Articles tagged with Coronavirus
The study estimates the risk of severe outcomes among symptomatic children aged 0-17 years in the European Union, with hospitalization rates highest among youngest age groups. The authors also note that most children with symptomatic COVID-19 have a low risk of death or hospitalization.
Scientists have developed a fusion protein that successfully blocks replication of SARS-CoV-2 and related viruses in cell culture tests. The protein combines ACE2 with human antibody fragments, providing reliable protection against future mutations.
A research team at Aarhus University has developed an RNA aptamer that attaches to the surface of SARS-CoV-2 virus particles, preventing it from entering human cells. This molecule is cheaper and easier to manufacture than current antibodies, making it a promising tool for detecting covid-19 infection.
Researchers from Osaka University found that over half of intensive care workers experienced moral distress during the pandemic due to limited communication with patients and families. Virtual communication and psychological support were identified as potential solutions to prevent burnout and ensure proper medical care.
Previous antibody responses to harmless coronaviruses contribute to SARS-CoV-2 immunity, reducing infection severity and hospitalization rates. Researchers found that people with strong immune responses to other human coronaviruses have some protection against SARS-CoV-2 infection.
A study analyzing data from 109 COVID-19 patients found that obesity is the key factor associated with endothelial dysfunction, a condition increasing heart attack and stroke risk. The results suggest an 17% higher cardiovascular risk for obese patients compared to those of normal weight.
Scientists have engineered enzymes to manufacture molnupiravir, resulting in a shorter and higher-yielding synthesis. The new method reduces the risk of hospitalization and death from COVID-19 for newly diagnosed patients, showing promise as an antiviral treatment.
Researchers at Penn State used traffic cameras and mobile device data to monitor COVID-19 cases in Centre County, PA. Movement data preceded increases in cases, suggesting that behavioral interventions like stay-at-home orders can be effective in controlling transmission.
A study of 2,329 academic journals found a significant gender gap in manuscript submissions during the first COVID-19 wave, with women submitting fewer papers than men, especially in health and medicine.
Researchers from University of Copenhagen discover a protein analysis that can predict COVID-19 patient death or hospitalization with high accuracy, predicting 78.7% of hospitalizations and 93.9% of non-serious infections. This discovery has the potential to save lives by identifying high-risk individuals.
Researchers in Japan developed a vaccination approach that promotes the production of antibodies neutralizing SARS-CoV-2 and other coronaviruses. The new strategy involves genetically engineering the spike protein receptor-binding domain to shield its head region, boosting antibody production against the core region.
The University of Kansas Chemical Biology of Infectious Disease Center has received a five-year, $11.35 NIH COBRE grant to expand research on next-generation drug therapies for infectious disease. The center will build on previous accomplishments to push forward biological research and foster a collaborative research network.
Researchers developed a dynamic respirator that modulates pore size in response to changing conditions like exercise and air pollution. The device features an AI-powered system that adjusts filtration characteristics wirelessly, providing improved breathability and comfort.
A new DNA sensor can detect both the presence and infectivity of viruses in minutes, providing a significant improvement over current methods that only detect genetic material. This breakthrough could aid in tracking and containing viral outbreaks, as well as understanding mechanisms of infection.
Researchers have developed a microneedle patch that delivers a COVID-19 DNA vaccine into the skin, causing strong immune responses in cells and mice. The patch can be stored at room temperature for over 30 days, making it an important tool for global COVID-19 vaccine distribution.
Researchers investigated aerosol production from singing and playing wind instruments to develop recommendations for minimizing COVID transmission. They found that placing a surgical mask reduced plume velocities and lengths, decreasing aerosol concentrations.
Researchers at the University of California - San Diego have developed COVID-19 vaccine candidates made from plant viruses and bacteriophages, which can be stored and shipped without refrigeration. These vaccines trigger high production of neutralizing antibodies in mice, offering a potential solution for global distribution efforts.
Researchers at South Ural State University used computer modeling to identify a substance that can block the spread of coronavirus. The study found that ligands must match RNA polymerase as closely as possible to be effective, and scientists have developed an equation to test other ligands' effectiveness on receptors.
A study found that SARS-CoV-2 antibodies remained stable or increased in healthcare workers seven months after infection, indicating potential protection from pre-existing antibodies against common cold coronaviruses. The results suggest that individuals with higher levels of anti-HCoV IgG and IgA had lower susceptibility to COVID-19.
