Researchers at CUNY ASRC identify distinct histone tag in adult oligodendrocyte progenitor cells that regulates their proliferation and may lead to innovative therapies for neurodegenerative diseases. The discovery holds promise for advancing myelin repair and improving patient outcomes.
SourceAdvanced Science Research Center, GC/CUNY·JournalJournal of Cell Biology·TypeExperimental study·DateAug 12, 2024
Parents who struggle with alcohol use disorders can pass along symptoms of early aging to their children, affecting them well into adulthood. These accelerated aging effects include high cholesterol, heart problems, arthritis, and early onset dementia.
SourceTexas A&M University·JournalAging and Disease·DateAug 8, 2024
A new study found that mTORC1 activity correlates with classical biometrics, such as height and macrocephaly, as well as specific neuropsychiatric diseases like anxiety and autism. The research suggests that human variability of mTORC1 gain of function may predict medication response.
SourceImpact Journals LLC·JournalAging-US·TypeNews article·DateAug 7, 2024
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study published in Cardiovascular Diabetology found that higher blood glucose levels at admission significantly increase the risk of a poor functional prognosis or death within three months of an ischemic stroke. The study revealed that even a 10% increase in glucose levels raises the risk by 7%, and mortality risk by 88%.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalCardiovascular Diabetology·DateAug 7, 2024
Researchers found that dopamine treatment increased neprilysin levels and reduced beta-amyloid plaques in mouse brains, improving memory function. Long-term L-DOPA treatment also showed improved cognitive performance in mice.
Researchers at UC Davis have developed a new method called CaST to track the activation of brain neurons and biomolecules by psychedelic drugs. The tool allows scientists to study the cellular mechanisms behind psychedelic treatments for brain disorders, such as depression and post-traumatic stress disorder.
SourceUniversity of California - Davis·JournalNature Methods·TypeExperimental study·DateAug 5, 2024
Researchers identified a common genetic variation that appears to protect against ALS by reducing levels of a protein blocking the IGF-1 signaling pathway. This finding suggests a potential new approach to targeting IGF-1 as a treatment for ALS.
SourceDuke University Medical Center·JournalNeurology·DateJul 30, 2024
A preclinical study led by Weill Cornell Medicine researchers found that the iron-chelating drug deferiprone can selectively target and kill ovarian cancer cells. By starving cancer cells of iron, deferiprone triggers a cellular stress response, prompting the immune system to attack them.
SourceWeill Cornell Medicine·JournalCancer Discovery·DateJul 29, 2024
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Viji Santhakumar, a UCR professor, has been awarded a $3.5 million NIH grant to study brain circuit function and its impact on memory formation and cognitive deficits in diseases like epilepsy and Alzheimer's disease.
The PD GENEration study has found that 13% of participants have a genetic form of Parkinson's disease, significantly higher than previous estimates. The study, which reached its goal of 15,000 participants ahead of schedule, provides insights into the genetics of the disease and its potential for precision medicine.
SourceParkinson's Foundation·JournalBrain·TypeObservational study·DateJul 29, 2024
A new study using live mice and influenza virus sheds light on how maternal immune response affects fetal brain development. Researchers found that only a subset of severe infections can cause changes in the developing fetal brain, increasing the risk for neurodevelopmental disorders like schizophrenia and autism spectrum disorder.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalMolecular Psychiatry·DateJul 29, 2024
Microglia establish contact with neurons through tunnelling nanotubes to clear toxic protein aggregates, reducing oxidative stress and restoring vital functions. Healthy mitochondria are also transferred from microglia to affected neurons, preserving energy production and neuronal survival.
SourceUniversity of Luxembourg·JournalNeuron·TypeObservational study·DateJul 26, 2024
A new study reveals specific brain regions and cell types that are vulnerable to Alzheimer's disease, while others show resilience. Gene expression analysis and lab experiments highlight the role of Reelin in neuronal vulnerability and choline/antioxidants in sustaining cognition.
SourcePicower Institute at MIT·JournalNature·TypeExperimental study·DateJul 24, 2024
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Scientists successfully mapped transcriptomes from 1.3 million brain cortex cells to gain molecular insights into Alzheimer's vulnerability and resilience. The resulting atlas holds promise for gene and molecular discovery across pathways affecting brain health.
SourceUniversity of Pittsburgh·JournalNature·DateJul 24, 2024
Researchers at KAUST have developed NanoRanger, an accurate and rapid method for genetically diagnosing Mendelian genetic disorders. This breakthrough enables diagnosis in just 12 minutes, providing a detailed picture of the genomic disorder.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalMed·DateJul 23, 2024
A study published in JAMA Network Open found that years of high systolic blood pressure increase the risk of stroke, with Black and Hispanic patients facing a higher risk. Early diagnosis and controlled high blood pressure are crucial to preventing stroke, especially in these populations.
