Articles tagged with Immune Cells
Microglia, the brain's immune cells, migrate to the retina using blood vessels as pathways and require neurogenesis for colonization. The study provides insights into microglial migration and its implications for neurodegenerative diseases.
A study by Weill Cornell Medicine scientists found that blocking a signaling pathway in brain immune cells can protect against Alzheimer's disease features in a preclinical model. The results suggest a new strategy to block the development of the disease or slow its progression.
New research found that physical activity is linked to lower microglial activation, a key factor in Alzheimer's disease pathology. The study, published in JNeurosci, suggests that exercise may help reduce inflammation and improve cognitive aging in older adults with more severe AD pathology.
Researchers discovered inhibiting or genetically deleting the MTHFD2 enzyme reduced disease severity in various inflammatory disease models. This suggests that MTHFD2 function is important for immune cell regulation, particularly for T cell subsets involved in inflammation.
Recent research highlights microglia's involvement in Alzheimer's development and progression. A better understanding of microglial dysfunction may help explore signs and mechanisms of the disease, as well as enable microglia as a potential therapeutic target.
A team of researchers at George Washington University has identified DDR1 as a key molecule that prevents immune cells from entering and killing breast tumor cells. Deactivating this molecule allows immune cells to infiltrate the tumor and kill cancer cells, opening up new avenues for therapeutic agents.
A new study identifies three functional subtypes of cancer-associated fibroblasts (CAF) in lung cancer, which correspond to patients' treatment responses. These subtypes have distinct biological functions and therapeutic implications, suggesting that CAFs could serve as a key to enhancing personalized treatment for lung cancer patients.
A study of young Swedish adults found that over one in four had SARS-CoV-2-specific antibodies, but fewer had measurable levels of memory B and T cells compared to other age groups. The researchers will continue to study long COVID and vaccination effects on immunity.
New study reveals that blocking interleukin-23 is more effective than targeting both interleukin-23 and interleukin-12 in treating psoriasis. Interleukin-12, previously thought to contribute to the disease, actually protects against it by maintaining normal skin cell function.
A study in rats found that a diet of highly processed foods led to inflammation and behavioral signs of memory loss in the brain. Supplementing with omega-3 fatty acid DHA prevented these effects almost entirely. The study suggests that limiting processed foods and increasing DHA consumption may help prevent rapid memory decline in old...
New research reveals that microglia in the brain take up more glucose than previously thought, leading to altered PET scan images. This finding has significant implications for understanding neurodegenerative diseases and developing new diagnostic tools.
A UCL-led research team has identified an anti-viral gene that increases the risk of both Alzheimer's disease and severe Covid-19. The study found that a specific variant of the OAS1 gene amplifies inflammation in the brain, highlighting the importance of the immune system in both conditions.
Researchers at Yale University found that aging immune cells within fat tissue lose their ability to produce heat in cold temperatures. Stimulating new production of these cells actually makes older mice more prone to cold-induced death.
Isaac Hilton is using non-integrating episomal DNA viruses to create a new platform technology for cell and gene therapies. He aims to hijack these viruses to safely program medicinal functions in human cells.
Researchers uncover a neuro-immune process by which brain signals instruct immune function in visceral fat stores, providing new approaches for fighting obesity and related illness. The study identifies a critical mediator of neuro-immune communication, mesenchymal cells, and reveals the molecular messages exchanged across all steps.
Researchers identified specialized immune cells in cauliflower coral and starlet sea anemone that can fight infection. These unique cell types were previously unknown and have implications for understanding coral resilience to climate change.
A newly discovered fat 'shield' protects natural killer cells from their own deadly biological weapons, but also allows some cancer cells to evade an immune system attack. The shield is made of lipids and reinforces the cell membrane before an attack, preventing the toxic substances from penetrating the membrane.
TRAIL-coated nanoparticles kill 57% of cancer cells in patient blood samples, with higher lipid raft death receptor 4 levels coinciding with increased treatment efficacy.
Researchers analyzed patient specimens and clinical trial data from thousands of patients to assess the importance of immune cell molecules called Fc gamma receptors (FCGRs) in the therapeutic efficacy of two antibody drugs. High levels of FCGR2B on tumor cells were found to prevent rituximab efficacy, while obinutuzumab was not impact...
MSU researchers have discovered how the skin's immune cells organize themselves in the epidermis to provide proper protection. The discovery sheds light on the skin's defense system, which was previously misunderstood and thought to be random in its distribution.
