Articles tagged with Salmonella
Scientists have engineered a nonpathogenic E. coli bacterium to carry a phage that specifically targets salmonella, resulting in a protective lining against infections. This breakthrough could lead to the development of new treatments for other diseases, particularly those with high global disease burdens.
Researchers found that macrophages and monocytes in the gut mesentery interact to prevent salmonella from spreading. Removing macrophages allows monocytes to flood the organ, highlighting the role of these immune cells in regulating tissue damage.
A new study from Ben-Gurion University of the Negev found that long-term Salmonella infections severely damage blood stem cells. However, researchers discovered that giving an effective course of antibiotics fully restores the stem cells' health and rebuilds their power.
A study of 6,165 Salmonella samples identified 128 types of toxins, including 45 previously unknown. The toxins act in competition among microorganisms and may inspire antibiotic development and biotechnological applications.
Researchers identified a defense mechanism in intestinal stem cells that actively responds to Salmonella infection, differentiating into antimicrobial Paneth cells to limit bacterial persistence. The study suggests that stem cell differentiation is part of an intrinsic protective program preserving intestinal function during infection.
Researchers have identified phage W5 as a safe and effective natural virus capable of eliminating harmful Salmonella on various foods and packaging materials. The study establishes a solid foundation for developing novel phage-based disinfectants or preservatives to combat antibiotic resistance and enhance food safety.
A new joint report from EFSA and ECDC highlights the ongoing threat of antimicrobial resistance in common foodborne bacteria such as Salmonella and Campylobacter. Despite some encouraging signals, progress has been limited, and continued action is essential to slow the emergence and spread of antimicrobial-resistant bacteria.
A Dartmouth study found that plasmids can form tight clusters within bacterial communities, making them resistant to antibiotics and clinical treatments. This phenomenon introduces a new avenue for bacterial infections to become more difficult to treat.
Researchers at University of Tsukuba discovered a regulatory small RNA, AdiZ, that directly negatively regulates genes involved in glucose uptake and glycolysis. This induction facilitates Salmonella's survival within macrophages by coupling acid resistance to metabolic reprogramming.
Researchers identified two antimicrobial peptides that can kill various types of Salmonella and reduce its load in chickens. The study's findings suggest these peptides could improve food safety and public health by mitigating antibiotic resistance.
A recurring seasonal outbreak pattern of Salmonella Strathcona cases has been identified in Europe since 2011, with small tomatoes from Sicily being the likely source. The investigation found that almost all cases were genetically related, suggesting a common source and food vehicle.
A Phase 1 clinical trial has successfully tested a new vaccine against typhoid fever and invasive non-typhoidal Salmonella, demonstrating strong immune responses in healthy adults. The vaccine triggered balanced immune defenses and showed potential for whole-body protection against Salmonella.
A yeast commonly found in the gut, Candida albicans, can make salmonella infections worse by binding to bacteria and triggering a chain reaction that allows it to invade cells. Removing Candida's ability to create arginine, an amino acid involved in protein synthesis, also reduces salmonella's ability to infect.
A new study reveals benztropine, a Parkinson's treatment, can boost the body's natural immune response to combat tuberculosis (TB) bacteria. The research found that benztropine can dramatically reduce TB bacterial counts in experiments with human and mouse immune cells.
A new study finds that Salmonella Dublin causes increased calf mortality, lower milk yield, and higher medication costs in dairy farms. The disease leads to hidden financial losses due to gradual infection without visible symptoms.
Researchers found that Salmonella bacteria target iron-rich regions within immune cells to survive and spread. The pathogens exploit these niches, where the remaining iron is still enough for them to grow, driving infection.
A new vaccine method using small extracellular vesicles has shown promise in protecting against Salmonella infections. The vaccine created antibodies in mice when tested with real-world strains of the bacteria.
Researchers from the University of Basel challenged the idea that persisters are responsible for antibiotic ineffectiveness. They found that nutrient starvation increases Salmonella resilience, making antibiotics less effective. This discovery could lead to more effective therapies against difficult-to-treat infections.
A new study by the University of Surrey found that warmer temperatures and certain weather conditions are associated with an increase in Salmonella cases. The research, which considered data from England, Wales, and the Netherlands, suggests that climate change is playing a significant role in the spread of this foodborne illness.
A new UC Davis Health study has uncovered the mechanisms by which Salmonella bacteria evade the body's natural defenses in the gut. The research found that Salmonella alters the gut's nutrient environment to fuel its replication in the large intestine, creating an imbalance that helps the pathogen survive. This new understanding could ...
