Articles tagged with Hormone Therapy
Females with more subcutaneous fat are protected against brain inflammation, a risk factor for dementia and stroke. Removing subcutaneous fat increases brain inflammation in females, even on low-fat diets.
Researchers characterized prostate cancer cell dynamics at single-cell resolution, revealing an expansion of intermediate cells that correlates with treatment resistance and poor clinical outcomes. A 5-gene signature associated with treatment resistance was also discovered.
A new study identifies anti-Müllerian hormone (AMH) as a key factor in regulating cholesterol levels during the menopause transition. High AMH levels are associated with lower HDL-C, or good cholesterol, which may indicate cardiovascular risk despite its traditionally protective effects.
The SERENA-2 trial found camizestrant significantly improves progression-free survival versus fulvestrant in patients with estrogen receptor-positive, HER2-negative breast cancer. Camizestrant demonstrates efficacy across various patient populations, including those with ESR1 mutations and prior CDK4/6 inhibitor treatment.
Researchers at Cedars-Sinai found that estrogen can prevent symptoms of delirium in mice with urinary tract infections, reducing IL-6 levels in the blood and protecting neurons. The study suggests estrogen may be a tool to mitigate delirium, particularly in older women with UTIs.
The phase 1 and phase 2 studies showed that ARV-471 was well-tolerated and could promote substantial estrogen receptor degradation in patients with advanced disease. The study has led to a randomized phase 3 trial comparing ARV-471 with a SERD in patients with ER-positive/HER2-negative advanced breast cancer.
A Northwestern Medicine study found that online platforms are offering therapies to men who don't meet guidelines for testosterone deficiency, while failing to convey the risks and benefits of therapy. The study recommends seeing a provider with expertise in hypogonadism for accurate care.
A team from the University of Pennsylvania led by Kotaro Sasaki coaxed stem cells to take on the characteristics and functions of a human adrenal gland. The researchers developed an organoid culture system to direct iPSCs to transition into adrenocortical progenitor-like cells, resulting in cells producing steroid hormones.
A 30-year follow-up study of patients with early breast cancer found that radiotherapy does not improve overall survival rates after 10 years but reduces the risk of recurrence in the same breast. The study's findings challenge traditional concepts of long-term anti-cancer benefits of radiotherapy.
A new treatment approach using surgery or radiation therapy has been shown to slow cancer progression in patients with solitary prostate cancer metastases. The study found that this approach, called metastasis-directed therapy (MDT), can delay the need for hormone-blocking treatments and improve survival rates.
Researchers evaluated the safety and efficacy of NTLA-2001 in patients with transthyretin amyloid cardiomyopathy. The results showed significant reductions in circulating TTR protein levels, which were sustained for up to six months after treatment.
A new preclinical study discovered the underlying cause of gender differences in immunotherapy-associated myocarditis and identified potential treatment strategies. Hormone therapies targeting the endocrine-cardiac-immune pathway may reduce this risk without affecting treatment efficacy.
A small clinical trial showed 40% of patients experienced progression-free survival when treated with a CD105 inhibitor, which prevented cancer cells from making splice variant proteins. This approach may resensitize select patients to androgen suppression therapy.
A Danish study found that systemically administered hormone therapy increases depression risk, especially immediately after initiation. Locally administered therapy is associated with a lower risk of depression for women over 54 years old.
A recent investigation by The BMJ reveals dozens of UK companies offering private blood tests with misleading claims, contradicting official medical guidance and potentially harming individuals. Experts argue for regulation to protect consumers and prevent unnecessary costs for the NHS.
A novel oxytocin derivative, PAS-CPPs-oxytocin, has been shown to improve cognitive function in mice with Alzheimer's-like symptoms. The derivative is delivered via intranasal administration and shows increased brain penetration compared to traditional intracerebroventricular delivery.
A new analysis by UCLA Jonsson Comprehensive Cancer Center found that men with prostate cancer benefit from adding androgen deprivation therapy to radiation treatment. The study showed improved metastasis-free survival for patients receiving short-term ADT before or after radiation, especially in those receiving prostate-only RT.
A study of over 700 adolescents who underwent puberty suppression and then started gender-affirming hormone treatment found that 98% continued use. The findings contradict recent concerns about regret and support the long-term benefits of hormone therapy for young people with gender dysphoria.
A new study found that hormone therapy experiences differ significantly by race among women experiencing menopause symptoms. White women reported higher rates of hormone therapy use and better quality of life compared to women of other ethnicities.
Research reveals that pregnant smokers decrease their daily cigarette count by an average of one cigarette per day before realizing they are pregnant. This trend continues in the month following pregnancy recognition, with a decline from nine to five cigarettes per day on average.
