Articles tagged with Gene Transcription
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Penn State will investigate ways to stimulate muscle growth by increasing ribosome production. Their goal is to find molecular targets that can be used to promote muscle growth without exercise or drugs. This study aims to prevent muscle loss due to aging, cancer, and other chronic diseases.
A UMass Chan clinical trial demonstrates the safety and efficacy of an antisense oligonucleotide in suppressing mutant C9ORF72, a common cause of familial ALS. The treatment led to reduced levels of neurotoxins and stable or improved ALS functional scores.
Researchers from the University of Tsukuba found that the FoxO-KLF15 axis regulates macronutrient metabolism in the liver in response to changes in insulin levels. This pathway promotes the conversion of protein to carbohydrate and prevents the conversion of carbohydrate to fat during fasting, but shuts down during feeding.
Researchers discovered a microRNA, miR-766-5p, that targets super-enhancers and reduces MYC expression in cancer cells, inhibiting growth rates. The study suggests this molecule could be used as an anti-cancer therapeutic to fight MYC-driven cancers.
Researchers have identified five Bacillus strains with antibiotic ability against the deadly Fusiarium wilt TR4 fungus, which is threatening global banana production. The study found that these strains can trigger direct or indirect antagonism on the fungus, providing a new biocontrol method to combat TR4.
A new protein, UAD-2, has been identified as essential for the genesis of piRNAs in Caenorhabditis elegans. The protein and its associated complex colocalize with histone marks in the nucleus.
Researchers studied age-related changes in kidney function, combining protein analysis with gene transcription. They found that aging kidneys have increased immune cells, inflammation, and decreased mitochondrial energy production. This suggests that therapies promoting protein building or slowing breakdown may help treat age-related k...
A recent study published in Cell Reports reveals that DNA supercoiling is involved in regulating gene expression, rather than being just collateral damage. The researchers found that specific genes are massively activated in response to stimuli, and topoisomerase TOP2A plays a crucial role in this process.
Researchers identified key gene networks controlling sugar and organic acid metabolism in watermelon fruit, shedding light on its sensory quality. The study's findings have important implications for improving watermelon breeding levels in China and the development of the watermelon industry.
A preclinical study by University at Buffalo researchers has identified new genes that could be key therapeutic targets for treating Alzheimer's disease. The study found that inhibiting certain enzymes involved in abnormal gene transcription can reverse memory deficits associated with the disease.
Researchers will investigate chromatin organization within cells and how it changes over time to identify disease targets. The study aims to develop navigable maps of chromatin architecture across multiple cell types, enabling new treatments for a range of diseases.
Sperm cells activate 90% of their genes, a pattern seen in other species, to repair DNA before passing it to the next generation. This process may influence the evolution of specific genes, with unexpressed genes containing fewer DNA code errors.
Historians have picked 500 favourite cases from the astrologers' notes, providing a unique insight into health and fertility concerns, bewitchment fears, and sexual desires of thousands of lives lost to history. The transcribed casebooks offer a trap door into the arcane archive of magic and medicine.
A new study found that court reporters transcribed African American English 82.9% accurately, falling short of the 95% requirement. This discrepancy can impact trial outcomes due to potential miscomprehension by jurors and judges.
Researchers uncovered a crucial quality-control mechanism inside cells that fails when contributing to major diseases including cancers. The discovery found an enzyme called casein kinase II adds molecular tags onto Spt6, a key protein in transcription, preventing inappropriate transcription.
A study found that HIV latency differs between the gut and blood, with unique mechanisms governing transcription in each. This discovery could inform new therapies aimed at curing HIV.
A team of University of Tsukuba researchers uncovered the essential role of a specific gene region in regulating blood pressure homeostasis. By deleting certain regions of the renin gene, they found that one particular region, known as -5E, plays a crucial role in the basal expression of the gene.
Researchers found that B2 RNA interacts with EZH2 enzyme to activate heat-shock genes and induce the cellular response to stress. The study reveals a new mechanism for EZH2 to activate genes outside of its typical PRC2 complex.
A study published in PLOS Biology shows that multiple mechanisms regulate expression of genes from the single X chromosome in Drosophila testes, reflecting a balance between chromosome-wide transcriptional suppression and compensatory evolution by sex-linked genes. This balance has consequences for gene expression and genome evolution.
The study found almost double the number of differentially expressed heart and liver genes in translation compared to transcription. This discovery sheds light on the genes and regulatory pathways underlying disease, offering new avenues for research.
Researchers at the Gladstone Institutes have identified a unique change in protein structure that guides the production of RNA from DNA. The study sheds light on key aspects of transcription, including polymerase pausing and acetylation, which are crucial for precise transcription and cellular processes.
Volunteers are transcribing decades-old pen strokes from historic log entries to add to the climate record, revealing past weather and climate patterns. The project aims to provide valuable data for scientists studying the Arctic's dramatic melt back.
The study reveals that inhibitory Smads bind directly to their targets without requiring phosphorylation, constituting a crucial step in the regulation of gene transcription. This discovery sheds light on how organisms achieve balance between TGF-beta signaling pathways, critical for maintaining tissue and organism health.
A new study in Canada found that breast imaging reports generated with automatic speech recognition (ASR) systems have a higher error rate compared to conventional dictation transcription. At least one major error was found in 23% of ASR reports, while 4% of conventional reports contained errors affecting patient management.
A new collaborative research center aims to study the diversity of Arabic manuscripts from a historical and comparative perspective. The project, led by Prof. Dr. Tilman Seidensticker, will analyze nine layout characteristics to understand their functions in everyday transcriptions.
A team of European researchers has generated a comprehensive digital gene expression atlas for the developing mouse embryo, revealing tissue-specific and overlapping gene networks. The atlas includes data for over 15,000 genes in hundreds of anatomical structures and provides insight into developmental processes.
Researchers at The Wistar Institute have discovered a new class of long non-coding RNA molecules that function like gene enhancer elements, promoting gene expression and potentially accounting for unknown genomic activity. This breakthrough joins a growing body of evidence challenging the central dogma of genetics.
A new study by University of Washington professor Virginia Berninger found that children can write more and faster with a pen than a keyboard for essay composition. Children consistently produced longer essays and composed them at a faster pace when using a pen.
Researchers have developed cells that can count up to three cellular events, mimicking computer chips with simple circuits. The RTC Counter uses a series of genes activated in a specific order, while the DIC Counter stores digital memory by encoding 'bits' of information.
Chromosomes in the cell nucleus exhibit directed, long-range movement that depends on actin and myosin, contradicting earlier theories on gene location. The study reveals a mechanism for actively moving chromosomes between the periphery and interior of the nucleus.
Researchers used acoustic measurements to recognize differences in vowel pronunciation among 160 Dutch and Flemish teachers. The study found that acoustic methods can map sociological differences in pronunciation with high accuracy, outperforming phonetic transcription methods which require manual expert analysis.
Researchers found that certain proteasome proteins, Sug1 and Sug2, are involved in gene activation when genes are turned on. This discovery challenges conventional wisdom and could lead to a better understanding of human development and disease causes.