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A chance to design better vaccines?

Researchers developed a bioinformatic tool that selects parts of proteins to elicit strong immune responses. This approach, grounded in immunological theory, was four times more efficient than current methods, suggesting better vaccine protection against diseases.

SourceOxford University Press USA·JournalBiology Methods and Protocols·TypeData/statistical analysis·DateJul 25, 2023

Treating bladder infections with viruses

Researchers at ETH Zurich have developed a rapid test that detects bladder infections using bacteriophages, which can identify the pathogenic bacteria in under four hours. The test also allows for tailored phage therapy, predicting patient response and increasing treatment effectiveness.

SourceETH Zurich·JournalNature Communications·TypeExperimental study·DateJul 21, 2023

Team develops all-species coronavirus test

Researchers at the University of Illinois have developed an all-species coronavirus test that can detect exposure to SARS-CoV-2 virus in any animal species. The new test focuses on antibodies against a protein called N-protein, which is more abundant and conserved across species, making it a good target for cross-species antibody tests.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalmSphere·TypeExperimental study·DateJul 6, 2023

Study supports “catch up” HPV test in older women

A Danish population-based nonrandomized intervention study found that a catch-up HPV screening intervention improved cervical cancer prevention in women aged 65 and above. The study showed that these women were more likely to be diagnosed with cervical neoplasia after receiving the test.

SourcePLOS·JournalPLOS Medicine·TypeObservational study·DateJul 6, 2023

State medical cannabis laws not associated with reduced use of opioid or nonopioid pain treatments

A study of commercially insured adults with chronic noncancer pain found that state medical cannabis laws did not lead to a reduction in the use of opioid or nonopioid pain treatments. The researchers also suggested slow implementation and reluctance among healthcare leaders may have contributed to these findings.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeData/statistical analysis·DateJul 3, 2023

Plant based compound Peruvoside could prevent spread of diverse medically important viruses: NUS Medicine

Peruvoside has been discovered to prevent up to 12 medically important viruses, including SARS-CoV-2, Hand, Foot and Mouth Disease (HFMD), and Influenza. The compound acts on GBF1 protein, disabling its functionality and stopping virus production.

SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalActa Pharmaceutica Sinica B·TypeExperimental study·DateJun 22, 2023

An app can transform smartphones into thermometers that accurately detect fevers

Researchers at the University of Washington created an app called FeverPhone that uses existing phone sensors and screens to estimate whether people have fevers. The app was tested on 37 patients in an emergency department and showed accuracy comparable to consumer thermometers, with potential for early intervention in viral outbreaks.

SourceUniversity of Washington·JournalProceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies·DateJun 21, 2023

CARD8 helps human immune system respond to some viruses, including COVID-19

A study published in PLOS Biology found that the CARD8 inflammasome sensor is essential for detecting coronavirus infections, but may detect different viruses in different people. The researchers also discovered that genetic variation among humans and across species affects the sensor's ability to detect viral enzymes.

SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateJun 8, 2023

Narrative risk messaging and vaccine hesitancy

Focusing public health messages on protecting oneself versus others has a significant impact on vaccination rates. A study found that messages emphasizing protection of one's community led to higher odds of COVID-19 vaccination than those focused on personal protection.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 18, 2023

Two-thirds of staff and residents of long-term care facilities in England were infected with COVID-19 during first 2 years of pandemic

A study found that two-thirds of staff and residents in long-term care facilities in England were infected with COVID-19 between March 2020 and March 2022. The analysis, which included over 5,000 individuals, estimated that the true rate of infection was higher due to under-diagnosis during the pandemic.

Targeted testing for HIV in hospital emergency departments has great potential, Spanish researchers say

Targeted testing for HIV in emergency departments has led to a significant increase in diagnoses, with numbers more than tripling in Spain. Early diagnosis is key to avoiding the spread of HIV infection, and targeted screening has been shown to be effective, especially in increasing tests ordered and diagnoses made.

Use of monoclonal antibodies reduces death, hospitalization risk by more than one-third after COVID-19 diagnosis

Researchers found that using monoclonal antibodies within two days of a COVID-19 diagnosis reduced the risk of hospitalization or death by 39% compared to those who did not receive treatment. This finding suggests that early treatment with monoclonal antibodies significantly reduced the severity of COVID-19.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeObservational study·DateApr 3, 2023

Frequent COVID testing of nursing home staff protected residents, saved lives

A new study found that frequent COVID surveillance testing protected nursing home residents by detecting infected staff earlier, disrupting transmission chains. The research showed that high testing frequency facilities had clinically meaningful reductions in resident cases and deaths, particularly before vaccine availability.

SourceUniversity of Rochester Medical Center·JournalNew England Journal of Medicine·DateMar 22, 2023

Study shows those infected with COVID in the first wave in 2020 were 40% less likely than those who were not to get COVID-19 during the first six months of Omicron activity

A Canadian study found that those infected with COVID-19 in the first wave in 2020 were 40% less likely to get infected during the first six months of Omicron activity. Older adults, particularly those aged 65 and above, were significantly less likely to be infected than younger adults.

Using sewage to forecast COVID-19 infections

A new mathematical model uses wastewater samples to predict COVID-19 cases five days in advance, detecting SARS-CoV-2 RNA with high sensitivity. The approach could help authorities tailor infection control policies when clinical surveillance is lacking.

SourceHokkaido University·JournalEnvironment International·TypeData/statistical analysis·DateFeb 20, 2023

Extracts from two wild plants inhibit COVID-19 virus, study finds

A study by Emory University researchers found that extracts from two wild plants, tall goldenrod and eagle fern, inhibited the ability of the SARS-CoV-2 virus to infect living cells. The active compounds are present in miniscule quantities, making it ineffective for self-treatment, but may hold promise as medicines against COVID-19.

SourceEmory University·JournalScientific Reports·TypeExperimental study·DateFeb 10, 2023

COMPASS for highly sensitive rapid tests

A new rapid test developed by the University of Würzburg uses magnetic nanoparticles to detect antibodies against SARS-CoV-2 with high sensitivity. The test takes only a few seconds to produce reliable results, enabling faster diagnosis and treatment of infectious diseases.

SourceUniversity of Würzburg·JournalNature Communications·TypeExperimental study·DateDec 21, 2022

From COVID-19 to the common cold: UBC scientists identify broadly-effective, infection-halting compound

Researchers have identified a compound that shows early promise at halting infections from a range of coronaviruses, including all variants of SARS-CoV-2 and the common cold. The findings reveal a potential path toward antiviral treatments that could be used against many different pathogens.

SourceUniversity of British Columbia·JournalMolecular Biomedicine·TypeExperimental study·DateDec 14, 2022

AI model proactively predicts if a COVID-19 test might be positive or not

Researchers developed an accurate predictive model to distinguish between COVID-19 positive and negative test outcomes. The study found that symptom features, such as fever and difficulty breathing, play a significant role in predicting test results, with molecular tests yielding lower positive rates due to their dependence on viral load.

SourceFlorida Atlantic University·JournalSmart Health·TypeComputational simulation/modeling·DateDec 13, 2022

An ounce of prevention: Differences in HIV prevention activities among rural and urban physicians

A recent study by Texas A&M University reveals that rural family medicine physicians are less comfortable providing sexual risk reduction counseling to adolescents compared to their urban counterparts. This disparity highlights the need for increased awareness and training of PrEP-related clinical activities among rural providers, whic...

SourceTexas A&M University·JournalThe Journal of Rural Health·DateDec 12, 2022