Articles tagged with Coronavirus
Researchers at Utrecht University have uncovered a sophisticated mechanism by which coronavirus spike proteins can be activated for cell entry. Sugar binding induces opening of the spike protein and exposure of the receptor binding domain, required for subsequent entry steps.
A new study reveals that COVID-19 triggers a dangerous immune response in hardened fatty deposits lining the heart's largest blood vessels. This inflammation can lead to immediate and longer-lasting heart issues, including plaque rupture and blockage of blood flow.
Researchers developed a self-decontaminating fabric that kills coronaviruses in under 5 seconds using Joule heating. The material can handle hundreds of uses with minimal waste, transforming the way personal protective equipment is made and used.
Researchers investigated the inactivation efficacy of different UV wavelengths against SARS-CoV-2 Omicron variants, finding similar inactivation properties across various wavelengths. The study highlights the potential of far-UVC light as a safe germicidal option for mitigating airborne virus transmission.
Researchers have developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA. This 'Purecap' technique extracted up to 100% pure Cap2-type mRNA, which showed improved protein production and lower immunostimulatory activity.
Researchers have identified four species of coronaviruses in UK bats, including two novel ones, which are related to COVID-19 and MERS viruses. Regular monitoring of wildlife viruses is crucial for public health preparedness and biodiversity conservation.
A new immunotherapy treatment developed by UCF researchers uses targeted IL-2 to fight respiratory viral infections with improved outcomes in animal studies. The treatment promotes an antiviral inflammatory response and reduces bronchial inflammation.
A recent LMU study found that the Covid-19 pandemic had a predominantly negative impact on families' emotional well-being, despite temporary recoveries. Parental stress was a major factor in this decline. Conversely, a strong parent-child relationship acted as a resilience factor to mitigate these effects.
A molecular autopsy revealed that a young child with mild COVID-19 symptoms died from cardiac arrest due to an atypical coronary artery anomaly and underlying Noonan syndrome, a rare genetic disorder.
A new study in Viruses journal reveals significant viral diversity in bats and pig farms in Viet Nam, highlighting the risks of CoV spillover. The research calls for increased surveillance and One Health action to prevent pandemic emergence.
Researchers identified potential neurological biomarkers of long COVID-19 in nonhuman primates, which could aid in diagnosis, monitoring, and treatment. The study found elevated proteins associated with neurodegenerative disorders in the brain, cerebrospinal fluid, and blood after SARS-CoV-2 infection.
A global analysis of coronavirus protein research found that countries with larger economies generated more 3D structure determinations for the protein components of coronaviruses. However, there were many outliers, with some advanced and prosperous countries publishing few or no structures, while others strongly affected by COVID-19 p...
Researchers suggest a four-part framework to identify animal viruses that may infect humans, focusing on viruses from repeat offender families and those with known human compatibility. By studying these viruses early, scientists can develop diagnostic tools and treatments, and be better prepared to combat future pandemics.
According to a UTHealth Houston survey, breakthrough COVID-19 infections occurred in 7.5% of vaccinated Texans, with higher odds associated with Hispanic ethnicity, larger household size, and multiple comorbidities. The study also found that healthcare workers had higher reports of breakthrough infections.
A study by Osaka University compared the sensitivity of rapid antigen tests (RATs) and polymerase chain reaction (PCR) tests for the Omicron variant of COVID-19. The results showed that RATs had a high enough sensitivity to suggest frequent testing using RATs may still be the best approach.
A new study found that COVID-19 primarily affected patients with a moderate to critical course, often with comorbidities, whereas many had mild courses despite metastatic melanoma and systemic therapy, recommending continued treatment whenever possible.
A team of researchers at Tokyo Medical and Dental University has designed and synthesized novel compounds that have the potential to be effective drugs against COVID-19. The compounds target the main protease enzyme of the SARS-CoV-2 virus, which is essential for viral replication.
A study published in Journal of Clinical Immunology found that four proteins - WFDC2, GDF15, CHI3L1, and KRT19 - are associated with severe COVID-19 progression. These proteins may serve as biomarkers to predict prognosis in patients with critical COVID-19.
Researchers found reduced levels of D-amino acids in patients with severe COVID-19 and IAV infection, suggesting they could be used as biomarkers. Supplementation with D-alanine improved survival rates and clinical outcomes in mouse models of both infections.
Researchers found that the COVID-19 vaccine can reduce the risk of SARS-CoV-2 placentitis, a condition that causes stillbirth and neonatal death. The vaccine not only protects pregnant women but may also be lifesaving for their unborn children.
