A new study introduces a computational framework that leverages alternative splicing events to predict protein isoform functions. The framework outperforms existing approaches and provides biological insights into how splicing shapes protein function, highlighting the importance of studying proteins at the isoform level.
SourceScience Exploration Press·JournalComputational Biomedicine·TypeComputational simulation/modeling·DateAug 10, 2026
Researchers reveal how single genes producing multiple proteins impact health and rare diseases, providing a new understanding of genetic mutations and their effects. The study identifies cases where mutations affect only one protein, leading to distinct symptoms and severity.
SourceWhitehead Institute for Biomedical Research·JournalMolecular Cell·TypeExperimental study·DateNov 7, 2025
A research team at the University of Cologne has identified a specific form of the tau protein, 1N4R, responsible for mediating toxic effects of protein clumps in human brain cells. This breakthrough understanding could lead to new treatments for Alzheimer's disease.
SourceUniversity of Cologne·TypeExperimental study·DateFeb 28, 2025
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers at Sanford Burnham Prebys used two sequencing methods to reveal new mRNAs associated with Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease. The study found vast mRNA isoform diversity in genes related to neurodegenerative diseases.
SourceSanford Burnham Prebys·JournaleNeuro·TypeExperimental study·DateDec 19, 2024
Cells produce three times as many 'unproductive' transcripts with mistakes or unexpected configurations as they do steady-state, finished RNA. These unproductive transcripts are quickly destroyed by a cellular process called nonsense-mediated decay (NMD), which suggests the cell intentionally makes mistakes to regulate gene expression....
SourceUniversity of Chicago·JournalNature Genetics·TypeData/statistical analysis·DateSep 2, 2024
SARS-CoV-2 uses machinery of defense cells to induce expression of unproductive isoforms of key antiviral genes, disrupting normal protein production and immune response. The study provides fundamental information on potential targets for antiviral medications and immunomodulatory interventions.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Molecular Sciences·DateAug 20, 2024
Researchers used long-read sequencing to map out gene isoform diversity in the brains of mice with human tau protein mutations. The study found hundreds of new isoforms associated with tau accumulation and differential expression in human Alzheimer's disease tissue.
SourceUniversity of Exeter·JournalNature Communications·TypeExperimental study·DateAug 2, 2024
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Researchers identified a viable path to developing a novel therapy that would make opioids more effective and safer as a treatment for chronic pain. The study found that selective Hsp90 inhibitors amplified the pain-relieving effects of morphine, reducing tolerance and side effects.
SourceUniversity of Arizona Health Sciences·JournalScientific Reports·TypeExperimental study·DateJul 16, 2024
A recent study has cataloged gene-isoform variation in the developing human brain, providing crucial insights into neurodevelopmental and psychiatric disorders. The research found thousands of isoform switches that occur during brain development, implicating previously uncharacterized RNA-binding proteins.
SourceUniversity of California - Los Angeles Health Sciences·JournalScience·TypeImaging analysis·DateMay 23, 2024
A team at Osaka University uses novel RNA sequencing techniques to reveal the molecular basis for sexual dimorphism in Daphnia, a species of water flea that can change its form and behavior despite being genetically identical. The study identifies genes that switch which isoforms are expressed in a sex-dependent manner.
SourceOsaka University·JournalScientific Reports·TypeExperimental study·DateMay 13, 2024
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at Weill Cornell Medicine have assembled a comprehensive atlas of messenger RNA variants in the mouse and human brain, revealing intricate patterns of gene expression and its relationship to major brain disorders. The study provides valuable insights into brain development, neuron specialization, and disease mechanisms.
SourceWeill Cornell Medicine·JournalNature Neuroscience·DateApr 9, 2024
The study found that APOE4 carriers have elevated LDL cholesterol levels, increasing their risk of developing subclinical atherosclerosis. In contrast, APOE2 carriers have lower cholesterol and reduced atherosclerosis prevalence.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalCirculation Research·TypeRandomized controlled/clinical trial·DateJan 23, 2024
Researchers found a strong positive correlation between BRD4 overexpression and chemoresistance in ovarian cancer. The study demonstrated that BRD4-L and BRD4-S isoforms play a role in promoting chemotherapy resistance in high-grade serous ovarian carcinoma.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeExperimental study·DateSep 13, 2023
Researchers from UCI have discovered the first crystal structures of botulinum neurotoxin E, revealing a novel mechanism for its recognition of human receptors. This finding may lead to the development of new BoNT/E variants with unique pharmacological and therapeutic features.
