Articles tagged with Blood Vessels
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Researchers at Hokkaido University found that inflammatory changes in tumors caused by chemotherapy trigger drug resistance in blood vessels, resulting in poorer cancer outcomes. The team also discovered a treatment strategy involving the combination of an ABCB1 inhibitor and anticancer drugs to overcome this resistance.
A new method allows for the creation of a complex network of microchannels in an extracellular matrix that resembles human tissues. Human endothelial cells were successfully cultured on the surface of the microchannel to form a tube mimicking blood vessels, achieving pulsatile flow under conditions of perfusion and stretch.
Blood vessels in the brain have evolved to form a protective barrier, but recent research shows they can also sense the metabolic state of neighboring neural cells. This allows them to respond to changes in nutrient availability and prevent disease states such as Alzheimer's and vascular dementia.
Researchers discovered a mechanism by which blood vessels' inner liner grows in response to transient increases in blood pressure. This process may lead to therapeutics that cut off tumors or help rebuild damaged vessels. The study's findings have implications for combating tumor growth and disease.
Surgeons at UT Southwestern Medical Center have developed a new technique that preserves the natural shape and color of nipples in men undergoing breast reduction surgery. The procedure involves cutting below the lower part of the breast and lifting it like a flap to remove unwanted tissue, reducing the risk of discoloration.
Researchers at Texas A&M University designed a microdevice that mimics tortuous blood vessels to detect and monitor blood clots in pediatric patients. The device, developed by Dr. Abhishek Jain's team, provides quick, reliable, and low-cost results within 10-15 minutes.
A Penn State study found that eating a meal with six grams of spice blend reduced inflammation markers compared to meals with less or no spices. The researchers discovered anti-inflammatory properties in the blend, which may help offset inflammation caused by high-carb and high-fat meals.
A study examining COVID-19 patient lungs found distinctive vascular features, including severe endothelial injury and blood clotting. Researchers also observed a unique pattern of pulmonary vascular disease progression in some cases compared to equally severe influenza infections.
Researchers at National University of Singapore discovered a critical protein, MFSD7c, in blood vessel cells that controls brain growth and development. The study found that loss of this protein causes microcephaly and neuronal cell death, highlighting the need for better understanding of essential nutrients required for brain health.
Researchers discovered a key mechanism behind eye vessel leakiness in diseases like age-related macular degeneration and diabetic retinopathy. By targeting this specific step, they hope to develop new treatments that can selectively block leak-inducing effects without harming nerve and blood-vessel cells.
Scientists have developed a new technology to study the inner ear using synchrotron X-rays, providing insights into cochlear implant success. The method allows for three-dimensional mapping of blood vessels in the inner ear, which may lead to improved electrode design and better hearing results.
Researchers discovered that tumors in lymph nodes are distinct from solid tumors, with a unique pattern of branching and signaling pathways. They identified VEGF-C as the primary driver of angiogenesis in early stages of lymphoma, which can be targeted to slow tumor growth.
Researchers at the NIH have successfully stopped tumor growth and blood vessel formation in mice by targeting enzymes that recycle phosphatidylinositol-(4,5)-bisphosphate. By blocking these enzymes, tumors were unable to replenish the molecule needed for new blood vessel growth, ultimately reducing tumor size and growth.
A study published in Immunity identifies an enzyme that blocks self-healing in blood vessels during inflammation, hindering regeneration. Removing this enzyme allows cells to fully regenerate, suggesting a potential therapeutic target for improving endogenous regeneration.
Using ultrasound localization microscopy, researchers can visualize blood vessels and measure oxygen levels in tumors with high resolution. This technique has the potential to improve cancer detection and therapy evaluation by providing accurate information on tumor hypoxia.
Researchers found that adrenomedullin helps resolve lung damage and pulmonary hypertension caused by oxygen exposure in mice, suggesting a potential new therapy for bronchopulmonary dysplasia (BPD) and pulmonary hypertension. Adrenomedullin may also improve the quality of life of BPD-associated PH patients.
A study has created a database on endothelial cells, which may enhance our understanding of the complex network of blood vessels in the mammalian body. The research team identified 78 endothelial cell subclusters, including unexpected subtypes, that can inform the development of new treatments for diseases.
Researchers found that drugs targeting T cells may be effective in treating cerebral malaria, a deadly disease mainly affecting young children. The study suggests that CTLs damage brain blood vessels, leading to brain swelling and death.
Researchers at the University of Illinois Chicago have identified distinct genetic profiles for endothelial cells in various organs, including heart, brain, and lungs. These findings suggest that targeting specific blood vessels could lead to more effective treatments for vascular diseases, such as Alzheimer's disease.
