Articles tagged with Stem Cells
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A team of researchers at Kyoto University successfully cryopreserved mouse stem cells and sent them to the International Space Station, where they returned healthy offspring after thawing. The study suggests that cryopreservation can maintain fertility for at least six months, paving the way for future human spaceflight.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
A study by Zhejiang University reveals how IL-6 reprograms PD-L1 expression in colorectal cancer stem cells, driving immunosuppressive effects. Dual-target therapy combining PI3K and STAT3 inhibitors shows promise in overcoming immunotherapy resistance.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
Researchers at UCLA have successfully created a continuous supply of functional T cells using genetically engineered stem cells. This breakthrough could lead to longer-lasting protection against cancer and potentially treat other diseases such as HIV or autoimmune disorders.
A study from The University of Tokyo predicts HSC quality based on real-time cellular behavior using advanced imaging technology and machine learning. The researchers discovered previously hidden diversity within HSC populations and found that kinetic features could predict the expression levels of a key gene related to 'stemness'.
A recent study published in The EMBO Journal reveals that the Setd8 gene plays a critical role in the premature aging of the brain by controlling neural stem cell activity and proliferation. Artificially lowering Setd8 levels mimicked molecular signatures of aging, highlighting its potential as a biomarker for early aging.
Scientists discovered a precise communication system in the gut, where telocytes deliver signals directly to intestinal stem cells using fine extensions. This finding challenges long-standing assumptions about gut healing and repair, potentially leading to better treatments for conditions like IBD and colon cancer.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers at Kyoto University have created a microphysiological system capable of simulating different regions of human lungs, including the airway and alveoli. This breakthrough enables accurate modeling of viral pathologies and holds promise for personalized treatment of respiratory diseases such as COVID-19.
Researchers have created a more efficient and controlled method to produce lab-grown inner ear hair cells, offering new hope for hearing loss research. The innovative approach uses a doxycycline-inducible transcription factor system, significantly increasing efficiency and reducing time compared to existing methods.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Researchers have developed a novel method to generate rats with ES cell traits using blastocyst complementation. This approach eliminates the need for fluorescent labeling and reduces costs compared to conventional techniques.
Researchers have developed novel three-dimensional liver organoids using bile acids, which retain hepatocyte-like features and can be sustained in long-term cultures. These organoids demonstrate a unique gene expression profile similar to fetal hepatocytes and support replication of hepatitis viruses.
Researchers from Karolinska Institutet have identified proliferating neural progenitors in the adult human hippocampus, confirming ongoing neuron formation. This discovery has implications for understanding brain changes during life and developing regenerative treatments for neurodegenerative and psychiatric disorders.
Researchers at Weizmann Institute of Science develop innovative blood test to detect leukemia risk and diagnose age-related conditions like MDS. The test may replace invasive bone marrow sampling procedure.
Researchers found that co-exposure to bisphenol A and retinoic acid disrupts neurodevelopmental gene signaling, leading to brain abnormalities. The study suggests a potential link between chemical exposure and neurodevelopmental disorders like autism spectrum disorder and attention deficit hyperactivity disorder.
Researchers at Uppsala University have created a model of human nerve tissue using 3D printing, enabling the testing of new drug treatments in a lab environment. This innovation allows for more precise medicine and could potentially lead to improved treatment options for ALS patients.
Researchers at MD Anderson have made significant progress in treating non-small cell lung cancer (NSCLC) by combining chemotherapy, immunotherapy, and surgery. They found that pre-surgical combination therapy showed promising results, with high rates of pathological complete response and major pathological response.
Researchers at Stockholm University and UK DRI have identified a common disease signature across all ALS-causing mutations in motor neurons, revealing early mitochondrial dysfunction. This discovery opens up new avenues for early treatment methods, targeting the energy factories of nerve cells before other signs of disease appear.
A team of scientists has identified seven genes that can transform embryonic stem cells into blood precursor cells, paving the way for a new era in regenerative medicine. The research, published in the journal Blood, uses an unbiased genome-wide screen to uncover the genes involved in hematopoietic stem cell fate.