SourceUniversity of California - Irvine·JournalNature Communications·DateApr 27, 2023
Researchers investigated the roles of STAT3α and STAT3β in aggressive breast cancer and found that differential silencing of these isoforms leads to changes in STAT3 activation. This study emphasizes the importance of distinguishing between STAT3 isoforms for accurate cancer diagnosis and therapy.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateApr 26, 2023
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DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Scientists have created a new method to model liver cancer tumor subtypes using CRISPR-Cas9, discovering that specific gene isoforms can lead to different cancer subtypes. This platform could help researchers develop new therapeutic interventions for treating cancer and other diseases.
SourceCold Spring Harbor Laboratory·JournalThe Journal of Pathology·DateApr 10, 2023
Researchers have discovered that Shigella bacteria can infect humans but not mice due to differences in the shape of a key protein, gasdermin-B. The protein has six different forms, and some isoforms cause cell death while others do not, explaining why Shigella is unable to infect mice.
SourceUniversity of Connecticut·JournalNature·TypeExperimental study·DateMar 30, 2023
Seer researchers identified four structurally distinct protein isoforms that were differentially expressed in non-small cell lung cancer patients. These findings suggest that these protein isoforms may play a role in NSCLC disease pathogenesis, potentially leading to the development of new diagnostic markers or therapeutic targets.
SourceConsort Partners·JournalPLOS ONE·TypeExperimental study·DateMar 29, 2023
Researchers found that suppressing AMPKα1 but not AMPKα2 isoforms improved aging-related impairments in mice. The study revealed novel insights into the roles of AMPK signaling pathway in cognitive aging.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateMar 7, 2023
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Children's Hospital of Philadelphia developed ESPRESSO, a new computational tool that can accurately discover and quantify RNA molecules from error-prone long-read RNA sequencing data. This will enable better diagnosis of rare genetic diseases and discovery of potential therapeutic targets in cancer.
SourceChildren's Hospital of Philadelphia·JournalScience Advances·DateJan 20, 2023
A recent study led by Dr. Luis Cuello and Alain J. Labro found that a known Shaker channel mutation differs structurally from its human counterparts, with implications for drug development and ion transport mechanisms. The research reveals a unique conformation of the W434F mutant that is distinct from wild-type channels.
SourceTexas Tech University Health Sciences Center·JournalScience Advances·TypeObservational study·DateOct 11, 2022
Scientists at Indiana University School of Medicine discovered differences in FOXP3 isoforms controlling Treg cells and their impact on the immune system. These findings may lead to new treatments for autoimmune diseases and allergies.
SourceIndiana University School of Medicine·JournalScience Immunology·DateJun 29, 2022
Researchers at SMU found a gene that enables both mechanosensation and olfaction, potentially leading to new treatments for loss of smell in COVID-19 patients. The gene mec-2 is crucial for activating touch neurons in worms and has similar isoforms that enable smell in humans.
SourceSouthern Methodist University·JournalNucleic Acids Research·TypeObservational study·DateFeb 23, 2022
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Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
The study of MUNC long non-coding RNA reveals the importance of experimentally determining its structure to identify functional domains. The researchers found that two structural domains, including six common 'hairpins,' were crucial for regulating gene expression and muscle cell differentiation.
SourceUniversity of Alabama at Birmingham·JournalCell Reports·TypeExperimental study·DateFeb 21, 2022
Researchers at Waseda University discovered a new protein isoform called Senp5S, which helps regulate Drp1 and mitochondrial dynamics during brain development. The study suggests a novel and vital role for post-translational SUMOylation in neuronal differentiation.
SourceWaseda University·JournaliScience·TypeExperimental study·DateJan 11, 2022
Researchers at the Max Delbrück Center have developed a therapeutic agent to improve treatment of heart failure with preserved ejection fraction. The new approach targets alternative splicing in cardiac disease, using antisense oligonucleotides to stabilize sensitive molecules and trigger desired response.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalScience Translational Medicine·TypeExperimental study·DateDec 1, 2021
Researchers have identified thousands of novel brain-expressed gene isoforms, revealing a complex web of protein production in the brain. The study suggests that genes expressed in the brain may produce far more proteins than previously thought, with potential implications for diseases such as Alzheimer's and schizophrenia.
SourceUniversity of Exeter·JournalCell Reports·TypeExperimental study·DateNov 16, 2021
Researchers have developed a novel mouse model that accurately replicates the pathological propagation of tau protein isoforms in Alzheimer's disease, corticobasal degeneration, and Pick's disease. The model shows endogenous expression of both 3R and 4R tau, which accumulates in brain regions characteristic of each disease.
SourceTokyo Metropolitan Institute of Medical Science·JournalBrain·TypeExperimental study·DateOct 5, 2021
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers from HSE University have discovered a nucleotide sequence characteristic of microRNA isoforms, which helps predict errors in microRNA behavior. This discovery has important applications for creating drugs that can detect targets more effectively.