Scientists at Inserm have cultivated human cells in the lab to produce extracellular matrix deposits high in collagen, which can be woven into yarn to replace damaged blood vessels. This biologically derived material is expected to be well-accepted by the body and could lead to clinical trials.
Researchers at UT Southwestern Medical Center have developed a new method for mapping out blood vessels before surgery to minimize the risk of complications in single breast reconstruction. The team found that this approach reduced fat necrosis by 2.7% compared to traditional methods, resulting in improved outcomes and breast shapes.
A study simulated city centre pollution levels and found that bad air for just two hours caused cardiovascular disease effects lasting a whole day. The research suggests even 'safe' pollution levels can be devastating to health, emphasizing the need for improved air quality in cities.
Researchers at NAU are developing a polypropylene glycol-based biomaterial to treat cerebral aneurysms, aiming to improve outcomes and reduce recurrence rates. The material, PPODA-QT, is designed to fill the aneurysm space effectively, leaving a smooth surface for healing.
Researchers discover that targeting VEGFA signaling in the epidermis prevents psoriasis development, including immune cell infiltration and blood vessel formation. A therapeutic anti-Nrp1 antibody demonstrates significant therapeutic benefit in treating psoriatic disease.
A new study by UCSF researchers found that JUUL delivers significantly higher levels of nicotine to the bloodstream compared to previous-generation e-cigarettes and cigarettes. The study also revealed that JUUL impairs blood vessel function similarly to cigarette smoke, which can have severe cardiovascular consequences.
Kyoto University researchers have developed a new 'tumor-on-a-chip' device that can better mimic the environment inside the body. The device allows for the growth of tumor cells and blood vessels in three dimensions, enabling scientists to test potential cancer fighting drugs more effectively.
Researchers at Massachusetts General Hospital found that slow spontaneous vessel pulsations drive the clearance of substances from the brain. Targeting vasculature health may prevent or treat Alzheimer's disease.
A study published in EMBO Molecular Medicine suggests that blocking the protease MT1-MMP could protect the vasculature in the inflamed gut and reduce severity of colitis. The research found that inhibiting this protease could have potential clinical implications, including identifying biomarkers for mild IBD.
Researchers at Johns Hopkins Medicine discovered a new pathway contributing to degeneration of the light-sensitive tissue in the eye. A potential treatment involves blocking a protein called angiopoietin-like 4, which acts synergistically with VEGF activity.
A two-year trial found that chronic smokers who transition to e-cigarettes demonstrated significant improvements in vascular health within four weeks. Women experienced greater gains by switching compared to men.
Researchers found that activating the apelin receptor led to increased blood pressure due to vasoconstriction, a process also affected by the α1A-adrenergic receptor. The study suggests a coordinated mechanism controlling blood vessel contraction and may support therapy development for vascular stenosis and vasospasm.
Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin complete with blood vessels. The advancement brings researchers closer to creating grafts that are more like the skin our bodies produce naturally, which can accelerate wound healing and improve patient outcomes.
A new technique captures and analyzes indirect light to reveal previously unseen details just under the surface, including blood vessels. The method uses commercially available cameras to create images at extraordinary resolution, improving diagnosis and treatment outcomes.
Exposure to secondhand smoke has been associated with differences in choroidal thickness among children, with non-exposed kids showing healthier eyes. The study examined over 1,400 young children in Hong Kong and found significant differences in eye health between those exposed and not exposed to secondhand smoke.
A new study has found that a father's low-protein diet can affect the quality of his sperm and impact the long-term cardiovascular health of his offspring. The study used mouse models to show that a poor-quality diet altered genetic information carried in sperm, changing blood vessel formation in developing fetuses.
A new study finds that severe sleep apnea is a risk factor for treatment-resistant diabetic macular edema, a complication of diabetes causing vision loss or blindness. Patients with severe sleep apnea were more likely to experience worsening eye disease and require multiple treatments.
Blood vessels play a significant role in chronic inflammatory bowel diseases, with highly permeable vessels found in patients. The researchers identified interferon-γ as the cause of this malfunction and discovered that inhibiting vessel permeability slows down disease progression.
A study published in Journal of the American College of Cardiology shows that oral anticoagulant dabigatran slows Alzheimer disease progression in mice by improving cerebral circulation. The treatment reduces typical symptoms like inflammation and amyloid protein plaques.
Researchers develop a novel therapy to protect neurons and stimulate regrowth of blood vessels in damaged tissue. In preclinical trials, rats injected with the hydrogel retained more functioning neurons and formed new blood cells at the injury site.
