Articles tagged with Fungal Infections
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Researchers have identified a new group of bacterial toxins that can destroy cells of bacteria and fungi without harming other organisms. The study reveals how these toxins are used by bacteria to compete with other microbes, offering exciting possibilities for clinical and biotechnological applications.
The prevalence of treatment-resistant vaginal thrush has increased significantly in the UK, with a fourfold rise in fluconazole resistance between 2018 and 2021. This trend follows a shift in clinical practice, with doctors now treating on signs and symptoms rather than confirmatory lab tests.
Researchers are working on a new method for preserving microbial samples using microfluidics, biomaterials, and protein engineering. The goal is to improve biosurveillance and protect soldiers and civilians from infectious diseases.
Researchers analyzed over 150,000 COVID-19 cases in Japan and found CAPA occurred in 0.4% to 2.7% of severe or critical patients, with higher risk seen in men, older adults, and those with respiratory diseases. Early detection and treatment with antifungal drugs are crucial for improved outcomes.
Researchers argue that placental pathology is underutilized clinically and deserves routine obstetric and neonatal care, as well as more research attention.
The World Health Organisation accounts for around 3.8 million deaths annually from fungal pathogens that are either resistant or rapidly acquiring resistance to antifungal drugs. The narrow focus on bacteria will not combat antimicrobial resistance effectively, and the authors demand a broader discussion on fungal pathogens.
A recent study found that DNA demethylation via 5-Azacytidine enhances tomato fruit defense against gray mold by upregulating key enzymes. This epigenetic approach primes tomatoes for swift defense gene activation, offering a robust response against fungal attacks.
A study by researchers from Brazil and Germany found that a surface protein on Aspergillus fumigatus spores suppresses the release of pro-inflammatory substances by immune cells, making it easier for the fungus to infect the body. The enzyme glycosylasparaginase plays a crucial role in this process.
Researchers identified seasonal patterns in Valley fever cases influenced by California droughts. The study found that while most cases occur from September to November, drought periods temporarily dampen these peaks, but lead to bigger surges once rain returns.
Researchers identify accessory genes linked to nitric oxide production that contribute to Foc TR4's virulence, offering potential treatments and strategies to slow its spread. Monocropping is also identified as a key factor in the disease's success, highlighting the importance of crop diversity.
Researchers have proposed a framework encompassing all discovered host immunological pathways, including TH1, TH2a, TH2b, TH3, TH9, TH17, TH22, TH1-like, and THαβ immune reactions. These relationships can help understand host defense mechanisms against invading pathogens and provide insights for developing better therapeutic strategies.
Researchers at Arizona State University have introduced a new sterilization technique using X-ray irradiation to reduce Aspergillus flavus viability in contaminated corn. The method stops the fungus from transmitting spores and producing aflatoxins, crucial for developing additional remediation techniques.
Researchers have discovered a new regulator affecting immune cells, which could lead to treatments reducing inflammation in diseases such as arthritis and severe COVID-19. The study found that the regulator, MICL, plays a key role in regulating inflammation in these diseases.
Researchers have developed a new class of synthetic polymers that effectively combat fungal infections by attacking the cells in multiple ways. These compounds mimic naturally occurring peptides and offer potential for sustainable treatment options with improved survival rates.
Researchers from Tokyo University of Science have developed an efficient method to synthesize eutyscoparol A and violaceoid C, two compounds with potential therapeutic properties. The new approach improves yields and simplifies synthesis steps, enabling further research into their pharmacological effects.
Researchers at Michigan State University characterized how fungi restructure their cell walls to thwart current antifungal medications. The study found that fungi enhance their survival odds by making specific changes to the structure and organization of the components in their cell walls, rendering existing drugs ineffective.
A new study found that heteroresistance, a phenomenon where a tiny fraction of bacteria remain resistant to antibiotics, is also present in fungal bloodstream infections in bone marrow transplant patients. The research identified the specific species of fungi responsible and developed a machine learning model to detect this type of inf...
Researchers from Singapore General Hospital and A*STAR's Genome Institute of Singapore have discovered a new Candida auris clade, bringing the total to six. The fungus is highly transmissible and affects patients with severe underlying medical conditions.
Researchers found that green and golden bell frogs can clear the infection when exposed to warmer temperatures in artificial 'frog saunas.' The study suggests that warm-preferring species may have an advantage over cold-preferring species, offering a potential solution for conservation efforts.
