Articles tagged with Blood Vessels
A study by Tokyo Medical and Dental University reveals that chronic kidney disease promotes vascular calcification by altering signaling molecules in blood vessel walls. The researchers identified four microRNAs that target a key pathway driving calcification, providing potential biomarkers and therapeutic targets for both diseases.
A University of Ottawa study found that almost two-thirds of Canadians with stroke experience disturbed sleep, and those affected are up to 7 times more likely to report multiple sleep problems. The study highlights the need for better awareness and guidance on managing sleep disorders in stroke patients.
Research suggests that females are more prone to salt sensitivity, leading to higher blood pressure, particularly after menopause. Salt sensitivity affects about half of hypertension cases and is often linked to treatment-resistant hypertension.
Researchers at Indiana University School of Medicine have identified a new type of cell called the vasculogenic fibroblast, which can help create new blood vessels for treatment. This discovery could lead to improved treatments for ischemic diseases such as diabetic wounds.
Researchers developed a microfluidic model of vascular malformation caused by PIK3CA mutation, allowing them to study disease mechanisms and test treatment efficacy. The model successfully replicated the disease's manifestations and responded to alpelisib, a newly approved PIK3CA inhibitor.
UVA scientists have discovered a new contributor to abnormal blood vessel growth in the eye, which could lead to new treatments for macular degeneration and other vision loss conditions. The discovery identifies a key protein that determines VEGF levels, blocking it has reduced VEGF levels significantly without unwanted side effects.
A new study has identified a biomarker, placental growth factor (PlGF), which is associated with cognitive impairment and dementia due to vascular brain injury. Higher levels of PlGF in the bloodstream are linked to increased risk of cognitive decline and cerebral small vessel disease.
Researchers at Hokkaido University used hydrogel materials in combination with neural stem cells to grow new brain tissue in areas of brain damage. The study showed that immune cells and blood vessels grew within the hydrogels, leading to some degree of integration between the hydrogel and host brain tissue.
A recent study found that recurrent stroke risk has declined over the past 20 years, with a greater decrease observed among women compared to men in South Texas. The study analyzed data from nearly 6,000 first-time ischemic stroke survivors and found that lifestyle changes and medication can help prevent recurrent strokes.
Women who experience five major pregnancy complications face an increased risk of ischemic heart disease up to 46 years after delivery. The study found that all major adverse pregnancy outcomes should be recognized as lifelong risk factors for heart disease.
Researchers developed a new tool using vortex ultrasound to break down blood clots in the brain, which eliminated clots more quickly than existing techniques. The approach works by inducing shear stress on the blood clot, reducing risk of hemorrhage in the brain.
Researchers found a link between astrocytes from schizophrenic patients and reduced vascularization in the brain, which may contribute to the disease's metabolic flux. The study suggests that astrocytes could be a target for novel therapies to address schizophrenia.
Researchers discover that tumour tracks, formed by transformed blood vessels, trap immune cells and promote healing processes. The tension of extracellular matrix fibers plays a key role in tumour development, allowing cancer cells to grow undisturbed.
A UCSF study suggests people who identify as lesbian, gay, bisexual, transgender, or non-binary may have a higher risk of stroke at a younger age. Non-traditional stroke risks include HIV and syphilis infections.
A new study from York University sheds light on biological underpinnings of sex differences in obesity-related disease. Female mice grow more new blood vessels to supply fat tissue with oxygen and nutrients, whereas males have a high level of inflammation-associated processes.
A study involving three volunteers found that skin scars treated with hair follicle transplants exhibited profound architectural and genetic shifts towards healthy, uninjured skin. The findings suggest the potential for new therapies to rejuvenate mature scars and restore organ function.
The CNIC study reveals two distinct mechanisms by which cells detect and respond to forces of varying strength, one mediated by caveolae and the other by newly discovered dolines. This finding has significant implications for understanding pathological processes such as atherosclerosis and neurodegenerative diseases.
Researchers at the Universities of Bonn and Heidelberg identified a mechanism that ensures nerve cells and blood vessels grow without interfering with each other. By releasing semaphorin 3C, motor neurons signal vascular cells to pause growth, allowing for coordinated development during embryonic stages.
A new method for creating freestanding hydrogel lumens that can accurately replicate blood vessels and facilitate vasodilation research. This approach allows researchers to study vasodilation in a more efficient and effective manner, overcoming limitations of existing methods.