SourceMichigan Medicine - University of Michigan·JournalJAMA Network Open·TypeObservational study·DateJul 23, 2024
A machine learning algorithm was trained to predict individuals with functional neurological disorder (FND) by analyzing their brain structure. The algorithm achieved significant above-chance accuracy in classifying FND participants against healthy controls and psychiatric samples, highlighting the importance of considering both brain ...
SourceMassachusetts General Hospital·JournalJournal of Neurology Neurosurgery & Psychiatry·TypeImaging analysis·DateJul 23, 2024
Salk researchers created tools to study neuropeptides, finding they control the brain's fear response in mice. Neuropeptides are released during a mild stimulus, triggering fear behaviors, which can be reduced by silencing their release.
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers developed a new NIPT-based method that reveals 33 pathogenic copy number variations (CNVs) in the Duchenne muscular dystrophy (DMD) gene. This study provides valuable insights into the frequency and spectrum of maternal CNV carriers in the Chinese population.
SourceBGI Genomics·JournalClinical and Translational Medicine·TypeData/statistical analysis·DateJul 17, 2024
Children with conduct disorder show significant reductions in brain surface area and volume of subcortical regions compared to typically developing children. These findings suggest that the development of the brain is different in individuals with CD, highlighting the need for further research into this under-recognized condition.
SourceUniversity of Birmingham·JournalThe Lancet Psychiatry·TypeObservational study·DateJul 16, 2024
Researchers at Rice University have developed a nanosized sensor that records the electrical activity of spinal neurons in action. The sensor, called spinalNET, can track individual neurons over multiple days, providing valuable insights into the mechanisms controlling movement and sensation in the spinal cord.
SourceRice University·JournalCell Reports·TypeExperimental study·DateJul 11, 2024
Researchers identified a fundamental imbalance in immune responses that patients with lupus make, leading to insufficient activation of the aryl hydrocarbon receptor pathway. This imbalance can be corrected by reprogramming disease-causing cells into Th22 cells promoting wound healing, offering a potential cure for lupus.
SourceNorthwestern University·JournalNature·TypeExperimental study·DateJul 10, 2024
A study published in Nature Communications has identified a neurological mechanism underlying anorexia nervosa and found a possible cure using donepezil, a medication increasing acetylcholine levels. Ongoing studies show positive results for patients with severe anorexia nervosa treated with low doses of donepezil.
SourceMcGill University·JournalNature Communications·DateJul 9, 2024
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers discuss the critical role of the retinal pigmented epithelium in human vision and its susceptibility to aging. The study highlights the importance of understanding molecular and cellular mechanisms driving age-related pathological changes in vision decline.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateJul 9, 2024
A recent study found that cerebellar neurons communicate with other brain regions in different ways, leading to various motor defects. The researchers discovered unique activity patterns responsible for different abnormal movements, providing a foundational framework for new treatment approaches.
SourceTexas Children's Hospital·JournaleLife·DateJul 3, 2024
A study by Cold Spring Harbor Laboratory researchers has discovered a crucial receptor protein that regulates the timing of temporary neural connections in the developing brain. Without this protein, mice exhibit atypical behaviors, highlighting its potential role in shaping brain circuits and preventing neurodevelopmental disorders.
SourceCold Spring Harbor Laboratory·JournalNature Communications·DateJul 1, 2024
Researchers have recognized the dynamic and active role of brain extracellular space (ECS) in regulating neural activity. Dysregulation of ECS contributes to neurological disorders, suggesting therapeutic modulation as a novel treatment pathway.
SourceShanghai Jiao Tong University Journal Center·JournalMed-X·DateJul 1, 2024
Researchers found individuals with schizophrenia struggle to discriminate between reward levels, leading to apathy and motivation deficits. The study suggests potential treatments, including brain stimulation and targeted psychotherapy.
SourceUniversité de Genève·JournalBrain·TypeNews article·DateJul 1, 2024
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A new study found that claustrum neurons regulate engagement with sensory information during tasks and sleep. Increased activity in these neurons reduces impulsivity and improves performance.
SourceThe Hebrew University of Jerusalem·JournalNature Communications·TypeExperimental study·DateJun 30, 2024
Researchers at the Gwangju Institute of Science and Technology (GIST) have developed an innovative robotic rehabilitation system called SPINDLE to enhance the strength and dexterity of individuals with tremors. The study revealed significant benefits, including improved motor control, coordination, and neuroplasticity.
SourceGIST (Gwangju Institute of Science and Technology)·JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering·TypeExperimental study·DateJun 27, 2024
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
SourceImpact Journals LLC·JournalAging-US·TypeCommentary/editorial·DateJun 26, 2024
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers at Boston University developed an AI model that analyzes speech patterns to predict the likelihood of Alzheimer's disease in patients with mild cognitive impairment. The model achieved an accuracy rate of 78.5% and could potentially revolutionize dementia screening, making it more accessible and efficient.