SourceNational Research University Higher School of Economics·JournalRNA Biology·DateJul 21, 2021
A study by CNIO researchers found that both isoforms of the KRAS oncogene are oncogenic and must be targeted for therapies to be effective. The research suggests that KRAS4A mutant is even more active than previously thought, inducing lung cancer and metastasis in 20% of individuals.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalProceedings of the National Academy of Sciences·DateJul 19, 2021
Scientists at Helmholtz Zentrum München developed a new bioengineered reporter system called EXSISERS, enabling non-invasive observation of fundamental cellular processes. The system detects specific protein isoforms being translated, with potential applications in neurodegenerative diseases like Parkinson's.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalNature Cell Biology·DateJun 4, 2021
Phytochromes help plants detect light direction, intensity, and duration, as well as temperature, allowing them to adapt to various environments. The study fully characterized the phytochrome family in Arabidopsis thaliana and found surprising differences between isoforms.
SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateMay 25, 2021
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A team of scientists found that the human 14-3-3 protein family has a universal binding site for the E6 oncoprotein from different subtypes of cancer-causing Human Papillomaviruses (HPV). This discovery suggests that targeting this site could lead to the development of novel antiviral therapies.
SourceFederal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Science·JournalNature Communications·DateApr 25, 2021
A novel HIPK2 isoform is identified that promotes YAP/TEAD transcriptional activity in non-small cell lung cancer cells. The study suggests that this isoform may play an oncogenic role in NSCLC and could be a potential therapeutic target.
SourceImpact Journals LLC·JournalOncotarget·DateMar 15, 2021
The study found that AKT isoforms have distinct expression patterns in triple-negative breast cancers, with AKT1 associated with invasiveness and sensitivity to drug treatment. Loss of AKT1 function was linked to reduced sensitivity to cisplatin, while the presence of AKT2 promoted stemness and invasion.
SourceImpact Journals LLC·JournalOncotarget·DateFeb 15, 2021
A new study identified an adenovirus gene therapy vector carrying a VEGF isoform that can improve uterine blood flow in placental insufficiency. Reduced uterine blood flow and lack of bioavailable VEGF are major causes of severe fetal growth restriction, leading to serious neonatal morbidity and death.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateDec 15, 2020
A new protein called FIMP plays a crucial role in sperm-oocyte membrane fusion during fertilization, a process critical to creating a new individual. The discovery of FIMP could lead to the development of novel fertility treatments and non-hormonal male-specific contraceptives.
SourceOsaka University·JournalProceedings of the National Academy of Sciences·DateApr 16, 2020
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Scientists identified a new control mechanism that enables stem cells to adapt their activity in emergency situations by modifying protein blueprints. Alternative polyadenylation regulates the amount of protein produced and controls protein isoform formation, affecting stability and localization.
SourceGerman Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)·JournalCell Stem Cell·DateMar 30, 2020
Researchers identified novel PMEPA1-e isoform and characterized its biological functions in prostate cancer. The study found that the methylation of PMEPA1 gene promoter accounts for silencing of PMEPA1 in prostate cancer cells.
SourceImpact Journals LLC·JournalOncotarget·DateJan 31, 2020
Researchers at MUSC have identified a critical lipid-binding pocket on the SET protein that can be targeted with rational drug design to develop better cancer therapeutics. Fingolimod and other FDA-approved drugs bind this pocket, restoring PP2A's growth-suppressive function and killing cancer cells.
SourceMedical University of South Carolina·JournalThe FASEB Journal·DateApr 29, 2019
A Kanazawa University study found that Xeno/endobiotic metabolism potencies differ significantly between rat strains and sexes. The study quantified the absolute mRNA expression of Ugt isoforms in rats' livers and small intestines, revealing variations in metabolism between strains and sexes.
SourceKanazawa University·JournalDrug Metabolism and Disposition·DateFeb 20, 2019
Researchers have discovered genetic switches that ignite axon formation, revealing the role of PTBP2 and SHTN1 genes. The study shows how alternative splicing enables neurons to produce long axons, essential for neural communication.
SourceUniversity of California - Riverside·JournalNeuron·DateFeb 4, 2019
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A study from Osaka University reveals how human pluripotent stem cells can be differentiated into corneal and retinal cells by growing them on specific forms of the protein laminin. The findings show that different laminin isoforms affect cell behavior, density, and interactions, which in turn influence the types of ocular cells produced.
A mathematic model developed by researchers at the University of Basel's Biozentrum demonstrates how different variants of genes enable random diversity in neurons. This diversity is achieved by combining isoforms in a way that results in precise and exclusive neuron function.
SourceUniversity of Basel·JournalCell Reports·DateSep 25, 2018
Researchers from RUDN University designed new compounds that selectively inhibit human carbonic anhydrase, reducing intraocular pressure and potentially treating glaucoma. The study's findings suggest a promising approach for developing new antiglaucoma drugs by modifying the compound's molecular periphery.
