Articles tagged with Stem Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers designed and tested textile fibers that can change shape and generate force like a muscle, showing promise for use as cell scaffolds. The findings suggest the fibers could be used to develop 3D models of living, moving systems in the human body.
Researchers at UC San Diego and Stanford University have developed a roadmap of root chemicals that are critical to plant growth, providing new insights into plant development. The study reveals that key small molecules are clustered in patches across the root, suggesting a purposeful distribution for optimal growth.
A team led by Professor Satoshi Yamazaki has established a novel culture system that supports long-term ex vivo expansion of human hematopoietic stem cells (HSCs), overcoming previous limitations. The new system, which uses chemically-defined cell culture media, significantly improves HSC growth and proliferation.
Researchers found variant cells in lungs of IPF patients that can drive fibrosis and inflammation. These cells may be targeted for future therapy, offering new hope for treatment.
Researchers found that scarring of the collagen framework prevents stem cells from healing damaged tissue in Duchenne muscular dystrophy. The study, published in npj Regenerative Medicine, used mice models to show how fibrosis disrupts cell behavior and hinders muscle regeneration.
A new study from Tokyo Medical and Dental University sheds light on the neural stem cell niche's composition during development. Researchers found that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in maintaining NSPCs under hypoxic conditions, promoting lower rates of cell death and increased cell proliferation.
The ISSCR 2023 Annual Meeting will showcase the year's most compelling stem cell research and clinical breakthroughs. Attendees can participate in dedicated poster sessions and interact with presenters.
Eleni Tomazou's project aims to create in vitro and in vivo models of pediatric sarcomas to accelerate drug discovery and precision medicine. Her work could lead to a significant impact on the treatment of these deadly cancers.
Researchers generated cochlear avatars from stem cells, recreating hair cell function and transmitting electrical signals. This breakthrough enables the investigation of sensorineural hearing loss mechanisms and potential treatments.
Leif Ludwig's analytical method allows for easier disentanglement of blood cell trajectories, enabling identification of leukemia cell development or degenerative changes. This breakthrough opens up possibility for human medicine to conduct studies in clinical practice and derive therapeutic interventions.
Researchers at Children's Hospital of Philadelphia developed ESPRESSO, a new computational tool that can accurately discover and quantify RNA molecules from error-prone long-read RNA sequencing data. This will enable better diagnosis of rare genetic diseases and discovery of potential therapeutic targets in cancer.
Researchers from Harvard University developed an efficient method to make large numbers of C4-secreting human astrocytes from stem cells. A small group of about 20 drugs were identified that reduced C4 secretion, effective in both healthy and Schizophrenia patients' astrocytes.
Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
Researchers at the University of Montreal discovered a key mechanism in muscle regeneration, enabling targeted therapies for diseases like muscular dystrophy. By biasing the conformation of a protein called ELMO2, they improved muscle fusion and regeneration in mouse models.
Researchers describe results using cladribine-based combination epigenetic and immunotherapy in MCL, achieving an increased overall survival greater than 40 months with durable remissions without relapse for longer than 5 years. The approach is promising in the treatment of MCL and potentially other previously treatment-refractory canc...
Researchers have identified a master gene that controls stem cell behavior, found in an ancient fish species, which can be used to improve human stem cell growth. The study sheds light on the evolutionary origins of pluripotent stem cells, a crucial step towards creating artificial organs.
Researchers discovered the cellular mechanism and molecular trajectory for formation of adult pluripotent stem cells in the acoel worm Hofstenia miamia. This study provides insight into regenerative abilities of certain animals and may lead to new understanding of how stem cells are made.
A team of engineers at UC Santa Cruz has developed an automated system for growing cerebral organoids, miniature models of brain tissue grown from stem cells. The new method, called Autoculture, precisely delivers nutrients to individual organoids, optimizing growth and reducing cellular stress.
Researchers at Kyoto University discovered METTL16's role in DNA repair and erythropoiesis, a process generating 200 billion new red blood cells daily. Tiny methyl groups on specific mRNAs play a pivotal role in this process, involving mechanisms mediated by RNA-binding proteins.
