Research on asthma and respiratory disease. Covers brain-structure links, prevention trials, weight-loss drugs, and exercise for symptom control.
A computer program has identified various subtypes of asthma, including one associated with poor quality of life and depression in obese women. The analysis used machine learning algorithms to track 112 variables for nearly 400 people, leading to potential personalized treatments.
Research reveals that preterm birth increases the risk of asthma and wheezing disorders, with a 70% higher risk among preterm babies compared to full-term infants. Children born before 32 weeks gestation face approximately three times the risk.
Researchers at San Diego State University will develop tailored asthma management strategies and community programs to improve control and minimize complications among Latino children. The project aims to address disparities in asthma care, informing a more culturally appropriate approach to treatment.
The trial will examine effectiveness of different doses of inhaled corticosteroids with or without long-acting beta agonists in 500 African American patients aged 5 and older. Researchers aim to identify the most effective combination of medications and dosing regimens to manage asthma symptoms.
Children exposed to cigarette smoke at home have lower levels of the enzyme HDAC2, which is required for steroid treatment to exert its beneficial effects. This reduces their ability to respond to asthma treatment, leading to increased symptoms and potentially higher doses of steroids.
A new study found that financial and social hardships are a major contributor to hospital asthma readmissions among black children. Nearly 23% of black children were re-admitted within a year, compared to 11% of white children.
A systematic review and meta-analysis of 30 studies found that preterm birth is associated with an increased risk of developing asthma and wheezing disorders during childhood. Children born before 32 weeks of gestation were nearly three times as likely to develop these conditions compared to those born at full term.
A quality improvement initiative in a primary care setting improved asthma control and outcomes for high-risk teenagers through standardized care, self-monitoring, and care coordination. The study showed significant improvements in patients' chronic asthma not well-controlled, with increased adherence to treatment.
Researchers found that rare gene variants significantly increased the risk of hospital admission for severe asthma episodes and urgent outpatient visits among patients treated with long-acting beta agonists. Non-Hispanic whites with these variants were more than twice as likely to experience uncontrolled symptoms during LABA therapy.
A study published in Infection and Immunity reveals that Salmonella infection can reduce asthma inflammation by regulating immune cells. Researchers hope to develop treatments based on probiotics or therapeutic applications of myeloid cells.
Research at Columbia University Medical Center found obese children are nearly three times as likely to develop asthma when exposed to high levels of air pollutants. Rates of childhood obesity and asthma have increased dramatically over the past 30 years, with urban minority populations disproportionately affected.
A new study found that high levels of depressive symptoms are associated with an increased risk of developing adult-onset asthma in African-American women. Women with depressive symptom scores of 16 or higher had a two-fold increase in asthma incidence compared to those with lower scores.
A new study finds that exposure to secondhand smoke at home or in the car increases the odds of children being readmitted to the hospital within a year of being admitted for asthma. Cotinine levels measured in the blood and saliva of over 600 children showed a significant correlation between tobacco exposure and increased risk of futur...
Researchers found that younger, less experienced runners are more prone to injuries, while stress fractures are relatively rare. Ultrarunners also showed a high incidence of asthma and allergies, which may be linked to increased outdoor exposure.
Research teams at Group Health Research Institute have been awarded funding by the Patient-Centered Outcomes Research Institute (PCORI) to study opioid therapy and asthma. The studies aim to improve patient outcomes and provide informed decision-making for patients with chronic pain and asthma, particularly in minority groups.
A study found that the prevalence of atopy, a predisposition towards allergic reactions, jumped from 7% to 20% in villages in southwest Poland between 2003 and 2012. Exposure to farm animals, especially at a young age, is thought to protect against developing allergies.
A recent study suggests that exposure to dust from homes with dogs can alter the immune response to allergens, reducing allergic inflammation. The researchers found that mice fed dog-associated dust were protected against airway inflammation triggered by cockroach allergen and respiratory syncytial virus.
Severe asthma is defined as requiring high-dose inhaled corticosteroids plus a second controller medication. The new guideline aims to improve diagnosis and treatment options for this condition, which accounts for less than 10% of all asthmatics but has the greatest healthcare burden.
A recent study has identified MUC5B as a key protein involved in various lung-related ailments, including MRSA infections and cystic fibrosis. The protein helps control certain infections by coating airway surfaces in the nose and lungs.
A new study led by Meghan Azad found that probiotics have no effect on preventing childhood asthma. However, the research did identify a potential association between probiotics and lower respiratory infections in babies who received them as infants or in utero.