Researchers have discovered that non-professional cells can detect changes in metabolism and activate defensive measures against pathogens. This finding has implications for understanding immunity in humans and potentially developing new tools to prevent and treat infections.
University of Minnesota Medical School researchers found that senescent immune cells drive tissue damage and shorten lifespan. The team identified these cells as the most dangerous type of senescent cell, paving the way for developing senolytic drugs targeting them.
A machine learning algorithm, FARDEEP, has been developed to assess an individual patient's risk of regenerative outcomes after surgical treatments of peri-implantitis. The study found that immune cell types central to microbial control are strongly correlated with superior clinical outcomes.
A study published in International Immunology found that a tropical ginger-derived compound, ACA, attenuates mitochondrial damage and reduces inflammation by blocking the activation of the NLRP3 inflammasome. This suggests ACA may be a promising therapeutic strategy for diseases such as rheumatoid arthritis.
Researchers created human intestinal cells to study SARS-CoV-2 infection process. The findings indicate the virus silences immune response in infected cells, suggesting new ways to treat it.
New research reveals fundamental differences in how baby and adult immune cells respond to TB, with a greater ability of adult cells to shift their energy profile after infection. The study highlights the importance of understanding how the immune system uses energy to develop better treatments for vulnerable populations.
Researchers at Lunenfeld-Tanenbaum Research Institute discover WAVE2's crucial role in regulating immune system balance. Disabling WAVE2 in mice leads to severe autoimmunity and inflammation, highlighting its importance in maintaining a balanced immune response.
A new study implicates a type of immune cell in the development of chronic lung disease following viral infection. Measuring dendritic cells may help doctors identify high-risk patients.
A new study reveals the immune system's 'tripwire' defense mechanism, which uses a protein called NLRP1 to detect and respond to invasive pathogens. This evolutionarily elegant way of detecting viral infection opens up new avenues for investigating potential future clinical applications.
The immune system surveils the brain from a distance and only enters when it finds a problem. This finding explains why the brain was thought to be immunoprivileged. Targeting immune cells at surveillance sites may lead to new treatments for conditions driven by brain inflammation, such as multiple sclerosis.
Researchers discovered that MS immune cells destroy excitatory synapses, impairing neural activity. However, the destruction is reversible upon inflammation resolution, offering new therapeutic approaches to slow disease progression.
Researchers at La Jolla Institute for Immunology created 3D maps of how enhancer sequences and genes interact in several types of immune cells. The new study opens the door to understanding individual risk for diseases from asthma to cancer.
A new study suggests that targeting the RANK signaling pathway can enhance antitumor immune responses, making breast cancer more responsive to immunotherapy. The findings come from a clinical trial and preclinical research, demonstrating the potential of this approach to convert 'cold' tumors into 'warm' ones.
Researchers have found that gut immune cells express an antibody called IgA, which helps protect against harmful bacteria and may help bring flare-ups under control. This discovery opens up new lines of research for therapeutics and suggests a potential new player in managing MS symptoms.
Researchers have discovered a general property for understanding how immune cell receptors sense and respond to microbial signals. The result led to a more effective cancer immunotherapy in mice, which could lead to more effective vaccines for existing and novel viruses.
Researchers at UCalgary's Clark H. Smith Brain Tumour Centre have made a breakthrough in combating glioblastoma by reprogramming the immune system to fight cancer instead of fueling it. By disrupting interleukin 33, a substance that recruits immune cells to tumours, survival rates increased from two months or less to over a year.
Researchers found that microglia direct neurons to modify their connectivity in response to visual stimuli, shaping the brain's neural circuits. This discovery sheds light on how sensory experience influences brain maturation and may have implications for neurodevelopmental disorders such as autism.
Researchers identified a non-coding RNA molecule, ALAL-1, that aids lung cancer cell proliferation and immune evasion. Lowering ALAL-1 levels reduces tumor growth in mice, suggesting it as a possible therapeutic target.
A new study reveals a potential link between brain inflammation and fatigue in multiple sclerosis, using PET imaging to identify specific brain regions correlated with fatigue scores. The findings open new avenues for diagnostic and therapeutic research into the debilitating symptom.
Researchers at Monash University have discovered a previously unknown way bacteria evade immune responses, targeting mitochondria for disarming. The study suggests potential new ways to combat resistant bacterial infections and could lead to new therapeutic possibilities.
