Articles tagged with Immune Cells
Researchers at Thomas Jefferson University discovered that after eye injury, immune cells travel along ciliary zonules to the lens, surveilling and protecting it from adverse impacts. This finding adds to evidence overturning accepted dogma in the field, suggesting an alternative mechanism for immune cell delivery.
Scientists have created a comprehensive atlas of toxic immune cells that damage the brain, revealing a potential new drug target for multiple sclerosis and possibly other neurodegenerative diseases. The 'atlas' was generated using a novel method called Tox-seq, which links gene expression to function in single cells.
Researchers have introduced a method to rapidly cycle through staining, destaining, and restaining of cell samples using black hole quenchers in under 1 hour. This allows for precise characterization of immune cells in tumors, enabling the selection of suitable treatments.
Scientists have identified a specific antibody that binds to brain immune cells and triggers processes that enhance microglia activity. This stimulates the immune cells to detect and degrade abnormal protein deposits, known as plaques, more effectively, potentially providing better protection against Alzheimer's disease.
Researchers have created the first detailed cell atlas of the human colon's immune cells and gut bacteria, showing changes in the microbiome and immune cells throughout the colon. This study will enable new research into diseases affecting specific regions of the colon, such as ulcerative colitis and colorectal cancer.
Researchers at University of Queensland found certain immune cells linked to distinct MND features, including impaired swallowing, speech, and breathing. The study suggests immune-blocking drugs could be personalized to treat each patient's unique disease symptoms and stages.
Researchers have developed a novel technique to isolate individual gut cells from mice infected with intestinal parasites, enabling the study of the immune response to these infections. The technique may help scientists understand how adult parasites evade the immune system and develop ways to boost the immune response.
Researchers find that free radicals produced by immune cells in the kidneys contribute to salt-sensitive hypertension. By targeting these ROS-producing immune cells, effective therapies may be developed to alleviate blood pressure and kidney damage.
A new study reveals that eating activates immune cells in the gut, protecting against pathogens and preserving health. Regular mealtimes also trigger an anticipatory response to increase immunity.
Researchers at the University of Freiburg have developed a light therapy approach that successfully treats severe autoimmune reactions in cancer patients. The extracorporeal photopheresis (ECP) treatment activates immune cells to stop inflammation, offering a promising alternative to cortisone therapy.
Scientists found that nerve cells release infection-fighting cytokines to combat bacterial invaders, rather than immune cells. This discovery provides new insights into the body's response to food poisoning and other illnesses.
MAIT cells play a key role in group A streptococcal toxic shock, producing large amounts of cytokines that cause over-reaction. The discovery has potential implications for diagnosis and treatment of life-threatening conditions.
Researchers found type 3 innate lymphoid cells (ILC3) are responsible for maintaining the gut's immune system. Targeting clock genes may lead to treatments for digestive ailments, such as inflammatory bowel disease and obesity.
A new study has identified 233 genetic sites that contribute to multiple sclerosis (MS) susceptibility, highlighting the involvement of peripheral immune cells and microglia. The findings confirm earlier results and provide a rich perspective on the molecular events leading to MS.
A subset of immune cells from PID patients exhibit increased cellular respiration, leading to inflammation and autoimmunity. Researchers successfully administered a targeted treatment with fewer side effects.
A novel targeting strategy using a click reaction-assisted immune cell targeting (CRAIT) method enables deep tumor penetration of drug-loaded nanoparticles. This approach has shown promising results in reducing tumor burden in aggressive breast cancer models, offering new hope for cancer treatment.
A new method, RAGE-seq, enables scientists to track rare immune cells reactive against cancer cells. The technique reveals unprecedented insight into armming the immune system to target cancer. By scanning thousands of immune cells at a time, it provides an accurate snapshot of how the immune cells in a tissue sample are related.
Researchers found that stress on immune cells and altered metabolism lead to different outcomes in individuals infected with the same virus, with potential targets for new treatments identified. Preventing conditions causing increased stress may also prevent disease from viral infections.
The approach demonstrated in mice enhances healing by reprogramming aggressive immune cells to work for the body, reducing inflammation and promoting regeneration. This technology could lead to new therapeutic strategies for patients with spinal cord injury and inflammatory diseases.
Researchers identified a master cell that coordinates the body's immune defenses in the first days after TB infection. Boosting this cell's activity could help prevent TB and reduce new infections. The findings suggest a new avenue for TB control and may aid development of more effective vaccines.
