Articles tagged with Immune System
Researchers found that training the innate immune system can exacerbate inflammatory bone loss in models of chronic diseases like periodontitis and arthritis. The study suggests that a previously thought beneficial effect of trained immunity may actually contribute to harm in certain contexts.
A new study published in The Lancet Digital Health found that accelerated ageing in specific organs can predict diseases across the entire body. Organ ageing rates were linked to increased risks of various diseases, including cardiovascular disease, respiratory infections, and dementia.
A recent study by LMU researchers has uncovered the important role of RORγt+ dendritic cells in the body's immune response. These immune cells can act flexibly, both preventing overreactions and triggering immune reactions, and their dual functionality opens the door to new treatment possibilities.
Researchers discovered that certain bacteria in commensal relationships with plants possess mechanisms to suppress plant immune responses, allowing them to thrive. This ability enables commensal bacteria to outcompete pathogens by avoiding recognition and allocation of resources towards defense.
Researchers have discovered double negative memory B cells, a novel subset of immune cells that are more dysfunctional when in close contact with tumors. These cells may be a useful diagnostic marker and a potential target for developing new immunotherapies.
Researchers found that Black women with triple-negative breast cancer are less likely to receive immunotherapy treatment, even when accounting for socioeconomic factors. The study analyzed data from over 10,000 patients and found a significant disparity in immunotherapy response between racial groups.
Researchers at Salk Institute discover SSRIs like Prozac regulate immune response, preventing sepsis in mice. The findings suggest a potential new use for the popular drug, which could lead to life-saving treatments and enhanced global preparedness for pandemics.
A study on Nigerian healthcare workers found that excessive iron levels increased the risk of catching COVID-19, while moderate deficiency didn't offer protection. The research highlights an evolutionary tradeoff between iron's benefits for immune function and its potential risk to pathogens.
Immunocompromised individuals require regular vaccine boosters to protect against severe infections and new variants, research shows. Boosters may need to be administered four or more times to offer adequate protection.
Researchers at Osaka University developed a new technique called single-cell suppressive profiling of regulatory T cells (scSPOT) that can pinpoint the effects of Tregs on all other immune cells. The study found that Tregs most strongly affect CD8-EM T cells, which play a key role in fighting cancer and infections.
Researchers found that flagellin from the gut disrupts immune checkpoint treatment in ovarian cancer patients. Inhibiting this pathway may enhance clinical outcomes and save lives. The discovery could lead to novel therapies capable of targeting ovarian tumors.
A new Northwestern Medicine study reveals that macrophages in newborns use a process called efferocytosis to produce thromboxane, which triggers the production of a bioactive lipid that signals heart muscle cells to divide and regenerate. This process is less effective in adults, leading to scar-tissue buildup and often heart failure.
Approximately 1 in 9 US residents used dietary supplements to boost their immunity before the pandemic. Label claims related to immune benefits were common on these supplements, especially among older adults and those in poorer health.
A team of international researchers found that tumor cells become drastically diverse when exiting the bone marrow, affecting immune cells in the cancer lesions. This discovery could contribute to more precise diagnostics and therapy for multiple myeloma, a incurable bone marrow cancer.
Researchers discovered immune cells that can recognise influenza (flu) viruses even as they mutate, providing a potential solution to the annual updates of flu vaccines. The study found that certain T cells, which play a critical role in fighting infections, can detect multiple flu strains, even those that have evolved over a century.
Scientists at the Institute for Systems Biology have discovered how T cells respond to infections like COVID-19, revealing a predictable pattern based on genetic interactions. This breakthrough could lead to improved treatments and vaccine strategies for diseases such as cancer and autoimmune disorders.
A Texas Tech University laboratory played a key role in identifying a genetic adaptation in bats that could help fight viral diseases. The study found that a gene common in some bat species can reduce the production of SARS-CoV-2 virus by up to 90%, presenting a potential new pathway for combating viral infections.
Researchers found positive correlations in susceptibility to viruses across diverse fruit fly species, suggesting a general pattern of resistance. The study's findings have implications for understanding viral evolution and predicting pandemics.
Researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition. The treatment, baricitinib, selectively blocks specific inflammatory pathways, reducing inflammation and suppressing the overactive immune response that contributes to the disease.