SourceBoston University·JournalAlzheimer’s & Dementia·DateJun 25, 2024
Researchers at U of T have harnessed CRISPR to efficiently and precisely control RNA splicing, enabling the systematic interrogation of gene functions and correction of splicing deficiencies in diseases. This new tool allows for targeted activation or repression of alternative exons with high specificity.
SourceUniversity of Toronto·JournalMolecular Cell·DateJun 24, 2024
Researchers have developed a blood test that can detect rare forms of dementia, such as frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP), as well as amyotrophic lateral sclerosis (ALS). The test uses biomarkers, including tau and TDP-43 proteins, to identify underlying pathology.
SourceDZNE - German Center for Neurodegenerative Diseases·JournalNature Medicine·TypeObservational study·DateJun 18, 2024
A Kobe University study finds that a new treatment for neuromyelitis optica spectrum disorder shifts the balance of immune cells, increasing anti-inflammatory signals. The discovery may enable clinicians to determine treatment effectiveness and move towards personalized medicine for autoimmune diseases.
SourceKobe University·JournalNeurology Neuroimmunology & Neuroinflammation·TypeExperimental study·DateJun 18, 2024
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Dorothee Dormann and Edward Lemke propose a new concept to measure the individual risk of getting age-related diseases by analyzing protein clumps in cells. This 'protein aggregation clock' could help diagnose age-related diseases at early stages or identify people at higher risk.
SourceJohannes Gutenberg Universitaet Mainz·JournalNature Cell Biology·DateJun 17, 2024
Researchers at Carnegie Mellon University have successfully integrated focused ultrasound stimulation into noninvasive BCIs, significantly boosting signal quality and enabling bidirectional brain-computer interfaces. The technology allows individuals to control a cursor or robotic arm using only their thoughts.
SourceCollege of Engineering, Carnegie Mellon University·JournalNature Communications·DateJun 17, 2024
Researchers find that a repurposed drug, crizanlizumab, stabilizes vision in patients with retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) after two years of treatment. The study suggests that this may give patients additional years to read, drive, and enjoy activities.
SourceWashU Medicine·JournalJournal of Clinical Investigation·TypeRandomized controlled/clinical trial·DateJun 17, 2024
Researchers developed an AI-based screening tool that differentiates Alzheimer's disease and Lewy body disease by analyzing eye movement patterns. The tool provides a reliable method for identifying and distinguishing between the two dementia forms, which can aid in mitigating their impact on daily activities.
SourceUniversity of Tsukuba·JournalFrontiers in Neuroscience·DateJun 12, 2024
A Pusan National University study finds that heatwaves significantly impact public health among individuals with disabilities, increasing the risk of hospitalizations by 1.07 times. This results in a substantial economic burden, highlighting the need for well-informed public health policies to address these vulnerable groups.
SourcePusan National University·JournalThe Lancet Planetary Health·TypeObservational study·DateJun 11, 2024
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A new study by Ohio University researchers shines a light on the challenges stunt professionals face regarding self-reporting of head injuries and the potential long-term consequences for their health and livelihoods. The research emphasizes the importance of understanding the emotional and psychological toll of health conditions on in...
SourceOhio University·JournalJournal of Occupational Medicine and Toxicology·TypeSurvey·DateJun 10, 2024
Senescent cells, 'zombie-like' cells that resist death, accumulate in the brain with age, contributing to cognitive declines and frailty. Researchers identified a specific pathway linked to senescence in fruit fly brains, potentially paving the way for therapies to delay age-associated pathologies.
SourceUniversity of Pennsylvania·JournalNature·TypeExperimental study·DateJun 5, 2024
Researchers discovered that PMP22 duplication disrupts lipid metabolism and plasma membrane organization in developing Schwann cells, leading to myelin degradation and nerve damage. Targeting dysregulated lipid pathways may reverse some detrimental effects of CMT1A.
SourceVlaams Instituut voor Biotechnologie·JournalBrain·TypeExperimental study·DateJun 4, 2024
A new AI-driven tool can accurately diagnose Lewy body dementia by analyzing changes in vocal emotional expressions. The study found that individuals with Lewy body dementia exhibited more negative and calmer emotional expressions compared to those with Alzheimer's disease and healthy controls.
SourceUniversity of Tsukuba·JournalAlzheimer s & Dementia Diagnosis Assessment & Disease Monitoring·DateJun 4, 2024
By 2050, at least 61% of US adults (184 million people) are projected to have some type of cardiovascular disease, with total costs tripling to $1.8 trillion. Population shifts, high blood pressure, and obesity will drive this increase.
