Articles tagged with Myocardial Infarction
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A recent study found that boosting levels of tiny RNA miR322 can reduce heart muscle death by 40% after a heart attack. The research suggests that miR322 regulates the enzyme FBXW7, which tags cells for elimination, and its overexpression can protect the heart from damage.
Researchers at University of Texas at Austin are developing noninvasive computational modeling technology to assess heart attack risk. The project uses computer simulation technology to analyze individual patients' vulnerability to plaque rupture, which can trigger a heart attack.
Research funded by the British Heart Foundation has challenged a long-held medical myth that women experience unusual heart attack symptoms. According to the study, both men and women present with similar key symptoms, such as chest pain and nausea, highlighting the need for awareness of common warning signs.
Geriatric patients with ST segment elevation myocardial infarction who undergo primary percutaneous coronary intervention have higher in-hospital mortality rates if they have a high mean platelet volume. This is also associated with higher Gensini scores, creatinine concentrations, and lower HDL cholesterol levels.
Researchers aim to decipher the mechanisms that govern the regenerative capacity of large neonatal mammalian hearts and manipulate them to remuscularize the heart after muscle death. The study may lead to novel techniques for pediatric and adult heart disease interventions, addressing the fundamental problem of heart failure.
Researchers discovered that intense light amplifies the PER2 gene, which bolsters blood vessels and offers protection against heart attacks. The study found that mice exposed to intense light had reduced cardiac tissue damage after a heart attack, suggesting a potential therapeutic strategy for humans.
Patients who received lifestyle counseling at least once a month had lower rates of cardiovascular events and death compared to those who did not. The study found a significant decrease in blood glucose levels among patients who received frequent counseling.
A new study found that individuals with familial hypercholesterolemia (FH) or atherosclerotic heart disease (ASCVD) experienced more cardiovascular events when they couldn't get their prescribed LDL-cholesterol lowering medication. Those whose PCSK9 inhibitors were rejected by insurance had a 16% increased risk of a cardiovascular even...
Researchers suggest a genetic mutation two to three million years ago led to a heightened risk of cardiovascular disease in all humans, while also setting up a further risk for red meat-eating humans. Human-like mice modified to lack the CMAH gene showed a significant increase in atherogenesis compared to control mice.
Pierre will explore a new Na/K-ATPase/Src pathway to limit cardiac dysfunction in hopes of developing new therapeutic interventions. The study aims to test two distinct interventions in both acute and chronic phases of myocardial infarction.
A large Kaiser Permanente-led study found that both systolic and diastolic blood pressure readings predict cardiovascular risk, contradicting decades of previous research. The study analyzed over 36 million blood pressure readings from 1.3 million people, revealing that high blood pressure is a strong predictor of heart attack or stroke.
A team of CNIC scientists identified SRSF3 as crucial for proper heart function and found that its loss leads to reduced expression of genes involved in contraction. Further research revealed that SRSF3 controls the alternative processing of mTOR, a major regulator of cell metabolism, which is essential for heart health.
A new study by Australian National University found that smoking harms all of the cardiovascular system, including the heart and major blood vessels. Quitting smoking markedly reduces risk of heart attacks, strokes, and dying from cardiovascular disease.
Researchers found that patients taking an additional injection of alirocumab, a PCSK9 inhibitor, had significantly reduced cholesterol levels and lower risk of heart attack. For patients with diabetes, the treatment was found to reduce cardiovascular risk by an average of 2.3%.
A new machine learning approach using coronary CT scans shows better results than existing models in predicting heart attacks and cardiac events. The study found that the AI-based method can identify patients at higher risk more accurately, leading to improved treatment outcomes.
Researchers at Temple University Health System have discovered that a small RNA molecule can reactivate heart cell proliferation and improve heart function in mice with severe heart attacks. The study, published in Circulation Research, shows that miR-294 treatment reawakens an embryonic signaling program in adult heart cells.
A meta-analysis of 21 clinical trials involving 83,000 patients found no association between vitamin D supplementation and reduced risk of cardiovascular disease events such as heart attack or stroke. The study's results were consistent across different doses and genders.
Adults with coronary heart disease experience faster cognitive decline in long-term studies, according to researchers. Cognitive tests reveal significant differences in verbal memory, semantic fluency, and temporal orientation among patients with angina or heart attack.
Researchers have developed a new method to predict the risk of cardiogenic shock in patients after a heart attack. The tool uses proteomics and biomarkers to identify patients at higher risk, enabling more precise treatment options.
A new research study uses polygenic risk scores to predict heart disease risk in French Canadians, with high accuracy and sensitivity, similar to other populations. The score can identify individuals at high risk for cardiac disease, allowing for early detection and effective therapeutic interventions.
