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From angiotensin receptor-neprilysin inhibitor exposure to a pragmatic pharmacist-led deprescribing intervention, & validating measures between the electronic health record and Medicare Claims, geriatrics research is shaping the future of care

Researchers explore pragmatic pharmacist-led deprescribing interventions, including ALIGN, to improve medication management in older adults with cognitive impairment. Validation of hospitalization, death, and hospice care data from skilled nursing facility EHRs and Medicare claims shows promise for improved care coordination.

Development of build better bones: A global resource for osteoporosis self management

A new platform, Build Better Bones, offers evidence-based guidance and practical resources for osteoporosis management. The platform, developed by the International Osteoporosis Foundation, provides a trusted place for people with osteoporosis to start their journey, with a focus on exercise, nutrition, and home safety.

SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·TypeContent analysis·DateMar 16, 2026

NRG Oncology/Alliance trial finds immunotherapy did not improve survival when added to chemoradiotherapy for small cell lung cancer

The NRG-LU005 trial found that immunotherapy atezolizumab did not improve survival for patients with limited-stage small cell lung cancer when added to chemoradiation. Twice-daily radiation therapy, however, was associated with improved survival in this population.

SourceAlliance for Clinical Trials in Oncology·JournalJournal of Clinical Oncology·TypeRandomized controlled/clinical trial·DateMar 12, 2026

Common drug class may increase risk of heart disease

A large cohort study found that people using anticholinergic medications, commonly prescribed for urinary incontinence and anxiety, have a higher risk of developing cardiovascular disease. The cumulative use of these drugs was associated with an increased risk of heart failure and arrhythmias.

SourceKarolinska Institutet·JournalBMC Medicine·TypeObservational study·DateMar 5, 2026

Physical function is a crucial predictor of survival after heart failure

Researchers developed a new model to predict long-term survival after heart failure in elderly Japanese patients. The Top-20 XGBoost model incorporates physical function metrics, rivaling the importance of traditional cardiovascular risk factors, and provides a more accurate estimation of mortality risk.

SourceJuntendo University Research Promotion Center·JournalThe Lancet Regional Health - Western Pacific·TypeComputational simulation/modeling·DateFeb 20, 2026

A non-invasive therapeutic strategy for improving bone healing in aged patients

Researchers identified ApoE as a systemic inhibitor of bone repair during aging, and showed that blocking its activity can restore bone regeneration and improve fracture healing. The study provides hope for therapies that actively restore regenerative capacity in older patients, reducing nonunion risk and improving recovery.

SourceEditorial Office of West China School of Stomatology, Sichuan University·JournalBone Research·TypeExperimental study·DateFeb 11, 2026

Japanese version of rPATD validated to assess attitudes toward medication reductions among patients and caregivers

The Japanese version of the rPATD questionnaire has been validated to assess attitudes towards medication reductions among older adults and their caregivers in Japan. The tool is reliable, valid, and easily understood, facilitating shared decision-making between healthcare providers and patients.

SourceUniversity of Tsukuba·JournalExploratory Research in Clinical and Social Pharmacy·DateJan 26, 2026

Use of potentially inappropriate medications during end-of-life cancer care: Patterns and factors associated with deprescribing

Researchers analyzed medical records of 1,269 elderly patients with advanced cancer to find that over 70% were prescribed potentially inappropriate medications (PIMs), which declined closer to death. PIM discontinuation was more common among female patients, those with polypharmacy, and palliative care unit admissions.

SourceUniversity of Tsukuba·JournalPalliative Care and Social Practice·DateJan 19, 2026

In patients’ homes, medical students learn what textbooks miss - new study

A new study found that year-long home visits with older adults helped first-year medical students develop stronger communication skills and challenge their age-related stereotypes. The program, which included gentle physical activity and open conversation, also promoted empathy and a patient-centered mindset among the students.

SourceThe Hebrew University of Jerusalem·JournalMedical Education Online·TypeObservational study·DateJan 14, 2026

Blood test reveals risk of multimorbidity

A new study from Karolinska Institutet identified seven blood biomarkers that predict the risk and progression of multimorbidity in older adults. These biomarkers reflect biological processes such as metabolism, inflammation, and neurodegeneration.