A Phase 1 clinical trial has successfully used banked deceased donor stem cells for an allogeneic transplant, expanding transplant options for patients with aggressive blood cancers. This innovative approach aims to reduce wait times and uncertainty around donor matching and collection.
An international team of scientists has mapped the entire genome of a northern white rhino, paving the way for stem cell-based reproduction. The complete genome can be used to analyze the health of previously developed northern white rhinoceros stem cells and may eventually generate sperm and eggs to yield new rhinos.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
The RSV protein subunit vaccine showed similar efficacy to clinical trials, with diminished immune response in immunocompromised patients. The vaccine was associated with a small increased risk of Guillain-Barré syndrome, but not immune thrombocytopenic purpura.
Researchers will gather in Italy to review a decade of work on promoting healthy aging and extreme longevity. The study aims to identify key factors that contribute to the remarkable health of residents over 100 years old.
The ISSCR has elected new Vice President, Treasurer, Clerk, and Directors to lead the organization. Fiona Doetsch, Lee Rubin, and Megan Munsie bring expertise in neural stem cells, iPSCs, and developmental biology to their new roles.
A new stem cell transplant treatment has shown promising results in clearing clinical safety hurdles for the treatment of wet age-related macular degeneration. The treatment involves removing abnormal blood vessels and transplanting stem cell-derived retinal cells to replace damaged or lost retinal cells.
Researchers have developed a new way to grow organoids using Invasin, a protein produced by bacteria, mimicking the original organ with its variety of cell types. This study provides an affordable, standardized and animal-free alternative to currently used methods.
Researchers have successfully transplanted stem cells from resilient individuals into sea anemones, which are closely related to corals, demonstrating the feasibility of this approach. This innovative method could potentially lead to a new way to revive and restore coral populations damaged by climate change.
A phase 3 trial shows that autologous stem cell transplants do not improve survival for mantle cell lymphoma patients in complete remission and undetectable minimal residual disease. Patients who remain MRD-positive after induction may benefit from ASCT, but longer follow-up is needed to confirm these findings.
Gene expression in cells occurs in short, unpredictable bursts due to transcriptional bursting. Researchers found that the folding and movement of DNA, as well as protein accumulation, changes depending on gene activity, with enhancers playing a crucial role in amplifying gene activity.
A new study has unveiled how stem cells respond to their environment, with implications for inflammatory bowel disease and colorectal cancer. Stem cells rely on PIEZO1 and PIEZO2 ion channels for survival, and loss of these channels leads to severe illness and rapid death.
Scientists have developed a new organoid that includes all three key cell types in the pancreas, allowing for a clearer understanding of its early development. The research discovered a new stem cell type that can develop into these cells, and found differences between human and mouse pancreatic development.
A $6 million grant from the California Institute for Regenerative Medicine is driving research into a new treatment for dry age-related macular degeneration, a leading cause of blindness in older adults. The therapy aims to halt or reverse disease progression using stem cell-derived healthy retinal pigment epithelium cells.
Boston Medical Center and Boston University researchers have made a breakthrough in developing cell-based therapy for hypothyroidism. They derived transplantable thyroid follicular epithelial cells from human induced pluripotent stem cells, which can be transplanted into thyroid-deficient animal models.
Researchers at Wake Forest University School of Medicine will investigate factors that facilitate or hinder conversations between physicians and patients about medical misinformation. The study aims to develop a toolkit to increase health literacy and counter misinformation among older adults, who are disproportionately affected by hea...
Researchers have created the largest collection of patient stem cell models of multiple sclerosis, identifying unique ways in which glia contribute to the disease. The study suggests that glial cells from MS patients have intrinsic hallmarks of disease, independent of immune system influences.
Researchers found anomalies in embryonic development of individuals with spinal muscular atrophy (SMA), which could lead to new treatment options. These abnormalities were recreated in laboratory-grown tissue cultures called organoids, revealing key insights into the disease's progression.
Researchers discovered beta-catenin as a new player in the formation of the main body axis during mammalian embryogenesis. A novel embryo-like model system was developed to identify this key player, revealing its importance in axis formation.
