Articles tagged with Lung Cancer
A study found that lung cancer patients coped better with the pandemic, showing lower levels of anxiety and depression compared to healthy individuals. The strength needed to face their disease helped them cope more effectively with COVID-19 fears.
Researchers have developed a new therapeutic approach to block mutated RAS proteins, which are frequently found in cancers. The method, using small molecules, has the potential to work with multiple mutant forms of RAS in various types of cancers, including pancreatic, lung, and colorectal cancers.
A recent study published in Developmental Cell reveals that Kras mutation causes chromatin rearrangement, leading to stem-like cell regeneration and tumor onset. The team discovered a protein complex called AP-1 as the mediator of this process, which can be targeted with small-molecule drugs.
The ACC cardiooncology course is designed to educate clinicians on improving awareness, identification, monitoring, and management of cardiovascular diseases in cancer patients. The course aims to help clinicians minimize cardiotoxicity from cancer therapies, leading to improved overall survival and quality of life for oncology patients.
A new study found that Hong Kong's remote sensing enforcement program significantly reduced harmful chemicals at the roadside and in the atmosphere. The program led to a 22-39% reduction in total hydrocarbons, carbon monoxide, and nitric oxide emissions from high-emitting vehicles.
Dr. John Pierce Wise leads a team to investigate chromosome instability in lungs caused by metal exposure, with hopes of preventing and reversing lung cancer in people. The research aims to understand why humans are more susceptible to metals-induced lung cancer than whales.
Ovarian cancer death rates are predicted to decrease by 17% in the UK and 7% in EU countries in 2022. The main contributor is the long-term use of oral contraceptives, reducing the risk by 40%. Other factors include improved diagnosis, treatment, and advancements in treatments for other cancers.
A study found that lung cancer screening among non-smoking women in Taiwan has led to a 6-fold increase in early-stage diagnoses, while late-stage cancer and death rates remain stable. The researchers estimate that between 7,000 and 12,000 Taiwanese women have been overdiagnosed with lung cancer.
Four MUSC Hollings Cancer Center researchers received American Cancer Society Institutional Research Grants worth $35,000 each. The grants support promising projects that aim to push cancer care forward. Researchers are working on various innovative projects, including a digital literacy training program for community health workers an...
A recent study by Wayne State University School of Medicine found that updated guidelines improve eligibility for lung cancer screenings across various racial groups. The research reveals a significant reduction in racial disparities in accessing screening services.
Dr. Mark S. Parker, MD, FACR, has been recognized as the 2022 ARRS Distinguished Educator for his outstanding contributions to radiological education. He will be formally recognized at the ARRS Annual Meeting in New Orleans, LA on May 1, 2022.
A blood test combining a four-marker protein panel with an independent model improves lung cancer risk assessment, identifying 9.2% more cases for screening and reducing referrals by 13.7%. The study shows the potential to determine who may benefit from lung cancer screening with improved accuracy.
Researchers at Massachusetts General Hospital found that inhibiting the OR5B21 gene significantly decreased breast cancer metastasis to the brain, bones and lung. This discovery may lead to new therapeutic targets to prevent or delay breast cancer's spread.
A recent study found that a substantial decline in lung cancer deaths is associated with earlier diagnosis of lung cancer through increased screening via computed tomography (CT) and follow-up scans. This approach can lead to surgical interventions, which can often be curative for precancerous nodules.
Researchers are part of a five-year global study examining the behavioral and long-term health impacts of different regulatory approaches to e-cigarettes and other new nicotine products among youth and adults in seven countries. The study aims to inform US public policy based on evidence, maximizing population health.
A predictive model based on magnetic resonance spectroscopy can detect lung cancer from alterations in blood metabolites, allowing for early-stage screening and potentially improving survival rates. The study screened tens of thousands of blood specimens and found accurate predictions using values from prior-to-diagnosis blood samples.
Yale scientists identified crucial ways immune system cells congregate and communicate to identify tumors, paving the way for new vaccines that could increase survival rates in several forms of cancer. Research found B cells interact with CD4 helper T cells to unleash a robust response by CD8 killer T cells.
Researchers at Saarland University have discovered that the lipid and cholesterol metabolism of immune cells collaborating with tumour cells is severely compromised compared to tumour tissue. This finding suggests a possible explanation for why cholesterol-lowering drugs are ineffective against non-small-cell lung carcinoma.
Researchers at Princeton University have discovered a new compound that can disable the MTDH gene, which is essential for cancer progression and metastasis. The compound shows promise in treating major human cancers, including breast, prostate, lung, and colon cancers.
Researchers found offering surgery to current smokers can lead to more equitable care, reducing disparities in lung cancer outcomes. A new study published in The Journal of Thoracic and Cardiovascular Surgery shows that risk of complications and death following surgery is similar between current and former smokers.