A team of researchers at UC Davis Health discovered a novel bioelectrical mechanism that allows Salmonella bacteria to navigate the gut lining and find vulnerable entry points. The study found that Salmonella bacteria detect electric signals in FAE, which helps them move towards openings in the gut where they can enter.
Researchers found that disease transmission between farms persists despite movement restrictions, with cattle movement activities being the strongest predictor of farm infections. The study calls for a multifaceted approach to managing Salmonella Dublin, including closer monitoring and targeted interventions.
Researchers have gained insight into how a deadly strain of salmonella adapts to invasion, flourishing in hostile environments and evading immune defenses. The study sheds light on the role of fluid shear forces in bacterial behavior, which may accelerate the design of new therapies for life-threatening infections.
Researchers discovered that Klebsiella oxytoca bacteria compete with salmonella for nutrients, employing multiple strategies to combat the spread of the infection. The bacteria also produce a toxin that has anti-salmonella effects, which may be harnessed to develop new treatments.
Researchers have identified spermidine as a key molecule that helps Salmonella survive inside macrophages by shielding it from oxidative stress. Targeting spermidine production with an FDA-approved drug, DFMO, may weaken the bacteria's ability to cause infection and improve survival rates in mice.
A study by North Carolina State University found that rates of Salmonella in fecal and environmental samples were more prevalent on larger commercial farms than on smaller backyard farms. The researchers also discovered multidrug resistance in Salmonella samples from both types of production systems.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a mechanism by which a bacterial virus limits Salmonella's ability to cause infection. By compromising protein synthesis, the virus can allow the host to rehabilitate and potentially treat resistant cases.
Researchers found an association between the number of ciprofloxacin prescriptions and the emergence of antibiotic-resistant S. Typhi isolates with QRDR mutations. The study suggests that increased antimicrobial use contributed to the emergence of resistance, highlighting the need for better diagnostics and vaccines.
The University of Missouri researchers are developing new technology to rapidly detect and mitigate salmonella and other foodborne pathogens throughout the entire poultry supply chain. The team aims to significantly reduce the risk of foodborne illness in people, with rapid results that can be produced in one hour or less.
Researchers found that tomato juice can kill Salmonella Typhi and other enteric pathogens by impairing their bacterial membrane. The study identified two effective antimicrobial peptides in tomatoes that can eliminate these harmful bacteria.
Pioneering work on bacteriophages to combat disease has received an £800,000 boost from the Biotechnology and Biological Sciences Research Council. The grant will advance production of phages to combat disease in the veterinary field and bring them to market.
A University of Massachusetts Amherst team demonstrates a protein antigen from a childhood vaccine can be delivered into malignant tumor cells to refocus the immune system against cancer. The bacteria-based intracellular delivering system shows promise in treating pancreatic, liver, and metastatic breast tumors.
Researchers at ETH Zurich found that Salmonella bacteria can thrive together in the gut and share information about antibiotic survival mechanisms through a metabolic strategy. This exchange of critical information enables the spread of antibiotic-resistant genes, highlighting the impact of dietary components on promoting this phenomenon.
A new packaging tray can signal the presence of Salmonella or other pathogens in raw or cooked food without opening it, preventing exposure to contamination. This technology simplifies lab-based detection processes, saving time and cost in food production.
A new study reveals that Salmonella uses a two-pronged approach to protect itself within the host's defense mechanisms, involving protein SopB. By altering phosphoinositide dynamics and preventing lysosome production, SopB allows the bacteria to survive inside macrophages.
A team of researchers developed a simple and portable test system to detect salmonella in food, eliminating the need for expensive analytical equipment. The assay uses a nucleic acid probe that is cleaved by an RNase enzyme specific to salmonella, resulting in a clear red spot on an absorbent pad indicating contamination.
Researchers at UC Davis School of Veterinary Medicine discovered that tissue resident memory cells are crucial for inducing a powerful immune response against Salmonella. Molecules like interleukin-1 and 2 enhance the formation of these cells in the liver, providing a rapid-response force.
McMaster University researchers developed a rapid and inexpensive test for Salmonella contamination in food, which provides accurate results in an hour or less. The test improves food safety, reduces the cost of processing fresh poultry and other foods, and helps limit broad recalls to batches identified as contaminated.
A study found that mutant strains of Salmonella cause more severe infections in commercial poultry than wild-type bacteria. The deletion of genes ttrA and pduA led to increased immune response and pathogenicity, emphasizing the importance of animal health measures and proper food conservation.
