Articles tagged with Pediatrics
Researchers analyzed 751 pediatric patients treated for solid tumors and found germline genomic sequencing details for inherited gene mutations. This information can help guide treatment, family screening, and prevent future cancers.
A recent NIH study found that women are less likely to be represented as chairs and reviewers on study sections, especially in institutes with higher total funding. Women are also more likely to hold lower academic ranks and temporary memberships.
Pediatric hospital admissions declined across various conditions in 2020, indicating potential gaps in pediatric care during the pandemic. The study's findings suggest a need for improved healthcare infrastructure and resource allocation.
The largest multi-center study of cisplatin-induced hearing loss reveals that permanent hearing loss occurs in 20-90% of patients, with higher doses and vincristine use increasing risk. The study establishes benchmarks for the prevalence of hearing loss and provides insights into how adjusting dosing approaches can minimize side effects.
Researchers have demonstrated a new treatment called KEDRAB to be safe and effective for use in children with rabies, marking the first pediatric trial of any human rabies immunoglobulin currently available in the US. The study found no deaths or serious adverse events among participants, and most side effects were mild.
Scientists have devised a new method to detect and potentially treat two rare pediatric diseases, Beckwith-Wiedemann syndrome and Silver-Russell syndrome, by measuring IGF2 levels in amniotic fluid. Treatment with an FDA-approved cancer medication before birth has shown promise in normalizing fetal growth in mouse models.
A new Northwestern University study found 2.9% of US adults have a current peanut allergy, with approximately one in five experiencing severe reactions each year. The study also revealed that patients who developed their peanut allergy after age 18 are less likely to report having an epinephrine auto-injector prescription.
A study by Weill Cornell Medicine found that COVID-19 transmission was extremely low among children and staff at North Carolina day camps, with only two cases linked to possible on-site transmission. The camps implemented strict safety measures, including masking, distancing, and frequent hand washing, which helped avoid viral spread.
A new screening tool, The Reading House (TRH), assesses early literacy skills in preschool-age children and has been validated as a potential identifier of reading difficulties. TRH measures core skills predictive of reading success and identifies relationships between screened skills and early brain development in the brain.
Researchers at University of Missouri-Columbia found that flu vaccination significantly reduces COVID-19 symptoms and complications in children. The review of over 900 pediatric patients with COVID-19 showed that those who received the flu vaccine had lower odds of experiencing respiratory problems or severe disease.
Researchers found that genetic mutations, such as IKZF1 deletion and CRLF2 translocations, occur more frequently in Hispanic and Latino children with B-cell acute lymphoblastic leukemia (B-ALL), leading to poorer outcomes. A novel therapeutic drug combination may help address this disparity.
Researchers developed an enhanced CMV detection method that accurately detects the infection in newborns with almost 90% accuracy. This improvement enables earlier intervention, which can improve hearing, speech, language, and intellectual/neurodevelopmental outcomes for affected children.
A study found that Black and Hispanic children are less likely to undergo medical imaging tests compared to White children. The disparity is attributed to both unnecessary testing in White children and underuse in minority children, potentially due to implicit bias among providers.
A study found that young autistic drivers have lower rates of moving violations and license suspensions, as well as similar crash rates compared to non-autistic peers. However, they were more likely to be involved in crashes while making left- or U-turns and failing to yield for other vehicles or pedestrians.
A new study by Nationwide Children's Hospital found that poor-quality housing is independently associated with poorer pediatric health, including asthma, and a greater number of medical visits. The study suggests ways healthcare providers and housing programs can address these findings to improve children's health.
Researchers evaluated new COVID-19-related pediatric resuscitation procedures using simulation to identify problems and improve guidelines. The study found that two nurses were needed at the patient's bedside during resuscitation to prevent task overload, and communication needed refinement due to PPE limitations.
A recent study assessed the increase in pediatric cases of alcohol-based hand sanitizer eye exposure during the COVID-19 pandemic. The severity and management of ocular lesions were also evaluated.
A study of 1,347 pediatric tumors found NTRK fusions in 29 cases, detected in 13% of papillary thyroid carcinomas and 1.9% of CNS tumors, offering new insights into prioritizing screening for targeted treatment with TRK inhibitors.
Researchers at the University of Pittsburgh have successfully used a new, biodegradable magnesium-alloy stent to treat pediatric laryngotracheal stenosis. The stent showed promising results in both lab testing and rabbit models, with low degradation rates and no adverse problems.
