Research on asthma and respiratory disease. Covers brain-structure links, prevention trials, weight-loss drugs, and exercise for symptom control.
A recent study by Mayo Clinic Children's Research Center found that kids with asthma who are exposed to secondhand smoke are twice as likely to be hospitalized for an asthma flare. The study analyzed data from over 430,000 children and strengthens the link between secondhand smoke exposure and increased asthma symptoms.
The American College of Physicians task force recommends counseling and pharmaceutical interventions to help adults and pregnant women quit smoking. Behavioral therapy or medications with FDA approval are recommended for nonpregnant adults, while pregnant women receive only behavioral interventions.
A major European study has identified key characteristics of severe asthma, which will help develop new treatments. Patients with severe asthma experience daily symptoms despite high doses of treatment and are more likely to be hospitalized.
Researchers analyzed data from Australia's 2006-2007 wildfires and found exposure to wildfire smoke was associated with increased hospital emergency department visits for asthma. Fine particulates in wildfire smoke are easily inhaled and remain deep in the lungs, causing harmful health effects.
Researchers at VIB discovered that exposure to farm dust reduces the severity of allergic reactions in mice. In humans, a deficiency in the protective protein A20 is found in those who suffer from allergies and asthma. The study paves the way for the development of an asthma vaccine.
Researchers identified three distinct groups of asthma patients characterized by different genes in airways, with Th2 and Th17 pathways reciprocally regulated. Blocking both pathways simultaneously may demonstrate better efficacy than targeting either alone.
A new article from the American College of Allergy, Asthma and Immunology recommends using epinephrine for all severe allergic reactions, regardless of symptom certainty. Experts stress that delays can have severe consequences, making epinephrine the most effective tool in combatting anaphylaxis.
Asthmatics are particularly sensitive to sulfur dioxide, which can cause airway irritation even at low concentrations. Scientists still don't know why asthmatics lack the ability to produce interleukin-10, a protein that stops inflammatory processes.
Researchers have discovered a stress pathway in immune cells that play a role in certain forms of asthma. The IRE1α/XBP1 pathway helps eosinophils, a type of immune cell implicated in asthma, develop and survive. This finding suggests a potential new therapeutic target for treating asthma.
A nationwide study finds that fine particulate matter, known as PM2.5, surge on July 4 due to fireworks, with concentrations 42% higher than usual on average. The study's results will help improve air quality predictions and raise awareness about the health risks of particle pollution.
Researchers from the University of Pittsburgh School of Medicine have discovered a unique immune response feature in patients with severe asthma, which may lead to new treatments. The study found that boosting levels of secretory leukocyte protease inhibitor (SLPI) reduces airway hyper-reactivity in animal models.
A recent UC Davis study highlights the need for improved primary care support structures to address high pediatric asthma rates in California. The research found that nearly 10% of state children suffer from asthma, with low flu vaccination rates and limited access to primary care providers contributing to these rates.
Researchers identified clusters where higher numbers of children who developed asthma were born in Toronto, suggesting early life factors at the neighbourhood level are relevant to childhood asthma. Air pollution during pregnancy and shortly after birth was found to be related to developing asthma later in childhood.
A new study found that older asthma patients, particularly those over 30, are more likely to experience treatment failure. The risk of treatment failure increases proportionally with age above 30 and is associated with lower lung function measurements and longer duration of asthma.
A study by the University of Arizona's BIO5 Institute has identified potential protective compounds in dust samples from Amish farming communities. The findings suggest that these natural environmental products could be transformed into medicines to promote lung health and prevent asthma. The research aims to understand the biological ...
Research suggests that aerobic exercise can curb asthma symptoms and improve quality of life by reducing bronchial hyperresponsiveness and inflammatory response. The study found significant improvements in symptom-free days, worsening symptom bouts, and quality of life scores among participants with moderate to severe asthma.
A Canadian study found weight loss reduced asthma severity by normalizing or improving airway hyperresponsiveness and quality of life in obese adults. The study supports treating comorbid obesity in individuals with asthma.
A study by researchers from the University of Seville found that high concentrations of fine particles (PM2.5) in urban areas increase hospital admissions for children with respiratory illnesses such as bronchiolitis, pneumonia, asthma, and bronchitis. Reducing PM2.5 levels to the recommended WHO threshold could lead to a daily saving ...
A randomized trial of nearly 400 children and adults with poorly controlled asthma found that supplementation with soy isoflavone did not improve lung function or clinical outcomes. The study suggests that this supplement should not be used for patients with poorly controlled asthma.