Researchers from Insignum AgTech and Purdue University have developed a collaboration to detect tar spot disease in corn using drone imagery. The technology aims to enable farmers to identify early stages of the disease, allowing for timely treatment and reducing yield losses.
Researchers found that rotifers acquire genes from bacteria and produce resistance weapons, such as antibiotics and antimicrobial agents. The team's findings suggest that rotifers could give important clues in the hunt for new antibiotics to treat human infections.
The University of Montana has received a $3 million federal grant to investigate three North American bat species' adaptations to white-nose syndrome and climate change. Researchers will use computational models, bioinformatics, and ecological data to forecast bat movement across landscapes and understand population resilience.
Researchers identify key steps in Pseudogymnoascus destructans infection, including epidermal growth factor receptor co-optation and manipulation of keratinocytes. The discovery opens potential treatment possibilities using FDA-approved drug gefitinib.
A study published in Nature used DNA sequencing to identify fungi from air samples worldwide, providing groundbreaking knowledge about their occurrence and seasonal variation. The research aims to predict the fate of fungal species under global change and has significant implications for biomonitoring and biodiversity forecasts.
A study published in Nature has found that artificial heat shelters can significantly reduce chytrid infections in frogs, allowing them to co-exist with the deadly disease. The simple intervention uses readily available materials and can be easily scaled up for community involvement.
Researchers discovered high levels of multidrug-resistant Aspergillus fumigatus in commercially available compost, soil, and flower bulbs. The fungus poses a significant risk to human health, particularly for individuals with compromised immune systems.
Researchers have discovered a new source of resistance to the devastating wheat blast disease, leveraging a gene that also protects against powdery mildew. The Pm4 gene, found in European wheat varieties, confers dual protection against the pathogen and its effector molecule AVR-Rmg8.
Researchers at Osaka Metropolitan University discovered that mycoviral infections can increase the sensitivity of oomycete plant pathogens to specific fungicides. This finding could lead to innovative approaches for controlling plant diseases and reducing chemical treatments.
Research found that weeds in cities have significantly more mildew than those in suburbs or countryside. Urban heat islands and human activity may contribute to the phenomenon. Potted plants placed in shaded areas had more mildew than full sun, but extreme summer heat is lethal to powdery mildew.
Researchers have identified 31 effector genes from the fungus Ceratocystis fimbriata, which causes devastating black rot in sweetpotatoes. This breakthrough provides a new approach to developing disease-resistant crops using effector-assisted breeding.
A recent study by Tokyo Medical and Dental University researchers suggests that a specific variant of the CARD9 gene prevalent across northern China, Korea, and Japan may have originated from a common ancestor. The c.820dup variant was found to be relatively common in China and has been estimated to be between 2,000 and 4,000 years old...
A new study combines bisphosphonates, commonly used for osteoporosis, with azole antifungals to treat fungal infections. The combination effectively targets dermatophytes and prevents resistance development.
Experts at NYU Langone Health have warned of a growing public health threat from hard-to-treat fungal skin infections in the US. Two new reports document cases of highly contagious forms of ringworm and jock itch that can take months to clear up with treatment.
Researchers at UC Davis Health discovered that mesalamine can replace good bacteria's work in fighting Candida albicans in the gut. The study found that mesalamine maintains a low oxygen environment that prevents fungal growth, reducing the risk of invasive candidiasis.
Researchers discovered that azole fungicides kill fungal pathogens by initiating self-destruction through two pathways: apoptosis and macroautophagy. This mechanism explains why azoles are losing effectiveness against resistant fungal strains.
A study by Charité researchers found that yeast cells can compensate for aneuploidy by exchanging proteins faster. This mechanism could be used to tackle treatment-resistant tumors and fungal infections. The study identified a previously unknown compensation system based on Saccharomyces cerevisiae.
A study by Duke University researchers found that combining a low-carb, high-fat keto diet with fluconazole significantly improved treatment outcomes against fungal meningitis. The keto diet increased the effectiveness of fluconazole by reducing fungal levels by up to ten thousandfold.
Researchers at the University of Toronto have found a family of natural compounds that stall the unique metabolic process used by parasites to survive in the human gut. The discovery offers potential as new and more effective treatments for parasitic worm infections, which cause debilitating symptoms and developmental defects.
The North American Bsal Task Force has helped keep the novel pathogen at bay by developing diagnostic techniques, a rapid response template, and a surveillance program. Thirty-five of 80 North American amphibians can be infected with Bsal, causing lethal skin disease in susceptible species.
