Articles tagged with Immune Cells
A new method, RAGE-seq, enables scientists to track rare immune cells reactive against cancer cells. The technique reveals unprecedented insight into armming the immune system to target cancer. By scanning thousands of immune cells at a time, it provides an accurate snapshot of how the immune cells in a tissue sample are related.
The approach demonstrated in mice enhances healing by reprogramming aggressive immune cells to work for the body, reducing inflammation and promoting regeneration. This technology could lead to new therapeutic strategies for patients with spinal cord injury and inflammatory diseases.
Researchers identified a master cell that coordinates the body's immune defenses in the first days after TB infection. Boosting this cell's activity could help prevent TB and reduce new infections. The findings suggest a new avenue for TB control and may aid development of more effective vaccines.
Researchers developed a chemical probe that enables live-imaging of microglia in the brain, crucial for understanding brain development and disease. The probe, CDr20, labels microglia in both human- and primate-derived cells, allowing for clinical-relevant studies.
Researchers at the Center for Genomic Regulation discovered a novel way to control inflammation by understanding how cells produce IL-1β, a crucial molecule involved in inflammation. By targeting the unfolded protein response and GRASP55 pathways, they identified potential avenues for developing anti-inflammatory drugs.
A recent study published in PLOS Pathogens reveals that whipworms disrupt the balance between gut immune cells and microbiota, leading to uncontrolled inflammation and tissue damage. The researchers discovered that a specific receptor, IL-10R?, plays a critical role in regulating these interactions.
Researchers have successfully engineered a protein that balances an overreaction of the immune system, making it a promising candidate for sepsis therapy. By understanding how interleukins mediate communication between immune cells, scientists can now modulate their reaction in a targeted manner.
Researchers have discovered that immune cells sacrifice themselves to release proteins that fight invasive bacteria and damage. This process, called pyroptosis, is an explosive form of cell death that warns other immune cells about the threat.
A new study reveals that klotho acts as a shield between the brain and immune system, protecting against age-related cognitive decline. The research found that low levels of klotho in the choroid plexus lead to increased brain inflammation, which can impair brain functions.
Researchers developed a gene analysis approach to spot immune cells in tumors, which could help doctors choose best treatments and predict therapy responses. This new method, called ImSig, provides a detailed picture of tumors and will aid scientists in studying the impact of immune cell types on cancer growth.
Researchers have developed a new method to deliver molecules into human cells using nanostraws, which are tiny glass-like protrusions that poke equally tiny holes in cell walls. The technique is more precise, faster, and safer than existing methods, with the ability to deliver molecules in just 20 seconds.
Researchers at UVA have discovered that lymphatic vessels in the brain carry messages from the brain to the immune system, triggering MS symptoms. Blocking these messages may offer a new way to treat the condition, but more research is needed to understand their role and potential therapeutic targets.
A new MSU study links a malfunctioning gene to the loss of vital immune cells, which may prevent ankylosing spondylitis. The findings put researchers closer to uncovering the role of this gene in the disease.
Researchers at Hospital for Special Surgery discovered a key role for Langerhans cells in protecting the skin from UV light-induced injury. The study found that impaired Langerhans cell function contributes to photosensitivity in lupus patients, providing a potential new target for treatment.
The study found that different shapes and formulations of nucleic acid nanoparticles triggered specific responses from immune cells, with varying effects on cytokine production. The researchers discovered an 'auxiliary' system for managing immune response, using a molecular alphabet to communicate with the human immune system.
New research explains how obesity leads to harmful inflammation, causing diabetes and other health problems. The study identifies two ways to combat this inflammation: blocking harmful oxidized lipids or promoting beneficial phospholipids.
Researchers at FAU and Charité hospital in Berlin will conduct studies on immune-epithelial communication in IBD. They aim to develop medication targeting bowel inflammation and improve treatment outcomes.
Researchers found that microglia's immune response to inflammation can create a 'memory' that worsens Alzheimer's and stroke. The study suggests that environmental factors could trigger long-term changes in the brain's immune cells, leading to increased disease severity.
Researchers discovered that a common Parkinson's gene mutation alters immune cells' reaction to generic infections like colds, triggering an inflammatory reaction in the brain. This 'second hit' initiates the destruction of brain areas responsible for movement.
Research suggests that irregular schedules can lead to inflammation, exacerbating metabolic disorders like obesity and diabetes. Disrupted biological clocks may contribute to these effects by altering inflammatory responses.
