Articles tagged with Stem Cells
A diet rich in cysteine has been shown to activate immune cells that help regenerate intestinal tissue, potentially offering a new way to heal tissue damage from radiation or chemotherapy treatment. The researchers found that cysteine initiates a chain of events leading to the activation of CD8 T cells, which produce cytokines like IL-...
Scientists successfully derive and maintain self-renewing and pluripotent ESCs from chickens and seven other bird species using a growing medium of egg yolk. The study holds promise for applications in studying embryonic development, producing lab-grown poultry, and reviving endangered birds.
Using embryoid models made of stem cells, researchers uncovered important processes mimicking the first moments of human development. The team applied AI neural networks to thousands of images collected with confocal fluorescent microscopy to detect features and protein marker expression data.
Researchers at Mayo Clinic found that transplanting patients' own stem cells into their veins can help prevent inflammation and vein narrowing in patients with end-stage kidney disease. This could extend the time before dialysis is required, reducing healthcare costs and improving patient outcomes.
Researchers have uncovered how mosquito-borne viruses invade the brain by exploiting specific proteins on blood-brain barrier cells. The study highlights promising molecular targets for future vaccines and antiviral drugs to prevent severe neurological complications.
Researchers demonstrate that intraoral administration of abaloparatide combined with orthodontic force supports alveolar bone thickening. ABL-induced alveolar bone formation is linked to the focal adhesion pathway, where FAK activation plays a crucial role.
A study led by Keck School of Medicine of USC found that a stem cell transplant performed one week after an ischemic stroke in mice led to significant brain cell growth and functional recovery. The treated mice showed improved fine motor skills, gait, and reduced inflammation compared to untreated mice.
Stem cell transplantation has been shown to reverse stroke damage in mice by regenerating neurons and restoring motor functions. The treatment also improved blood-brain barrier integrity, reduced inflammation, and promoted new blood vessel formation.
Researchers at Cold Spring Harbor Laboratory have mapped two known stem cell regulators across thousands of maize and Arabidopsis shoot cells. This discovery reveals new stem cell regulators in both species and links some to size variations in maize.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
UC San Diego researchers have discovered that spaceflight accelerates the aging of human hematopoietic stem and progenitor cells, leading to increased DNA damage and telomere shortening. The study's findings offer insights into aging and disease risks during long-duration space travel and suggest potential rejuvenation strategies.
Researchers discovered that breast cancer cells co-opt iron-recycling immune cells in bone marrow to acquire essential minerals, disrupting red blood cell production. This adaptation enables cancer cells to survive in low-oxygen environments and proliferate, ultimately leading to anemia and poor patient outcomes.
Researchers found that increased levels of EPS8 drive pathological protein aggregation and neurodegeneration in worms and human cell models. By reducing EPS8 activity, they prevented toxic protein accumulation and preserved neuronal function.
A scientific team co-led by Dr. Lishomwa Ndhlovu at Weill Cornell Medicine has received an NIH MERIT Award to study a handful of people who have managed to clear HIV after a stem cell transplant. The goal is to identify the immune mechanisms that led to remission and develop a broadly applicable immunotherapy for eliminating HIV.
Researchers at the University of Minnesota have developed a groundbreaking process to combine 3D printing, stem cell biology, and lab-grown tissues for spinal cord injury recovery. The method involves creating 3D-printed scaffolds with microscopic channels that promote the growth of new nerve fibers.
Scientists have developed a new approach to analyze proteins in individual cells during blood cell formation, bypassing mRNA intermediates. This study reveals the correlation between mRNA levels and protein expression, shedding light on the role of essential proteins in maintaining stem cell populations.
Dr. Greenblatt's discovery of distinct types of bone-building stem cells has opened new areas of research into targeted therapies for bone cancer, osteoporosis, and rare bone conditions. His work has identified potential therapeutic targets to block spine metastases in breast and prostate cancer.
Researchers have developed a novel method to stimulate and mature human brain organoids using graphene, accelerating disease research and enabling brain-machine interfaces. The approach allows for safe, non-genetic, biocompatible stimulation of neural activity over days to weeks.
Several companies in the UK are promoting tooth stem cell banking as a treatment for autism, type 1 diabetes, and other conditions, despite a lack of evidence. Experts say these claims are 'outrageous' and risk exploiting vulnerable parents.