Researchers at Kennesaw State University investigated how various types of face coverings affect students' understanding of their teachers. They found that some masks performed well acoustically, but not as effectively against virus transmission.
A new study by the University of California, San Francisco found that US adults with fever are often not tested for coronavirus, contributing to community transmission. The research suggests that increased access and timely testing could reduce the spread of the virus.
Recalling autobiographical self-efficacious behavior can boost personal resilience by making it easier to view stressful situations in a different light. This technique may be particularly useful during the coronavirus crisis where negative impacts of the pandemic can be shielded against.
Researchers at Texas A&M University have shown that existing water purification plants can effectively remove nearly all enveloped viruses from drinking water. Using a coronavirus surrogate, they found that coagulation reduced viral quantities by 99.999%, meeting EPA regulations.
A survey of over 1,600 people found that neurotic individuals reported more negative feelings and greater emotional variability during the pandemic. The study suggests that personality traits can play a significant role in coping with crisis situations.
A recent study found that people prefer a combination of human and app-based contact tracing for the coronavirus. The research suggests that trust in the provider of the app is more important than privacy concerns when it comes to choosing a contact tracing method.
Three new pathways for organisations to manage digital transformation have been defined by research from Professor Feng Li. The findings highlight the need for diversification and portfolio management to mitigate costs of failure in a highly volatile sector.
Researchers from Shinshu University found that nanofiber masks can withstand repeated sterilization and reuse without losing their filtration efficiency. The study compared the effects of ethanol disinfection on melt-blown and nanofiber filters, with the latter showing no significant decline in performance after multiple uses.
A new study from the University of Notre Dame found that government-imposed restrictions on consumption can have unintended consequences for conservatives. The research showed that conservatives increased mobile phone usage in vehicles after a law was enacted, and were more likely to purchase unhealthy foods and view e-cigarettes more ...
A University of Tartu study found a low prevalence of the coronavirus in Estonia, with just 12 cases identified among 6,024 adult residents. The researchers concluded that the infection is not widely spread in society and that the prevalence remains stable over time.
A Louisiana State University meteorologist is studying how coronavirus-induced lockdowns improved air quality in China, which could have implications for global temperatures and weather patterns.
A low-cost, easy-to-build non-invasive ventilator has been developed and tested, performing similarly to conventional commercial devices. The prototype provides effective breathing support for patients with respiratory failure, potentially improving outcomes and alleviating pressure on health systems.
Researchers develop AI-based computer models to calculate an individual patient's risk of requiring a ventilator or intensive care. The models will analyze vast amounts of data from multiple sources, including electronic health records and test results.
The new journal 'Coronaviruses' will publish original research, letters, reviews, and case reports on all aspects of coronaviruses. It will be essential reading for virologists, epidemiologists, microbiologists, and healthcare workers interested in the latest information about coronaviridae.
Researchers at Carnegie Mellon University developed a mathematical theory that takes into account evolutionary changes in pathogens or information. This theory was tested against thousands of computer-simulated epidemics and found to be more accurate than traditional models.
A quarantine on the Diamond Princess cruise ship resulted in a much higher number of coronavirus infections than initially expected. The study found that passengers were exposed to each other for an extended period due to strict social distancing measures, leading to increased transmission.
A team of complexity scientists have developed a 'meme' model for multiple diseases, revealing that interacting contagious diseases follow the same complex spreading patterns as social trends. The study found that even one more contagion can dramatically shift dynamics and trigger macroscopic jumps in epidemic size.
Researchers at Umeå University reviewed 12 studies on coronavirus transmissibility, finding it to be significantly higher than WHO estimates. The reproduction number calculated from these studies ranges from 2.79 to 3.28, indicating a high risk of rapid spread.
Experts advise against using steroids to treat lung injury caused by coronavirus due to potential harm. Steroids can impair the immune system's ability to fight viruses, leading to prolonged illness and increased risk of complications.
Researchers discovered that a neutralizing antibody from SARS survivors can activate coronavirus membrane fusion by mimicking receptor-attachment. This breakthrough provides new insights into understanding the mechanisms of coronavirus infection and potentially lead to vaccine design.
Human antibodies manufactured from transchromosomic cattle have been found safe in healthy volunteers, suggesting a potential novel technique for rapidly producing antibodies for passive immunotherapy against emerging infectious diseases like MERS. The treatment, SAB-301, was well-tolerated and showed promise in countering the virus.