A new study found that hormone therapy may protect against adhesive capsulitis, a painful orthopedic disorder affecting perimenopausal women. The research suggests estrogen plays a role in musculoskeletal function and reducing inflammation, supporting the hypothesis that hormone therapy is protective against the disorder.
Studies show improved mental health and quality of life in transgender women using hormone therapy, with some concerns about cardiovascular risk. The therapy's effects on breast cancer risk are mixed and more research is needed.
A study of 15 transgender women found they exceeded the cardiopulmonary capacity and muscle strength of their cisgender peers even after years of hormone therapy. However, their performance was lower than that of cisgender men. The findings could inform policy on transgender women's sports participation.
A new study from Uppsala University found that using a weighted blanket at bedtime increases melatonin production by about 30 percent. The researchers also discovered that the weight of the blanket (12% of participant's body weight) reduced stress system activity, but had no effect on oxytocin and cortisol levels.
A new study reveals that androgen receptor inhibitors can fundamentally rewire prostate tumors, making them more aggressive. The researchers found that most tumors remain fuel-dependent after treatment, but a small percentage convert to double-negative prostate cancer.
A Rutgers study finds CBD improves glucose disposal, burns energy, and enhances bone density in estrogen-deficient mice. The compound also reduces inflammation and boosts beneficial gut bacteria.
Researchers at Nagoya University have discovered a new treatment for type 1 diabetes that uses leptin to improve insulin-alternative effects in mice. The combination of leptin and a PTP1B inhibitor normalizes blood glucose levels without the need for insulin, reducing hypoglycemia risk.
A review article suggests that retinol-binding protein-4 (RBP4) may be a potential target for clinical intervention in non-alcoholic fatty liver disease. The study highlights the importance of RBP4 in the pathogenesis of NAFLD, including its role in inducing hepatic de novo lipogenesis and impairing fatty acid oxidation.
Researchers at Cleveland Clinic link HSD3B1 genotype to higher risk of type 2 endometrial cancer, which is more aggressive and has lower survival rates than type 1. The study builds on previous associations with breast and prostate cancer, suggesting the gene could serve as a biomarker for certain subtypes.
A new study suggests that neoadjuvant novel hormonal therapy followed by prostatectomy can reduce the risk of recurrent and progressive cancer in high-risk prostate cancer patients. After treatment with NHAs, patients were more likely to have negative margins after surgery and fewer cases of biochemical recurrence.
Researchers from Johns Hopkins Medicine and Dana Farber Cancer Institute found that irisin reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice. Irisin also speeds up the transport and degradation of alpha synuclein via fluid-filled sacs called lysosomes in brain cells.
A randomized phase III trial found that combination hormonal therapy, delivered for a finite treatment interval of 12 months, more durably suppresses PSA levels compared to hormone injections alone. The treatment approach improved disease progression in patients with high-risk biochemically relapsed prostate cancer.
Scientists at UC San Diego have illuminated the role of key neurons that alter function in response to seasonal changes in light exposure. The study found that neurons change expression of neurotransmitters in response to day length stimuli, triggering behavioral changes.
A study by researchers at Washington University School of Medicine found that low testosterone levels are an independent risk factor for COVID-19 hospitalization in men. Men with chronically low testosterone who developed COVID-19 were 2.4 times more likely to require hospitalization than those with normal testosterone levels.
Researchers developed a therapy using GnRH pulsatile injection to restore cognitive and olfactory functions in trisomic mice. In a pilot clinical trial, the treatment improved cognitive performance in 6 out of 7 patients with Down syndrome, including better reasoning, attention, and episodic memory.
Recent evidence suggests hormone therapy at menopause does not significantly increase the risk of invasive breast cancer. However, estrogen combined with progesterone increases breast cancer risk for women with an intact uterus. Menopause experts offer reassurance to women and their healthcare providers about the safety of hormone ther...
A recent case study at Kobe University reports a 15-month recovery process for a patient with impaired ACTH secretion due to COVID-19. The research team successfully restored hormone levels through ACTH replacement therapy, and the patient's condition improved significantly after one year and a half.
Researchers have identified key molecular differences between cancer cells that cling to initial tumors and those that spread to distant sites. The study found unique properties in cells that gain migratory ability and survival advantages, leading to the development of new treatment targets.
A study published in NeuroReport reveals that ultrasound exposure improves depressive behavior in a rat model of depression. OB rats exposed to USV had significantly lower hyperemotionality scores and plasma corticosterone levels than unexposed rats, suggesting potential anti-depressant effects.
