Research on heart attacks and their treatment. Covers care for older patients, cardiac rehabilitation, rapid testing, and updated diagnostic definitions.
Researchers have invented a Trojan Horse nanoparticle that selectively targets and eats away at plaque-causing cells, reducing plaque size and stabilizing it. This approach shows promise as a potential treatment for atherosclerosis, the leading cause of death in the US.
A recent study published in the Journal of the American College of Cardiology found that approximately 2 million adults in the US who have cardiovascular disease currently use or have used marijuana. The review also reveals that cannabinoids can interact with drugs used to treat heart disease, increasing the risk of adverse effects.
A large study of over 22,000 patients after a first heart attack found that abdominal obesity is independently associated with fatal and non-fatal heart attacks and strokes. Waist circumference was a stronger marker of recurrent events than overall obesity in men, while women had a U-shaped relationship between waist circumference and ...
A new radiotracer, 68Ga-FAPI-04 PET, can effectively image fibroblast activation after myocardial infarction, identifying a time window during which cardiac fibrosis can be prevented. This technology may aid in the clinical management of patients after a heart attack.
A new study has shown that a protein therapy called rhPDGF-AB can improve the quality of scar tissue after a heart attack, leading to the formation of new blood vessels and reduced rates of dangerous heart arrhythmia. The treatment has increased survival rates in animal models and holds promise for improving patient outcomes.
A new study by Oxford University Press USA reveals that machine learning can predict long-term risks of heart attack and cardiac death. The research used machine learning to assess cardiovascular risk factors in subjects, aligning accurately with actual events over a 15-year period.
A new national study found that walking and cycling to work were associated with a significant reduction in heart attacks. For women who walked to work, there was an associated 1.7% reduction in heart attacks the following year, while men who cycled to work experienced the same decrease.
A study published by the American Heart Association found that low-dose aspirin did not reduce the risk of a fatal heart attack among African Americans, unlike in white populations. The study used data from over 65,000 participants and suggested genetic differences and poor control of other risk factors may contribute to this result.
A new study suggests that taking aspirin daily to prevent a heart attack or stroke may no longer be recommended for adults without a history of these events. The study found that the potential benefits of aspirin are similar to its potential harms for most people, highlighting the need for personalized advice from doctors.
A $1 million international study aims to develop a new therapeutic treatment for people who have suffered heart attacks with extensive cardiac damage. The project, led by UniSA Professor Janna Morrison, explores whether changing the expression of a specific molecule can repair cardiac damage.
Researchers found that mice lacking an inflammation resolution sensor developed spontaneous obesity, heart disease, and shortened lifespan, indicating impaired inflammation resolution. This study sheds light on the sensor's integrative role in managing cardiometabolic health and inflammation-resolution processes.
A study found striking disparities in in-hospital care and mortality between homeless and non-homeless adults hospitalized for urgent cardiovascular conditions. Homeless patients were significantly less likely to receive important diagnostic or therapeutic procedures and generally had higher in-hospital death rates compared to non-home...
Research reveals that only one LDL subclass causes significant damage, while others are harmless. Accurate diagnosis using LDL subclass composition could improve cardiovascular disease rates.
Preliminary research found that men who maintained high levels of moderate to vigorous physical activity both before and after their heart attacks were 39% less likely to die from any cause. Regular physical activity after a heart attack is associated with better survival, even in older adults.
Patients who underwent metabolic surgery had a lower risk of developing systolic heart failure and dying from recurrent myocardial infarction compared to those without surgery. The study found significant cardiovascular benefits of metabolic surgery, emphasizing its potential as part of the treatment plan for patients with severe obesi...
Chronic kidney disease patients are at an increased risk of heart attacks, congestive heart failure, stroke, and other adverse cardiovascular events. The study found that chronic kidney disease is associated with a 95% higher risk of heart attack during the follow-up period.
Researchers at Université de Genève and University of Lyon identified deoxydihydroceramide as the molecule causing tissue necrosis. Inhibiting its synthesis reduced tissue damage by 30% in mice, suggesting a new model for treating heart attacks and strokes.
A new blood test increased diagnoses of women with heart attacks by 42%, but the gender gap in treatment remains. Women were 50% less likely to receive recommended treatments after a heart attack diagnosis.
A new study finds that dog owners have a lower risk of death from heart attacks and strokes, with significant reductions in mortality rates for those living alone or with a partner. Dog ownership is associated with increased physical activity, decreased depression, and reduced social isolation.
New research warns Canadians against taking daily aspirin for primary prevention due to increased risk of major internal bleeding and potential increase in cancer deaths. Experts recommend alternative preventive measures such as smoking cessation, exercise, blood pressure tracking, and considering the Mediterranean diet.