A novel oral amphotericin B formulation, MAT2203, has demonstrated encouraging results in treating invasive mucormycosis. The study showed MAT2203 was as effective as the current standard treatment, LAMB, in extending survival time and improving overall health.
A researcher will study how plants defend themselves against nematode infections, which could lead to novel drugs or antibiotics for humans and livestock. The project aims to increase food security in Africa and Asia by understanding the molecular mechanisms behind plant resistance.
Researchers have discovered a virus that infects the fungus Batrachochytrium dendrobatidis, which causes heart failure in frogs and toads. The virus could be engineered to control the fungal disease and potentially save amphibian species.
Researchers identified two disease-resistant germplasm resources and analyzed physical and chemical defense mechanisms contributing to resistance. The study highlighted the importance of trichome density, wax content, VOCs, and terpenoids in disease resistance.
The fungus C. albicans uses both yeast and hyphae forms to colonize the intestine efficiently when a complex bacterial community is present. The hyphal form produces Candidalysin, which inhibits bacterial metabolism, giving the fungus a competitive advantage.
The study highlights the emergence and spread of harmful pathogens due to climate change. The medical community must update their education and training to combat global warming and its impact on disease behavior.
Researchers identified a yeast that can displace Candida albicans, preventing invasive candidiasis. The novel yeast Kazachstania weizmannii lives harmlessly in intestines and competes with C. albicans for space, reducing its population.
Researchers warn of a growing problem with severe fungal infections, resulting in over 150 million cases annually and 1.7 million fatalities globally. The emergence of multidrug-resistant fungal species, such as Candida auris and Trichophyton indotineae, poses a significant threat to patient outcomes.
Researchers at Leibniz-HKI deciphered the function of Candidalysin's unusual protein structure, which reduces pathogenicity and opens up new treatment options. Nanobodies neutralize the toxin, blocking its activity and inhibiting tissue damage.
Researchers discover that certain bacteria can evade the immune system by circumventing antibody coating, leading to severe inflammation. The study identifies IgG2 as a key player in this process, providing potential biomarkers and targets for new treatments.
Researchers found GZ17-6.02 alone and in combination with standard-of-care agents was effective in killing MF cells, activating key pathways including ATM, AMPK, NFκB, and macroautophagy. The compound's unique multi-factorial mechanism suggests potential for treating mycosis fungoides.
Researchers at Texas A&M University have developed a coating that bolsters the safety of fresh produce and provides enhanced protection against bacteria and fungi. The coating combines wax with nano-encapsulated cinnamon-bark essential oil in protein carriers to enhance antibacterial properties.
Renowned expert John Galgiani, MD, shares current body of knowledge about endemic fungal diseases, focusing on Valley fever and histoplasmosis. Early diagnosis is crucial to avoid unnecessary treatments and complications.
The new guideline aims to improve diagnosis and treatment of cryptococcosis, a fatal fungal infection that affects mainly the lungs and brain. It provides practical guidance for medical staff to recognize and manage invasive fungal infections, with the goal of improving patient survival rates.
Researchers document various reasons for long-term clinical symptoms in patients infected with SARS-CoV-2. Key findings include immune system alterations, chronic inflammation, endothelial dysfunction, and mitochondrial issues contributing to post-COVID syndrome.
A life-threatening mold infection known as Fusarium solani meningitis can cause devastating brainstem and blood supply injuries among healthy patients. The fungus was resistant to all antifungal agents except Fosmanogepix, leading to the development of an experimental treatment.
Researchers at the University of Illinois have identified genomic regions associated with resistance to four diseases in corn: Goss's wilt, gray leaf spot, northern corn leaf blight, and southern corn leaf blight. The study found that multiple genes working together can provide durable resistance against different pathogens.
A new study warns that climate change could reduce global wheat production by 13% by 2050 due to the spread of the fungal disease wheat blast. The affected regions will include South America, southern Africa and Asia, where up to 75% of total wheat acreage could be at risk.
A special Journal of Intensive Medicine issue explores the latest research findings on ICU infections, prevention strategies, and innovative approaches to sepsis management. The studies shed light on key challenges and advancements in critical care, highlighting the need for personalized treatment methods.
Researchers identified hundreds of genes subject to recent selection in six Candida species, providing valuable knowledge for developing better treatments. The study also found a potential spread of resistance through mating between susceptible and resistant strains.
Researchers developed a biodegradable sponge that releases medication slowly into the organism, improving treatment efficacy for vulvovaginal candidiasis. The device is made from soft, biocompatible materials and can be inserted by patients themselves, making treatment more comfortable.