A European-wide recall of Kinder Chocolate products, including eggs, prevented thousands of extra cases of Salmonella Typhimurium. The recall, triggered by intensive collaboration between public health experts, food safety agencies, and regular surveillance, saved lives and reduced the risk of devastating global outbreak.
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
A new study finds that exposure to salmonella bacteria increases colon cancer risk, with tumors developing earlier and growing larger in infected mice. The research highlights the potential for salmonella as an environmental risk factor for chronic diseases like colon cancer.
Researchers at UConn have identified a protective bacterial culture, Hafnia alvei B16, that can prevent infection by two strains of Salmonella, including those resistant to multiple antibiotics. The culture works by inhibiting the growth of pathogens and reducing their virulence, potentially providing a new path forward in combating su...
Researchers discovered that small RNAs regulate Salmonella's virulence genes by stabilizing mRNA stability through the hilD 3' untranslated region. The study found that Spot 42 and SdsR sRNAs are crucial for controlling SPI-1 expression, leading to improved understanding of Salmonella's pathogenicity.
Half of online sellers fail to disclose law and disease risks associated with small turtles. Despite federal regulations, many US sellers circumvent public health guidelines when selling these pets.
A new treatment option for multi-resistant bacteria has been identified by a UNIGE team, which uses the drug edoxudine to weaken the defence mechanisms of Klebsiella pneumoniae, making it easier to eliminate. This approach could be a game-changer in the fight against antibiotic resistance.
A study by Taiwanese researchers found that patients with atherosclerosis are at higher risk for life-threatening vascular infections from non-typhoidal Salmonella bacteremia. The study suggests the use of a scoring system to predict infection risk and identifies interleukin-1 beta as a potential biomarker.
A new study published in Applied and Environmental Microbiology suggests that oil formulations with food-grade organic acids can kill dried Salmonella on stainless steel surfaces. This approach has the potential to replace water-based cleaning methods, which promote microbial growth and are often challenging to use.
Researchers developed CRISPR-SeroSeq technology to identify multiple strains of salmonella in live bird samples, revealing three serotypes known to cause human illness. The study provides a framework for poultry producers to inform their salmonella control practices and reduce the risk of contamination.
A study found that Brazil's Salmonella vaccine for poultry contributed to the emergence of antibiotic-resistant strains. However, these resistant bacteria have not increased food poisoning cases in humans in the UK.
A new study published in Cell Host & Microbe finds that friendly bacteria in the gut, such as Escherichia coli Nissle 1917, can compete with harmful bacteria like Salmonella for energy resources like nitrate. This competition allows the probiotic to occupy both niches and protect against infection.
A multistate outbreak in 10 European countries linked to chocolate products has been linked to monophasic Salmonella Typhimurium, primarily affecting young children. The outbreak strain demonstrated a multidrug-resistant profile, highlighting the importance of including uncommon AMR profiles in early international communications.
Researchers whole-genome sequenced 375 Salmonella enterica strains from wild birds collected in 41 US states to examine bacterial resistance to antibiotics and heavy metals. They found that only 1% of isolates were multi-antimicrobial resistant, with all cases isolated from waterbirds or raptors, not songbirds.
Researchers found that nitrate triggers Salmonella bacteria to switch from a sessile, biofilm lifestyle to a motile, free-swimming lifestyle in the intestine. This switch enables the bacteria to cause active infection and establish transmission to a new host.
Research at University of Basel discovered that certain areas in tissue allow bacteria to survive despite antibiotic therapy. Immune system plays a critical role in eradicating bacteria, and boosting defenses with immune therapy can lead to more effective clearance.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
Researchers from the University of Seville discovered that a single amino acid mutation in Salmonella enzymes enables them to modify more proteins in infected cells, leading to increased virulence. This finding has significant implications for developing inhibitors as alternative antibacterial treatments.
Researchers have identified a new prophage-mediated defence system in Salmonella Typhimurium ST313 called BstA, which efficiently suppresses phage attacks. This discovery opens up a new avenue of research and could potentially lead to the development of new biotechnologies.
A virulent Salmonella Enteritidis strain has been sequenced from two consecutive poultry flocks in North Carolina State University. The strain, SE_TAU19, exhibits seven antimicrobial resistance genes and 120 virulence genes, posing a threat to human health. Genome sequencing provides valuable data for tracing outbreaks and preventing f...
Researchers found that fasting decreases signs of bacterial infection and inflammation in mice. Fasting also alters gut microbiomes, which appear to sequester nutrients and prevent pathogens from infecting the host.