A recent international trial showed that patients requiring emergency heart attack treatment also benefit from further intervention to reduce the risk of future heart attacks. The study found that additional stenting for significant narrowings in other untreated arteries significantly reduces the risk of future heart attacks and death.
A new study based on SWAN data shows that frequent and persistent menopausal hot flashes are associated with a higher risk of heart problems. The study found that hot flashes at the beginning of the transition doubled the risk of clinical CVD events, while persistent hot flashes over 20 years increased the risk by 80%.
A recent study published in Nature Communications found that a circular RNA called circFndc3b plays a critical role in tissue repair after a heart attack. The RNA acts like a 'sponge' to bind harmful molecules, preventing cell death and promoting vascular growth, which aids the repair process.
Researchers at Temple University Health System have identified a new target regulating mitochondria during stress, which could lead to a new approach to treating conditions such as heart failure, heart attack, stroke, and neurodegeneration. The discovery highlights the role of MCUB in mitigating calcium overload in injured heart tissue.
Researchers at Vanderbilt University have developed an antibody to target cadherin-11, a major contributor to inflammation in cardiac fibrosis. The study shows that the antibody can fine-tune inflammation and reduce scarring, leading to improved cardiac function.
Researchers discovered that border zone cells in humans and mice develop a gene program that helps them survive a heart attack. This response is crucial for long-term recovery of the heart, but further research is needed to induce this response in humans.
A pre-clinical study published in Redox Biology reveals that vitamin E may help preserve heart function after a heart attack by reducing inflammation and oxidative stress. The findings suggest that vitamin E could be an effective and inexpensive therapy for patients with heart attacks, providing new hope for cardiovascular health.
A new study by researchers at Uppsala University found that attending Sweden's 'Heart School' program significantly lowers mortality risk for patients with a first heart attack. The program focuses on lifestyle-related risks and teaches patients the importance of healthy habits.
Researchers will examine biomarkers and chemicals in thirdhand smoke to understand its impact on cardiovascular health. The five-year study aims to design better therapies for thirdhand smoke-induced cardiovascular disease.
A new NIH-funded study found that hospital emergency room closures can adversely affect health outcomes for heart attack patients at neighboring hospitals. Conversely, when a new emergency department opens, health outcomes for those patients improve.
A new study projects a cost-effective polypill to be the standard of care for secondary prevention of cardiovascular disease, offering excellent clinical and health economic returns on investment. The polypill is expected to save lives and money by reducing medication burden and increasing patient adherence.
Researchers developed a 'fat fingerprint' using machine learning to identify inflammation, scarring, and changes to blood vessels. The new biomarker can predict heart attacks with higher accuracy than current tools.
A study of nearly 1.7 million 18-year-old boys found that higher body mass index (BMI) is linked to a greater risk of heart attack before age 65. The research suggests that monitoring BMI during puberty and preventing obesity with healthy eating and physical activity may help reduce this risk.
A new study comparing heart attack care in Sweden and the UK found that patients in Sweden had lower mortality rates for both STEMI and NSTEMI forms of heart attacks. The results suggest improved outcomes due to increased use of invasive treatments and recommended medications in Sweden.
A new study of nearly half a million people found that sleeping between 6 and 9 hours nightly can cut the risk of heart attack by up to 18% for those with genetic predisposition. Sleeping too little or too much also boosts heart attack risk, with optimal sleep duration being critical for overall heart health.
A new study published in the New England Journal of Medicine shows that opening all clogged arteries after a serious heart attack leads to a 26% reduction in patient risk of dying or having a recurrent heart attack. This approach also shows no major downside to additional procedures.
A study found that bacteria in coronary plaques were pro-inflammatory, whereas gut bacteria were diverse and varied. Patients with acute coronary syndrome had different gut microbiota compared to those with stable angina. The research suggests a possible role for microbes in plaque destabilization and heart attack onset.
The European Society of Cardiology recommends reducing air pollution and environmental noise to minimize heart attack and stroke risk. Lifestyle changes, such as quitting smoking, eating a balanced diet, and exercising regularly, are also emphasized.
A recent study found that boosting levels of tiny RNA miR322 can reduce heart muscle death by 40% after a heart attack. The research suggests that miR322 regulates the enzyme FBXW7, which tags cells for elimination, and its overexpression can protect the heart from damage.
Research funded by the British Heart Foundation has challenged a long-held medical myth that women experience unusual heart attack symptoms. According to the study, both men and women present with similar key symptoms, such as chest pain and nausea, highlighting the need for awareness of common warning signs.