SourceKarolinska Institutet·JournalNature Medicine·TypeObservational study·DateJan 7, 2026

Do natural disasters have long-term impacts on mortality in older adults?

A study analyzing Medicare claims data found that older adults who lived through Hurricane Harvey had a 3% elevated risk of dying within 1 year. Mortality risk was highest among those with chronic health conditions like Alzheimer's disease, and Black and Hispanic/Latino populations experienced higher mortality risks than other groups.

SourceWiley·JournalJournal of the American Geriatrics Society·DateDec 17, 2025

AI supports home-based balance training

A new machine learning model developed at the University of Michigan uses data from wearable sensors to predict how physical therapists would assess balance training performance. The model was trained with sensor data combined with analysis from physical therapists and predicted patients' balance ratings with nearly 90% accuracy.

SourceUniversity of Michigan·JournalJournal of NeuroEngineering and Rehabilitation·DateDec 8, 2025

NEJM Group launches NEJM Clinician

NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.

SourceNEJM Group·JournalNew England Journal of Medicine·DateDec 8, 2025

Developing dehydration and other age-related conditions following major surgery linked to dramatically worse outcomes for older adults

A national study found that older adults who develop geriatric syndromes after major surgery face higher risks of poor outcomes, including complications, fewer days spent at home, and increased likelihood of dying within a year. The study emphasizes the need for specialized surgical care approaches to optimize outcomes for older adults.

SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·DateNov 20, 2025

Ultra-processed food consumption linked to declines in physical function in older adults

A new study found that ultra-processed food consumption is associated with smaller but significant declines in physical function, including slower gait speed and weaker grip strength in men. Limiting UPF intake may be crucial for preserving physical function and supporting healthy aging.

SourceHebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research·JournalNutrients·TypeData/statistical analysis·DateOct 30, 2025

Wayne State University’s vice president for research & innovation announces new leader of the Institute of Gerontology

Dr. Ana Daugherty, a cognitive neuroscientist with expertise in aging and Alzheimer's disease, joins Wayne State University's Institute of Gerontology as its new director. She will lead interdisciplinary collaboration, training for emerging scholars, and research on risk and resiliency in aging and dementia.

Common hospice medications linked to higher risk of death in people with dementia

A new study finds that benzodiazepines and antipsychotics prescribed to patients with dementia receiving hospice care may carry major unintended risks, including increased mortality. The study highlights two policy issues: lack of oversight of medication use in hospice and a mismatch between hospice policy and dementia care.

SourceMichigan Medicine - University of Michigan·JournalJAMA Network Open·TypeData/statistical analysis·DateOct 14, 2025

Traumatic brain injuries in older adults linked to increased risk of dementia

New traumatic brain injuries in older adults are associated with a higher risk of developing dementia. Research published in the Canadian Medical Association Journal found that TBI is linked to an increased rate of incident dementia, even when sustained in late life, and how this risk changes over time.

SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·TypeObservational study·DateOct 6, 2025

Researchers uncover why mental maps fade with age

Researchers found that older mice showed less stable spatial memory and difficulty navigating between familiar and unfamiliar environments. In contrast, younger mice developed distinct firing patterns for each track, allowing them to remember hidden reward locations on alternating tracks with ease.

SourceStanford Medicine·JournalNature Communications·TypeExperimental study·DateOct 3, 2025

New research in JNCCN offers a simplified way to identify harmful medications in older adults with cancer

Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.

SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·DateSep 10, 2025

Closing the care gap: IOF position paper identifies barriers and solutions to global undertreatment of osteoporosis

The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.

SourceInternational Osteoporosis Foundation·JournalOsteoporosis International·TypeLiterature review·DateSep 9, 2025

Moderate-to-regular daily sleep patterns are associated with enhanced cognitive function

A new study published in Sleep Medicine found that daily sleep patterns have a significant impact on cognitive function. Researchers discovered that individuals with moderate-to-regular sleep patterns performed better in cognitive assessments than those with highly irregular or rigid sleep patterns.