A new model simulates fluid dynamics in arteriovenous grafts, finding that vein flexibility can reduce disrupted blood flow. The study suggests several options for improving AVG designs to prevent thrombosis and extend their lifespan.
A novel initiative called the Stroke Preclinical Assessment Network (SPAN) is testing six potential new stroke therapies, including compressing the arm with a blood pressure-like cuff. This approach, known as remote ischemic conditioning, may reduce stroke size and improve patient recovery.
A recent study published in the Journal of Nutrition found that consuming four servings of cheese per day alongside a high sodium diet may protect blood vessels from damage. The researchers discovered that antioxidants in cheese may play a role in preserving vascular health, providing an alternative strategy to reduce cardiovascular risk.
Researchers discovered that tryptase enzyme causes blood vessel leakage in severe dengue, leading to shock and bleeding. A possible new treatment strategy using nafamostat mesylate is being explored to prevent hemorrhaging and reverse shock.
Researchers have discovered bone-like particles in the peripheral circulation of individuals with advancing age, which may lead to vascular calcification and restricted blood flow. These particles are potentially more dangerous due to their sharp edges and could contribute to diseases such as heart attack and stroke.
Researchers at Trinity College Dublin discovered that claudin-5 plays a crucial role in the development of dry Age-Related Macular Degeneration. The study suggests that regulating blood vessel integrity may prevent the disease.
A recent study by Anna M. Gruener et al., published in JAMA Ophthalmology, investigated the association between giant cell arteritis and race. The researchers found a significant association between the disorder and certain ethnic groups, with increased risk observed in African Americans, Hispanics, and individuals of mixed ancestry.
A team of scientists has identified a key molecular connection between diabetes and vascular disease, finding that high blood glucose activates an enzyme that constricts blood vessels. The study aims to develop new treatments targeting this pathway for reducing vascular complications of diabetes.
A study by IRB Barcelona demonstrates that p38 inhibition boosts blood vessel formation in human and mice colon cancers, critical for cancer growth. The research reveals the role of p38 in mesenchymal stem cells and its involvement in angiogenesis.
Scientists at the University of Edinburgh have developed a system to study endothelial cells, which line blood vessel walls. This breakthrough could lead to therapies that promote new blood vessel growth and help treat conditions like heart disease.
A new therapy has shown promise in promoting vascular repair following a stroke, leading to improved motor functions and regeneration of damaged blood vessels. Researchers used anti-Nogo-A antibodies in mice and found better recovery and reduced motor function impairment compared to control groups.
A novel marker for non-classical monocytes has identified their direct regulatory role in the adaptive immune response. Monocytes can infiltrate specific tissues, modulating immune cell activities.
A study from the University at Buffalo found that people experience a 'paralyzing paradox' when faced with too many options, leading to fear of making the wrong choice. To manage this, considering the relative importance of the choice and having clear guidelines can help scale down decision-making process.
Researchers found that early alcohol exposure restricted placenta growth and blood vessel formation, leading to reduced nutrient delivery to the embryo. This study has significant implications for understanding pregnancy-associated conditions like fetal growth restriction.
Researchers from University of Warwick modelled effects of high blood glucose on human endothelial cells, revealing a key mechanism in blood vessel damage. The study identifies increased hexokinase-2 activity and methylglyoxal formation as drivers of metabolic dysfunction and inflammation.
Researchers have developed artificial molecules that selectively target abnormal vascular smooth muscle cells without affecting endothelial cells. This could lead to new, safer stent treatments.
Researchers developed a new method using magnetic beads to reduce blood levels of harmful sFlt-1 molecule during preeclampsia, freeing up angiogenic factors. The approach showed promising results in reducing sFlt-1 by 40% and PIGF by up to two times more.
Johns Hopkins Medicine researchers have created a 3D image-based model of tumor behavior that captures the complexity of cancer growth. The model uses high-quality imaging data and mathematical formulas to represent blood flow, oxygenation, and structural changes within tumors.
Researchers developed a peptide called FRW that binds specifically to endothelial cell junctions in the blood-brain barrier, paving the way for novel diagnostic imaging strategies and therapies. The new technique also reveals differences between the blood-retina and blood-brain barriers.
Researchers have successfully grown 3D paper organs with artificial blood vessels that can be populated with cells, providing a more complex structure than traditional 2D cell cultures. The paper organs can mimic the architecture of real tissues, influencing how cells grow and respond to external stimuli.
MIT engineers designed tiny robots that use magnetic fields to push nanoparticles out of blood vessels and into tumors, improving drug delivery efficiency. The robots create fluid currents that drag nanoparticles along, overcoming one major obstacle to targeted nanoparticle delivery.