Researchers at Wyss Institute develop in vitro method to induce meiosis in human cells, enabling replication of critical step in egg and sperm cell development. The breakthrough could lead to modeling defects and creating healthy gametes for individuals with infertility.
A team of researchers at Kyoto University successfully cryopreserved mouse stem cells and sent them to the International Space Station, where they returned healthy offspring after thawing. The study suggests that cryopreservation can maintain fertility for at least six months, paving the way for future human spaceflight.
Researchers have discovered a new type of stem cell that can transform from muscle to bone, which may lead to more effective treatments for fractures. The study found that Prg4+ cells were crucial in repairing bones and could be stimulated or introduced directly to the fracture site to accelerate healing.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
Researchers have discovered a specialized mesenchymal-endothelial crosstalk that supports angiogenesis and osteogenesis, enabling periodontal bone regeneration. This communication network between mesenchymal stem cells and endothelial cells drives tissue repair and regeneration, holding promise for dental therapeutic strategies and bro...
A study by Zhejiang University reveals how IL-6 reprograms PD-L1 expression in colorectal cancer stem cells, driving immunosuppressive effects. Dual-target therapy combining PI3K and STAT3 inhibitors shows promise in overcoming immunotherapy resistance.
Researchers at UCLA have successfully created a continuous supply of functional T cells using genetically engineered stem cells. This breakthrough could lead to longer-lasting protection against cancer and potentially treat other diseases such as HIV or autoimmune disorders.
A study from The University of Tokyo predicts HSC quality based on real-time cellular behavior using advanced imaging technology and machine learning. The researchers discovered previously hidden diversity within HSC populations and found that kinetic features could predict the expression levels of a key gene related to 'stemness'.
A recent study published in The EMBO Journal reveals that the Setd8 gene plays a critical role in the premature aging of the brain by controlling neural stem cell activity and proliferation. Artificially lowering Setd8 levels mimicked molecular signatures of aging, highlighting its potential as a biomarker for early aging.
Scientists discovered a precise communication system in the gut, where telocytes deliver signals directly to intestinal stem cells using fine extensions. This finding challenges long-standing assumptions about gut healing and repair, potentially leading to better treatments for conditions like IBD and colon cancer.
A novel 3D culture method enables self-organization of precursor cell types into functional liver organoids capable of producing essential clotting factors. The breakthrough advances organoid-based therapies, drug testing, and disease modeling for liver diseases, including hemophilia A.
Researchers at Kyoto University have created a microphysiological system capable of simulating different regions of human lungs, including the airway and alveoli. This breakthrough enables accurate modeling of viral pathologies and holds promise for personalized treatment of respiratory diseases such as COVID-19.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Researchers have created a more efficient and controlled method to produce lab-grown inner ear hair cells, offering new hope for hearing loss research. The innovative approach uses a doxycycline-inducible transcription factor system, significantly increasing efficiency and reducing time compared to existing methods.
Researchers have developed a novel method to generate rats with ES cell traits using blastocyst complementation. This approach eliminates the need for fluorescent labeling and reduces costs compared to conventional techniques.
Researchers have developed novel three-dimensional liver organoids using bile acids, which retain hepatocyte-like features and can be sustained in long-term cultures. These organoids demonstrate a unique gene expression profile similar to fetal hepatocytes and support replication of hepatitis viruses.
Researchers from Karolinska Institutet have identified proliferating neural progenitors in the adult human hippocampus, confirming ongoing neuron formation. This discovery has implications for understanding brain changes during life and developing regenerative treatments for neurodegenerative and psychiatric disorders.
Researchers at Weizmann Institute of Science develop innovative blood test to detect leukemia risk and diagnose age-related conditions like MDS. The test may replace invasive bone marrow sampling procedure.
Researchers found that co-exposure to bisphenol A and retinoic acid disrupts neurodevelopmental gene signaling, leading to brain abnormalities. The study suggests a potential link between chemical exposure and neurodevelopmental disorders like autism spectrum disorder and attention deficit hyperactivity disorder.
Researchers at Uppsala University have created a model of human nerve tissue using 3D printing, enabling the testing of new drug treatments in a lab environment. This innovation allows for more precise medicine and could potentially lead to improved treatment options for ALS patients.
Researchers at MD Anderson have made significant progress in treating non-small cell lung cancer (NSCLC) by combining chemotherapy, immunotherapy, and surgery. They found that pre-surgical combination therapy showed promising results, with high rates of pathological complete response and major pathological response.
