Articles tagged with Gram Negative Bacteria
A component of bacteria's cell walls, cardiolipin, may hold the key to fighting antibiotic-resistant microbes. Without it, the outer membrane becomes penetrable, making bacteria vulnerable to antibiotics.
Scientists have discovered a natural inhibitor of topoisomerases II that can combat fluoroquinolone-resistant gram-negative bacteria. Nybomycin, a 'reverse antibiotic,' blocks the gyrase enzyme, rendering it effective against strains previously resistant to other antibiotics.
A recent study reveals that international travellers are highly susceptible to virulent strains of drug-resistant bacteria, often acquiring multiple types during a single trip. Researchers found that 70% of European volunteers colonised with MDR-GN bacteria, highlighting the need for improved infection control measures.
Researchers studied bacterial predation behavior in Myxococcus xanthus, revealing a mix of direct contact and protein-based killing methods to tackle different prey types. The findings provide insights into dynamic interactions in bacterial communities, paving the way for future antibacterial strategy development.
A new method was developed to investigate how Helicobacter pylori locates its target in the stomach. The technique successfully reported the probability of clockwise rotation in H. pylori and showed similarities with E. coli's flagellar control mechanism. This could lead to better understanding of chemotaxis and potential dietary inter...
Researchers at the University of Queensland have discovered that synthetic cannabidiol can kill certain types of bacteria responsible for serious infections. The study's findings suggest that cannabidiol could lead to the development of new antibiotics, which would be a major breakthrough in combating antibiotic resistance.
Researchers discovered a novel mechanism by which mycolic acid-containing bacteria form diverse types of membrane vesicles in response to DNA damage and envelope stress. This finding provides insight into the mechanisms of membrane vesicle formation, which could be helpful for developing novel therapeutics or vaccines.
Wistar scientists have discovered a new class of compounds that combine direct antibiotic killing with a rapid immune response to combat antimicrobial resistance. These dual-acting immuno-antibiotics target an essential bacterial pathway and stimulate the adaptive immune system, showing promise in treating pan drug-resistant infections.
Researchers at Princeton University have identified a new protein involved in the assembly and maintenance of the outer membrane of Gram-negative bacteria. The discovery sheds light on the complex process of transporting phospholipids between membranes, a critical step in preventing bacterial infection.
Researchers at NUST MISIS have developed antibacterial nano-coatings based on boron nitride that are highly effective against microbial pathogens, including up to 99.99% efficacy against E. coli bacteria. The coatings work by releasing the antibiotic gentamicin locally, reducing the need for high doses and minimizing side effects.
Researchers found a link between gram-negative bacteria and cerebral cavernous malformations, which can cause hemorrhagic strokes, seizures, or headaches. The study showed that gut bacteria from CA patients produced more lipopolysaccharide molecules, driving CA formation in mice.
A Princeton team has discovered a compound, SCH-79797, that can target both Gram-positive and Gram-negative bacteria without inducing resistance. This breakthrough could lead to the development of new, effective antibiotics against antibiotic-resistant superbugs like MRSA and Neisseria gonorrhoeae.
A new study found patients with cavernous angioma have distinct gut microbiomes compared to healthy individuals. The imbalance of bacteria produces lipopolysaccharide molecules that cause brain lesions.
Researchers at the University of Leeds have discovered a key mechanism in how bacteria build their outer wall, potentially leading to new antibiotic therapies. The study focused on gram-negative bacteria Escherichia coli and found that disrupting this process could destroy or slow bacterial growth.
Researchers at the University of Bristol identified new mechanisms by which nanopillar structures kill bacteria, including cell impedance and oxidative stress. This breakthrough aims to develop antimicrobial surfaces for biomedical applications, such as medical implants and devices.
Researchers identified a novel L-fucose metabolic pathway in Veillonella ratti, which encodes enzymes for a previously unknown non-phosphorylating L-fucose pathway. The study also discovered another L-2-keto-3-deoxyfuconate aldolase involved in the same pathway in Campylobacter jejuni.
Researchers have identified cannabigerol (CBG) as a potent antibacterial agent against methicillin-resistant Staphylococcus aureus (MRSA). CBG targets the cell membrane of gram-positive bacteria, showing promise in treating MRSA infections.
Researchers at RMIT University have developed a new technology to destroy bacteria and bacterial biofilm without harming good cells, offering a potential solution to the deadly problem of antibiotic resistance. The technology uses precision-engineered liquid metals to physically rip bacteria to shreds and smash through the biofilm wher...
Certain bacteria, such as Shigella, use lipopolysaccharides to block caspases and prevent apoptosis, allowing them to multiply intracellularly. This strategy is essential for their survival and spread within the human body.