The UC San Diego Alpha Stem Cell Clinic will receive $8 million in funding to launch new clinical trials and improve accessibility of stem cell therapies. The clinic has already launched 59 clinical trials and treated 277 patients with various diseases.
A novel framework uses remote-controlled, internet-connected microscopes to bring project-based STEM education to students worldwide. Users in Latinx communities and multinational students successfully conducted tissue culture experiments, exploring the scientific method in a scalable and affordable approach.
Researchers have identified changes in chromatin accessibility that occur in aging muscle stem cells, which may be reversible. By understanding these changes, scientists can develop new approaches to prevent or reverse cellular aging.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
Researchers created iPSCs from Okinawa rail, Japanese ptarmigan, Blakiston's fish owl, and Japanese golden eagle for conservation. The cells can differentiate into various cell types, providing a valuable resource for evaluating disease risks and pollution.
Researchers at NC State University have developed a reproducible method for studying cellular communication in plant cells using 3D bioprinting. The study found that more than half of the bioprinted cells were viable and divided over time, with soybean embryonic cells remaining viable for two weeks after bioprinting.
Researchers found a drastic decrease in bacterial abundance on the skin of patients with graft-versus-host disease, while an increased occurrence of staphylococci was observed. This discovery may lead to improved treatment measures for GVHD, which affects approximately 30-70% of stem cell transplant recipients.
A landmark surgery using stem cells has been performed on a fetus with spina bifida, aiming to repair the defect before birth. The surgery was successful, and the baby was born healthy with no significant complications.
The USC COMPASS program aims to recruit and support students from historically underrepresented backgrounds to pursue careers in regenerative medicine. Scholars will receive a minor in Stem Cell Biology and Regenerative Medicine, as well as paid summer internships and mentorship opportunities.
Researchers at UVA Health System have made a groundbreaking discovery that could boost platelet production on demand to alleviate blood shortages. The finding offers hope for patients with thrombocytopenia and those receiving cord-blood transplants.
Researchers from the University of Copenhagen have identified a new mechanism in ARVC that could lead to a potential treatment strategy. They found that activating sirtuin-3 can slow down disease progression, and honokiol, a natural product extracted from the tulip tree, has been shown to work similarly.
Researchers are using in vitro skeletal muscle models to study Type 2 diabetes and its treatment. These models enable the exploration of disease characteristics and discovery of new medicines tailored to individual patients' muscles.
The University of California, San Diego is part of the National Institutes of Health's Bridge to Artificial Intelligence program, aiming to create comprehensive AI-ready datasets. The program will support researchers in developing interpretable and trustworthy AI technologies to improve human health.
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Researchers use human tissue models to study myocardial infarction, a leading cause of mortality worldwide. These models allow for early detection of discrepancies between animal and human responses, enabling faster and safer clinical trials.
Researchers developed optimized human small intestinal organoids with mature Paneth cells, mimicking the original human intestine. The discovery highlights the importance of Interleukin-22 in activating Paneth cells, which helps prevent infections and maintain barrier function.
Researchers at Brigham and Women's Hospital identified Basal Cell Adhesion Molecule (BCAM) as a key population of proliferative cells involved in corneal regeneration. BCAM plays a crucial role in mediating corneal differentiation, which could lead to future medical therapies for corneal disease.
Scientists aim to improve vein health for patients undergoing heart bypass surgery and dialysis. They discovered that two genes play a crucial role in smooth muscle cell differentiation, enabling veins to mature and function like arteries.
A recent study published in Science reveals that hyaluronic acid plays a key role in controlling muscle repair. The natural compound awakens stem cells to start the repair process after a 40-hour cleanup job by immune cells is complete.
Newborn neurons in Rett syndrome organoids migrate slowly and erratically compared to non-mutated cells. The study provides new insight into how MECP2 mutations affect brain development, revealing larger ventricles and thinner neural zones.