The Independent Task Force Report emphasizes the need for a One Health approach to prevent or respond adequately to the next pandemic. Key findings highlight the importance of 'Smart Surveillance' to identify high-threat pathogens and invest in R&D for innovative diagnostics, antiviral strategies, and therapeutic research.
Researchers developed DNA nets to detect and impede COVID-19, offering a fast, sensitive, and low-cost testing platform. The technique also showed potential as an antiviral treatment, inhibiting the virus's spread in live cell cultures.
A new study found that young Swiss military personnel with confirmed Covid-19 infections experienced symptoms like fatigue, reduced sense of smell, and psychological problems for up to 180 days. Long-term effects included increased BMI, high cholesterol, and lower physical stamina, suggesting a higher risk of metabolic disorders and ca...
Researchers developed a methodology to forecast outbreaks of pathogens such as coronavirus and monkeypox, identifying host species at risk of infection. The machine-learning approach analyzes variables like location and climate to predict community hot spots at risk.
The COVID-19 pandemic had a devastating impact on Mayotte, with over 4,000 laboratory-confirmed cases causing interruptions in work and healthcare services. The island's unique socioeconomic vulnerability and communication challenges affected the surveillance and monitoring of the outbreak.
A study by Osaka University researchers comprehensively analyzed mRNA and microRNA expression patterns in the blood of patients with severe COVID-19, revealing specific mRNAs and microRNAs associated with the immune response pathway. The findings suggest that interferon-β plays a crucial role in COVID-19 severity.
A randomized controlled trial found that virtual museum visits significantly improved the health of seniors stuck at home, reducing social isolation and improving well-being, quality of life, and frailty. The study recruited 106 participants aged 65 and older who attended guided tours online once a week for three months.
The researchers developed a versatile model that takes into account factors such as infection rates, mortality, and recovery. They found that limiting contacts through quarantine is effective in reducing disease incidence and suppressing the virus.
The new phage T4-COVID-19 vaccine elicits superior mucosal immunity in mice, inducing robust humoral and cell-mediated immune responses. The vaccine provides complete protection against SARS-CoV-2 variants with minimal lung lesions and no impact on gut microbiota.
CoVaRR-Net is investing $6.9 million in 15 research projects focused on understanding Omicron subvariants and finding solutions to curb their spread. The studies will explore various aspects of variants, including viral transmission between animals and people, new variant mutations, and the impact of social factors on Indigenous Peoples.
The first global dataset of SARS-CoV-2 infections in animals has been published, providing a comprehensive overview of the virus's impact on animal populations worldwide. The dataset shows an increasing number of reported cases globally, with high diversity of variants detected in various species.
Aerosols generated by musicians dissipate within 6 feet, settling into the background air draft. Flute-generated aerosols traveled farther due to airflow over the instrument.
Researchers found that SARS-CoV-2 surrogates can survive on meat products in the refrigerator or freezer for up to 30 days. The study used chicken, beef, pork, and salmon, as well as viruses with spikes similar to those on SARS-CoV-2.
Researchers created an atomic-level computational model of the COVID-19 spike protein, finding that human cell modifications increase its flexibility and mobility. The study suggests that these modifications can enhance virus infectivity and immune avoidance.
Researchers at The University of Tokyo have created a new antibody-based method for detecting SARS-CoV-2 that does not require a blood sample. This innovative approach uses interstitial fluid from human skin to detect antibodies within 3 minutes.
Researchers from Osaka University found that SARS-CoV-2 infection activates the IRF1 gene and impairs insulin/IGF signaling in various tissues, including lung, liver, adipose tissue, and pancreatic cells. This disruption can lead to new-onset diabetes in some patients.
Researchers analyzed antibodies to internal and surface proteins of SARS-CoV-2, finding that profiles of internal proteins predicted survival outcomes as well as those for surface proteins. The study suggests targeting other parts of the virus could enhance COVID-19 vaccines and therapies.
A fourth dose of the Pfizer-BioNTech vaccine provided high protection against severe outcomes from Omicron infection among elderly residents in Israeli long-term care facilities. The vaccine also offered modest protection against COVID-19 infections among this population during a surge in Omicron variant cases.
The SHIELD program employed rapid saliva testing, real-time data analysis, and fast reporting to mitigate the spread of COVID-19. The program's success led to a significant reduction in cases and deaths on campus, with Champaign County experiencing a third less COVID-19 cases than expected.
