Articles tagged with Transforming Growth Factor
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The review article examines the relationship between anemia and retinopathy of prematurity, focusing on iron deficiency and underlying molecular mechanisms. Anemia reduces oxygen delivery to the retina, exacerbating hypoxia and promoting pathological neovascularization.
The American Heart Association emphasizes the importance of brain health, citing a growing burden of dementia and neurological conditions worldwide. By adopting healthy behaviors and addressing modifiable risk factors, individuals can improve their cognitive function and reduce the risk of age-related decline.
Researchers have discovered Flickering Gamma-Ray Flashes (FGFs), a phenomenon that could be the missing link between Terrestrial Gamma-ray Flashes and gamma-ray glows. Studies reveal dynamic gamma-ray emissions in tropical thunderclouds, challenging previous assumptions about these events.
Non-Communicable Diseases (NCDs) are a major global health issue, characterized by their chronic nature and long-term impact on quality of life. In China, understanding the extent and distribution of NCDs is essential for developing effective public health strategies.
A growth factor called BMP7 has been found to promote cardiomyocyte proliferation and regeneration in both zebrafish and adult mice. This discovery offers a promising new approach to treating heart disease by stimulating cardiac muscle cell regrowth even in later stages of life.
Researchers develop technology that alleviates retinal pathologies by targeting mitochondrial chaperone TRAP1, which is implicated in the breakdown of blood-retinal barrier and pathological neovascularization. This treatment approach holds great promise for revolutionizing the treatment landscape for ischemic retinopathy.
Researchers developed novel small molecule inhibitors of CPSF3, a key regulator of transcription termination in ovarian cancer cells. These inhibitors exhibited potent antiproliferative effects and suppressed tumor growth in vivo.
Researchers discuss new drugs available for HER2-positive breast cancer patients with brain metastasis, showing improved outcomes and quality of life. The development of targeted therapies has led to better survival rates among these patients.
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
Researchers at the University of Tsukuba found that the Newtic1 protein plays a crucial role in limb regeneration by secreting TGFβ1 growth factors. This discovery sheds light on the regenerative abilities of adult newts and their potential as a model for regenerative medicine.
Researchers found that cells do not rely on a snapshot to decide whether to replicate, but instead continuously integrate the availability of growth factors. Cells remember past growth factor signaling and adjust their behavior accordingly.
Researchers clarify the process by which gamma-ray flashes are generated from thunderstorms, discovering they can produce an ultraviolet emission known as an Elve. The findings reveal that high-electric fields produced just prior to a lightning bolt within the thunderstorm cloud trigger the TGF.
Researchers at University of Illinois Chicago developed a system to deliver stem cells and provide mechanical stress for new bone formation. The addition of growth factors mimics embryonic bone development, leading to enhanced healing of bone defects in rat models.
Researchers at the University of Illinois have developed a technology platform that digitally counts growth factor binding in individual cells. This breakthrough allows for direct cause-and-effect relationships between growth factors and cell behavior, leading to a better understanding of cell signaling and resistance to cancer treatme...
Researchers at Joslin Diabetes Center found that exercise causes dramatic changes to fat, releasing factors into the bloodstream that improve glucose tolerance. The study identified transforming growth factor beta 2 as an adipokine released from fat that has positive effects on health.
TGF-β1 is a potent modulator of immune and glial cell functions, regulating processes like fibrosis, atrophy, and muscle regeneration. Researchers discuss therapeutic strategies to inhibit the deleterious actions of TGF-β1 in skeletal muscle.
Researchers observed a downward beam of positrons in Hurricane Patricia's eyewall, creating powerful gamma-rays and x-rays. The detection confirms a theoretical prediction made years earlier, suggesting TGFs can be detected via the reverse positron beam using ground-based instruments.
A team led by the University of Utah has observed lightning-triggered gamma-rays in more detail than ever before, detecting 10 bursts of downward terrestrial gamma ray flashes between 2014 and 2016. The study provides a major advance in understanding the production mechanism of these rare and high-energy radiation events.
Researchers at UPV/EHU develop biodegradable gelatin scaffolds that release growth factors to promote bone tissue regeneration. The scaffolds successfully imitate the body's natural processes, including protein release profiles and angiogenesis.
Scientists analyzed dozens of TGFs launched by tropical storms, confirming that storm intensity alone is not the key factor for producing these events. Most TGFs occurred as systems intensified, with stronger electric fields driving clouds higher into the atmosphere.
The UK government is investing £17.7 million in four new healthcare technology research programmes to tackle the growing need for treatments of diabetes, dementia, and cancer. The programmes will develop innovative solutions for wound care, neural rehabilitation, cell therapeutics, and immunotherapeutics.