Researchers discovered a mechanism by which schistosomes, parasitic worms infecting over 200 million people, evade the host's immune system. The parasite's esophageal gland mediates this protection, allowing it to survive and feed without being destroyed by immune cells.
Researchers studied cavefish and surface fish for clues on immune system adaptations. The study found that cavefish have a more sensitive innate immune system but lower levels of inflammation due to their unique environment. This could provide insights into human autoimmune diseases like Type 1 diabetes.
A study by universities of Bonn and Nijmegen found that BCG vaccination enhances immune response to multiple infections, including TB and Covid-19. The vaccine's effect is attributed to trained immunity, which allows innate immune cells to become more efficient independently of reinfection.
Researchers at Thomas Jefferson University discovered that after eye injury, immune cells travel along ciliary zonules to the lens, surveilling and protecting it from adverse impacts. This finding adds to evidence overturning accepted dogma in the field, suggesting an alternative mechanism for immune cell delivery.
Scientists have created a comprehensive atlas of toxic immune cells that damage the brain, revealing a potential new drug target for multiple sclerosis and possibly other neurodegenerative diseases. The 'atlas' was generated using a novel method called Tox-seq, which links gene expression to function in single cells.
Researchers have introduced a method to rapidly cycle through staining, destaining, and restaining of cell samples using black hole quenchers in under 1 hour. This allows for precise characterization of immune cells in tumors, enabling the selection of suitable treatments.
Scientists have identified a specific antibody that binds to brain immune cells and triggers processes that enhance microglia activity. This stimulates the immune cells to detect and degrade abnormal protein deposits, known as plaques, more effectively, potentially providing better protection against Alzheimer's disease.
Researchers have created the first detailed cell atlas of the human colon's immune cells and gut bacteria, showing changes in the microbiome and immune cells throughout the colon. This study will enable new research into diseases affecting specific regions of the colon, such as ulcerative colitis and colorectal cancer.
Researchers at University of Queensland found certain immune cells linked to distinct MND features, including impaired swallowing, speech, and breathing. The study suggests immune-blocking drugs could be personalized to treat each patient's unique disease symptoms and stages.
Researchers find that free radicals produced by immune cells in the kidneys contribute to salt-sensitive hypertension. By targeting these ROS-producing immune cells, effective therapies may be developed to alleviate blood pressure and kidney damage.
Researchers have developed a novel technique to isolate individual gut cells from mice infected with intestinal parasites, enabling the study of the immune response to these infections. The technique may help scientists understand how adult parasites evade the immune system and develop ways to boost the immune response.
A new study reveals that eating activates immune cells in the gut, protecting against pathogens and preserving health. Regular mealtimes also trigger an anticipatory response to increase immunity.
Researchers at the University of Freiburg have developed a light therapy approach that successfully treats severe autoimmune reactions in cancer patients. The extracorporeal photopheresis (ECP) treatment activates immune cells to stop inflammation, offering a promising alternative to cortisone therapy.
Scientists found that nerve cells release infection-fighting cytokines to combat bacterial invaders, rather than immune cells. This discovery provides new insights into the body's response to food poisoning and other illnesses.
MAIT cells play a key role in group A streptococcal toxic shock, producing large amounts of cytokines that cause over-reaction. The discovery has potential implications for diagnosis and treatment of life-threatening conditions.
Researchers found type 3 innate lymphoid cells (ILC3) are responsible for maintaining the gut's immune system. Targeting clock genes may lead to treatments for digestive ailments, such as inflammatory bowel disease and obesity.
A new study has identified 233 genetic sites that contribute to multiple sclerosis (MS) susceptibility, highlighting the involvement of peripheral immune cells and microglia. The findings confirm earlier results and provide a rich perspective on the molecular events leading to MS.
A subset of immune cells from PID patients exhibit increased cellular respiration, leading to inflammation and autoimmunity. Researchers successfully administered a targeted treatment with fewer side effects.
A novel targeting strategy using a click reaction-assisted immune cell targeting (CRAIT) method enables deep tumor penetration of drug-loaded nanoparticles. This approach has shown promising results in reducing tumor burden in aggressive breast cancer models, offering new hope for cancer treatment.
Researchers found that stress on immune cells and altered metabolism lead to different outcomes in individuals infected with the same virus, with potential targets for new treatments identified. Preventing conditions causing increased stress may also prevent disease from viral infections.