The technology involves delivering a human chemokine on site in wounds, increasing immune cell recruitment and specialization to accelerate healing. In preclinical studies, the treatment demonstrated potent effects on acceleration of wound healing in mice and models of diabetes and peripheral ischemia.
A recent study published in Scientific Reports suggests that the eye is not as immune as previously thought, with some components being accessible to immune cells. This discovery has implications for wound healing and changes in vision such as cataracts, and may change the way we think about eye disorders.
Researchers at Karolinska Institutet discovered that oxysterols stimulate specific immune cells to form lymphoid tissue in both health and disease. Oxysterols also contribute to chronic inflammation in ulcerative colitis, leading to tissue damage.
Researchers at Radboud University Medical Center discovered that mevalonate, a byproduct of cholesterol production, trains the immune system. A Western diet rich in cholesterol can also induce trained immune cells, leading to long-lasting inflammation. Statins may inhibit this training, while boosting it could help weakened immune systems
A new study from Stockholm University shows that the parasite Toxoplasma gondii takes control of immune cells, turning them into 'zombies' that spread the infection. This allows the parasite to infect the brain, which may be linked to mental illnesses such as schizophrenia and depression.
Researchers analyzed audio clips from 143 adults to find individual language patterns related to gene expression and adversity; they discovered that these patterns better predicted adverse gene profiles than self-reported measures of anxiety and stress. This study provides a new link between spoken language and immune system regulation.
Scientists discovered that antibodies taken from dengue patients are effective in treating zika infection in rodents and even protect unborn pups. The discovery could lead to a single therapy to protect against both viral threats if replicated in humans.
Researchers at WashU Medicine found that a specific bacterium, Lactobacillus reuteri, can induce the development of tolerance-promoting immune cells in mice when fed a tryptophan-rich diet. This could lead to relief for people with inflammatory bowel disease.
Researchers have discovered that corticosteroids, a main treatment for asthma, can actually exacerbate the disease in certain cases. The study found that high levels of inflammatory protein CXCL10 and interferon-gamma are linked to poor lung function and worsening symptoms.
A recent study published in Diabetes Care found that almost half of patients with type 1 diabetes for over ten years still produce some insulin. Higher levels of interleukin-35 were detected in these patients, suggesting a link between this protein and the regeneration of remaining insulin-producing cells.
Researchers have discovered that directly injecting a tumor suppressor activator into a cancer can increase tumor destruction, while reducing toxic side effects. The agent, nutlin-3a, activates the natural p53 gene, which helps immune cells target and kill cancer cells.
New research examines the impact of Ebola virus proteins packaged in exosomes on the immune system, impairing its ability to fight off the infection. The study highlights the potential for exosomal VP40 to have a substantial impact on Ebola virus disease.
A study by Brigham and Women's Hospital investigators found that 55 out of 270 genetic loci associated with seven autoimmune diseases could be mapped back to causal genes using eQTLs in immune cells. However, this only accounts for a small fraction of the genetic loci examined.
A recent study by Georgia State University researchers found that female brains have more active immune cells in pain processing regions. This leads to improved response to opioid pain medication, often less effective in females.
Researchers found that a genetic immunodeficiency and delayed acquired immunity combine to produce life-threatening infection. The study identified a critical protein TIRAP that plays a key role in immune defense against invading bacteria.
Researchers found that bacterial infections have vastly different outcomes depending on oxygen levels in the body. Exposure to low oxygen before infection may protect against illness without compromising immunity.
Researchers found that pancreatic beta cells release proteins and their packaging, exosomes, which target the immune system. The study suggests a new direction for treatments focused on inhibiting immune cell activation.
New research clarifies why wounds heal more slowly with age by examining molecular changes in aging mouse skin. The results show that disruptions in communication between skin cells and immune cells slow down the healing process.
Researchers at Umeå University found that reactive oxygen species (ROS) can dampen inflammatory processes and weaken the immune system's ability to combat bacterial infections. This discovery challenges the long-held assumption that ROS always contribute to inflammation.
Joanna Kreitinger, a University of Montana graduate student, has been awarded a prestigious immunology fellowship to study immune cell development and contribute to understanding lung diseases. Under Professor David Shepherd's leadership, her research aims to develop new drugs to treat diseases of the immune system.