Researchers at the University of Melbourne have identified a rare type of immune cell, called stem-like T cells, that holds the key to maintaining powerful, long-term immune responses. ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time.
Research from RIKEN Center for Integrative Medical Sciences found that infant gut bacteria are associated with food sensitivities and allergies, particularly to eggs. The study suggests that probiotic supplements, such as Bifidobacterium, may help prevent food allergies in at-risk infants.
Researchers propose systems immunology to tackle sepsis, identifying early warning signs and potential subtypes, which can lead to improved diagnostics and treatment. Targeted funding is urgently needed to develop large-scale omics studies and translate these insights into clinical results.
Researchers at Memorial Sloan Kettering Cancer Center have made a breakthrough in creating allogeneic CAR T cells that can persist in fighting cancer without being rejected by patients. By modifying donor cells with the HIV protein Nef, the cells can survive and remain potent in treating various types of cancer.
Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.
Researchers at La Jolla Institute for Immunology discovered that tissue-resident memory CD8 T cells rise up to fight infections in the small intestine, using spatial transcriptomics technology. These immune cells are split between villi and crypts, with progenitor-like cells replenishing effector T cells.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
Cancer vaccines hold transformative potential, leveraging neoantigens to activate the immune system against tumors. UK researchers are positioning themselves for a strategic shift in cancer vaccine trials, recognizing opportunities for improvement.
Researchers at the University of Florida have identified a crucial link between a gene mutation and immune system signaling in canine hemangiosarcoma, a potentially life-threatening condition. The study findings reveal an important discovery about how this cancer grows and spreads, providing new insights for novel therapies.
A new study published in Cell reveals significant differences in the immune response of children and adults to cancer, with potential implications for targeted therapies. The research shows that children's tumours are generally less inflammatory and have fewer mutations, making them appear less foreign to their immune system.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
Researchers found significant differences in immune cell populations between healthy individuals and people with schizophrenia, with the CD4/CD8 ratio emerging as a potential biomarker for predicting treatment response. Lower levels of mucosal-associated invariant T cells may signify immune dysregulation in schizophrenia.
Scientists at Salk Institute discovered that removing bile acid-creating protein BAAT and adding bile acid UDCA controls tumor growth in mice with liver cancer. UDCA supplements may be a quick solution to improving liver cancer patient outcomes.
Researchers developed a novel inhalable therapeutic delivery system for lung cancer using mucoadhesive protein nanoparticles inspired by marine mussels. The approach leverages the adhesive properties of mussel proteins to enable selective payload release and minimize adverse effects.
The Neuron special issue sheds light on the science of aging, focusing on how age-related changes impact the brain's ability to clear waste and transport energy. The collection also explores the link between the immune system and brain health.
Researchers found significant functional variations between rodent and human PD-1 due to evolutionary divergence. The study reveals a unique motif present in most mammals but missing in rodents, leading to uniquely weaker rodent PD-1.
Neuroscientist Professor Raz Yirmiya reveals a vital link between inflammation and depression through groundbreaking research. His work suggests that both activation and suppression of the immune system can trigger depressive symptoms, highlighting the need for personalized treatment approaches.
A researcher at the Medical University of South Carolina is developing a new approach to boost the immune system's ability to detect and kill kidney tumors. By targeting mitochondrial DNA, he aims to reactivate the immune system to recognize and target cancer cells more effectively.
Scientists at Goethe University Frankfurt have discovered a new way to tailor natural killer cells to target leukemia cells, improving their efficacy. The researchers used CRISPR/Cas9 gene editing to disable an immune checkpoint, allowing the modified cells to attack cancer cells more effectively.
Research from Radboud University Medical Center shows that lockdowns during the COVID-19 pandemic strengthened the immune system's response to microorganisms. The study found that after lockdowns, inflammation levels in the body were low but the immune system reacted more intensely to viruses and bacteria.
A team of University of Melbourne researchers has developed a novel drug delivery system composed of metal-biomolecule networks (MBNs), which eliminate the need for toxic drug carriers. The MBNs show antiviral, antibacterial, antifungal, anti-inflammatory and anti-cancer properties, potentially increasing success in drug development.
Researchers at Salk Institute establish a novel framework for the relationship between nutrition and cell identity. They found that a nutritional switch from acetate to citrate plays a key role in determining T cell fates, shifting them from active effector cells to exhausted cells.