A national group of pediatric addiction medicine experts developed six principles of care for young adults with substance use disorder, emphasizing compassion, therapeutic optimism, and social justice. The supplement aims to elevate national discussions on addressing these challenges and improve outcomes for this unique population.
The System of Hospitals for Innovation in Pediatrics - Medical Devices (SHIP-MD) Virtual Workshop will focus on accelerating medical device development for children. The workshop aims to enhance safe and effective pediatric care options by addressing challenges such as clinical trials, funding, and regulatory approval.
A study found nearly half of summer camps didn't have official policies requiring campers be vaccinated, with only 39% mandating staffers vaccinations. Camps allow unvaccinated children with nonmedical exemptions to attend programs.
Researchers analyzed COVID-19 hospitalization trends in 22 states to assess severity and spread of the virus in pediatric population. The study found significant variations in hospitalization rates across states, highlighting the need for targeted interventions to prevent further transmission.
The COVID-19 pandemic has had a disproportionate impact on children with disabilities, with those requiring rehabilitation often facing delays in care. Telemedicine is emerging as a vital tool to mitigate this impact and improve healthcare outcomes for vulnerable populations.
A year after COVID-19's impact on children was first assessed, researchers have found that children are less likely to get severely sick than adults, yet some still experience serious symptoms. The study provides guidance for keeping families safe as children grow and thrive.
A new study from Children's National Hospital found that children and young adults are more impacted by COVID-19 than previously believed. Minority children had a higher likelihood of infection compared to non-Hispanic white children.
Researchers at Nationwide Children's Hospital found a 10% drop in MMR vaccine uptake among children aged 16 months. The study highlights the need for preventive care visits during the pandemic, despite safety concerns.
The Endocrine Society and Pediatric Endocrine Society call for evidence-based policies governing transgender and gender diverse health care. Reversible treatments are recommended for adolescents, and patients should determine the course of treatment with healthcare providers.
A study of 1,226 individuals with Takayasu arteritis identified new genetic associations that can predict individual susceptibility to the disease. The researchers also discovered novel molecules and pathways that can be targeted for therapy, providing hope for developing more effective treatments.
A new study has found that bullied lesbian, gay, and bisexual students are more likely to carry weapons. The research also reveals that bullying and harassment are strongly associated with weapon carrying among sexual minority youth.
The COVID-19 pandemic has worsened existing health disparities in pediatric care, with increased gaps in physical and mental health services. Telehealth can help bridge these gaps, reducing healthcare disparities.
A new study published in the Annals of the American Thoracic Society found a significant decrease in pediatric asthma-related emergency department visits during the spring 2020 COVID-19 lockdown. The rate of ED visits dropped by 80% compared to previous years, indicating improved symptom control and reduced exacerbations.
A $2.1 million federal grant will enhance clinical trial access in five areas, including care before birth and obesity, with the goal of improving health outcomes for all Louisiana children and potentially slowing or preventing chronic diseases like asthma.
The American Pediatric Society has announced its new class of 55 distinguished members, including leaders in child health education, research, policy, and clinical practice. These individuals have made significant contributions to advancing the field of academic pediatrics.
Researchers found that linking outpatient providers to hospitalists improved reduced hospital days, readmissions, and PICU stays. Parents also reported higher satisfaction rates with inpatient care.
A comprehensive analysis of proteins, genes, and RNA transcription in pediatric brain tumors has provided new understanding of these tumors. The study identified two distinct subgroups of pediatric craniopharyngioma with potential therapeutic avenues for treatment.
A study of over 135,000 pediatric patients found that 4% tested positive for SARS-CoV-2, with severe disease seen in 7%, mostly among those with underlying medical conditions. Children from ethnic minorities and adolescents were more likely to test positive.
A new study by Boston Medical Center reveals that opioid overdose deaths involving multiple substances are more prevalent among youth than opioid-only deaths. Cocaine and other stimulants were found to be the most common substances involved in these deaths, contributing to a significant increase in rates between 2010 and 2018.
This observational study describes testing and outcomes for nearly 136,000 US pediatric patients. The study found no significant association between SARS-CoV-2 infection and COVID-19 illness in this population.
A study found that pediatric CT use for abdominal pain decreased from 1.2% to 0.6% between 1997 and 2016, while adult CT use increased from 3.9% to 37.8% during the same period., Children evaluated in pediatric EDs were at lower odds of receiving CT than those in general EDs for abdominal pain with appendicitis diagnosis.
A medical case series presents three teenagers with unexplained breathing problems during the COVID-19 pandemic, highlighting similarities between vaping-related lung injury and COVID-19 symptoms. The study emphasizes the importance of considering EVALI in pediatric patients with respiratory failure and recommends vaping cessation coun...