A study published in the Journal of Allergy and Clinical Immunology found that bronchial thermoplasty reduces severe asthma exacerbations, emergency department visits, medication use, and missed workdays for at least 5 years. The treatment also shows stable rates of respiratory adverse events and respiratory-related hospitalizations.
Researchers at University of British Columbia and Vancouver Coastal Health study show that a combination asthma therapy does not harm British Columbians, contradicting FDA safety concerns. The study, covering 46,000 people over 15 years, found no statistically significant increase in hospitalization rates for users.
An international team of researchers has identified the genes that put children at high risk of severe asthma attacks, which can be prevented and treated with more effective medicine. The study found a new gene called CDHR3 to play a key role in the development of asthma.
A novel gene variant associated with severe childhood asthma has been discovered through a genome-wide association study. The study found that the CDHR3 gene is particularly active in epithelial cells lining airways and may disrupt normal functioning, leading to increased risk of asthma.
Research from Bispebjerg University Hospital in Denmark found that women with asthma took longer to conceive compared to those without. The study revealed a higher proportion of prolonged time to pregnancy among asthmatic women, particularly those with untreated asthma.
Researchers suggest that specific parts of food can be safe for consumption in individuals with food allergies, and substitutes can be eaten safely. For example, someone with an egg allergy may be able to tolerate egg yolk but not the whites.
A study by Timothy Craig, MD, found that allergy shots decrease anxiety and depression in those allergic to wasp, bee, and ant stings. Allergy shots are the only treatment known to modify disease progression, making them life-saving for severe allergy sufferers.
A new study suggests that asthma inhalers with dose counters can significantly reduce emergency room visits by 55 percent. The study found that patients who use these inhalers are more likely to know if they have enough medication left and receive timely treatment, resulting in fewer severe attacks. According to the American College of...
Adult females are more prone to allergies, asthma and autoimmune diseases compared to males, with gender differences changing after puberty. Genetics play a role in determining allergy and asthma risk, with personalized medicine being key to effective treatment.
A study by the American College of Allergy, Asthma and Immunology reveals that asthma sufferers allergic to cats has more than doubled over an 18-year period. Those with asthma are also 32% more likely to be allergic to cats than those without asthma.
A recent study by University Hospitals Rainbow Babies & Children's Hospital found that children aged 1 to 3 years accounted for one-fifth of all emergency department visits caused by asthma complications. Additionally, the study revealed that nearly half of all ED visits due to asthma occurred in boys, and fall months had a higher prop...
A new study from RIKEN and Keio University reveals that Pimozide can restore steroid effects on natural helper cells in severe asthmatic patients. Researchers found that thymic stromal lymphopoietin (TSLP) induces corticosteroid resistance in these cells.
A new class of drug RPL554 has been developed to treat obstructive airway diseases like asthma and COPD. It works by both reversing the narrowing of the airways and reducing inflammation, producing a 17% increase in respiratory function.
Research on an aerosol that induces a rapid immune response to prevent viral respiratory infections and asthma attacks has earned major funding from the National Institutes of Health. The NIH-funded project aims to translate preclinical findings to clinical trials to prevent asthma attacks.
Researchers at Uppsala University found that combining two test methods can provide better asthma diagnosis. The combination of exhaled nitric oxide and blood eosinophil counts increases the likelihood of individuals reporting asthma symptoms or attacks.
A new study published by Cincinnati Children's Hospital Medical Center found a strong link between exposure to diesel exhaust and increased asthma severity in children. The research suggests that neutralizing the protein IL-17A could be a useful potential therapeutic strategy to counteract the effects of traffic-related air pollution.
A study at the European Respiratory Society Annual Congress found that a music video produced by Dr. Tapas Mukherjee increased awareness of new guidelines for managing acute asthma. The video was shared on social media sites, leading to improved knowledge among healthcare professionals.
People with severe asthma are less likely to respond to corticosteroid treatment, even when taking high doses. Researchers found that 55% of adults with severe asthma showed greater airway obstruction despite regular oral corticosteroids. The study aims to develop personalized medicine for individual patients with asthma.
A small study has found evidence of a risk associated with the use of argan powder during the industrial production of cosmetics. Four out of nine workers displayed asthma or rhinitis symptoms when handling argan powder.
Good asthma control is crucial during pregnancy to prevent adverse effects on maternal and fetal outcomes. Studies suggest that poor asthma control can lead to increased risks of hypertension, caesarean section, and low birth weight.
