Articles tagged with Epigenetic Inheritance
Researchers found a progressive shift in RNA contents of sperm with age, potentially contributing to health risks of having kids later in life. The discovery may lead to improved fertility outcomes and diagnostic tools.
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
A study by Meng Wang and her team found that histone modifications can be transferred from parent to offspring through epigenetic changes, enabling the transfer of longevity markers across generations. This mechanism has implications for understanding transgenerational effects beyond longevity.
A recent study found that childhood maltreatment is associated with specific epigenetic patterns in sperm, which may mediate effects on offspring brain development. The study also reveals changes in sperm DNA methylation and small non-coding RNA molecules in men with high levels of maltreatment.
A study published in Cell reveals that Mrc1 is crucial for epigenetic inheritance, ensuring cells maintain their genetic identity and function. The discovery has significant implications for understanding diseases like cancer and aging, where epigenetic landscapes deteriorate over time.
A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.
A new study by Lund University researchers confirms that epigenetic changes can contribute to the development of type 2 diabetes. The study identified 5584 sites with differing epigenetic changes in individuals with and without the disease, as well as a key gene RHOT1 involved in insulin secretion.
Researchers have discovered how plants pass along chemical markers that instruct cells on using DNA codes, a process known as epigenetic inheritance. The study reveals the role of protein DDM1 in making way for enzymes that add regulatory marks to new DNA strands, preserving genetic controls across generations.
A recent study has found that impaired histone inheritance accelerates breast cancer growth and metastasis by disrupting the epigenetic state of cells. This disruption leads to the reactivation of genes associated with development, promoting tumor progression.
A recent study found that American children are experiencing higher rates of autism and attention deficit/hyperactivity disorder, with special education services increasing by 10.4%. Poor nutrition and heavy metal exposure, particularly in ultra-processed foods, are thought to be primary epigenetic factors contributing to the developme...
Research found that male rats exposed to ifosfamide during adolescence had offspring and grand-offspring with increased incidence of diseases, including kidney and testis problems. The study's epigenetic analysis revealed changes passed down through sperm and ova, indicating a potential risk for future generations.
A new study by UC Santa Cruz researchers demonstrates 'transgenerational epigenetic inheritance,' where epigenetic marks are transmitted from parents to offspring and grandoffspring. This can lead to altered gene expression patterns in tissues, affecting health and development.
A recent study suggests that epigenetic information, normally reset between generations, is more frequently carried from mother to offspring than previously thought. This discovery could have implications for women with SMCHD1 variants and their children.
Researchers have identified the Xist gene as a critical regulator of fetal development in mice, leading to miscarriage and abnormal placentas when epigenetic instructions are missing. The study's findings suggest that failed Xist imprinting can be 'cured' by targeting specific genes involved in histone modifications.
A team of researchers has discovered a novel epigenetic mark in bdelloid rotifers, small freshwater animals, that allows them to control jumping transposons. This marks the first time a horizontally transferred gene has reshaped the gene regulatory system in a eukaryote.
Researchers found that epigenetic inheritance can affect the genetic composition of a population for multiple generations. Exposure to high temperatures accelerated the rate of evolution, increasing the spread of genes through mating.
A new study found that pollutants can be transmitted over many generations in water fleas, persisting long enough to influence the evolutionary process. The effects of low doses of pollutants were detected even after switching to clean water, indicating stable epigenetic marks passed down through generations.
Researchers found that stressed worms produce more sexually attractive offspring by transferring small RNAs, which influence gene expression. This epigenetic inheritance allows the trait to persist across generations without DNA changes.
A study at Tampere University identified a link between foetal DNA methylation and adult health, particularly glucose and lipid metabolism. The research found that individuals with specific genetic expressions had lower insulin levels and higher cholesterol levels in adolescence.
Research at the University of Turku found that a father's childhood stress exposure is connected to faster white matter tract development in his child's brain. The study suggests potential epigenetic inheritance of this trait.
Researchers at KAUST found evidence of intergenerational transfer of DNA methylation patterns in corals, which could help develop new strategies for coral conservation. The study suggests that chronically stressed corals can pass on epigenetic changes to their offspring, potentially increasing resilience to climate change.
Researchers from the University of Bath have conducted double-blind experiments showing that healthy mice pups can be born from sperm without acquired short RNA chains, challenging a proposed mechanism of epigenetic inheritance. The study undermines claims made by two 2018 papers that reported RNA addition was necessary for fertility.
