Articles tagged with Coronavirus
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The new platform developed by UVA Health scientists can produce vaccines much faster, cheaper, and more easily than traditional approaches. The platform's proof-of-concept demonstrates its ability to produce highly immunogenic vaccines that can be manufactured at extremely low cost.
A study published in EBioMedicine found changes in blood samples from almost 1,000 people hospitalized for COVID-19 may pinpoint patients at risk of long-term lung disease. The study identified elevated levels of certain molecules, which could lead to the development of simple blood tests to detect ongoing lung problems.
A study from UMBC reveals a conserved RNA-protein interaction as a promising target for broad-spectrum enterovirus antivirals. The researchers found that a fusion protein called 3CD recruits proteins to assemble the replication complex, and targeting this interface could lead to universal drugs.
Researchers have identified promising compounds that can combat resistant COVID-19 variants by targeting an enzyme similar to one used by Chagas disease. Compounds 5a and 5b, synthesized from older chemical libraries, demonstrated strong Mpro inhibition with low toxicity.
The new guideline recommends full-time infection prevention staff, comprehensive training, and support for all staff, as well as partnerships with hospitals and public health agencies. This guidance aims to reduce the risk of infections in nursing homes, saving lives and money.
Researchers discovered a 'sticky' molecule, P-selectin, that can cause blood clots and organ failure during COVID-19. A new mRNA therapy that drives P-selectin expression provides broad protection against coronavirus infection.
Researchers outline 22 opportunities and strategies to help communities better prepare for and mitigate the effects of next pandemic; focusing on adaptable urban planning and smart technologies to ensure equitable and effective pandemic preparedness.
At least eight bat species frequent pig farms in Northern Italy due to lack of physical barriers, increasing risk of coronavirus transmission. Researchers used a multi-disciplinary approach to study the interfaces between bats and pigs.
Researchers at The Wertheim UF Scripps Institute have identified a potential new drug against COVID-19 and developed a powerful new platform for finding medicines to fight many types of infectious diseases. Their approach uses systematic chemistry, computational, and robotic methods to find compounds that can target RNA-based viruses.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
Scientists at Scripps Research have pinpointed dozens of human proteins that SARS-CoV-2 needs to complete its full life cycle. Two promising drug targets, perlecan and BIRC2, show potential in blocking coronaviruses at multiple stages of infection.
Scientists from La Trobe University and Kumamoto University have identified an internal protein particle hidden within the SARS-CoV-2 virus, which can trigger a strong immune response in killer T cells.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
A synthetic glycosystem mimics natural sugars on human cells, binding to virus's spike protein and preventing infection. The molecule was found to be effective at low doses and worked against multiple SARS-CoV-2 strains.
A new Cornell University research study reveals that juvenile and subadult bats are the most likely to spread new coronaviruses to other species. Young bats shed viruses more easily when weaned, leading to a high-risk scenario for emerging novel viruses.
A comprehensive study of over 2,500 bat faecal samples reveals that young bats are frequently infected with multiple coronaviruses. This finding could inform the prediction of emerging riskier coronaviruses and highlights the importance of understanding coronavirus evolution in their natural host.
A new study from the University of Kansas has identified a small protein domain called Mac1 as a critical target for inhibiting coronavirus replication. The research team developed molecules that bind to Mac1 and inhibit viral activity in cell cultures, providing potential antiviral therapies for future pandemics.
The Families First Coronavirus Response Act led to a significant decrease in Medicaid health insurance loss. The study found that the Act reduced the risk of losing health insurance for individuals enrolled in the Medicaid program.
Researchers have identified a critical step in SARS-CoV-2 viral infection: the protective role of ORF3a, which forms dense bodies surrounding the spike protein to prevent it from being cut into smaller components. This finding could lead to new therapeutic targets and vaccine development strategies.
Researchers have developed new bat cell lines and reagents to study the bat's antiviral immune response, providing insights into susceptibility to hantaviruses and coronaviruses. The study aims to improve our understanding of viral infections in bats.
Researchers have found that a specific protein modification to the immune protein MDA5 can block viral replication and reduce heart inflammation. The study's findings could lead to the development of broad-spectrum antiviral treatments that target multiple viruses.
A recent study identifies 11 natural compounds that can inhibit the SARS-CoV-2 spike protein, including caffeine, which exhibits high binding stability and excellent solubility. The discovery highlights the potential of natural products in combating COVID-19 and demonstrates the versatility of widely known compounds like caffeine.