Researchers found that a specific part of the spike protein, called the RBD, is crucial for infection but also targets by antibodies. The RBD has three long loops that vary between strains, allowing it to modulate its affinity with host cells and evade immunity.
A new antiviral drug candidate, GS-5734, has been shown to inhibit a broad range of coronaviruses, including the SARS and MERS coronaviruses. The compound was effective against human and animal coronaviruses, reducing viral load in lung tissue and improving respiratory functions.
Researchers have discovered a direct association between strain OC43 of the human coronavirus and neurological diseases, including multiple sclerosis, Alzheimer's disease, Parkinson's disease, and encephalitis. This breakthrough paves the way for targeted therapies that can address specific patient conditions.
Researchers have found that common cold coronaviruses originate from camels, similar to the MERS virus. The study suggests a potential scenario for MERS emergence and highlights the need for a vaccine against MERS.
Researchers solved the structure of a key coronavirus protein, revealing its conformation and potential vulnerabilities. This finding could guide future treatments for viruses like SARS and MERS.
Research reveals three coronavirus species co-existing in camels in Saudi Arabia, including one closely related to the human 229E virus. The study also finds that young camels are more susceptible to respiratory infections and that winter is the peak season for virus replication.
Researchers at INRS have discovered a coronavirus protein mutation that slows the spread of the virus in the central nervous system and reduces its neurovirulence. The study sheds light on how persistent coronavirus infections take hold and may help prevent associated neurological diseases.
The article highlights Stanley Perlman's career journey from studying mouse viruses to researching human coronaviruses like SARS and MERS. His work demonstrates the importance of basic research in understanding virus interactions with the immune system, which can inform strategies for preventing or treating diseases.
NIH-supported scientists studied lab-grown human lung cells infected with the novel coronavirus (nCoV) and found that certain drugs could inhibit viral replication. The study identified a set of 207 human genes whose expression was disrupted by nCoV, which may be targets for new treatments.
Scientists studying the Human Coronavirus-Erasmus Medical Center have discovered a potential treatment strategy for the new Middle East virus. The researchers found that certain compounds could treat the infection by altering lung cells' response to infection, which might help prevent the virus from reproducing.
A combination of two licensed antiviral drugs, ribavirin and interferon-alpha 2b, has been shown to inhibit the replication of novel coronavirus in laboratory-grown cells. The study suggests that this drug combination could be used to treat patients infected with the new coronavirus.
The NIH team developed a nonhuman primate model in December 2012 to study the emerging coronavirus. Clinical signs of the disease appear within 24 hours of infection, including reduced appetite and respiratory issues. The model is helping scientists evaluate potential vaccines and treatments.
A study published in mBio reveals that the novel coronavirus HCoV-EMC is highly infectious and can evade the human immune system, but it is also susceptible to treatment with interferons, which could be a potential mode of treatment for large-scale outbreaks
A new coronavirus, hCoV-EMC, has been linked to severe disease in humans and can infect cells from various bat species and pigs. The virus uses a different receptor than SARS, but its ability to transmit between animals and humans repeatedly remains uncertain.
Researchers at Vanderbilt University and the University of North Carolina discovered a way to create a safer live vaccine for SARS and novel coronaviruses by disabling the ExoN proofreading protein. The new approach accelerates viral mutation, crippling its ability to cause disease in animals.
New research reveals that coronavirus replication relies on the host's secretory pathway and disrupts the Golgi complex, a crucial cellular process. The study found that inhibiting this pathway can slow down or prevent viral infection.
Scientists investigate key clues behind coronavirus illness, including its ability to evade the immune system. They aim to design better vaccines and treatments for diseases like pandemic flu. By understanding virus-host interactions, researchers hope to refine their approach to combating emerging public health threats.
A recent study published in The Journal of Infectious Diseases found no association between Kawasaki disease and coronavirus NL63. This conclusion contradicts an earlier study suggesting a potential link, which was later disputed due to selection bias concerns.
Scientists at the University of Texas Medical Branch have discovered a unique mechanism used by the SARS coronavirus to evade the immune system. The virus's nsp1 protein breaks down messenger RNA instructions that trigger the production of interferon beta, crucial for host immunity.
A team of researchers has developed an antiviral inhibitor that is active against several coronaviruses, including those causing the common cold and SARS. The compound targets the main protease enzyme, which is crucial for viral replication, and shows promise as a potential treatment for coronavirus-related diseases.