Research reveals that lymphatic capillaries communicate with intestinal stem cells to regulate their activity and promote regeneration. The findings provide new insights into the role of lymphatics in maintaining the health of the intestine.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Scientists uncovered a biophysical mechanism steering stem cells in the intestine, shedding light on their behavior and renewal process. The findings suggest that location plays a crucial role in determining which cells act as stem cells, with more frequent movements in the small intestine leading to increased stem cell activity.
A new strategy using nanoparticles restores damaged stem cells, enabling them to grow new tissues again. The approach, which uses specially formulated 'backpacks' to deliver medicine, shows promise for treating gestational diabetes and other pregnancy complications.
A study by Charité researchers found that SARS-CoV-2 causes limited direct tissue damage, instead triggering an inflammatory response through alveolar macrophages. This suggests that most cases of SARS-CoV-2 infection show relatively moderate disease severity.
Researchers have discovered that human urine-derived stem cells have the ability to regenerate tissue and become various cell types, making them a promising source for stem cell therapy. The study also highlights the importance of telomerase activity in maintaining regenerative potential.
Researchers at the Salk Institute have identified an unexpected molecular target of a common treatment for alopecia, a condition where the immune system attacks hair follicles. They found that glucocorticoid hormones instruct regulatory T cells to activate hair follicle stem cells, leading to hair growth and regeneration.
Researchers at the University of Houston have made a groundbreaking discovery in repairing and regenerating heart muscle cells in mice. The technology uses synthetic mRNA to deliver mutated transcription factors, which increases the replication of cardiomyocytes. This finding has the potential to become a powerful clinical strategy for...
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
Researchers at Cedars-Sinai have discovered that zinc, a common mineral, plays an important role in reversing lung damage and improving survival for patients with idiopathic pulmonary fibrosis (IPF). By identifying a molecular pathway involving zinc, the team hopes to develop new therapies to reverse IPF-related lung damage.
A team of researchers at the University of Texas at Austin has developed a new therapeutic that uses transmembrane stem cell factor to treat ischemia and stroke without causing allergic reactions. The therapeutic, delivered in engineered lipid nanocarriers, shows promise in enhancing revascularization in ischemic tissues.
In a mouse model, stromal cells developed before weaning age promote the maturation of the intestinal barrier by forming a specialized niche. Absence of these cells induces defect in postnatal growth and increases susceptibility to intestinal inflammatory diseases.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
Researchers discovered that chromatin entropy increases during aging, leading to epigenetic dysregulation and cellular senescence. The study found that aberrant expression of placenta-related genes is a key driver of cellular aging.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A new study maps the distinct differences among cells in the retina's retinal pigment epithelium (RPE), which nourishes and supports photoreceptors. The research identifies five subpopulations with varying levels of disease sensitivity, opening doors to more precise cell and gene therapies for specific degenerative eye diseases.
Scientists at Osaka University created 3D human stem cell-derived lacrimal gland organoids that mimic the human tear duct. The organoids exhibited organization and branching patterns characteristic of the human lacrimal gland, demonstrating potential as a platform for regenerative therapies for dry eye syndrome.
A team of researchers at UC Riverside has discovered that a protein complex called CAF-1 controls genome organization to maintain lineage fidelity in blood stem cells. The study found that CAF-1 keeps specific genomic sites compacted and inaccessible to transcription factors, ensuring the expression of lineage-specific genes.
A recent study published in Stem Cell Reports found that sleep deprivation negatively affects corneal stem cells, leading to increased rates of cell multiplication and reduced tear film antioxidants. This can result in serious effects on corneal health, such as thinning and ruffling of the cornea.
Researchers at Charité - Universitätsmedizin Berlin have discovered a novel mechanism that restricts cell division in healthy stomach tissue, protecting against cancerous changes. However, Helicobacter pylori infection deactivates this mechanism, enabling cells to grow uncontrollably and increasing the risk of stomach cancer.
Researchers at EPFL's School of Life Sciences have identified a critical link between cellular lipids and the determination of cell fate. They found that changes in lipid composition can influence the behavior of cells in response to external stimuli, even if the original cell type is identical.