Researchers developed a free online app, eNTRyway, to speed up the discovery of new antibiotics for Gram-negative bacteria. The tool quickly evaluates potential drug compounds and can convert existing drugs into potent killers of Gram-negative pathogens.
Researchers have developed a new assembly that enhances photodynamic inactivation of bacteria, achieving significantly improved efficiency against gram-negative E. coli. The assembly combines a photosensitizer and a membrane-intercalating peptide, resulting in nearly 0% survival rate of E. coli upon light irradiation.
Researchers at Baylor College of Medicine discovered that amoebae build a barrier around their colonies to counteract bacterial attacks. The protein CadA enables the amoebae to recognize specific species and adapt to survive, forming clumps with Gram-negative bacteria and allowing for feeding on the edges.
A recent study by the University of Birmingham has identified a key pathway involved in protecting bacteria against antibiotics. The researchers discovered that phospholipids are transported towards the outer membrane through a series of proteins, which could lead to the development of new antibiotic treatments.
Scientists at Emory Health Sciences have found that combining certain antibiotics can effectively target and defeat bacteria with heteroresistance, a previously underappreciated form of antibiotic resistance. This approach may offer a new strategy for treating resistant infections in hospitalized patients.
Scientists at the University of Sheffield have discovered a new compound that kills antibiotic-resistant gram-negative bacteria, including E. coli. The compound's unique properties make it difficult for resistance to emerge in the bacteria, paving the way for new treatment options.
Dr. Ana Rita Brochado's research focuses on gram-negative bacteria, which are difficult to treat due to their complex cellular envelope. Her work has shown that certain bacterial strains can be effectively combated using antibiotic combinations and food compounds, like vanillin.
A team of researchers at POSTECH has developed a fluorescent probe called BacGo that can detect Gram-positive bacteria precisely and promptly. The probe is more sensitive than the traditional Gram staining method, which has several limitations, including slow detection and limited selectivity against Gram-positive bacteria.
Bacteria can create a wide range of derivatives from simple basic structures through mechanisms similar to pharmaceutical research. This diversification allows them to counteract unknown competitors and exhibit a wide range of biological activity.
Gram-negative bacteria's outer membrane is constructed with lipopolysaccharide (LPS) using an integral machine that builds each bacterium's powerful protection. Researchers have discovered how LPS gets to the outer membrane, including a protein bridge and ATP shuttling mechanism.
Researchers at Binghamton University discovered how a Gram-negative bacterium delivers toxins that make us sick. The study found that the communication molecule inserts itself into the membrane to physically stimulate vesicle production, which contains highly concentrated toxins.
A team of researchers isolated a peptide named emericellipsin A from soil fungi, which possesses antitumor and antibacterial properties. The substance was proved to be effective against various types of bacteria and fungi, including those resistant to other antibiotics.
Researchers found natural antibiofilm and antimicrobial peptides in bacteria, fungi, and yeast that can treat infections. The APD3 database reported 333 bacteriocin and peptide antibiotics with varying amino acid lengths and structures.
A new bacterial imaging probe has been shown to be safe for patient use and can detect deadly pneumonia infections in under 60 seconds. This technology uses chemical probes that light up when they attach to specific types of infectious bacteria, allowing for real-time detection and monitoring.
A team of scientists developed a fluorescent imaging probe that can rapidly visualize Gram-negative bacteria in human lungs. The probe successfully detected bacterial lung infections in six patients with bronchiectasis and seven ventilated ICU patients without causing major adverse effects.
Gram-negative bacteria build their outer membrane using a glycolipid called lipopolysaccharide (LPS), which can be weakened by preventing its transport. Researchers in the Kahne Lab have developed a quantitative method to monitor LPS transport rates, revealing crucial new details about its molecular mechanisms.
Engineers at UCR have created gold nanobeads with spiky and hollow structures by modifying the M13 bacteriophage virus. The discovery could lead to more efficient production of electronic components and new applications for wastewater treatment.
Researchers have discovered that the outer membrane of bacteria like E. coli can act as a strong physical barrier protecting the cell, making it a potential target for new antibacterial drugs. This finding suggests a new approach to fighting infections in roughly half of all bacterial species.
Researchers discovered a carbapenem-resistant, hypermucoviscous Klebsiella pneumoniae isolate with enhanced virulence and colistin heteroresistance from a patient in the US. The bacteria's increased virulence poses a significant threat to healthcare settings.
A new study found that salivary RNA can regulate oral bacteria growth, influencing diseases such as periodontitis. The research discovered a channel of communication between RNA messengers and bacteria in the mouth.