A new study published in Menopause finds that prasterone effectively improves urinary urge incontinence symptoms in women with genitourinary syndrome of menopause. This treatment option may offer relief for women experiencing pressure in the bladder, making it difficult to hold urine.
Researchers have found that infusing glucagon-like peptide-1 (GLP-1) hormone can improve impaired islet cell function in the pancreas of cystic fibrosis patients, potentially improving blood sugar control and treatment burden. The study suggests a new therapeutic approach for treating cystic fibrosis-related diabetes.
A large prospective study found that women with endometriosis have a higher risk of ischemic and hemorrhagic strokes compared to those without the condition. The study analyzed data from over 112,000 women and found an association between endometriosis and stroke risk, suggesting that clinicians should consider the whole woman's health...
A large cohort study found that hormone replacement therapy for breast cancer survivors is not associated with an increased risk of recurrence. The study included over 8,400 Danish postmenopausal women and found no link between vaginal estrogen or menopausal hormone therapy and breast cancer reoccurrence.
Researchers have found that high levels of iron can generate toxic free radicals, which damage lipids and ultimately lead to cell death. The team is exploring the use of compounds like JKE-1674 to induce ferroptosis in prostate cancer cells, making them more vulnerable to treatment.
The North American Menopause Society has released its 2022 Hormone Therapy Position Statement, reaffirming the effectiveness of hormone therapy in treating hot flashes and other menopause symptoms. The updated statement also highlights its role in preventing bone loss and fractures.
Abemaciclib, a CDK4 & 6 inhibitor, showed profound inhibition of cell proliferation and triggered senescence and apoptosis in breast cancer cells. Continuous dosing provided sustained inhibition with irreversible effects through apoptosis, supporting the differentiated safety and efficacy profile.
Researchers at the Netherlands Cancer Institute discovered that prostate cancer cells hijack the circadian rhythm to become resistant to hormone therapy. The study found that proteins regulating the circadian clock play a crucial role in tumor cell survival, offering a potential target for new treatment strategies.
Research at Kyoto University found that estradiol suppresses severe skin inflammation in females compared to males, revealing its therapeutic potential. The hormone regulates immune cells and reduces IL-17A and IL-1β cytokines production.
A study published in PLOS ONE found an association between reduced estrogen and progesterone levels and increased risk of snoring and obstructive sleep apnea in postmenopausal women. Low estrogen levels were linked to a 19% decreased odds of snoring, while low progesterone levels were associated with a 9% decrease.
Researchers at Johns Hopkins Kimmel Cancer Center developed a targeted immunotoxin that delivers into breast ducts, eliminating visible and invisible precancerous lesions in laboratory studies. The treatment showed strong cancer-killing effects in all cell lines and was well-tolerated in mouse models.
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
A new study published in Science Translational Medicine reveals that consecutive molecular modifications of the androgen receptor can contribute to drug resistance in prostate cancer. Researchers identified a potential treatment approach using an ACK1 inhibitor to block this resistance.
Researchers found higher AR signaling and better response rates for female patients treated with BRAF/MEK inhibitors. Blocking the AR improved response to BRAF/MEK targeted therapy in both males and females.
Menopause is often perceived as a hormone deficiency, but experts argue this can lead to negative expectations. Instead, a more nuanced approach emphasizes the positive aspects of menopause, such as freedom from menstruation and reduced symptoms. Normalizing ageing and celebrating women's strengths can also improve experiences.
A University of Jyväskylä study found that menopausal women's ability to use fat as an energy source is not impaired by estrogen levels or menopause. Women who burned more fat during exercise had higher fitness and physical activity levels, while those with better glucose tolerance did not necessarily burn more fat.
A mouse study suggests that active testosterone therapy can lead to fewer and less developed eggs retrieved during IVF. Discontinuing testosterone therapy appears to have no significant impact on reproductive capacity, however.
A study of 56 transgender youth found that longer treatment with puberty-delaying medications was associated with lower bone mineral density. The researchers recommend discussing the impact of these medications on bone health and exploring interventions to improve bone health.
A Phase 3 study found fezolinetant to significantly reduce the frequency and severity of moderate-to-severe vasomotor symptoms associated with menopause. The treatment also improved sleep disturbances, supporting its use for treating moderate-to-severe hot flashes.
The joint position statement from British Menopause Society, RCOG, and SfE provides evidence-based guidance for healthcare professionals caring for women experiencing menopause. It recommends an individualised approach to care, considering the risks and benefits of therapies as well as lifestyle choices.
A comprehensive analysis of testosterone replacement therapy found no increased risk of heart attack, stroke, and other cardiovascular events in the short-to-medium term. Testosterone treatment was also found to reduce serum cholesterol levels, but no significant differences were observed in blood pressure or glycaemic parameters.