A University of Colorado Cancer Center study identifies epiregulin as a potential biomarker for lung cancer, with mice lacking the growth factor developing fewer tumors and reduced inflammation. The findings suggest epiregulin increases cell proliferation, promoting tumor growth.
Researchers at Monash University have found that perforin-like proteins control the release of a critical growth factor governing head and tail development in fruit flies. This discovery may provide new opportunities for treating brain developmental disorders, such as Autism Spectrum Disorder.
Scientists analyzed 2,279 TGFs detected by Fermi's GBM to identify the types of thunderstorms involved and their atmospheric conditions. They found that any thunderstorm can produce gamma rays, even weak ones, and that storm intensity is not a key factor in TGF production.
Researchers create implantable tissue scaffold coated with bone growth factors that induce rapid formation of new bone. The scaffold induces the body to rapidly form new bone that looks and behaves like original tissue.
NASA's Fermi and Aqua satellites captured two distinct views of Hurricane Julio as it intensified: a gamma-ray flash produced by the powerful electric fields in thunderstorms, and a more structurally organized storm. These findings provide insights into the complex relationship between thunderstorms and hurricane dynamics.
A new study reveals that astrocytes regulate inhibitory synapse formation through the protein TGF β1 and CaMK2 signaling. This discovery has significant implications for understanding neurological disorders associated with impaired inhibitory synapses.
A NASA-led mission called Firefly aims to study lightning and terrestrial gamma ray flashes from space. The instrument will gather data for up to a year, shedding light on the global electric circuit's most critical component.
Researchers found that tumors may switch dependence from VEGF-A to related growth factors like VEGF-C, VEGF-D, and placental growth factor when targeted by bevacizumab. This change allows colorectal cancer to continue growing despite the blockage of VEGF-A.
Researchers have identified fibroblast growth factor 18 (FGF18) as a predictive marker for poor overall survival in ovarian cancer patients. The study found that overexpression of the FGF18 gene is associated with enhanced tumor blood vessel formation and expression of cancer-promoting cytokines.
The Firestation experiment will study the link between lightning and terrestrial gamma ray flashes (TGFs), which are brief but intense bursts of gamma rays produced in Earth's atmosphere. The study aims to understand the cause and effect mechanisms behind TGFs and their relationship with lightning.
Researchers at Duke University Medical Center have found that epidermal growth factor speeds the recovery of blood-making stem cells after exposure to radiation. The finding could lead to new treatments for cancer patients and those affected by dirty bombs or nuclear disasters.
The Fermi Gamma-ray Space Telescope has improved its ability to detect terrestrial gamma-ray flashes, which are brief outbursts of high-energy light produced above thunderstorms. The enhanced detection rate revealed that TGFs also generate a strong burst of radio waves, changing how scientists study this phenomenon.
Researchers at Baylor College of Medicine discovered a positive feedback loop between Notch and TGF beta proteins that maintains basal cell population in the prostate. Disrupting this loop may contribute to prostate cancer initiation.
A recent study by Duke University researchers has identified pleiotrophin as a protein that can promote the growth of blood stem cells. The finding may lead to new treatments for patients undergoing chemotherapy or bone marrow transplants, enabling them to quickly regenerate healthy blood levels.
Researchers have developed modular growth factors that can stimulate bone and blood vessel growth in sheep, showing promise for treating orthopedic injuries and defects. The approach uses flexible proteins to activate specific signaling pathways, reducing the risk of unwanted side effects like cancer.
Researchers at Case Western Reserve University developed a method to engineer cartilage replacements using mesenchymal stem cells and tiny beads filled with growth factor. The new approach showed promising results in creating thicker, stiffer cartilage than previous methods.
Researchers found that elevated TGF beta levels lead to fascin overexpression, promoting tumor metastasis. High fascin expression is associated with poor prognosis.
Researchers block PlGF to increase life expectancy in CML mice, even those resistant to imatinib. Chronic myeloid leukemia's uncontrolled white blood cell production is disrupted by a disruption in maturing process.
Researchers discovered that cancerous cells quickly divide after receiving a growth factor signal because their p53 gene is defective. Healthy cells, on the other hand, wait eight continuous hours before dividing to ensure they receive necessary signals.
Researchers at NYU Langone Medical Center created a novel protein molecule derived from progranulin, which may offer alternative treatments for chronic inflammatory diseases like rheumatoid arthritis. The protein has been shown to have a high affinity and specificity for binding to tumor necrosis factor receptors.