The updated guidelines lower the age eligibility from 55 to 50 years and reduce pack-years of smoking from 30 to 20. This shift increases the proportion of Black women eligible for screening, from 22.7 percent under previous guidelines to 33.9 percent, with some former smokers now also eligible.
Researchers evaluated lung cancer screening eligibility among Black women under USPSTF guidelines, revealing significant disparities in access to screening. The study found that Black women were less likely to meet screening criteria due to socioeconomic and insurance factors.
Researchers from the University of Copenhagen have discovered a natural substance, a flavonoid, that can inhibit cancer cells' ability to defend themselves against chemotherapy by targeting efflux pumps. This could lead to more effective treatment and potentially even combat antibiotic resistance.
A study found that lung cancer screening rates increased significantly among high-risk males who gained access to Medicare, with a 16% jump in screenings reported. The rise is attributed to the reduced out-of-pocket costs and greater access to care for these individuals, many of whom were previously uninsured.
A new study found that SARS-CoV2 vaccines are safe and effective in patients with thoracic cancer, with an 88% immunization rate after a third dose. The study also showed that older age, chemotherapy, and corticosteroid treatment were associated with lower immunization rates.
A retrospective study found that Lung-RADS performed well in assessing lung cancer risk on follow-up CT scans, with a weighted cancer risk of 5% for new nodules. Strict application of Lung-RADS criteria downgraded some malignant nodules, highlighting the need for category 4X for suspicious features.
A nationwide study published in JAMA Oncology found that immunotherapy use among trial-ineligible solid-tumor cancer patients increased significantly between 2014 and 2019, yet no survival benefit was observed. Researchers emphasize cautious use of immunotherapies for this population due to potential early harm.
The November issue of CHEST journal includes 69 articles on topics such as asthma, COPD, critical care and thoracic oncology. The journal also offers complementary web and multimedia activities to expand the reach of its research.
A study analyzing 93 precision oncology studies revealed significant underrepresentation of racial and ethnic minority populations in cancer research. These disparities affect the representation of diverse patient groups in clinical trials, which can impact treatment efficacy and outcomes.
A positive correlation was found between MET gene amplification and PD-L1 expression in patients with NSCLC and no other actionable oncogenic driver. The study suggests that MET amplification up-regulates PD-L1 expression, which may impact treatment strategies for these patients.
Researchers discovered a new biomarker, inactive AMPK (lo-P-AMPK), that may predict immune evasion in lung cancer. The finding could enable better personalized care for lung cancer patients by identifying those most likely to benefit from immunotherapies.
Deaths from smoking-related cancers in China are projected to rise by nearly 50% over the next two decades, with an estimated 8.6 million excess deaths anticipated. If current trends continue, the goal of reducing smoking rates to 20% by 2030 may not be met, leaving a significant impact on the country's ageing population.
Researchers found that certain T cells stop working before entering the tumor due to changes in gene expression, making ICB therapies less effective. Combining ICB with other forms of immunotherapy targeting different aspects of T cell function may improve response rates for non-small cell lung cancer patients.
Researchers developed a molecular agent that can target lung and other cancer cells for imaging and treatment, distinguishing between healthy and cancerous cells. The new approach uses a unique chemistry method to tune the reactivity of the molecule, avoiding off-target effects.
A new study identifies three functional subtypes of cancer-associated fibroblasts (CAF) in lung cancer, which correspond to patients' treatment responses. These subtypes have distinct biological functions and therapeutic implications, suggesting that CAFs could serve as a key to enhancing personalized treatment for lung cancer patients.
A new study finds that high-dose radiation therapy can lengthen progression-free survival for people with advanced lung cancer when systemic therapy has not fully halted tumor growth or spread. Stereotactic body radiation therapy (SBRT) shows promise in treating oligoprogressive, metastatic lung and breast cancer.
A study by Temple University Hospital found that virtual single-visit screenings are just as effective as in-person screenings, especially for African American patients. The telemedicine approach helped preserve access to lung cancer screening during the pandemic, despite a 75% decline in overall screenings.
Researchers developed a compact photonic resonator absorption microscope for point-of-care diagnostics, using photonic crystal biosensors to detect proteins or other biomarkers linked to gold nanoparticles. The portable instrument costs $7,000 and has potential applications in detecting various cancers.
A woman with non-small cell lung cancer experienced a 76% tumor reduction after taking CBD oil for 2.5 years, raising hopes for alternative cancer treatments. However, more research is needed to confirm the mechanism of action and potential side effects.
A new study has found that worsening depression after diagnosis significantly reduces the survival of lung cancer patients. The trajectory of depressive symptoms was found to be a key factor in understanding how depression relates to premature death. Patients with worsening depression had shorter lifespans, even when receiving advanced...