Researchers developed a chemical probe that enables live-imaging of microglia in the brain, crucial for understanding brain development and disease. The probe, CDr20, labels microglia in both human- and primate-derived cells, allowing for clinical-relevant studies.
Researchers at the Center for Genomic Regulation discovered a novel way to control inflammation by understanding how cells produce IL-1β, a crucial molecule involved in inflammation. By targeting the unfolded protein response and GRASP55 pathways, they identified potential avenues for developing anti-inflammatory drugs.
A recent study published in PLOS Pathogens reveals that whipworms disrupt the balance between gut immune cells and microbiota, leading to uncontrolled inflammation and tissue damage. The researchers discovered that a specific receptor, IL-10R?, plays a critical role in regulating these interactions.
Researchers have successfully engineered a protein that balances an overreaction of the immune system, making it a promising candidate for sepsis therapy. By understanding how interleukins mediate communication between immune cells, scientists can now modulate their reaction in a targeted manner.
Researchers have discovered that immune cells sacrifice themselves to release proteins that fight invasive bacteria and damage. This process, called pyroptosis, is an explosive form of cell death that warns other immune cells about the threat.
A new study reveals that klotho acts as a shield between the brain and immune system, protecting against age-related cognitive decline. The research found that low levels of klotho in the choroid plexus lead to increased brain inflammation, which can impair brain functions.
Researchers developed a gene analysis approach to spot immune cells in tumors, which could help doctors choose best treatments and predict therapy responses. This new method, called ImSig, provides a detailed picture of tumors and will aid scientists in studying the impact of immune cell types on cancer growth.
Researchers have developed a new method to deliver molecules into human cells using nanostraws, which are tiny glass-like protrusions that poke equally tiny holes in cell walls. The technique is more precise, faster, and safer than existing methods, with the ability to deliver molecules in just 20 seconds.
Researchers at UVA have discovered that lymphatic vessels in the brain carry messages from the brain to the immune system, triggering MS symptoms. Blocking these messages may offer a new way to treat the condition, but more research is needed to understand their role and potential therapeutic targets.
A new MSU study links a malfunctioning gene to the loss of vital immune cells, which may prevent ankylosing spondylitis. The findings put researchers closer to uncovering the role of this gene in the disease.
Researchers at Hospital for Special Surgery discovered a key role for Langerhans cells in protecting the skin from UV light-induced injury. The study found that impaired Langerhans cell function contributes to photosensitivity in lupus patients, providing a potential new target for treatment.
The study found that different shapes and formulations of nucleic acid nanoparticles triggered specific responses from immune cells, with varying effects on cytokine production. The researchers discovered an 'auxiliary' system for managing immune response, using a molecular alphabet to communicate with the human immune system.
New research explains how obesity leads to harmful inflammation, causing diabetes and other health problems. The study identifies two ways to combat this inflammation: blocking harmful oxidized lipids or promoting beneficial phospholipids.
Researchers at FAU and Charité hospital in Berlin will conduct studies on immune-epithelial communication in IBD. They aim to develop medication targeting bowel inflammation and improve treatment outcomes.
Researchers found that microglia's immune response to inflammation can create a 'memory' that worsens Alzheimer's and stroke. The study suggests that environmental factors could trigger long-term changes in the brain's immune cells, leading to increased disease severity.
Researchers discovered that a common Parkinson's gene mutation alters immune cells' reaction to generic infections like colds, triggering an inflammatory reaction in the brain. This 'second hit' initiates the destruction of brain areas responsible for movement.
Research suggests that irregular schedules can lead to inflammation, exacerbating metabolic disorders like obesity and diabetes. Disrupted biological clocks may contribute to these effects by altering inflammatory responses.
The technology involves delivering a human chemokine on site in wounds, increasing immune cell recruitment and specialization to accelerate healing. In preclinical studies, the treatment demonstrated potent effects on acceleration of wound healing in mice and models of diabetes and peripheral ischemia.
A recent study published in Scientific Reports suggests that the eye is not as immune as previously thought, with some components being accessible to immune cells. This discovery has implications for wound healing and changes in vision such as cataracts, and may change the way we think about eye disorders.
Researchers at Karolinska Institutet discovered that oxysterols stimulate specific immune cells to form lymphoid tissue in both health and disease. Oxysterols also contribute to chronic inflammation in ulcerative colitis, leading to tissue damage.
