Articles tagged with Transcriptomics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed PASTE, a method to analyze spatial transcriptomics data in three dimensions, enabling biologists to better understand cell environments and identify rare cell types. The technique can integrate information from multiple tissue slices, providing a more complete picture of gene expression within tissues.
An international team led by BGI-Research has produced the first spatiotemporal maps of cellular dynamics in mice, Drosophila, zebrafish, and Arabidopsis using Stereo-seq technology. This breakthrough enables scientists to analyze the distribution and placement of molecules and cells in situ and over time.
The study provides a single-cell transcriptome map of 45 tissues and organs from long-tailed macaque monkeys, identifying 113 major cell types. This will improve the ability to pinpoint how to develop potential treatments for human diseases with greater precision.
A UT Dallas team analyzes how pain is generated by nociceptors in human dorsal root ganglia neurons using spatial transcriptomics. This provides neuroscientists with a better understanding of which genes are expressed in DRG neurons, helping to clarify why proposed treatments struggle to produce results in humans.
Researchers will use transcriptomics and chemogenetics to identify molecular targets for pain management. The project aims to advance knowledge on pain mechanisms and develop novel therapeutic strategies.
Researchers have revealed mechanisms by which polyps develop into colorectal cancer, setting the stage for improved surveillance utilizing precision medicine. The study found that serrated polyps derive from metaplasia, an abnormal change of cells into non-native tissue.
Researchers found hundreds of genes awaken in human one-cell embryos, remaining active until the four-to-eight cell stage. The study's findings could illuminate events that initiate cancer and provide new diagnostic opportunities.
A study found that spaceflight alters liver gene expression and reduces antioxidant capacity in mice, leading to increased oxidative stress. However, exposure to artificial gravity can mitigate some of these effects, suggesting potential for dietary supplementation to offset changes during spaceflight.
A team of researchers has reconstructed the evolutionary history of dragonflies and damselflies, determining when they first emerged around 200 million years ago. The study provides the most comprehensive divergence time estimates for Odonata to date.
Researchers create maps of senescence in heart and lung cells, comparing different types of senescent cells across the lifespan. The goal is to understand how senescent cells contribute to age-related diseases and develop therapies called senolytics.
Researchers at University of Pittsburgh and Prairie View A&M University developed an algorithm to repurpose cancer drugs for pulmonary hypertension, a devastating lung disease. Two compounds improved human cells and rodent markers, supporting broader drug-repurposing platform use.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
A comprehensive molecular map of lung squamous cell carcinoma has identified potential new drug targets, including the gene NSD3, and highlighted immune regulation pathways that could help cancer evade immunotherapies. The study's findings have also revealed metabolic dysregulation and crosstalk between different cellular processes.
Researchers mapped the molecular mechanisms of primate hippocampal aging, identifying key cell types and molecules affected by age. The study provides a valuable resource for diagnostic biomarkers and therapeutic targets for neurodegenerative diseases.
Researchers identified microglia as key cell type responsible for brain changes in OUD, revealing a critical role for neuroinflammation in driving pathological alterations. The study also uncovered new mechanisms by which opioids alter brain structure and function, leading to behavioral changes.
Researchers discovered RNA editing events in lung adenocarcinoma and identified a new molecular subtype EC3 with the poorest prognosis. A simplified prediction model using eight RNA editing sites accurately distinguishes this subtype, which is associated with sensitivity to specific chemotherapy drugs.
The conference aims to share experience in developing and applying bioinformatics algorithms, with topics including sequencing technologies, molecular sequence analysis, and genome assembly. Selected abstracts will be published as part of the BiATA 2021 BMC Bioinformatics supplement.
A new method called ACME has revolutionized single-cell transcriptomic technologies by enabling accurate cell fixation and dissociation without causing cell stress. This allows scientists to study thousands of individual cells from living organisms, one-by-one, and sequence each cell's genetic material.
Researchers at OIST Graduate University have identified previously unknown sections of DNA that are silenced by epigenetic regulation in plant cells. The study reveals a crucial role of these sites in suppressing the activity of disruptive 'jumping genes' called transposons, which can threaten genome integrity.
A study reveals the three-dimensional genomic structure of male germ cells, showing a fine-tuned balance between chromatin remodelling and architectural proteins. This structure determines gene expression in these cells, which are essential for reproduction.
A new study compared traditional Illumina platforms to an alternative BGISEQ-500 short-read sequencing platform for single-cell transcriptomics. The authors found that BGISEQ-500 was highly comparable in sensitivity, accuracy, and reproducibility of detected RNA molecules.