A Kaiser Permanente study found that the 2021 USPSTF guidelines will likely increase lung cancer screening of women, racial and ethnic minority groups, and individuals with lower socioeconomic status. This is expected to lead to an estimated 30% increase in lung cancer diagnoses compared to the 2013 recommendations.
Researchers found that combining an Aurora Kinase A inhibitor with a KRAS inhibitor or WEE1 inhibitor showed efficacy against lung cancer cells resistant to KRAS inhibition. The study suggests that Aurora Kinase A activation contributes to intrinsic and acquired resistance to sotorasib in KRAS-mutated lung cancer cells.
A phase Ib study found that combining sotorasib, a KRAS G12C inhibitor, with afatinib, a pan-ErbB tyrosine kinase inhibitor, showed antitumor activity in patients with KRAS-mutant non-small cell lung cancer. The combination demonstrated a high disease control rate and improved efficacy compared to prior therapies.
A recent study found that non-Hispanic Black patients who received immunotherapy for advanced-stage non-small cell lung cancer had a lower risk of death compared to non-Hispanic white patients. The researchers controlled for access-related issues and found disparities persisted in certain populations.
Researchers found that older adults with non-small cell lung cancer have low life-space mobility before treatment, which declines after starting treatment. A lower body mass index prior to treatment is associated with an improvement in life-space mobility during treatment.
New studies show that patients with abnormal screening results may face significant out-of-pocket costs for follow-up tests, potentially delaying care. For women, colposcopy costs rose sharply over 13 years, with some facing bills of nearly $1,000. Lung cancer screening CT scans also led to high costs for invasive procedures.
A new analysis suggests that most never-smokers' lung tumors have actionable mutations, making them treatable with existing FDA-approved drugs. The study found that 78-92% of lung cancers in patients who have never smoked can be targeted with precision drugs.
Researchers mapped cancer through protein interactions, revealing biomarkers and potential new treatments for breast and head and neck cancers. The study provides a new definition of biomarkers based on large, multi-protein complexes, offering a more precise way to explain mutation effects.
A new study compared the molecular profiles of lung cancer cells grown in 3D and 2D cultures, finding significant differences in protein expression and regulation. The research used a membrane proteomics approach to analyze the NCI-H23 cell line and identified exclusive expressions of CD molecules in 3D culture.
Researchers analyzed data from over 3,200 brain metastatic tumors and discovered that different types of cancer tend to spread to specific parts of the brain. The study's findings may help predict where a particular cancer will metastasize and inform treatment strategies.
The VCU Massey Cancer Center has established a Translational Research Center in Lung Cancer Disparities (TRACER) to address racial disparities in lung cancer. TRACER will investigate the interaction between stress, smoking, and gene expression to raise lung cancer risk in Black men.
A new study found that benzo(a)pyrene plays a small part in the global risk of developing PAH-associated cancer, with 89% of the risk coming from other unregulated chemicals. Degradation products formed in the atmosphere can also be more toxic than the emitted PAHs.
Researchers at Johns Hopkins Kimmel Cancer Center discovered differences in gene activity between immune cells from patients with lung cancer who responded and did not respond to immunotherapies. The findings suggest that non-responders' immune cells can be reprogrammed to act more like responders', potentially leading to new treatment...
A new study finds that racial/ethnic minorities remain less likely to be eligible for lung cancer screening under the revised guidelines, highlighting the need for more nuanced risk models. Incorporating social determinants of health and family history could help address disparities in lung cancer screening eligibility.
The IMpower010 trial demonstrates that atezolizumab significantly improves disease-free survival in resected, early-stage NSCLC patients compared to best supportive care. Tumors expressing PD-L1 > 50% show a greater benefit of treatment.
Researchers at Weill Cornell Medicine identified club cell factors that inhibit immunosuppressive cells in tumors, leading to increased antitumor T cells and improved effectiveness of PD1 immunotherapy. A
A clinical trial found that over half of patients with non-small cell lung cancer (NSCLC) with a HER2 gene mutation had their tumors stop growing or shrink after treatment with trastuzumab deruxtecan. The drug showed durable responses in 54.9% of patients, with median survival period of 17.8 months.
A study identifies four novel subgroups of EGFR mutations that predict drug response, offering a more accurate framework to match patients with targeted therapies. The findings reveal that certain mutations respond better to specific classes of TKIs, providing new clinical opportunities for approved treatments.
Researchers developed a treatment using cowpea mosaic virus nanoparticles that target lung tumors, slowing tumor growth and preventing cancer spread. The treatment showed efficacy against aggressive cancer cell lines and may offer protection to patients at high risk of metastatic disease.
Eosinophils, a type of white blood cell, play a crucial role in destroying malignant tumors by recruiting T-cells and releasing destructive proteins. The study, published in Cancer Research, reveals that eosinophils combat cancer effectively but require the help of T-cells to do so.