Princeton researchers found that learned avoidance behavior in C. elegans can be inherited for multiple generations through the germline, with the behavior remaining elevated for up to four generations before returning to normal levels. This study provides new insights into transgenerational epigenetic inheritance and its potential rol...
Researchers have demonstrated that epigenetic information carried by parental sperm chromosomes can cause changes in gene expression and development in the offspring. Epigenetic changes involve chemical modifications to either the DNA itself or to the histone proteins with which DNA is packaged in the chromosomes.
Scientists identify epigenetic marker and genes that cause heart failure in fruit fly offspring, even when fed a normal diet. Reversing the epigenetic modification or over-expressing these genes protects subsequent generations from negative heart effects.
Researchers from the University of Cambridge found that epigenetic marks are reprogrammed from one generation to the next, contradicting previous theories. Only a small percentage of variably-methylated transposable elements showed evidence of epigenetic inheritance.
Researchers found that physical and mental exercise improves learning ability and reduces disease risk in mice, with the effect being passed on to the next generation through epigenetic inheritance. The study identified two microRNA molecules, miRNA212 and miRNA132, as responsible for this inherited learning capacity.
Researchers found that impaired DNA replication can lead to genome-wide epigenetic changes, resulting in the inheritance of new gene expression states for up to five generations. These epigenetic alterations establish new gene expression patterns that can be passed down through multiple generations.
Researchers at Max Planck Institute of Immunobiology and Epigenetics found that epigenetic marks passed from mother to embryo are essential for embryogenesis. These marks, such as H3K27me3, regulate gene expression and can be inherited through generations.
Researchers are studying tiny roundworms to understand how grandparents' diets and experiences affect their grandchildren's health. The study aims to create a detailed map of epigenetic markings and explore the consequences of inherited epigenetic information.
A new Tel Aviv University study reveals the rules that dictate which epigenetic responses will be inherited, and for how long. The research identifies specific genes, called MOTEK, that control the inheritance of epigenetic information.
Research in rats reveals that stress experienced by mothers, grandmothers, or even great-grandmothers can lead to shorter pregnancies and higher glucose levels in their offspring. The study's findings suggest a potential link between inherited epigenetic effects and preterm birth risk.
Researchers identify machinery of epigenetic inheritance, a process by which traits are passed between generations without DNA sequence changes. The discovery reveals that chemical marks on chromatin serve as molecular memory, allowing cells to recognize and remember to silence specific genes in each new generation.
Researchers discovered a mutation in a gene can impact offspring and subsequent generations with developmental abnormalities, epigenetic changes, and severe health effects like spina bifida. Folate fortification programs have reduced the risk but not eliminated health problems.
A study by the University of Cambridge reveals that folic acid deficiency not only affects immediate offspring but also has detrimental health effects on subsequent generations. Researchers found that epigenetic changes caused by a specific gene mutation led to developmental abnormalities in great, great grandchildren.
Research finds that exposure to certain plastics and hydrocarbons can cause reproductive diseases and obesity in descendants, leading to epigenetic inheritance. The study identifies nearly 200 molecular markers for exposure and disease, paving the way for diagnostic tools and new therapies.
Research reveals mechanism of epigenetic reprogramming and how it may affect gene expression, potentially leading to disease susceptibility in offspring. The study found that some methylation marks can escape reprogramming and be passed on to offspring.
Researchers at Cold Spring Harbor Laboratory discovered that small RNAs guide epigenetic modifications of DNA in plants, allowing for inherited traits and influencing cross-breeding practices. This finding has important implications for agriculture and crop selection.
A Tel Aviv University researcher warns that environmental stressors like pollution and stress can alter gene expression in a way that affects the human genome. This epigenetic inheritance can be passed down to future generations, with potential long-term impacts on health.
The study found that non-genetic variation acquired during an organism's life can be passed on to offspring through epigenetic means, affecting traits such as eye outgrowths and reproductive hormones. This phenomenon has significant implications for the study of evolution, heredity, and development.
Epigenetic modifications, such as DNA methylation and DNA packaging, can be inherited and affect gene expression. Recent studies in mice and rats have shown that early nutritional environment and behavioral experiences can influence epigenetic marks, which can be 'remembered' in cell divisions.
A new genetic hypothesis proposes that most cases of autism can be explained by a complex model for genetic malfunction, involving both inherited and de novo genetic factors. The study suggests epigenetic components, including genetic imprinting, play a major role in the etiology of autism.