Researchers have developed a therapeutic approach that utilizes the endogenous process to turn off inflammation and promote healing in the heart muscle. Annexin A1 protein stimulates new blood vessel formation, increasing blood flow and improving cardiac function.
Research reveals undetected glucose disorders significantly increase risk of myocardial infarction and severe periodontitis, prompting closer collaboration between dentistry and healthcare. The study emphasizes the importance of considering patients' dental health in diabetes diagnosis.
A new Michigan Medicine research found that intensive care unit admission was associated with improved 30-day mortality rates for patients who had a STEMI heart attack and weren't clearly indicated for an ICU or non-ICU unit. The study analyzed Medicare data from over 100,000 patients hospitalized with STEMI and showed a clear benefit ...
Researchers discovered that widowed men are 11% more likely to die from a heart attack compared to widows, while divorced men with atrial fibrillation have a 14% higher risk. Single women actually have a 13% lower risk of death from heart failure than single men.
Research shows that heart attack patients with prolonged depression or anxiety are at a higher risk of death. Patients who experienced chronic emotional distress were more likely to die from cardiovascular and non-cardiovascular causes during follow-up.
Researchers at Imperial College London have developed lab-grown heart patches that are safe for human trials after clearing important hurdles. These patches contain up to 50 million human stem cells programmed to turn into working heart muscle, potentially curing debilitating heart failure.
A recent study by Dr. Ganesh Halade and colleagues found that lipoxygenase deficiency delays heart failure progression and improves survival in mice. The researchers discovered that epoxyeicosatrienoic acids facilitate cardiac healing after a heart attack, reducing diabetes risk biomarkers and altering plasma metabolic signaling.
A new study published in JAMA Internal Medicine found that nonfasting lipid levels were similar to fasting lipid levels in the same individuals, predicting cardiovascular risk just as well. The results suggest it may be unnecessary for most patients to fast before having bloodwork done to measure lipid levels.
A study of over 8,000 participants found that elevated troponin I levels are associated with cardiac outcomes like heart attacks and fatal coronary disease. Adding troponin I to a risk prediction model improves accuracy in predicting heart failure risk, highlighting the potential for improved treatment strategies.
Nearly one in 10 young adults who had a heart attack met the clinical definition for familial hypercholesterolemia. Many patients continued having elevated cholesterol levels a year after their heart attack, highlighting opportunities for more aggressive treatment.
A new minimally invasive treatment option has been shown to dramatically lower rates of low-density lipoprotein (LDL) cholesterol in patients following a heart attack. The procedure, called LDL-apheresis, decreases LDL levels by 50-80 percent in two to three hours.
The expert consensus paper recommends using intracoronary imaging to guide treatment for acute coronary syndromes, including heart attacks. Imaging provides a more accurate diagnosis and helps tailor therapy, especially for younger patients with complex lesions or plaque erosion.
Researchers found that circadian rhythms impact immune responses, with morning immune cells elevated and nighttime levels suppressed. This discovery may lead to time-tailored therapies for human patients.
A joint statement from the American Heart Association and others suggests home-based cardiac rehabilitation as a viable option for patients who cannot attend traditional programs. Effective home-based care requires scientifically-based, standardized care with remote supervision and coaching.
Imaging techniques like cardiac MRI and intravascular imaging can help diagnose the underlying cause of MI in women without obstructive CAD. These methods provide crucial information for treatment decisions.
Researchers at King's College London have made a groundbreaking discovery that genetic therapy can heal heart damage caused by a heart attack. The study used microRNA-199 to stimulate cardiac regeneration in pigs, resulting in almost complete recovery of cardiac function.
Researchers at UT Southwestern have found that SR-B1 and DOCK4 proteins ferry LDL particles into and across endothelial cells, driving the development of atherosclerosis. Deleting these proteins from endothelial cells reduces LDL entry and atherosclerotic plaque formation.
A Northwestern University and UC San Diego team has created a novel way to deliver a bioactivated, biodegradable substance through a noninvasive catheter without clogging. The approach uses self-assembling peptides that turn the body's inflammatory response into a signal to heal rather than a means of scarring.
A study from Yale University finds that low mobility is a significant predictor of hospital readmission in older heart attack patients. Patients who took more than 25 seconds on the Timed Up and Go test were nearly twice as likely to be readmitted after a heart attack.
A new prediction tool uses functional impairments and traditional factors to identify patients over 75 who may require repeat hospitalization. Impaired mobility, measured by the Timed Up and Go test, is the only functional impairment associated with 30-day readmission.