SourceAmerican Heart Association·JournalCirculation·DateJun 4, 2024
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers have used BARseq to map the brains of nine mice, tracing gene expression in the visual cortex. The results show that losing vision leads to changes in gene expression across neighboring cortical areas, highlighting the complex connections between brain regions.
SourceCold Spring Harbor Laboratory·JournalNature·DateJun 3, 2024
Researchers at the University of Rochester Medical Center found that ketones can rescue impaired neuronal function in the hippocampal network. This study suggests a potential therapeutic approach for preventing or delaying neurodegenerative diseases like Alzheimer's.
SourceUniversity of Rochester Medical Center·JournalPNAS Nexus·DateMay 31, 2024
Researchers at the University of Toronto discovered a new RNA virus, Apocryptovirus odysseus, associated with severe inflammation in humans infected with Toxoplasma gondii. The virus is found in two hypervirulent strains of the parasite, exacerbating toxoplasmosis disease and triggering an immune response.
SourceUniversity of Toronto·JournalVirus Evolution·DateMay 31, 2024
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A study by NIH-funded researchers visualizes the full network of blood vessels across the cortex of awake mice, revealing that blood vessels rhythmically expand and contract leading to 'waves' washing across the surface of the brain. The function of these waves remains a mystery.
SourceNIH/National Institute of Neurological Disorders and Stroke·JournalNeuron·DateMay 29, 2024
A study published in Nature Human Behaviour reveals that the ventromedial prefrontal cortex (vmPFC) is critical for prosocial behaviors, including helping others. Participants with vmPFC damage exhibited reduced motivation to help, exert less effort, and earned less money compared to control groups.
SourceUniversity of Birmingham·JournalNature Human Behaviour·TypeExperimental study·DateMay 27, 2024
Researchers at Okayama University developed a novel AAK1 inhibitor using Kinobeads technology, shedding light on its inhibitory mechanism and targeting various neurological disorders and viral infections. This breakthrough paves the way for rapid and cost-effective enzyme inhibitors with clinical applications.
SourceOkayama University·JournalScientific Reports·TypeExperimental study·DateMay 24, 2024
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A recent study has cataloged gene-isoform variation in the developing human brain, providing crucial insights into neurodevelopmental and psychiatric disorders. The research found thousands of isoform switches that occur during brain development, implicating previously uncharacterized RNA-binding proteins.
SourceUniversity of California - Los Angeles Health Sciences·JournalScience·TypeImaging analysis·DateMay 23, 2024
A UCLA Health study has unveiled the link between genetic risk of autism and observed cellular activity in the brain. Researchers analyzed post-mortem brain tissue from 66 individuals, including those with autism spectrum disorder, to identify changes in cortical cell types and transcription factor networks.
SourceUniversity of California - Los Angeles Health Sciences·JournalScience·DateMay 23, 2024
Two studies published in Science reveal significant advances in understanding the molecular biology of neuropsychiatric disease, including a comprehensive map of regulatory components of the brain. The research provides critical insights into the pathogenesis of mental health disorders and holds promise for therapeutic applications.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalScience·TypeData/statistical analysis·DateMay 23, 2024
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
The study reveals that FLVCR1 and FLVCR2 transport choline and ethanolamine across cellular membranes, supporting cell growth and stability. This discovery contributes to understanding rare diseases and developing new therapies for patients suffering from severe neurological and muscular disorders.
SourceMax-Planck-Gesellschaft·JournalNature·DateMay 23, 2024
Researchers develop a new CRISPR screen technology to determine disease mechanism from tissues, accelerating analysis of neurological disorders. The method provides a way to rapidly examine brain cell types linked to key developmental genes, helping unravel genetic and cellular drivers of different diseases.
SourceScripps Research Institute·JournalCell·DateMay 20, 2024
New research reveals exercise reverts aged microglia gene expression patterns to those of young microglia, supporting the formation of new neurons in the hippocampus. Exercise also reduces T cell accumulation in the brain, a common feature of aging.
A new study has revealed that high-income individuals have a 32% lower risk of post-stroke mortality. Those with higher education also face a 26% lower risk of death post-stroke.
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers used CRISPR/Cas9 DNA editing to insert genetic mutations found in humans with Tourette disorder into mouse embryos, creating a model to study the neurobiology and test new medications. The mice exhibited repetitive motor behaviors and sensorimotor gating deficits, similar to those seen in humans with the disorder.
SourceRutgers University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMay 6, 2024
Researchers at UC Riverside identify NMD pathway as crucial for early brain development and preventing microcephaly. The study links NMD regulation of brain size control to the tumor suppressor gene p53, suggesting potential new connections between NMD and cancer.
SourceUniversity of California - Riverside·JournalNeuron·TypeExperimental study·DateMay 1, 2024