Research from the University of Adelaide found that pregnant women with asthma who smoke are at greater risk of complications, including preterm birth and low birth weight. The study suggests that quitting smoking during pregnancy can lead to some improvement in risks to the child.
A new University of Melbourne-led study found that heavy traffic pollution and wood smoke from heaters significantly worsen asthma symptoms in middle-aged adults. The study revealed a 80% increase in symptoms for those exposed to heavy traffic pollution and an 11% increase for those exposed to wood smoke.
Research from Boston University found that African-American women who reported frequent experiences of racism were more likely to develop adult-onset asthma. The study, which followed 38,142 women over 14 years, also discovered a significant link between increased racism and asthma incidence.
Researchers found that toll-like receptor 4 is activated by fibrinogen cleavage products, which are generated by proteinase enzymes. This activation leads to the production of pro-inflammatory cytokines and the recruitment of immune cells to the airways, resulting in asthma-like symptoms.
Researchers at LA BioMed discovered a link between maternal nicotine exposure during pregnancy and asthma in the third generation. The study found that even though the third generation was not directly exposed to nicotine or smoking, they were still more likely to develop asthma due to epigenetic modifications caused by maternal smoking.
Children's perceptions of living with asthma may differ significantly from those of their caregivers, a new study shows. The study found that both children and caregivers should be interviewed during doctor visits to ensure accurate understanding of the child's condition.
Researchers have discovered that a small protein chemokine called CCL26 plays a crucial role in the development and severity of asthma. CCL26 induces a greater migration of eosinophils in asthmatic airways compared to healthy volunteers, making it a potential target for new treatments.
A new study found that morbidly obese patients who underwent gastric bypass surgery experienced a decrease in the activity of genes tied to asthma, suggesting a potential link between obesity and asthma. The study also found higher concentrations of inflammatory compounds in obese individuals.
Researchers at VCU are studying the biology of allergic disease with a $1.8 million NIH grant. They aim to understand how mast cells respond to signals, potentially leading to new therapies for conditions like asthma and rheumatoid arthritis.
A new study found that children with higher genetic risks for asthma are not only more likely to develop the condition at a young age but also experience persistent symptoms in adulthood. Those with higher risk scores had poorer quality of life, missing work and school, and were hospitalized more often due to asthma.
A recent study suggests that genetic risk assessments could predict which children with asthma are likely to grow out of the condition. The analysis of data from a 40-year longitudinal study revealed that higher-risk genetic variants linked to asthma were associated with a greater likelihood of developing life-long-persistent asthma.
A research team at UCSF has found that exposure to nitrogen dioxide during infancy is strongly linked with later development of childhood asthma among African Americans and Latinos. The study indicates that traffic-related pollution might be a cause of the disease, calling for tightened U.S government standards for annual exposure to NO2.
A new study suggests that vitamin D deficiency may play a role in the increased allergy and asthma risk in overweight and obese adolescents. Researchers found significant correlations between the severity of obesity, adipokine levels, and biochemical measures of allergic disease.
Exercise-induced bronchoconstriction affects 10% of the population, causing symptoms like cough, wheezing, and shortness of breath. Vitamin C has been shown to halve the FEV1 decline caused by exercise in three randomized trials, indicating a potential benefit against this condition.
An Indiana University study found that a unique omega-3 supplement, Lyprinol/Omega XL, significantly improved lung function and reduced airway inflammation in asthmatics. The supplement, derived from the New Zealand green-lipped mussel, was effective in reducing symptoms and potentially improving athletic performance.
A study reveals a unique form of childhood asthma connected to impaired sphingolipid synthesis, bypassing typical allergen and inflammation pathways. This discovery may lead to precision medicine approaches for treatment.
A Phase IIa clinical trial found that dupilumab reduced asthma exacerbations by 87% and improved lung function, morning peak expiratory flow, and asthma symptoms. The study suggests dupilumab may be an effective treatment option for patients with persistent asthma.
A study of 170 parent-child dyads found that compromised lung function corresponded with poor sleep efficiency and impaired academic performance in urban schoolchildren. Family-level interventions aimed at asthma control and improving sleep quality may help improve academic performance in vulnerable populations.
A study found that exposure to nitrogen dioxide from traffic was associated with increased asthma severity levels in pregnant asthmatic women. The study used a sophisticated air pollution modeling system to assess community-level exposures, which were linked to higher risk of wheeze and asthma severity score.
A study suggests that early childhood respiratory infections, rather than analgesic use, may be driving the link between asthma and acetaminophen or ibuprofen. Researchers found a higher exposure to acetaminophen both prenatally and during infancy compared to ibuprofen.