'anti-hunger' function may not be crucial for rats. Unlike mice, NMU expression is restricted in the rat brain and does not suppress feeding behavior.
Researchers discover chemical inhibitor TIS108 significantly lowers Striga infestation without affecting plant growth or grain yield. The study shows canonical strigolactones contribute to seed germination in root parasitic weeds and play a major role in stimulating invasion by Striga.
Researchers have successfully treated six children with relapsed and treatment-resistant B-ALL using CRISPR-edited T cells, achieving deep remission in four patients. The treatment has shown promise as a viable alternative to currently available treatments.
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
Researchers at Rice University have developed a procedure to quantify unintended changes that accompany on-target CRISPR-Cas9 gene editing, potentially threatening the efficacy and safety of therapies. The new method uses single-molecule sequencing with unique molecular identifiers to detect large deletions, insertions, and chromosomal...
Researchers at Northwestern University developed a new CRISPR-based therapy platform that can deliver cargo to a broader range of tissue and cell types, increasing its potential for treating various diseases. The platform achieves this by transforming the Cas-9 protein into a spherical nucleic acid and loading it with critical components.
The event will cover various topics including microbiota dysbiosis, oral and vaginal microbiota, and their impact on diseases like depression, cancer, and respiratory infections. The meeting aims to accelerate Microbiota medicine applications through strategic discussions.
Researchers at UCI have made significant progress in precision genome editing for treating inherited retinal diseases, enabling precise gene correction and disease rescue. The study highlights the potential of this technology to revolutionize treatment of genetic disorders of vision, with over 270 causative genes identified.
Researchers developed an engineered Cas13 system that detects SARS-CoV-2 in biological samples with high sensitivity and speed. The new platform outperforms traditional PCR testing, finding 10 out of 11 positives and no false positives in clinical samples.
Researchers are exploring ways to target and manipulate the human microbiome, with potential applications in treating diseases such as depression, obesity, and retinal disorders. The conference will feature presentations on innovative strategies and recent findings in modulating microbiota and microbial components.
Researchers at Gladstone Institutes and UCSF have developed a new approach to introduce long DNA sequences into cells with remarkable efficiency. The technology, which uses single-stranded DNA templates, overcomes the limitations of traditional viral vectors and has the potential to make cell therapies faster, better, and less expensive.
A team of researchers from Princeton University and the Broad Institute created a fast, accurate, and equipment-free diagnostic test for COVID-19. The test uses CRISPR technology to detect SARS-CoV-2 variants and can be performed at home without special equipment, improving sensitivity and specificity compared to existing tests.
Researchers at IRB Barcelona have found that CRISPR/Cas9 gene editing can trigger cell toxicity and genomic instability, particularly in regions near the tumour suppressor protein p53. The study identified 3,300 targeted spots with strong toxic effects, highlighting the need for safer CRISPR reagents.
A team of researchers, backed by a £30m grant from the British Heart Foundation, aims to develop the first cures for inherited heart muscle diseases using ultra-precise gene therapy technologies. They plan to deploy CRISPR technology to correct or silence faulty genes, potentially delivering an injectable cure within years.
Scientists have identified a key gene that can improve wheat grain yield by increasing the number of spikelets per spike. The discovery provides a promising solution to address the food security crisis and could lead to significant improvements in wheat yields.
Researchers generated simple kidney-like structures called organoids and used them to identify potential drugs for adult-onset polycystic kidney disease. They found nine compounds that inhibited cyst growth without stunting overall growth.
Experimental study finds large DNA insertions caused by retrotransposition can increase cancer risk in human cells edited with CRISPR/Cas9. In contrast, base editing and prime editing show much lower rates of retrotransposition.
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
A UVA researcher is using a harmless amoeba to develop an innovative treatment for deadly C. difficile infections in young children. The approach has the potential to deliver specific antibodies directly to the gut, reducing the need for antibiotics and addressing a growing public health threat.
Researchers have developed a novel CRISPR-Cas9 method for gene editing in cockroaches, achieving efficiency rates of up to 22% and over 50% in the red flour beetle. The technique, named DIPA-CRISPR, allows for efficient and accessible gene editing without requiring expensive equipment or skilled laboratory personnel.
A team of researchers from Kumamoto University has developed a transformable polyrotaxane carrier that can facilitate genome editing using Cas9RNP with high efficiency. The carrier, called amino-PRX, is multi-step transformable and has low cytotoxicity, making it an enormously promising candidate for safe and efficient delivery.
Researchers at the University of Illinois Chicago found that gene editing can reverse epigenetic changes in the brain caused by adolescent binge drinking, leading to a decrease in anxiety and excessive drinking behavior. The study used CRISPR-dCas9 technology to manipulate histone acetylation and methylation processes at the Arc gene.
Researchers used CRISPR gene editing to understand how deletions in one area of the genome affect nearby genes. They found that deleting a small region led to increased foetal globin expression and reduced adult globin levels, suggesting a key mechanism for asymptomatic patients with sickle cell disease.
Hokkaido University scientists have identified CDK6 as a promising target for treating adult T-cell leukemia/lymphoma (ATLL) with the drug palbociclib. The combination of palbociclib with everolimus also showed significant tumor growth reduction and minimal side effects in mice models.
Researchers at ChristianaCare's Gene Editing Institute describe a new process for evaluating the impacts of gene edits that alter rather than completely disabling DNA code. The study validates the safety and efficacy of their novel approach for using CRISPR to improve lung cancer treatments.
Scientists at the University of Texas at Austin have redesigned a key component of the widely used CRISPR-based gene-editing tool Cas9 to be thousands of times less likely to target the wrong stretch of DNA. The new version, called SuperFi-Cas9, is as efficient as the original but reduces off-target interactions, making it potentially ...