Researchers found that simultaneously targeting two signalling switches can severely inhibit tumour angiogenesis, cancer growth and metastasis in multiple models of cancer. This approach has the potential to restrict a cancer's ability to escape therapy by rapidly destroying the VEGF receptor when both receptors are targeted.
Researchers found that tumor cells directly interact with blood vessel cells, altering their normal clockwise orientation to a counterclockwise position. This interaction may play a role in cancer metastasis and could be targeted for prevention and treatment.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
Researchers developed a nanofiber aerogel that promotes faster and more effective healing of diabetic wounds. The aerogel facilitates cell migration, oxygen, and nutrient delivery to the wound bed, while incorporating an anti-microbial peptide prevents bacterial growth and promotes healing.
Researchers found that metabolic disease affects blood vessels in different organs, leading to vascular dysfunction and increased risk of diseases. A healthy diet can partially reverse this damage, but some blood vessels may retain the disease signature, making it difficult to fully reverse.
A new study published in the journal Nature has identified medin as a key player in Alzheimer's therapies. Medin, a protein that accumulates in the blood vessels of the brain, promotes vascular pathology and cognitive decline. The researchers hope to develop a treatment targeting medin to prevent vascular damage and cognitive decline.
A new injectable hydrogel has been developed with enhanced shear-thinning properties, improved cellular biocompatibility, and significantly reduced clotting times. The biomaterial was created by adding sodium phytate to a gelatin-based compound, promoting even greater cohesion and triggering the initiation of blood coagulation.
A study of 1779 adolescents found that early-life elevated lipids and dyslipidemia are linked to worsening subclinical atherosclerosis. Conversely, treatment at age 17 effectively halted progression and even reversed it. This critical evidence emphasizes the need for early-life screening and prevention.
A study of 11,945 people found that those with type 2 diabetes are more likely to be diagnosed with advanced cancer if the condition is not screened for routinely. Researchers identified a 26% increased risk of metastasis in patients with pre-existing type 2 diabetes.
A large study found that children who experienced adversity, including serious family illness or death, poverty, neglect, or dysfunctional relationships, are at increased risk of developing cardiovascular disease in early adulthood. The study, published in the European Heart Journal, followed nearly 1.3 million children and found a 60%...
Researchers identified Spns2, an S1P transporter, as a novel drug target for Multiple Sclerosis treatment. Targeting this protein may improve safety profiles and reduce side effects associated with current therapies.
A collaborative study reveals how genes controlling blood vessel cells influence motor neuron development, allowing them to navigate the body's systems. The discovery sheds light on diseases such as ALS and SMA, where motor neuron connections are destroyed.
Researchers have discovered a new role for VWF in regulating immune responses at sites of blood vessel injury, leading to potential treatment options for inflammatory and blood clotting disorders. The study found that VWF plays a key role in repairing damaged blood vessels, which could help prevent heavy bleeding and blood clots.
A team of researchers at USC is launching a comprehensive study to investigate the connection between type 2 diabetes and dementia in adults with Hispanic ancestry. The five-year study will examine brain structure and activity, blood flow, blood glucose and insulin levels, and cognitive functioning in 200 participants.
A new study from the University of Missouri School of Medicine found that short-term exposure to reduced physical activity and increased sugar consumption disrupts insulin response in blood vessels, with men more prone to vascular insulin resistance. In contrast, young women are protected against this condition.
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
Two NIH-funded studies show long-term e-cigarette use can impair blood vessel function, increasing the risk for cardiovascular disease. The findings also suggest combining e-cigs with tobacco may increase health risks compared to using them individually.
Researchers at Brigham and Women's Hospital developed a novel bioink capable of constructing functional and mechanically strong blood vessels. The bioink enables bioprinting of conduits with key physiological characteristics similar to native vessels, potentially serving as vascular models for grafts in surgeries and disease studies.
Researchers at Osaka University have developed a mouse model that shows Favine protein can protect against atherosclerosis and thrombosis. The study also found that reduced levels of Favine are associated with calcification and thrombus formation, revealing a new potential therapeutic target for treating atherosclerosis.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
A study from Linköping University shows that individuals with type 1 diabetes should keep their mean long-term sugar level below 53 mmol/mol (7.0%) to avoid serious damage. The risk of eye- and kidney complications increases as the level increases.