Researchers explore the role of diverse bacteria in common urologic diseases affecting children, including urinary tract infections and urge urinary incontinence. Probiotics and dietary modifications show potential to prevent or treat these conditions.
Researchers have discovered a key member of the SEDS protein family, RodA, which builds bacterial walls. Altering its structure can disrupt this function, making it an attractive target for new antibiotics.
Researchers developed a monoclonal antibody targeting BamA in Gram-negative bacteria, inhibiting its function and compromising outer membrane integrity. The treatment shows promise for developing therapeutics against these bacteria.
Researchers at VIB have devised a novel approach to develop antibacterial drugs using protein aggregation technology, which can effectively target Gram-negative bacteria like E. coli. The technology has shown strong antibacterial activity against these resistant bacteria and will be further explored by biotech company Aelin Therapeutics.
Research highlights graphene oxide's exceptional antibacterial properties, which differ from traditional antibiotics. The review emphasizes the importance of understanding structure-activity relationships and molecular initiating events to improve biosafety.
Researchers have shed light on the mechanism behind important proteins on N. gonorrhoeae's outer membrane, potentially leading to new antibiotics or a vaccine. The findings suggest that BamE could be a new vaccine target against N. gonorrhoeae.
Researchers have re-evaluated an overlooked antibiotic, increasing its effectiveness against extensively drug-resistant bacteria. Octapeptin showed superior antimicrobial activity to colistin against resistant Gram-negative bacteria.
Researchers found that increasing distance between bacterial membranes can block protective response, making them vulnerable to antibiotics. This new insight could lead to novel treatments and make currently available antibiotics more effective.
Researchers at Lund University developed a specially designed protein that targets and kills multiple bacterial species, including Gram-positive bacteria. The fusion protein works by removing Factor H from the surface of bacteria, activating the immune system to kill them.
The ASCB Celldance program premiered two new videos at the 2017 ASCB|EMBO Meeting in Philadelphia. The videos, created by Guillaume Duménil, Dyche Mullins, and Lillian Fritz-Laylin, visualize how pathogens invade the body and proliferate, as well as single cells crawling through complex environments.
A team of researchers from Newcastle University discovered the MlaA protein, which removes lipids from the outer membrane to increase permeability for toxic compounds. This process could be exploited by drugs to decrease bacterial virulence and enhance antibiotic effectiveness.
Researchers have found that bacterial cell wall constituents can cause abnormal clotting, leading to inflammation in Type 2 diabetes. A new treatment option involves using LPS-binding protein (LBP) to reverse this process, offering a new approach to treating the disease.
Researchers at the University at Buffalo have discovered a novel combination of aztreonam, amikacin, and polymyxin B that is capable of eradicating the deadly E. coli bacterium carrying mcr-1 and ndm-5 genes. The triple combination was found to eliminate the bacteria within 24 hours and prevent regrowth.
A novel LpxC inhibitor, LPC-069, has been shown to be effective in treating multi-drug resistant bacterial infections, including those caused by Yersinia pestis. The compound was found to have no serious side effects at high doses.
Wonpil Im's open-source biomolecular modeling tool CHARMM-GUI simulates bacterial membrane channels and transport of antibiotic molecules, supporting the fight against antibiotic resistance. Gram-negative bacteria's outer membrane poses a significant challenge to antibiotic penetration.
A hospital nurse's opioid diversion led to a cluster outbreak of Serratia marcescens bacteria, infecting five patients. The tampered syringes were linked to the outbreak, and the nurse was terminated.
Researchers at KFU's Structural Biology Lab have made significant breakthroughs in understanding Staphylococcus ribosomes using cryo-electron microscopy. This discovery holds great promise for developing new treatments against deadly infections, such as pneumonia and septicemia.
A study found that Lactobacillus parafarraginis isolated from commercial yogurt inhibited the growth of several multidrug-resistant bacterial pathogens. The bacteriocin-like peptide responsible for this inhibition is heat stable and may hold promise as a therapeutic agent.
A study in mice and humans suggests that intestinal bacteria can influence the structure of brain blood vessels, leading to stroke or epilepsy. Researchers found that eliminating bacteria reduced lesion formation, while a drug blocking TLR4 also showed therapeutic potential.
Researchers have developed a new method to generate diverse molecules that could serve as vaccine adjuvants, improving immunogenic response. The approach uses bacterial enzymatic combinatorial chemistry to create novel lipid A structures with potential adjuvant activity.
Researchers found that altering the gut microbiome may be an effective therapy for CCMs, a cerebrovascular disease causing stroke and seizures. Genetic variations affecting TLR4 signaling linked to higher numbers of CCM lesions.