Xue Sherry Gao has won a prestigious CAREER Award to create versatile toolkits for controlling gene expression. Her research aims to develop broadly applicable platforms for gene regulation, with a focus on precision dosing and safety features.
Researchers successfully edited the genomes of black-legged ticks using CRISPR-Cas9, overcoming technical challenges and advancing tick genetic research. The study's findings have significant implications for understanding tick-pathogen-host interactions and developing new approaches to tick-borne disease control.
Researchers have developed two new gene editing methods for ticks, allowing scientists to alter parts of the tick genome involved in harboring and transmitting pathogens. The methods use CRISPR/Cas9 technology and could lead to the development of new control methods for diseases like Lyme disease.
Researchers at Gladstone Institutes and UC San Francisco have developed a CRISPR activation method that allows them to activate genes in human immune cells, revealing key regulators of cytokine production. This breakthrough accelerates immunotherapy research and may lead to more powerful cancer treatments.
Gladstone Institutes researchers have pioneered a new method to edit genes in human cells using retrons, which can produce abundant copies of template DNA from inside cells. The optimized system has shown improved efficiency and precision compared to current approaches.
A new report by The Hastings Center suggests that releasing gene-edited species into the wild demands deep public engagement. The report proposes a path forward for inclusive, values-based decision-making through public deliberation.
Scientists at Oak Ridge National Laboratory developed a self-detect solution to monitor CRISPR gene editing tools in organisms. The system uses a biosensor guide RNA and reporter protein to trigger the technology's reveal itself, enabling real-time detection of CRISPR activity.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
Researchers have expanded the number of naturally occurring CRISPR-Cas systems, giving a wealth of potential new tools for large-scale gene editing. The discovery could lead to treating complex diseases associated with multiple genes.
Researchers from the University of Manchester have discovered a new way to manipulate key assembly line enzymes in bacteria using CRISPR-cas9 gene editing. This approach could lead to the production of improved antibiotics with potentially improved properties, addressing the growing threat of antimicrobial resistance.
Researchers at Karolinska Institutet found that CRISPR gene-editing causes DNA damage, activating the p53 protein, which can lead to an accumulation of mutated cancer cells. The study identified a network of linked genes with similar mutations and suggests transient inhibition of p53 as a potential strategy to prevent their enrichment.
Researchers at Princeton University developed a novel method called Repair-seq to understand genome editing tools, revealing complex mechanisms of DNA repair. This work improves the CRISPR gene-editing method by identifying new pathways and optimizing systems.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
Researchers at UMD are developing CRISPR-Combo systems to improve genome editing and crop regeneration. The technology aims to reduce the time and cost of breeding new crop varieties with enhanced nutritional and agronomic traits.
A compact CasMINI CRISPR system has been engineered for efficient gene regulation and editing in mammalian cells. The system, derived from the naturally occurring archaeal protein Cas12f, is highly specific and efficient, making it suitable for various therapeutic applications.
Researchers at Temple University's Lewis Katz School of Medicine have been awarded a prestigious grant from the National Institutes of Health to develop novel treatments for individuals living with HIV using CRISPR technology. The $4.8M grant will fund four major research laboratories working towards eliminating HIV DNA from infected c...
Isaac Hilton is using non-integrating episomal DNA viruses to create a new platform technology for cell and gene therapies. He aims to hijack these viruses to safely program medicinal functions in human cells.
Researchers have developed a new way to deliver molecular therapies to cells using a programmable system called SEND, which harnesses natural proteins in the body to encapsulate and deliver different RNA cargoes. This could lead to safer and more targeted delivery of gene editing and other molecular therapeutics.
Researchers have mapped the structure of CRISPR-Cas12j3 from bacteriophages, a discovery that reveals how it works and solves packaging problems for genome editing. The new system has vast potential for precise genome editing with improved efficiencies and alternative targeting mechanisms.
Yiping Qi's team will test new delivery technologies for CRISPR-Cas12a to develop a pipeline for genome editing in carrots. They aim to create more nutritious and hypoallergenic carrot varieties with improved nutritional value and reduced allergenicity.
A new genetic engineering platform has been established in methylotrophic yeast Pichia pastoris, enhancing homologous recombination rates and genome editing efficiency. This breakthrough can enable the stable loading of over 100 exogenous genes and precise regulating of gene expression.
The new CRISPR 3.0 system allows for simultaneous activation of up to seven genes at once, demonstrating high accuracy and efficiency. This multiplexed gene activation system has significant potential for crop breeding and enhancement, enabling the discovery and translational science in plants.
Researchers have successfully used CRISPR-Cas9 gene editing technology to manipulate glucosinolate levels in broccoli, reducing their accumulation in the leaves and florets. This study highlights the potential of gene editing to improve crop health and adaptability in challenging environments.
Researchers have developed a new method to select efficient gRNA molecules for CRISPR-Cas9 gene editing, achieving high efficiency and precision. The algorithm uses deep learning and large datasets to predict the efficiency of gRNAs, promising improved outcomes in genetic disorders and biotechnology applications.
Researchers at UT Southwestern Medical Center have successfully employed a new CRISPR-Cas9-based gene therapy approach to treat mice with Duchenne muscular dystrophy, restoring nearly full production of the dystrophin protein. The approach could lead to a treatment for DMD and inform the treatment of other inherited diseases.
An international research team proposes combining organic farming with gene editing to achieve greater sustainability in agriculture. The study suggests that this approach could lead to more robust plants with high yields, improved nutrition, and reduced environmental impact.
A peptide nucleic acid-based gene editing technique has been identified as a crucial part of the gene editing toolkit, offering an alternative to CRISPR-Cas systems. The technique, developed by Carnegie Mellon's Danith Ly and Yale University's Peter Glazer, allows for in vivo gene editing using nanoparticles.