The American College of Chest Physicians (CHEST) has developed an educational program and formal certification exam for nurse practitioners and physician assistants/associates in critical care. The program validates clinical expertise and demonstrates professional acumen, aiming to improve patient care.
Researchers from Osaka University found that Japan's state of emergency declarations led to increased hygienic behaviors and risk perception, which persisted even after the policy was lifted. However, older people became less fearful of COVID-19 and were less likely to wear masks.
Dartmouth researchers propose a new way of thinking about masking and social distancing rules using game theory, considering them as two distinct actions. The study finds that people respond differently to these measures based on their perception of the disease's severity, trending towards masking or no protective action over time.
Researchers have discovered that seemingly 'broken' genes in coronaviruses are retained due to their functional role beyond protein production. These extra genes help control the activity of other viral genes.
Researchers from Osaka Metropolitan University have developed a method to detect coronavirus spike proteins quickly and selectively using a light-induced immunoassay. The technique uses a milliwatt-level laser and can complete the entire process in under 5 minutes.
Researchers at Stowers Institute for Medical Research have identified the dengue virus genome's use of less efficient codons in its host's machinery to replicate and spread. This discovery has implications for developing novel antiviral treatments and vaccines, as well as understanding the relationship between viruses and their hosts.
Researchers at Cornell University have developed a bioelectric device that can detect and classify new coronavirus variants, identifying those most harmful. The device uses a biomembrane on a microchip to recreate the cellular environment for infection, allowing for quick characterization and analysis of variant mechanics.
The team created finely detailed images of the viral RNA and replication structures, revealing spherical shapes around the nucleus of infected cells. The images provide insight into how the virus evades cell defenses and could lead to new therapeutic targets for drug development.
Researchers developed a new 'proactive vaccinology' approach to build vaccines before disease-causing pathogens emerge. The Quartet Nanocage vaccine trains the immune system to target specific regions of eight coronaviruses, providing broad protection against known and unknown strains.
A UK study of over 650 patients hospitalised with severe COVID-19 found distinct patterns of inflammation in the blood that could be targeted by immune therapies. The research suggests existing drugs modulating the immune system may help treat long COVID.
A new study published in Risk Analysis found that COVID-19's origin is unlikely to be natural, using a modified risk assessment tool. The researchers suggest an unnatural origin, potentially from a laboratory, cannot be easily dismissed.
A UC Riverside-led study has devised a way to make large quantities of the Membrane protein, which plays a crucial role in how SARS-CoV-2 acquires its spherical structure. The researchers found that when the M protein interacts with the membrane, it coaxes the membrane to curve, leading to the virus's characteristic shape.
Researchers found that e-liquids containing propylene glycol and vegetable glycerin enhance COVID-19 infection, while those with benzoic acid prevent it. Vapers are advised to quit or switch to e-liquids with acidic pH for better protection.
Researchers document various reasons for long-term clinical symptoms in patients infected with SARS-CoV-2. Key findings include immune system alterations, chronic inflammation, endothelial dysfunction, and mitochondrial issues contributing to post-COVID syndrome.
A recent study by University of Missouri researcher Knoo Lee found that school nurses are well-positioned to identify students at-risk for chronic school absenteeism. Students who have many partial-day absences often proactively seek out school nurses as a source of comfort and support, presenting an opportunity for intervention before...
Researchers found that SARS-CoV-2 protein fragments can mimic innate immune peptides, amplifying the immune response and causing rampant inflammation. This discovery may account for some COVID-19 infection peculiarities and could influence treatment.
A new study from Tulane University found that perlecan LG3, a protein commonly found in blood vessels and the brain, forms a stable bond with the COVID spike protein, enhancing the virus's ability to bind with cells. This discovery may lead to new forms of treatment or prevention for COVID-19.
The Pirola variant of SARS-CoV-2 has rediscovered an entry pathway into lung cells that was previously used by earlier variants, which may promote the development of pneumonia. The virus uses the cellular enzyme TMPRSS2 for entry and is resistant to most therapeutic antibodies.
The BA.2.86 omicron subvariant can infect human lung cells more efficiently than previous omicron variants, raising concerns about potential severe disease symptoms. While bivalent mRNA vaccines can neutralize BA.2.86, the efficiency is reduced, emphasizing the importance of getting a newer booster vaccine.
