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SMART researchers uncover novel bacterial communication system to combat antimicrobial resistance

A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.

SourceSingapore-MIT Alliance for Research and Technology (SMART)·JournalNature Communications·TypeExperimental study·DateJul 19, 2023

Study identifies a protein that could be a target for a vaccine against spotted fever

Researchers at the University of São Paulo identified a protein in Amblyomma ticks essential to their survival while feeding, making it a promising target for developing a vaccine. The study found that silencing gene expression of an inhibitor of apoptosis protein reduced bacterial proliferation and made ticks more resistant to infection.

Research project analyzes medical, nutritional and environmental applications of new Antarctic bacteria

Researchers discovered two new psychrophilic species of bacteria with cold-adapted enzymes, which can be used in biotechnology to produce refrigerated foods, improve detergent quality, and remove pollutants from cold environments. The study was conducted in collaboration with Uruguayan scientists and supported by FAPESP.

How an ocean-fertilising bacterium forms aggregates

Researchers discovered that Trichodesmium filaments form aggregates through a simple behavioural strategy, controlling density and light penetration. This mechanism enables the formation of visible aggregates with unique shapes, providing essential nutrients for other marine organisms.

SourceETH Zurich·JournalScience·TypeObservational study·DateMay 25, 2023

Nature favors creatures in largest and smallest sizes

A study by McGill University and University of British Columbia found that the planet's biomass is concentrated in organisms at either end of the size spectrum. The researchers discovered a universal upper limit for maximum body size across multiple species and environments, with similar sizes reached by trees, fish, and other organisms.

SourceMcGill University·JournalPLOS ONE·TypeData/statistical analysis·DateMay 10, 2023

Study finds stool transplants more effective than antibiotics for treating recurring, life-threatening gut infections

A new Cochrane Review found that stool transplantation can increase the number of people recovering from Clostridioides difficile (C. diff) infection by 77%, compared to 40% with standard antibiotic treatment. The study also showed a decrease in side effects with stool transplantation.

SourceCochrane·JournalCochrane Database of Systematic Reviews·TypeSystematic review·DateApr 24, 2023

Scientists identify compounds that reduce the harmful side effects of antibiotics on gut bacteria

Researchers identified protective drugs that shield two abundant gut bacterial species without compromising antibiotic effectiveness against disease-causing bacteria. The study found a novel combination of antibiotics with antidote drugs, such as dicumarol and tolfenamic acid, which protected the gut microbiome and maintained antibioti...

Boosting survival of a beneficial bacterium in the human gut

A Yale study found that beneficial gut bacterium Bacteroides thetaiotaomicron responds to starvation for carbon by sequestering essential transcription factor in membrane-less compartment, increasing its activity and modifying gene expression. This mechanism enables colonization of mammalian gut and reveals a vital strategy for

SourceYale University·JournalScience·DateMar 17, 2023

Journal of Pharmaceutical Analysis studies explore key traditional and modern therapeutics

Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...

SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateFeb 14, 2023

Myalgic encephalomyelitis/chronic fatigue syndrome is associated with distinct changes in the microbiome and gut metabolites

Two studies reveal that ME/CFS is associated with reduced levels of butyrate-producing microbes and differences in gut metabolites. Researchers found distinct changes in the microbiome of patients with short-term and long-term ME/CFS, suggesting a potential link between gut dysbiosis and the disease's severity.

SourceCell Press·JournalCell Host & Microbe·TypeExperimental study·DateFeb 8, 2023

Harmful bacteria can elude predators when in mixed colonies

A study by Dartmouth College researchers found that bacteria can form protective clusters with rival species, making it harder to kill harmful bacteria. This discovery highlights the importance of studying multispecies biofilm structures and may impact the development of bacteriophages and predatory bacteria as antimicrobial alternatives.

SourceDartmouth College·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 2, 2023

Genomic methods aid study of Seattle 2017-2022 Shigella outbreak

A genomic study of the Seattle 2017-2022 Shigella outbreak revealed its origin as international travelers from areas where Shigella was common. The study also found that multi-drug resistant Shigella has become a growing global health concern, primarily affecting men who have sex with men and those experiencing homelessness.

SourceUniversity of Washington School of Medicine/UW Medicine·JournalThe Lancet Infectious Diseases·TypeObservational study·DateJan 31, 2023

Portland State study discovers immense diversity and interdependence in high temperature deep-sea microorganism communities

A new study by Portland State University researchers found that deep-sea microorganisms thrive in high-temperature environments and exhibit a staggering level of diversity, with over 500 new genera discovered. The microbes also rely on each other for survival through metabolic handoffs, revealing a complex interdependence.

SourcePortland State University·JournalMicrobiome·TypeData/statistical analysis·DateJan 23, 2023

Study finds microbiota transfer therapy provides long term improvement in gut health in children with autism

A new study by Arizona State University researchers found that microbiota transfer therapy significantly improved the abundance of beneficial bacteria and normalized altered bacterial gene expression in children with autism. The treatment showed substantial increases in populations of beneficial bacterial species and improvements in ge...

SourceArizona State University·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateDec 13, 2022

COVID-19 virus increases risk for other infections by disrupting normal mix of gut bacteria

A new study found that COVID-19 infection directly interferes with the healthy balance of microbes in the gut, further endangering patients. The research revealed that antibiotic-resistant species can escape into the bloodstream, putting patients at greater risk for life-threatening secondary infections.

SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNature Communications·TypeExperimental study·DateNov 1, 2022