Scientists using NASA's Fermi Gamma-ray Space Telescope have detected beams of antimatter produced above thunderstorms, a phenomenon never seen before. The detection is attributed to terrestrial gamma-ray flashes (TGFs) associated with lightning and the spacecraft's ability to magnetically connect with distant storms.
Scientists discover that tidal forces may have triggered the devastating Sumatra earthquake of 2004 and that rising levels of atmospheric carbon dioxide are leading to ocean-basin-wide acidification. A new catalog of terrestrial gamma ray flashes has also been created, providing insights into these mysterious bursts of energy.
Scientists have discovered a protein that can restore motor function in rats with impaired mobility after a stroke, with administered directly to the brain showing 99% regain. The intranasal method also demonstrates significant behavioral improvements and regenerative anatomical process.
Researchers at Georgetown University Medical Center found that a growth factor implicated in mental retardation disorders regulates dendritic spine development and spatial learning. Increasing the transport of this growth factor may be a way to treat these conditions.
Researchers identified eight risk factors for the transformation of choroidal nevi, benign flat pigmented growths inside the eye, into melanoma. These factors include tumor thickness greater than 2mm, fluid beneath the retina, and orange pigment.
A study found that transforming growth factor B1 (TGF-B1) is higher in blacks compared to whites, increasing the risk of hypertension and renal disease. Higher levels of TGF-B1 are also linked to body mass index and metabolic syndrome.
A UAB study reveals the human protein TGF beta-1 plays a crucial role in balancing bone resorption and formation. The discovery could lead to better bone-building therapies and new osteoporosis drugs, offering hope for patients with bone diseases.
Scientists at Schepens Eye Research Institute found that TGF-β helps maintain the health of blood vessels in the retina. The study's results suggest that blocking TGF-β can cause retinal dysfunction and lead to diseases like diabetic retinopathy and macular degeneration.
A new study found that administering GM-CSF to premature babies did not reduce the risk of sepsis or improve survival rates. The trial, which studied 280 babies, showed that while white blood cell counts rose with GM-CSF treatment, there was no significant difference in infection-free survival between the two groups.
The NSF CubeSat program represents a new 'low cost access to space' approach to performing high-quality science. Firefly will explore the relationship between lightning and Terrestrial Gamma Ray Flashes (TGFs), with potential implications for understanding Earth's upper atmosphere and near-Earth space environment.
Herbal compound 861 delays and reverses hepatic fibrosis due to HBV infection through the inactivation of LX-2 cells. The TGF beta1/ALK1/Smad1 signaling pathway is activated by TGF-beta1 and inhibited by Cpd861, making it a potential target for anti-fibrotic therapy
Researchers have discovered a new potential cancer therapy that targets angiogenesis, the formation of blood vessels that feed tumor cells. Anti-PLGF inhibits the growth of VEGF(R)-resistant tumors without affecting healthy vessels, offering a promising alternative to existing treatments.
A study published in the Journal of the National Cancer Institute found that women with breast cancer who received growth factors during chemotherapy had a higher risk of developing leukemia or myelodysplastic syndrome. The absolute risk is small, but it should be considered when making treatment decisions.
Researchers have discovered that losartan can prevent the development of aortic aneurysms in mice with Marfan syndrome, suggesting a potential new treatment. The drug works by lowering transforming growth factor beta activity, which is responsible for the syndrome's catastrophic developmental defects.
A study led by Steven Cummer of Duke University and Walter Lyons found that sprites are generated by major lightning strikes. The total charge, as it moves from the cloud to the ground, is most critical in sprite development. Sprites are brief, lasting only 3 to 10 milliseconds, but can be monitored globally using a single sensor.
Scientists detected gamma rays in thunderstorms, contradicting a long-held theory. The study found lightning strokes preceding the gamma rays, suggesting a negative cause-and-effect relationship.
Researchers have deciphered a crucial link between genetic microdeletions and DiGeorge syndrome, shedding light on the disease's pathogenesis. The study reveals that TGF signaling plays a pivotal role in neural crest development, which is disrupted in DiGeorge patients leading to characteristic malformations.
Scientists have detected over 50 gamma-ray flashes per day, with energies comparable to those emitted by black holes and neutron stars. The exact mechanism behind these bursts remains uncertain, but researchers suspect it involves lightning discharges and electric fields in the upper atmosphere.
Transforming growth factor-alpha (TGF-α) has emerged as a paradigmatic growth factor, defining cell- and context-specific actions attributed to many growth factors. Dr. Anita Roberts will discuss TGF-α's role in wound healing, autoimmune disease, fibrosis, and cancer, and several therapeutic strategies based on the growth factor.