A new study from Northwestern University finds that soy supplements do not improve lung function for patients with asthma. Lifestyle and diet may play a role in managing the disease, rather than relying on individual strategies like increasing soy consumption.
Researchers at Johns Hopkins Medicine found that men with a history of asthma are 29% less likely to be diagnosed with lethal prostate cancer. Overall, asthmatic men were 36% less likely to die from the disease.
A new school-based program helps reduce absenteeism among urban minority children with asthma. The program, called Building Bridges for Asthma Care, identifies children with inadequately controlled asthma and provides support to help manage their disease and stay in school.
A new study found that nearly 22% of children with asthma also demonstrate a sensitivity to peanuts, which can lead to increased morbidity and mortality. The study suggests that peanut sensitivity screening may be beneficial for these children, especially when controlling wheezing and coughing is difficult.
A new study suggests pharmacies can reduce asthma-related illnesses by dispensing more asthma controller medications. Pharmacies located in high utilization census tracts dispense more rescue medications than controller medications.
A US study found that spirometry was underutilized for asthma diagnosis and management in adults from 2001 to 2011, despite national guidelines recommending its use. The test provides accurate measurements of air volumes and flows, playing a vital role in asthma diagnosis and management.
Researchers identified a genetic pathway linked to poor response to corticosteroid treatment in children with asthma. Targeting the VNN-1 pathway may offer new therapeutic strategies for difficult-to-treat patients.
Researchers created a model that predicts asthma-related emergency room visits with 75% accuracy by analyzing Twitter data and air quality sensors. The study highlights the potential of big data to address health challenges, particularly for chronic conditions like asthma and diabetes.
Researchers found asthma rates to be similarly high in urban Detroit and rural Georgia, contrary to the widely held theory that city life poses a risk factor. Poverty was identified as a common underlying cause of both conditions.
Researchers have identified a cellular receptor, CDHR3, for rhinovirus C, a cold-causing virus strongly associated with severe asthma attacks. A variant of the gene has been linked to an increased risk of childhood wheezing illnesses and asthma.
Researchers will investigate biophysical factors, environmental exposures and allergens associated with asthma control in older adults. The five-year study aims to develop interventions to improve symptoms, reduce emergency room visits and enhance overall well-being for seniors with asthma.
A study led by Massachusetts General Hospital investigators suggests that bariatric surgery can significantly reduce the risk of asthma attacks in obese patients. Significant weight reduction after surgery resulted in a half reduction in serious asthma-associated events, including emergency department visits and hospitalizations.
Researchers at Keck School of Medicine of USC have identified a crucial molecule in the survival of type 2 innate lymphoid cells, which trigger primary asthma symptoms. Targeting these molecules could lead to a cure for asthma or exacerbations caused by these cells.
Researchers found that teen girls from rural areas were more likely to have undiagnosed asthma, with a higher rate of depression among asthmatic teens. The study suggests that depression can be a barrier to diagnosis and treatment of the disease, making it essential to address this issue.
A new investigational drug, reslizumab, has been shown to reduce asthma attacks in patients who have difficulty controlling the disorder with standard medications. The study found that patients treated with reslizumab were at least 50% less likely to experience severe asthma exacerbations.
Research by Henry Ford Hospital reveals that breastfeeding and early exposure to bacteria stimulate the immune system, boosting protection against allergies and asthma. The study found distinct gut microbiome compositions in breastfed vs non-breastfed infants, with breastfed babies at lower risk of developing allergies.
A study published in Journal of Biological Chemistry identifies CCL28 as a key player in inducing asthma pathology even without a viral infection. This finding opens the door for developing potent and specific CCL28 inhibitors to prevent post-viral asthma in young children.
Researchers from INSERM have demonstrated gallopamil's clinical efficacy in treating severe asthma by reducing bronchial smooth muscle mass and airway obstruction. The study involved 31 patients with severe asthma, who showed significant improvements in BSM thickness and asthma attacks after treatment.
Researchers at CU School of Medicine have identified Muc5ac, a protein involved in airway hyperreactivity, as a potential target for reducing obstruction in asthma. The study found that genetic removal of Muc5ac eliminated airway hyperreactivity, offering new hope for treating this chronic respiratory disease.
A recent epigenetic study has identified over 30 genes that predispose individuals to allergies and asthma, providing potential new drug targets. The research also found biomarkers that may predict which patients will respond to existing therapies.