A study from Imperial College London found that previous exposure to the dengue virus may increase the potency of Zika infection, potentially leading to more severe symptoms. The research suggests that the Zika virus uses the body's own defences as a 'Trojan horse', allowing it to enter human cells undetected and replicate rapidly.
Researchers have created a new mouse model to evaluate CD40-antibody drugs with improved accuracy, advancing those more likely to be effective in patients. The study found that engagement of the human Fc receptor FcRIIB is essential for therapeutic activity, while FcRIIA compromises it.
Melbourne researchers have identified the genes Hobit and Blimp1, which control a universal molecular program for placing immune cells at the front lines of the body to fight infection and cancer. This discovery has major implications for developing strategies to induce immune cells in tissues that protect against infectious diseases.
Researchers found that certain gut bacteria can shield the brain from stroke by directing immune cells to protect it. Modifying the microbiotic makeup of the gut may become a novel method to prevent stroke, particularly for high-risk patients.
A study by Cedars-Sinai researchers found that the C9orf72 gene is crucial for immune cell function in the brain, leading to potential new therapies for ALS. The discovery highlights the active contribution of the brain's immune system to disease progression.
Researchers found that carbon nanomaterials, like C60 molecules, can enter immune cell membranes without triggering a response. This passive entry allows the materials to escape and evade the cell's disposal mechanisms.
Researchers have identified a potential treatment for traumatic brain injury (TBI) by targeting the inflammatory response. The experimental drug MW151 appears to dampen down detrimental inflammatory responses without suppressing the normal functions cells need to maintain health.
Researchers at the Tata Institute of Fundamental Research found that cholesterol-rich domains on phagosome membranes facilitate the transport of pathogens to lysosomes for degradation. This process is disrupted by certain parasites, potentially allowing them to survive and spread infection.
Researchers at Rockefeller University have captured atomic images of the herpes simplex 1 virus revealing how it inserts itself into another protein to evade detection by immune cells. The study provides a mechanistic explanation for the virus's ability to escape immune system recognition.
A new study by UC San Francisco scientists shows that the proportion of normal cells in tumor samples can skew genetic analysis results. The team used a massive dataset to examine how tumor purity affects three common genomic methods, revealing potentially disruptive effects on cancer research findings and clinical classifications.
A network of immune cells helps the appendix maintain digestive system health by preventing damage and inflammation during bacterial attacks. This discovery suggests the appendix may be more relevant to our health than previously thought, potentially even serving as a natural reservoir for 'good' bacteria.
Researchers have discovered that neuroblastoma cells produce a molecule called 'arginase' that breaks down arginine, an essential energy source for immune cells. This creates an immunosuppressive microenvironment that impairs the body's ability to fight the disease.
Researchers found that mutations in one copy of the AIRE gene can cause symptoms of a rare autoimmune disorder, paving the way for specific diagnostic and treatment strategies. Dominant AIRE mutations are also more common than previously thought, occurring in at least 1 in 1,000 individuals.
Researchers discovered that immune cells are drawn to damaged sites via hydrogen peroxide and a well-established immune signaling pathway. This knowledge could help design therapies to control immune cell behavior and prevent diseases like autoimmunity and chronic inflammation.
As we age, our gut's immune system regulator IL-6 increases, leading to chronic low-grade inflammation and a weakened barrier, making us more susceptible to infections and diseases.
Scientists have found that certain bacteria produce tiny particles called vesicles that can provoke an immune response in the gut, leading to inflammatory bowel disease (IBD). The study highlights a potential target for IBD treatments, a bacterial enzyme that could help prevent symptoms.
Researchers found that a Rab protein boosts PIP2 production, enabling HIV-1 assembly. Immune cells lacking this protein show impaired viral replication.
Researchers discovered that immune cells secrete molecules across a small gap, which larger drugs struggle to penetrate. Smaller molecules are key to targeting immune cells, offering new ideas for treating auto-immune diseases and increasing cancer reactivity.
Researchers found that fibroblastic reticular cells from lymph nodes improved survival in mouse models of sepsis, even when treatment was delayed by up to 16 hours. FRC administration prevented damage to the spleen and death of immune cells, leading to reduced bacterial levels in the bloodstream.
A new study suggests that gut microorganisms support the production of immune cells, which are essential for fighting infection. The research found that mice lacking gut microbes were more susceptible to bacterial infections, highlighting the importance of maintaining a healthy balance of gut microbes in our immune system.