The ATS Foundation/Boehringer Ingelheim Pharmaceuticals, Inc. Research Fellowship in Idiopathic Pulmonary Fibrosis aims to advance understanding of the disease through single cell transcriptomic analysis.
Researchers at EPFL discovered that different TFs vary greatly in their ability to scan the genome, with some being highly efficient while others are less effective. The study found that TFs that associate with mitotic chromosomes are more efficient in finding specific binding sites and regulating gene expression.
Researchers from the Luxembourg Institute of Health uncover distinct microglial signatures in response to acute inflammation, highlighting potential benefits for resolving inflammation. Their single-cell transcriptomic study provides new resources for understanding brain disorders and developing novel therapeutic strategies.
The Biogerontology Research Foundation and collaborators announce the development of a novel approach to analyzing transcriptomic data sets, titled iPANDA. The system applies deep learning algorithms to identify patient-specific pathway signatures associated with breast cancer patients.
Researchers at Gladstone Institutes found that three transcription factors -- NKX2-5, TBX5, and GATA4 -- must interact for proper heart development. Without these interactions, severe congenital heart defects occur. The study revealed the proteins' genomic and physical interactions, providing new insights into treating heart disease.
The MD Anderson Cancer Center has been selected as a Genome Characterization Center to analyze patient samples from multiple NCI programs. The center will focus on functional proteomics, enabling the study of protein expression and modification in cancer tumors.
Researchers developed a novel approach to deciphering gene regulation networks by leveraging biological knowledge and computational algorithms. They found that combining laboratory experiments with motif information can accurately predict DNA-binding behavior of transcription factors.
Scientists have discovered a new role for Dicer in preventing genome damage caused by collisions during DNA replication. The protein helps free transcription machinery from DNA, preserving the integrity of the genome. This discovery may help explain why mutations in Dicer are associated with increased risk of cancer and aging.
Researchers have developed a protocol for collecting saliva and stool samples for genomic and transcriptomic analyses, eliminating the need for specialized personnel and facilities. This method provides critical insight into the genetic makeup of the microbiome and its association with diseases such as celiac disease, oral cancer, and ...
Bing Ren has been awarded the distinction of Fellow by the American Association for the Advancement of Science (AAAS) for his outstanding contributions to genome-wide analysis and understanding of human disease. He is a member of the Ludwig Institute for Cancer Research and has directed various projects, including the Roadmap Epigenome...
The ENCODE project has published a series of articles annotating the functional elements in the human genome, revealing new information on pseudogenes and regulatory elements. The study's findings are now freely available online as part of BioMed Central's open access policy.
Scientists have identified how E. coli O157:H7 colonizes fresh-cut lettuce, providing new insights for food safety. The bacteria breaks down leaf cells, releasing carbohydrates and antimicrobial compounds that can be used as energy sources.
Researchers at UCSD have made a breakthrough discovery that enables the experimental annotation of genomes. By combining multiple genome-scale measurements, they can identify the location and use of genomic elements with precision. This innovation has significant implications for metabolic engineering, disease research, and drug design.
The FANTOM4 consortium has published several milestone papers in Nature Genetics and BioMed Central journals, providing new data on genomic regulatory blocks and chromatin conformation signatures. These findings have the potential to revolutionize our understanding of gene regulation and cell differentiation.
The launch of BioMed Central's Genome Medicine journal marks a significant milestone in the field of personalized medicine. The journal will focus on the latest technologies and findings impacting human health and disease, covering topics such as genomics, epigenetics, and computational approaches to disease management.
Researchers discovered a positive role for gene recruitment to the nuclear periphery, with significant implications for cell polarity and development. The study's findings suggest a complex interplay between nuclear organization and transcriptional regulation.
The study reveals that antisense transcripts (SATs) are widely expressed in various mouse tissues and cell cultures, exhibiting tissue-specific expression patterns. SATs tend to be poly(A)-negative and enriched in the nucleus, suggesting a functional role in gene regulation.
The Neisseria meningitidis genome contains hundreds of repetitive elements that facilitate genome fluidity and antigenic variation. The most abundant element is the neisserial DNA uptake sequence, which enables transformation among different species.
Dr. Julie R. Korenberg's comprehensive map integrates three ways of looking at the human genome, marking critical points with fluorescent signposts for rapid translation of clinical problems into genome-based solutions. The guide has significant practical applications in cancer treatment and genetic diagnosis.
A recent University of Georgia study suggests that retroviruses, including HIV, may have an ancient origin. Researchers analyzed the genome of a worm called Caenorhabditis elegans and found evidence of retroviral-like elements in its DNA. This finding challenges previous assumptions about the evolution of complex retroviruses.