The LoCKAmp device uses lab-on-a-chip technology to detect Covid-19 and other pathogens in just three minutes, providing rapid and accurate results. The device has the potential to be used in remote healthcare settings and could also detect conditions like cancer.
A new project will monitor how changing environmental conditions shape viral outbreaks in wild rodent populations to identify hotspots with high potential for spillover into people. The team will use metaviromics and AI to analyze data from wild rodents in the UK and Eastern Uganda.
Researchers at Institut Pasteur have identified the TMPRSS2 enzyme as the receptor that allows HKU1 virus to enter human cells. This discovery may help explain why SARS-CoV-2 causes more severe disease than other coronaviruses, and could lead to targeted therapies.
Researchers at Osaka University have developed a novel platform that combines nanopore technology with artificial intelligence to detect different coronavirus variants quickly. The platform was tested on 241 saliva samples and detected the Omicron variant 100% of the time.
The Cumming Global Centre for Pandemic Therapeutics is offering global grants of up to $200,000 per annum for three years to develop novel therapeutics for pathogens of pandemic potential. Researchers are invited to submit expressions of interest for Round Two of the Foundation Grants program.
Researchers at Utrecht University have uncovered a sophisticated mechanism by which coronavirus spike proteins can be activated for cell entry. Sugar binding induces opening of the spike protein and exposure of the receptor binding domain, required for subsequent entry steps.
A new study reveals that COVID-19 triggers a dangerous immune response in hardened fatty deposits lining the heart's largest blood vessels. This inflammation can lead to immediate and longer-lasting heart issues, including plaque rupture and blockage of blood flow.
Researchers developed a self-decontaminating fabric that kills coronaviruses in under 5 seconds using Joule heating. The material can handle hundreds of uses with minimal waste, transforming the way personal protective equipment is made and used.
Researchers investigated the inactivation efficacy of different UV wavelengths against SARS-CoV-2 Omicron variants, finding similar inactivation properties across various wavelengths. The study highlights the potential of far-UVC light as a safe germicidal option for mitigating airborne virus transmission.
Researchers have developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA. This 'Purecap' technique extracted up to 100% pure Cap2-type mRNA, which showed improved protein production and lower immunostimulatory activity.
Researchers have identified four species of coronaviruses in UK bats, including two novel ones, which are related to COVID-19 and MERS viruses. Regular monitoring of wildlife viruses is crucial for public health preparedness and biodiversity conservation.
A new immunotherapy treatment developed by UCF researchers uses targeted IL-2 to fight respiratory viral infections with improved outcomes in animal studies. The treatment promotes an antiviral inflammatory response and reduces bronchial inflammation.
A recent LMU study found that the Covid-19 pandemic had a predominantly negative impact on families' emotional well-being, despite temporary recoveries. Parental stress was a major factor in this decline. Conversely, a strong parent-child relationship acted as a resilience factor to mitigate these effects.
A molecular autopsy revealed that a young child with mild COVID-19 symptoms died from cardiac arrest due to an atypical coronary artery anomaly and underlying Noonan syndrome, a rare genetic disorder.
A new study in Viruses journal reveals significant viral diversity in bats and pig farms in Viet Nam, highlighting the risks of CoV spillover. The research calls for increased surveillance and One Health action to prevent pandemic emergence.
Researchers identified potential neurological biomarkers of long COVID-19 in nonhuman primates, which could aid in diagnosis, monitoring, and treatment. The study found elevated proteins associated with neurodegenerative disorders in the brain, cerebrospinal fluid, and blood after SARS-CoV-2 infection.
A global analysis of coronavirus protein research found that countries with larger economies generated more 3D structure determinations for the protein components of coronaviruses. However, there were many outliers, with some advanced and prosperous countries publishing few or no structures, while others strongly affected by COVID-19 p...
Researchers suggest a four-part framework to identify animal viruses that may infect humans, focusing on viruses from repeat offender families and those with known human compatibility. By studying these viruses early, scientists can develop diagnostic tools and treatments, and be better prepared to combat future pandemics.
According to a UTHealth Houston survey, breakthrough COVID-19 infections occurred in 7.5% of vaccinated Texans, with higher odds associated with Hispanic ethnicity, larger household size, and multiple comorbidities. The study also found that healthcare workers had higher reports of breakthrough infections.