Researchers at University of Texas at Austin are developing noninvasive computational modeling technology to assess heart attack risk. The project uses computer simulation technology to analyze individual patients' vulnerability to plaque rupture, which can trigger a heart attack.
Geriatric patients with ST segment elevation myocardial infarction who undergo primary percutaneous coronary intervention have higher in-hospital mortality rates if they have a high mean platelet volume. This is also associated with higher Gensini scores, creatinine concentrations, and lower HDL cholesterol levels.
Researchers aim to decipher the mechanisms that govern the regenerative capacity of large neonatal mammalian hearts and manipulate them to remuscularize the heart after muscle death. The study may lead to novel techniques for pediatric and adult heart disease interventions, addressing the fundamental problem of heart failure.
Researchers discovered that intense light amplifies the PER2 gene, which bolsters blood vessels and offers protection against heart attacks. The study found that mice exposed to intense light had reduced cardiac tissue damage after a heart attack, suggesting a potential therapeutic strategy for humans.
Patients who received lifestyle counseling at least once a month had lower rates of cardiovascular events and death compared to those who did not. The study found a significant decrease in blood glucose levels among patients who received frequent counseling.
A new study found that individuals with familial hypercholesterolemia (FH) or atherosclerotic heart disease (ASCVD) experienced more cardiovascular events when they couldn't get their prescribed LDL-cholesterol lowering medication. Those whose PCSK9 inhibitors were rejected by insurance had a 16% increased risk of a cardiovascular even...
Researchers suggest a genetic mutation two to three million years ago led to a heightened risk of cardiovascular disease in all humans, while also setting up a further risk for red meat-eating humans. Human-like mice modified to lack the CMAH gene showed a significant increase in atherogenesis compared to control mice.
Pierre will explore a new Na/K-ATPase/Src pathway to limit cardiac dysfunction in hopes of developing new therapeutic interventions. The study aims to test two distinct interventions in both acute and chronic phases of myocardial infarction.
A large Kaiser Permanente-led study found that both systolic and diastolic blood pressure readings predict cardiovascular risk, contradicting decades of previous research. The study analyzed over 36 million blood pressure readings from 1.3 million people, revealing that high blood pressure is a strong predictor of heart attack or stroke.
A team of CNIC scientists identified SRSF3 as crucial for proper heart function and found that its loss leads to reduced expression of genes involved in contraction. Further research revealed that SRSF3 controls the alternative processing of mTOR, a major regulator of cell metabolism, which is essential for heart health.
A new study by Australian National University found that smoking harms all of the cardiovascular system, including the heart and major blood vessels. Quitting smoking markedly reduces risk of heart attacks, strokes, and dying from cardiovascular disease.
Researchers found that patients taking an additional injection of alirocumab, a PCSK9 inhibitor, had significantly reduced cholesterol levels and lower risk of heart attack. For patients with diabetes, the treatment was found to reduce cardiovascular risk by an average of 2.3%.
A new machine learning approach using coronary CT scans shows better results than existing models in predicting heart attacks and cardiac events. The study found that the AI-based method can identify patients at higher risk more accurately, leading to improved treatment outcomes.
Researchers at Temple University Health System have discovered that a small RNA molecule can reactivate heart cell proliferation and improve heart function in mice with severe heart attacks. The study, published in Circulation Research, shows that miR-294 treatment reawakens an embryonic signaling program in adult heart cells.
A meta-analysis of 21 clinical trials involving 83,000 patients found no association between vitamin D supplementation and reduced risk of cardiovascular disease events such as heart attack or stroke. The study's results were consistent across different doses and genders.
Researchers have developed a new method to predict the risk of cardiogenic shock in patients after a heart attack. The tool uses proteomics and biomarkers to identify patients at higher risk, enabling more precise treatment options.
Adults with coronary heart disease experience faster cognitive decline in long-term studies, according to researchers. Cognitive tests reveal significant differences in verbal memory, semantic fluency, and temporal orientation among patients with angina or heart attack.
A new research study uses polygenic risk scores to predict heart disease risk in French Canadians, with high accuracy and sensitivity, similar to other populations. The score can identify individuals at high risk for cardiac disease, allowing for early detection and effective therapeutic interventions.
Researchers have developed a therapeutic approach that utilizes the endogenous process to turn off inflammation and promote healing in the heart muscle. Annexin A1 protein stimulates new blood vessel formation, increasing blood flow and improving cardiac function.
Research reveals undetected glucose disorders significantly increase risk of myocardial infarction and severe periodontitis, prompting closer collaboration between dentistry and healthcare. The study emphasizes the importance of considering patients' dental health in diabetes diagnosis.