A Virginia Tech student is exploring a potential new treatment avenue for Lupus using DNA-like molecules, with the goal of alleviating symptoms and reducing organ damage. The researcher's approach has shown promise in cell cultures and may lead to less invasive treatments that harness the body's natural immune responses.
Researchers at Washington University in St. Louis are developing vaccines to target misfolded proteins in the brain, with a focus on preventing inflammation and using peptide nanofibers. The goal is to prevent dementia by training the immune system against amyloid beta and tau proteins.
Researchers at Gladstone Institutes and UCSF identified MED12 as a crucial switch that regulates T cell rest and activation. The study found that MED12 promotes rest in resting cells and activation in activated cells, and its removal led to blurred lines between rest and activation.
Researchers domesticated a bacterial species that lives on human skin, discovering it triggers an immune response similar to vaccinations. The team engineered the bacteria to produce a protein that induces a powerful immune reaction, creating a living, topical vaccine.
Researchers combine a precision cancer drug with an antibody and radiation therapy to eliminate tumors without causing side effects. The approach uses the cancer drug as a molecular flag for cancerous cells, allowing immune cells to target them. This method has shown promise in eliminating lung cancer in mice with minimal side effects.
A study from King's College London reveals that the dural sinuses and skull bone marrow act as a likely interface between the central and peripheral immune systems, suggesting a potential link between brain and body inflammatory signals. The research highlights areas of the skull that work as 'traffic lights' between the two systems.
New research from the University of Pittsburgh found that opioids can suppress the immune system and reduce the effectiveness of immunotherapy for head and neck cancer. However, peripherally restricted OPRM1 antagonists (PAMORAs) may block opioid-induced immunosuppression and improve response rates to immune checkpoint inhibitor therapy.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
Chronic fatigue syndrome patients' immune T cells become exhausted, a condition well-studied in cancer. Researchers now explore potential treatments to reverse this state, which may benefit ME/CFS patients.
Researchers have developed bio-inspired micro-nanostructured systems for targeted cancer therapy, offering enhanced biocompatibility and precise tumor targeting. The systems' unique characteristics and design inspirations hold potential for improved therapeutic outcomes and reduced adverse effects.
A new study finds that fine particulate air pollution (PM2.5) exposure is associated with altered immune responses and increased inflammation in pregnant women, leading to adverse birth outcomes. The study highlights the importance of minimizing air pollution exposure in pregnant women to protect maternal and fetal health.
Researchers found that immunosuppression in prostate cancer is associated with a specialised epithelial subtype. This interaction between the immune system and club-like epithelial cells can lead to treatment resistance in patients with advanced, treatment-resistant prostate cancer.
Researchers have deciphered how the beneficial fungus Serendipita indica successfully colonizes plant roots of Arabidopsis thaliana. The fungus secretes enzymes that produce a molecule called deoxyadenosine (dAdo), which activates cell death in plants, enabling colonization without causing significant harm.
Researchers found impaired PD-1 activity can significantly reduce antibody diversity and quality in memory B cells. This may explain the increased rates of infection reported in patients with cancer receiving checkpoint inhibitor therapy.
A new gene-editing tool enables precise study of variable proteins that allow malaria parasites to stick to red blood cells and evade the immune system. The study introduces a platform to explore how malaria causes disease and identifies new proteins involved in the cytoadhesion process.
Brigham researchers found that intestinal infections alter bile composition to promote intestinal defense, highlighting the liver's role in defending against infection. The study identified hundreds of new bile metabolites and revealed a shift in bile function during enteric infection.
A comprehensive map of gene expression in the mouse intestine reveals unique regions tightly regulated by the immune system, including a region controlled by immune signals. The findings suggest resilience and adaptability of the intestine to perturbations.
Researchers at the Hebrew University of Jerusalem developed a Bayesian metamodeling technique to analyze T-cell activation, revealing intricate patterns in early signaling. The study sheds light on the molecular processes behind T-cell activation and has implications for improving treatments for various diseases.
Researchers developed a nasal vaccine combining traditional pertussis antigens with an innovative adjuvant called T-vant to boost immune response. The new vaccine was shown to prevent the bacteria's colonization in the respiratory tract, significantly curbing whooping cough spread.