Experts advocate for a new framework that embeds social factors, is guided by antiracist principles and considers contextual factors like race and ethnicity. The goal is to move beyond biological explanations and address structural racism and other societal issues.
A pediatric patient with anomalous origin of the left coronary artery from the pulmonary artery developed severe heart failure at 3 months old. The authors review a case and discuss the challenges in early diagnosis, highlighting the importance of considering ALCAPA as a differential diagnosis.
Dr. Lisa R. Young is recognized for her research and leadership in pediatric pulmonary medicine and rare lung diseases. Her work has led to a greater understanding of these diseases and will drive novel diagnostic and treatment strategies.
A single institution study found that half of children diagnosed with multisystem inflammatory disease in children (MIS-C) developed cardiac complications, including coronary artery abnormalities. The study highlights the need for further research into the syndrome's specific differences from Kawasaki disease.
A retrospective study of over 2,800 children with Type 1 diabetes reveals racial disparities in treatment modalities, clinical outcomes, and appointment attendance. Non-Hispanic Black children are more likely to have poor glycemic control and reduced long-term complications due to inadequate technology use.
A team of healthcare providers and advocates led by Pediatric Surgeon Lorraine Kelley-Quon established the first-ever guidelines for safe opioid prescribing in children. The guidelines acknowledge the risks of opioid misuse and addiction in teens and adolescents, while promoting education and safe storage/disposal practices.
A new study finds that e-cigarette use is associated with a higher risk of cigarette smoking among adolescents who had no prior intention of taking up conventional smoking. E-cigarette users are more than four times more likely to start smoking cigarettes one year later compared to non-users.
The American Pediatric Society recognizes Dr. Devaskar's outstanding leadership, research, and education efforts in pediatric medicine, particularly in neonatal care. Her work has made a significant impact on improving children's health and well-being, and she is an inspiration to many in the field.
A recent NIH study found that approximately 1 in 4 women experience high levels of depressive symptoms at some point in the three years post-childbirth. Women with underlying conditions like mood disorders and gestational diabetes are more likely to have persistent symptoms.
A Dartmouth study found that involving pediatric practices in promoting private well water testing can significantly influence parental compliance. The study, which tested two interventions, showed that providing both parents and clinic access to results and follow-up reminders increased testing completion rates.
A study of 339 asymptomatic and 478 symptomatic children found that those without symptoms had relatively low viral loads compared to their symptomatic counterparts. The timing of infection and diagnostic testing may impact viral load levels in asymptomatic children.
Dr. Penny M. Heaton is honored with the PIDS Distinguished Research Award for her outstanding contributions to vaccine clinical research and development. She leads efforts at the Bill & Melinda Gates Medical Research Institute, optimizing therapeutics, vaccines, and monoclonal antibody candidates.
A new study published in Pediatrics found that critically ill newborns who receive blood transfusions prior to surgery have a 50% increased rate of complications or death. The findings suggest that a 'wait and see' approach to giving infants blood during surgery may reduce surgical complications and the risk of death.
Children with chronic kidney disease experience prolonged hospital stays (30% longer) and increased hospital expenses ($8,755 vs. $5,016). They also have a higher risk of in-hospital mortality, with a 50% increase compared to other chronic conditions.
Patients with anorexia nervosa who received higher-calorie diets recovered faster and had shorter hospital stays compared to those on lower-calorie diets. The study found that patients in the higher-calorie group reached medical stability three days earlier and gained weight faster.
Three new trans-Atlantic research teams will tackle neuroblastomas, Ewing sarcoma and other difficult-to-treat cancers in children. They aim to develop precision radiotherapy, re-engineer T-cells for immunotherapies and target cancer-causing gene mutations.
A new study summarizes over 30 years of clinical experience in treating glutaric acidemia type 1 (GA1), a rare and devastating metabolic disorder. The clinic's therapies have reduced brain injury risk by 83%, improving treatment outcomes for individuals with GA1.
A computer model reveals that a specific region of the SARS-CoV-2 spike protein acts as a superantigen, triggering a massive immune response and leading to severe inflammation in some COVID-19 patients. The study also suggests that therapies targeting toxic shock syndrome may be effective for managing MIS-C and cytokine storm in adults.
A study found that non-driving-related license suspensions are given to over 90% of drivers in New Jersey, affecting low-income neighborhoods and communities of color. These suspensions disproportionately limit access to employment and healthcare, with failure to pay fines being the most common reason.