A new study from USC researchers uncovers the sequence of early molecular changes caused by APOE4, a discovery that may help identify potential treatment targets in the brain's blood vessels. The research reveals problems with the blood-brain barrier and synapses, leading to behavioral deficits and cognitive dysfunction.
A substance produced by gut microorganisms, TMAO, can lead to scarring and vascular damage in scleroderma. The Western diet rich in meat contributes to TMAO formation, which reprograms cells to become scar-forming myofibroblasts.
A study reveals that four nonexcitatory amino acids can cause irreversible brain destruction after a stroke or traumatic brain injury. The amino acids flood the brain cells, leading to swelling and cell death.
Researchers at National University of Singapore have identified S1P as a potent signaling molecule crucial for maintaining blood vessel integrity and function. The study highlights the importance of S1P export from blood cells and blood vessels in preventing complications and mortality related to vascular diseases.
Higher aldosterone concentrations are associated with lower eGFR, lower potassium levels in blood, and higher potassium and protein concentrations in urine. The risk of CKD worsening was independent of diabetes status. Finerenone may help prevent CKD progression by targeting aldosterone's action.
A team of researchers has discovered that malignant tumors accumulate lipid delivery molecules called LDL and attract immune suppressor cells called neutrophils, leading to tumor progression. The study also shows that targeting the LOX-1/oxidized LDL axis may be a promising strategy for treating both cancer and cardiovascular disease.
Researchers developed artificial microtubules to transport microscopic cargo along magnetic stepping stones, overcoming fluid flow obstacles. The technology could facilitate targeted drug delivery and treat blocked vessels or cancerous tumors.
Children born to mothers with polycystic ovary syndrome (PCOS) are at a higher risk of developing infections, allergies, and other childhood illnesses by age 13. The study found that children of mothers with PCOS were 32% more likely to be admitted to hospital for various health problems.
A systematic review of US-based studies on Hereditary Hemorrhagic Telangiectasia (HHT) reveals a lack of racial and ethnic data, potentially impacting treatment and diagnosis. The study highlights the need for inclusive research designs to address growing concerns about racial disparities in HHT care.
YAP1 controls angiogenesis by expressing genes involved in blood vessel formation, and its activity is regulated by PHD2 and VHL under normal oxygen conditions. In hypoxic conditions, YAP1's nuclear localization enables it to interact with HIF1α, leading to increased expression of pro-angiogenic proteins.
Researchers at the University of Illinois Urbana-Champaign have developed a low-cost ultrasound imaging method to study the relationship between Alzheimer's disease and the brain's vascular system. The technique, which provides high-resolution images of animal microvasculature, may aid in early detection of the disease.
Researchers discovered that midgestation leptin surge in preeclampsia leads to endothelial dysfunction, blood vessel constriction, and restricted fetal growth. This finding highlights the crucial role of leptin in pregnancy and its potential consequences on maternal and infant cardiovascular health.
Cases of Kawasaki disease fell in the US during the COVID-19 pandemic and remained low during masking and school closure. The findings suggest a respiratory portal of entry for the trigger agent(s), consistent with social behavior influencing exposure.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
Researchers found that 'killer' T-cells used in immunotherapy can also destroy tumour lymphatic vessels, greatly reducing the risk of metastasis. This synergistic effect could increase treatment effectiveness against cancers with high lymphangiogenesis.
A molecule in mosquito spit called sialokinin has been identified as a potential new target for vaccination against Yellow Fever, Dengue and Zika. Researchers found that sialokinin causes blood vessels to become permeable, allowing viruses to infect the host.
Researchers will track changes in the blood-brain barrier, neurovascular function, and cognition in over 850 participants with genetic variants at risk of developing Alzheimer’s disease. The study aims to improve understanding of the onset and progression of Alzheimer’s disease and identify effective interventions.
Researchers developed a new ultrasound localization microscopy technique to image blood vessels and measure blood flow in the brain. The method uses microscopic bubbles as a contrast agent and accelerates post-processing to 10-30 seconds, enabling rapid imaging of whole-brain microvasculature.
Researchers at TU Wien develop a method to guide individual cells with laser precision, enabling reproducible production of artificial tissue and testing new drugs without animal testing. The technique involves adding special molecules to hydrogel surrounding cells, which become softer and more permeable when activated by a laser beam.
Researchers from NTU and NUS found a link between NAFLD and blood vessel damage, leading to increased risks of cardiovascular diseases. High levels of chemokines attract immune cells into blood vessels, causing inflammation and damage.