A new coronavirus has been identified in Swedish bank voles, with the virus found in 3.4% of voles between 2015 and 2017. Researchers from Uppsala University discovered the 'Grimsö Virus' in red-backed voles caught around Grimsö in Örebro County.
A new study analyzing 8 cohorts of COVID-19 patients found that antibody responses in previously infected individuals were relatively stable, providing protection from reinfection unless the new infection was the Omicron variant. Vaccination also boosted protection, with rapid immune responses observed even after a single vaccine dose.
A recent study by the University of Helsinki found that scent detection dogs can accurately identify individuals with a coronavirus infection from skin swabs. The dogs' sensitivity and specificity were 92%, with only small differences in accuracy observed between individual dogs.
Research found that SARS-CoV-2 relies on human transmembrane proteins, especially IFITM2, to replicate efficiently and produce infectious viruses. Antibodies targeting IFITM2 can protect lung cells from infection, suggesting a promising therapeutic approach by targeting host factors instead of viral ones.
A new canine coronavirus variant has been identified in human patients with pneumonia, showing a shift from infecting both the intestines and respiratory system to only the respiratory system. Researchers used state-of-the-art tools to assess evolution pressures that may have influenced this shift.
Researchers from Osaka University have developed an engineered ACE2 decoy that effectively reduces the rate and severity of infection with the Omicron variant under laboratory conditions. The decoy mimics the SARS-CoV-2 receptor, preventing the virus from binding to cells and entering them.
The study found an increase in mass shootings and proportion of women and children shot, highlighting worsening structural inequalities. The researchers emphasize the need for investment in public education, employment, and social services to address gun violence.
Researchers characterized viral protein binding to sialic acids on animal and human coronaviruses, revealing host-specific patterns. This adaptation enables coronaviruses to quickly jump species, driving cross-species transmission.
A new model suggests that antibodies select antigens based on their surface characteristics, similar to a child playing on stepping stones. The researchers used DNA origami to simulate the behavior of antibodies and found that they tend to favor closer antigen distances.
Researchers at Max Planck Institute of Molecular Physiology discovered that vaccination after COVID-19 recovery increases neutralizing antibody levels by up to five times, providing better protection against current coronavirus variants. The study involved 140 volunteers and showed that antibody levels remained high even after 300 days.
Genetic testing of saliva samples has been shown to be more quick and sensitive than nasal swab testing for detecting SARS-CoV-2 virus, with implications for improving public acceptance of COVID-19 testing and reducing healthcare worker risks
A study found that double vaccinated individuals generate a potent and broad neutralizing antibody response after a delta breakthrough infection. This response provides protection against current variants of concern, including omicron.
Researchers have used super-resolution light microscopy to pinpoint the location of viral molecules within human cells during coronavirus infection. The study reveals that the virus-replicating machinery and RNA product are physically separated in the cell, providing new insights into the viral life cycle.
A new study from the University of Copenhagen concludes that lockdowns did not have a significant impact on young people's mental health, with some short-term decline. Young people with depressive symptoms showed improvement in mental health after lockdowns, contrary to previous assumptions.
Researchers at University of Texas at Austin create first-ever biologically authentic computer model of HIV-1 virus liposome, shedding light on replication and infectivity. The study reveals key characteristics of the liposome's asymmetry and its role in shaping macroscopic properties.
A team of scientists from Martin-Luther-University Halle-Wittenberg and the Max Planck Institute discovered the essential final step in mRNA production. The process involves 16 proteins that precisely control the structure of mRNA, which determines protein function and disease risk.
Researchers examined Kappa and Delta variant structures using cryo-EM, finding Delta's spike protein binds stronger with human ACE2 receptor. This explains the rapid global dominance of the Delta variant. The study provides insight into COVID-19 variants' evolution.
Researchers detected SARS-CoV-2 in the exhaled breaths and coughs of individuals with COVID-19. The presence of virus RNA was mainly found in cough samples, but also in normal breaths and airway opening breaths.
Roswell Biotechnologies has developed a molecular electronics sensor on a semiconductor chip, enabling real-time detection of single molecules for diverse applications including drug discovery, diagnostics, and DNA sequencing. The platform offers unlimited scalability in sensor pixel density and high resolution measurements.
Researchers at UCSF have identified a new potential drug target, BRD2, which regulates the ACE2 receptor, a key entry point for SARS-CoV-2. Blocking production of BRD2 prevents virus from infecting various human cell types.
Researchers found scarring in COVID-19 patients' kidneys, which may lead to long-term kidney outcomes. The virus directly causes cell damage, independent of the immune system, according to a new study published in Cell Stem Cell.