A new study found that percutaneous coronary intervention (PCI) significantly reduced overall mortality in older heart attack patients. The procedure saved lives for 49 young-olds, 53 middle-olds, and 54 old-olds, with a 53% reduction in death among those 75-79 years old.
Researchers have identified two microRNA family members that can provide both immediate and long-term protection against heart damage. The therapy targets the miR-19a/b microRNAs, which regulate proliferation of cardiomyocytes and reduce inflammation, leading to improved heart function.
A study published in the European Journal of Preventive Cardiology found that people who skip breakfast and eat dinner near bedtime have a four to five times higher likelihood of death, another heart attack, or angina within 30 days after hospital discharge for heart attack. Late-night dinner eating was also associated with poorer outc...
Researchers have developed a water-based hydrogel material that can be placed directly on the heart to prevent stretching of the heart muscle, a common problem after a heart attack. The patch outperformed existing patches and showed promising results in reducing post-heart attack damage.
Patients with acute coronary syndromes can return to work in two to three months, but one in four quit after a year. Psychological factors like lack of confidence, depression, and anxiety are significant predictors of failure. Attending cardiac rehabilitation and gradual reintegration into the workplace can help patients succeed.
Researchers found that older heart attack patients were less likely to receive timely percutaneous coronary intervention (PCI) to open blocked heart arteries, resulting in more complications and poorer outcomes. Despite longer hospital stays, older patients had lower total charges due to reduced use of costly interventions like PCI.
Despite improvements in heart attack and heart disease care for older women, black women continue to face significant racial disparities in treatment. Postmenopausal black women were 50% less likely and Hispanic women 16% less likely to receive treatment when arriving at the hospital with symptoms compared to white women.
A genetic study of over 160,000 adults in China found that moderate drinking has no protective effects against stroke and may even increase the risk. Blood pressure also rises with increased alcohol consumption.
Patients treated at hospitals with low care scores are at greater risk for another heart attack or death due to cardiovascular causes. Teaching hospitals have a lower risk, with patients having 25% lower chance of readmission within one month and 10% lower chance of cardiovascular death at one year.
A recent study found that both radial and femoral approaches for percutaneous coronary intervention (PCI) are equally effective in terms of survival rates at 30 days. The research, which enrolled nearly 2,300 patients, suggests that operators can achieve similar results with either approach if they have efficient systems and teams in p...
A new study shows that a 4 gram dose of icosapent ethyl significantly reduces the occurrence of ischemic events, including heart attacks, strokes, and related deaths. The drug also prevents subsequent cardiovascular events and may be a cost-effective way to prevent CV complications in patients with elevated triglycerides.
Researchers found that ticagrelor has comparable efficacy to clopidogrel in patients treated with clot busters for a heart attack. The trial also showed that ticagrelor is safe for use in this patient population, with low rates of major bleeding.
The REDUCE-IT trial found that high-dose icosapent ethyl significantly reduced the burden of first and subsequent cardiovascular events, including heart attacks, strokes, and deaths from cardiovascular causes. The study showed a 30% relative risk reduction in total cardiovascular events.
Patients treated with apixaban and a P2Y12 inhibitor had lower rates of bleeding and no increase in heart attacks or strokes compared to those receiving warfarin and aspirin. The combination reduced the risk of major bleeding by up to 47% without increasing mortality or hospitalization.
Researchers found that systematic depression screening after a heart attack did not impact patients' quality of life. Depression was identified in about 7% of screened patients, and interventions such as medication, phone-based psychotherapy sessions, or a combination both were shown to be effective in reducing depressive symptoms.
A Yale study of over four million Medicare patients found that hospitalizations for heart attacks have declined by 38% since the 1990s, while the 30-day mortality rate has dropped to an all-time low of 12%. These gains are attributed to national efforts to prevent heart attacks and improve care.
A study of over 27,000 heart attack patients found an increase in heat-induced heart attacks in recent years, particularly among individuals with diabetes or hyperlipidaemia. Climate change is suspected to be a contributing factor, but the exact mechanism behind these deaths remains unclear.
Researchers found that lower blood pressure is associated with increased risk of death in adults over 80, and those who've had a heart attack or stroke. This study's results suggest adjusting antihypertensive treatment based on individual needs, moving away from blanket approaches.
A study presented at the 30th Annual Conference of the Saudi Heart Association found that waterpipe and cigarette smoking are associated with heart attacks at a younger age in Saudi Arabians. Smokers have more complications, bigger heart attacks, and poorer outcomes compared to non-smokers.
A study has revealed that young adults under 40 are experiencing an alarming increase in heart attacks, despite having the same mortality rates as older survivors. Substance abuse and diabetes may be contributing to this trend, emphasizing the need for prevention and early detection of cardiovascular disease.