Researchers at Radboud University Medical Center discovered that mevalonate, a byproduct of cholesterol production, trains the immune system. A Western diet rich in cholesterol can also induce trained immune cells, leading to long-lasting inflammation. Statins may inhibit this training, while boosting it could help weakened immune systems
A new study from Stockholm University shows that the parasite Toxoplasma gondii takes control of immune cells, turning them into 'zombies' that spread the infection. This allows the parasite to infect the brain, which may be linked to mental illnesses such as schizophrenia and depression.
Researchers analyzed audio clips from 143 adults to find individual language patterns related to gene expression and adversity; they discovered that these patterns better predicted adverse gene profiles than self-reported measures of anxiety and stress. This study provides a new link between spoken language and immune system regulation.
Scientists discovered that antibodies taken from dengue patients are effective in treating zika infection in rodents and even protect unborn pups. The discovery could lead to a single therapy to protect against both viral threats if replicated in humans.
Researchers at WashU Medicine found that a specific bacterium, Lactobacillus reuteri, can induce the development of tolerance-promoting immune cells in mice when fed a tryptophan-rich diet. This could lead to relief for people with inflammatory bowel disease.
Researchers have discovered that corticosteroids, a main treatment for asthma, can actually exacerbate the disease in certain cases. The study found that high levels of inflammatory protein CXCL10 and interferon-gamma are linked to poor lung function and worsening symptoms.
A recent study published in Diabetes Care found that almost half of patients with type 1 diabetes for over ten years still produce some insulin. Higher levels of interleukin-35 were detected in these patients, suggesting a link between this protein and the regeneration of remaining insulin-producing cells.
Researchers have discovered that directly injecting a tumor suppressor activator into a cancer can increase tumor destruction, while reducing toxic side effects. The agent, nutlin-3a, activates the natural p53 gene, which helps immune cells target and kill cancer cells.
New research examines the impact of Ebola virus proteins packaged in exosomes on the immune system, impairing its ability to fight off the infection. The study highlights the potential for exosomal VP40 to have a substantial impact on Ebola virus disease.
A study by Brigham and Women's Hospital investigators found that 55 out of 270 genetic loci associated with seven autoimmune diseases could be mapped back to causal genes using eQTLs in immune cells. However, this only accounts for a small fraction of the genetic loci examined.
A recent study by Georgia State University researchers found that female brains have more active immune cells in pain processing regions. This leads to improved response to opioid pain medication, often less effective in females.
Researchers found that a genetic immunodeficiency and delayed acquired immunity combine to produce life-threatening infection. The study identified a critical protein TIRAP that plays a key role in immune defense against invading bacteria.
Researchers found that bacterial infections have vastly different outcomes depending on oxygen levels in the body. Exposure to low oxygen before infection may protect against illness without compromising immunity.
Researchers found that pancreatic beta cells release proteins and their packaging, exosomes, which target the immune system. The study suggests a new direction for treatments focused on inhibiting immune cell activation.
New research clarifies why wounds heal more slowly with age by examining molecular changes in aging mouse skin. The results show that disruptions in communication between skin cells and immune cells slow down the healing process.
Researchers at Umeå University found that reactive oxygen species (ROS) can dampen inflammatory processes and weaken the immune system's ability to combat bacterial infections. This discovery challenges the long-held assumption that ROS always contribute to inflammation.
Joanna Kreitinger, a University of Montana graduate student, has been awarded a prestigious immunology fellowship to study immune cell development and contribute to understanding lung diseases. Under Professor David Shepherd's leadership, her research aims to develop new drugs to treat diseases of the immune system.
A study from Imperial College London found that previous exposure to the dengue virus may increase the potency of Zika infection, potentially leading to more severe symptoms. The research suggests that the Zika virus uses the body's own defences as a 'Trojan horse', allowing it to enter human cells undetected and replicate rapidly.
Researchers have created a new mouse model to evaluate CD40-antibody drugs with improved accuracy, advancing those more likely to be effective in patients. The study found that engagement of the human Fc receptor FcRIIB is essential for therapeutic activity, while FcRIIA compromises it.
Melbourne researchers have identified the genes Hobit and Blimp1, which control a universal molecular program for placing immune cells at the front lines of the body to fight infection and cancer. This discovery has major implications for developing strategies to induce immune cells in tissues that protect against infectious diseases.