Researchers at Stockholm University and UK DRI have identified a common disease signature across all ALS-causing mutations in motor neurons, revealing early mitochondrial dysfunction. This discovery opens up new avenues for early treatment methods, targeting the energy factories of nerve cells before other signs of disease appear.
A team of scientists has identified seven genes that can transform embryonic stem cells into blood precursor cells, paving the way for a new era in regenerative medicine. The research, published in the journal Blood, uses an unbiased genome-wide screen to uncover the genes involved in hematopoietic stem cell fate.
A Phase 1 clinical trial has successfully used banked deceased donor stem cells for an allogeneic transplant, expanding transplant options for patients with aggressive blood cancers. This innovative approach aims to reduce wait times and uncertainty around donor matching and collection.
An international team of scientists has mapped the entire genome of a northern white rhino, paving the way for stem cell-based reproduction. The complete genome can be used to analyze the health of previously developed northern white rhinoceros stem cells and may eventually generate sperm and eggs to yield new rhinos.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
The RSV protein subunit vaccine showed similar efficacy to clinical trials, with diminished immune response in immunocompromised patients. The vaccine was associated with a small increased risk of Guillain-Barré syndrome, but not immune thrombocytopenic purpura.
Researchers will gather in Italy to review a decade of work on promoting healthy aging and extreme longevity. The study aims to identify key factors that contribute to the remarkable health of residents over 100 years old.
The ISSCR has elected new Vice President, Treasurer, Clerk, and Directors to lead the organization. Fiona Doetsch, Lee Rubin, and Megan Munsie bring expertise in neural stem cells, iPSCs, and developmental biology to their new roles.
A new stem cell transplant treatment has shown promising results in clearing clinical safety hurdles for the treatment of wet age-related macular degeneration. The treatment involves removing abnormal blood vessels and transplanting stem cell-derived retinal cells to replace damaged or lost retinal cells.
Researchers have developed a new way to grow organoids using Invasin, a protein produced by bacteria, mimicking the original organ with its variety of cell types. This study provides an affordable, standardized and animal-free alternative to currently used methods.
Researchers have successfully transplanted stem cells from resilient individuals into sea anemones, which are closely related to corals, demonstrating the feasibility of this approach. This innovative method could potentially lead to a new way to revive and restore coral populations damaged by climate change.
A phase 3 trial shows that autologous stem cell transplants do not improve survival for mantle cell lymphoma patients in complete remission and undetectable minimal residual disease. Patients who remain MRD-positive after induction may benefit from ASCT, but longer follow-up is needed to confirm these findings.
Gene expression in cells occurs in short, unpredictable bursts due to transcriptional bursting. Researchers found that the folding and movement of DNA, as well as protein accumulation, changes depending on gene activity, with enhancers playing a crucial role in amplifying gene activity.
A new study has unveiled how stem cells respond to their environment, with implications for inflammatory bowel disease and colorectal cancer. Stem cells rely on PIEZO1 and PIEZO2 ion channels for survival, and loss of these channels leads to severe illness and rapid death.
Scientists have developed a new organoid that includes all three key cell types in the pancreas, allowing for a clearer understanding of its early development. The research discovered a new stem cell type that can develop into these cells, and found differences between human and mouse pancreatic development.
A $6 million grant from the California Institute for Regenerative Medicine is driving research into a new treatment for dry age-related macular degeneration, a leading cause of blindness in older adults. The therapy aims to halt or reverse disease progression using stem cell-derived healthy retinal pigment epithelium cells.
Boston Medical Center and Boston University researchers have made a breakthrough in developing cell-based therapy for hypothyroidism. They derived transplantable thyroid follicular epithelial cells from human induced pluripotent stem cells, which can be transplanted into thyroid-deficient animal models.
Researchers at Wake Forest University School of Medicine will investigate factors that facilitate or hinder conversations between physicians and patients about medical misinformation. The study aims to develop a toolkit to increase health literacy and counter misinformation among older adults, who are disproportionately affected by hea...
Researchers have created the largest collection of patient stem cell models of multiple sclerosis, identifying unique ways in which glia contribute to the disease. The study suggests that glial cells from MS patients have intrinsic hallmarks of disease, independent of immune system influences.
Researchers found anomalies in embryonic development of individuals with spinal muscular atrophy (SMA), which could lead to new treatment options. These abnormalities were recreated in laboratory-grown tissue cultures called organoids, revealing key insights into the disease's progression.