Researchers from IBEC investigated how mechanical properties of colorectal cancer stem cells influence metastasis. Cells expressing LGR5 protein exhibit softer, less sticky properties and better adhere to blood vessel walls.
A breakthrough discovery by Nara Institute of Science and Technology researchers identifies EPHA2 as a critical surface protein for preserving stem cell potency. This finding holds promise for safer regenerative medicine by reducing the risk of tumorigenesis, paving the way for organ repair and treatment of degenerative conditions.
Researchers at UC Santa Cruz discovered a secondary population of platelets that appears with aging, exhibiting hyperreactive behavior and unique molecular properties. This 'shortcut' pathway bypasses normal differentiation processes, producing problematic cells that can cause blood clotting diseases.
Scientists have discovered that aging clocks measure stochastic changes in cells, rather than damage accumulation. This finding suggests that aging can be predicted using the variation in cellular processes.
A new AI model generates realistic images of single cells, which are used as synthetic data to train an AI model for better cell segmentation. The researchers found that providing a more diverse dataset during training improves performance.
A team of scientists has created a single-cell atlas for the highly regenerative worm Pristina leidyi, revealing new insights into its regenerative abilities. The study characterizes all major annelid cell types and provides molecular signatures that could inform stem cell technologies and regenerative medicine.
Researchers at Salk Institute find a new method to interrupt sperm production using an HDAC inhibitor, which blocks fertility without affecting libido. The treatment's reversibility is attributed to its ability to modulate gene expression downstream of retinoic acid.
Researchers at Michigan State University have developed highly accurate synthetic human mini hearts that can be studied in a dish. This advancement is facilitating the development of new therapies and pharmaceutical drugs to treat various heart-related diseases. The mini heart organoids are becoming increasingly complex and realistic, ...
The Exploratorium's new exhibit allows visitors to sync their heartbeat with living heart cells, sparking discussion about the heart and health, as well as stem cell science. Visitors reported increased engagement with the exhibit, sharing reactions and experiences with others.
Researchers from Osaka University and University of Hawaii found that environmental microorganisms boost fruit fly reproduction by modifying hormone levels and increasing the production of germline stem cells. This discovery could lead to new avenues for improving reproductive health and fertility treatments.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
Deepak Srivastava, president of Gladstone Institutes, has made significant original and sustained scientific contributions advancing cardiovascular science. His laboratory has deciphered new ways to generate cardiac cells that repair heart damage, translating into novel approaches for treating disease.
A UCLA-led team has identified RBFox1, an RNA splicing regulator, as a key player in promoting human stem cell-derived heart muscle cell maturation. This finding offers a deeper understanding of heart muscle cell development and hints at future therapeutic applications for regenerative therapies.
Researchers discovered an anti-nucleolin DNA aptamer that modulates gene expression and nucleolin localization to determine a cell's lineage during differentiation. The study shows promise as a regenerative therapy for cardiovascular diseases.
A team of researchers at Tokyo Medical and Dental University has identified a gene called Rasip1 as crucial for blood cell development. SOX17, a transcription factor, is found to activate Rasip1, leading to the formation of hematopoietic stem cells and associated hematopoietic activity.
Researchers at HKUST have found that the stem cell niche uses gap junctions to transport cAMP into stem cell progeny, controlling their differentiation. This discovery is significant for developing stem cell therapies to treat diseases such as Parkinson's and Alzheimer's.
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
Researchers at UC San Diego demonstrate that hematopoietic stem cell transplants can protect against multiple signs and symptoms of Alzheimer's in a mouse model of the disease. The therapy leads to enhanced microglia health, which protects against Alzheimer's pathology, including β-amyloid build-up and neuroinflammation.
A Japanese research team identified two critical signaling pathways regulating stem cell differentiation in the stomach, promoting healthy homeostasis and protecting against gastric diseases. The study, published in Nature Communications, sheds light on the mechanisms behind cellular renewal and differentiation.
Researchers at Northwestern University have discovered a way to soften stiff hair follicle stem cells, enabling them to grow hair again. By boosting the production of microRNA-205, they promote hair growth in both young and old mice, offering potential for human hair regrowth.