SourceRUDN University·JournalBioorganic Chemistry·DateNov 3, 2017
A Korean research team created a comprehensive computational model of human metabolism, enabling accurate prediction of personal metabolic features. The model incorporates alternative splicing information and was validated with over 11,000 Gene-Transcript-Protein-Reaction Associations.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalProceedings of the National Academy of Sciences·DateOct 25, 2017
A KAUST-led team reveals a short regulatory gene that adapts to dynamic environments by tagging genes for repression. This discovery offers a new paradigm for gene regulation, linking the genome with the environment and providing insights into cellular plasticity.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Structural & Molecular Biology·DateJun 11, 2017
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A new study has identified a protein called high mobility group box-1 (HMGB1) that may help patients with epilepsy respond more positively to drug therapies. The research found that HMGB1 isoforms can predict how an epilepsy patient's seizures will respond to anti-inflammatory drugs.
SourceUniversity of Liverpool·JournalJournal of Clinical Investigation·DateMay 15, 2017
Nagoya University researchers have discovered a link between RNA binding proteins FUS and SFPQ and the development of frontotemporal lobar degeneration, a type of dementia that starts in middle age. The study suggests that rebalancing the tau protein ratio may prevent FTLD-like phenotypes.
SourceNagoya University·JournalCell Reports·DateFeb 12, 2017
In mouse models, NRP2a inhibited tumor cell proliferation while NRP2b promoted metastasis and progression. Cancer stem cells were also reduced in NRP2b knockdown models, providing new insights into lung cancer progression. The study suggests that targeting NRP2b may lead to improved therapies for non-small cell lung cancer.
SourceMedical University of South Carolina·JournalScience Signaling·DateJan 17, 2017
Researchers found that four key muscle-cell proteins undergo a critical splicing transition in fetal forms, essential for adult muscle function. Disrupting this transition leads to major structural problems and muscle weakness in adult mice, highlighting the importance of alternative splicing in maintaining muscle health.
SourceUniversity of North Carolina Health Care·JournalCell Reports·DateNov 16, 2016
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers develop a new method to analyze genetic sequences, known as SURVIV, which can predict cancer patients' survival times with greater accuracy. This technique may also enable doctors to target specific genetic sequences that could fight disease, according to the study published in Nature Communications.
SourceUniversity of California - Los Angeles·JournalNature Communications·DateJun 9, 2016
Carbonic anhydrases are essential enzymes regulating the carbon cycle; recent studies focus on naturally occurring products inhibiting CA activity. Various natural product classes, including coumarins, phenols, polyphenols, and terpenes, have demonstrated CA modulator properties.
SourceBentham Science Publishers·JournalCurrent Pharmaceutical Design·DateJun 7, 2016
A University of California, Riverside study explains how the balance of two transcription factor isoforms in the colon influences the risk of developing colon cancer and colitis. Maintaining a balance between these isoforms is crucial for reducing disease risk.
A recent study has found that most protein isoforms encoded by the same gene have radically different roles within tissues and cells, despite being structurally alike. This discovery suggests that each protein isoform needs to be studied individually to understand its normal role and potential involvement in disease.
SourceDana-Farber Cancer Institute·JournalCell·DateFeb 11, 2016
Scientists at Helmholtz Zentrum München have identified a new isoform of neutrophil elastase involved in the pathogenesis of pulmonary emphysema. The cleaved form of the enzyme is particularly aggressive and resistant to inhibitors, leading to increased tissue damage.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalNature Communications·DateApr 13, 2015
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers have found that the length of Klf4 mRNA affects iPS cell reprogramming, with shorter forms leading to incomplete reprogramming. Longer forms result in more complete reprogramming and higher protein expression levels.
SourceCenter for iPS Cell Research and Application - Kyoto University·JournalStem Cell Reports·DateMar 13, 2015
Researchers have found that microRNA isoforms are more common than initially assumed, with certain variants exhibiting population-dependent and gender-dependent expression profiles. These findings suggest that miRNAs may serve a purpose beyond regulation of protein-coding genes.
SourceThomas Jefferson University·JournalOncoTargets and Therapy·DateSep 23, 2014
Researchers at University of São Paulo identified INXS RNA, which modulates BCL-X gene and induces programmed cell death. Local injections of plasmid containing INXS reduced subcutaneous malignant tumors by 10-fold in mice.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalNucleic Acids Research·DateJul 29, 2014
Researchers at the University of Western Australia discovered that soluble NRG1 plays a role in early peripheral nerve regeneration phases, promoting axon degeneration and regrowth. Soluble NRG1, already used in human trials for heart failure treatment, may be an effective therapeutic candidate to promote nerve regeneration.
SourceNeural Regeneration Research·JournalNeural Regeneration Research·DateJul 24, 2014