Researchers have identified over 30 genes with a strong impact on Immunoglobulin E, allergies, and asthma. These genes offer potential novel drug targets for treating these conditions, which affect 30% of the population.
A large-scale Danish study shows that premature babies are more likely to suffer from asthmatic symptoms and lung conditions in early life. However, the study found that they tend to grow better and eventually suffer no more lung conditions than others as adults.
A recent study by scientists at the University of Granada and the High Resolution Hospital in Loja reveals a moderate relation between asthma control and xerostomia severity. Inhaled corticosteroids (ICs) used to treat asthma can lead to dry mouth syndrome, which affects quality of life and mouth health.
A new study from Johns Hopkins Medicine reveals that urban living is not a significant risk factor for asthma, instead highlighting the importance of poverty, African-American race, and Puerto Rican ethnicity as potent predictors. The research found no differences in asthma rates between children living in urban areas and their suburba...
Two UChicago research teams have received $1.7 million grants from the NIH to develop new treatments for sleep apnea and severe asthma. The projects focus on disrupting molecular processes to target breathing problems, with hopes to bring patients closer to life-changing medications.
A large-scale study found rare genetic mutations in three genes (GRASP, GSDMB, and MTHFR) associated with asthma risk, but only in specific ethnicities. These findings suggest gaps in the current understanding of asthma genetics.
Participants with asthma had a higher risk of developing obstructive sleep apnea compared to those without asthma. Asthma duration was also found to be related to the development of new OSA and habitual sleepiness.
Researchers found that the common cold virus, rhinovirus, replicates more efficiently in cooler temperatures, such as inside the nose. The study suggests that lower body temperature impairs the innate immune response to the virus, making it easier for the virus to replicate.
A new UTMB study found that most patients using epinephrine autoinjectors incorrectly, with only 16% using the device properly. Inhaler users also made significant mistakes, with 63% missing three or more steps. Improving patient training is crucial to maximize medication effectiveness.
A new study by the University of Exeter Medical School found that residents in energy-efficient social housing may have a greater risk of developing asthma. The presence of mould doubled this risk, highlighting the need for residents to properly ventilate their homes to prevent health issues.
Scientists are exploring how bitter compounds cause airway constriction and searching for potential new treatments using a slime mould model. The study aims to identify cellular mechanisms that could reverse or prevent asthma attacks.
A new study published in the European Respiratory Journal suggests that toddlers who share a bed with their parents are more likely to develop asthma in later childhood. Researchers found an association between bed-sharing at two years old and increased wheezing symptoms in early childhood.
A senior GP argues that UK government plans to extend diagnosis targets in primary care to six other conditions are problematic and unscientific. The data on which they are based is flawed, leading to potential overdiagnosis and unnecessary tests and treatments.
Researchers at Karolinska Institutet have found no causal link between antibiotics and childhood asthma, contradicting previous studies. The study of half a million children suggests that respiratory infections may increase the risk of asthma, regardless of antibiotic treatment.
Research suggests respiratory infections play a key role in childhood asthma development. The link between paracetamol exposure and asthma is weakened when respiratory infections are considered.
Research found that people with asthma had a 27% higher incidence of Crohn's disease, while those with COPD had a 55% higher incidence compared to the general population. The study highlights the importance of early detection and treatment of bowel diseases in airway patients.
Research studies presented at the American Heart Association's Scientific Sessions 2014 found that people with active asthma are more likely to experience a heart attack. Participants in the Multi-Ethnic Study of Atherosclerosis (MESA) who required daily medications for asthma were 60% more likely to have a cardiovascular event.
Research at Mayo Clinic reveals that patients with active asthma are at a twofold risk of having a heart attack. Patients with inactive asthma were not found to be at an increased risk, highlighting the need for better control of asthma symptoms and medication use.
A new study suggests that individuals with more severe asthma may be more motivated to lose weight, making them a key target for intervention. Gender tailoring of weight loss programs could also enhance success rates among adults with asthma.
A new program has been shown to reduce asthma symptoms and hospitalizations in low-income children by training their parents over the phone. The peer coaching model, which was tested in a two-year trial, resulted in significant reductions in ER visits and hospitalizations among families with Medicaid insurance.
The University of Wisconsin-Madison will continue its Inner-City Asthma Consortium research with a $70 million, seven-year grant from the National Institute of Allergy and Infectious Diseases. The project aims to reduce asthma severity in inner-city children and develop effective treatments.