Articles tagged with Blood Vessels
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Researchers from Göttingen University and Hannover Medical School have detected changes in heart muscle tissue of people who died from Covid-19. The study used innovative X-ray imaging to visualize the affected tissue in three dimensions, revealing a network of chaotic vessel formations.
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
Researchers found that defibrotide suppresses neutrophil release of NETs and reduces downstream blood-clotting in mice with antiphospholipid syndrome. The treatment neutralizes toxic histones, preventing activation of blood vessel cells.
Microglia, the brain's immune cells, migrate to the retina using blood vessels as pathways and require neurogenesis for colonization. The study provides insights into microglial migration and its implications for neurodegenerative diseases.
Researchers at Skoltech have created an optoacoustic endoscopic probe that can analyze atherosclerotic plaques by forcing molecules to sound their presence. The device uses laser light to make biomarkers oscillate, producing ultrasound signals that can be detected by a sensitive microphone.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
Women with breast cancer are at a higher risk of developing atrial fibrillation and dying from heart-related issues within the first year. The condition was more common in women who did not receive surgery or radiation as their initial treatment.
A study by Karolinska Institutet found that low levels of microRNA-210 in red blood cells cause vascular damage in type 2 diabetes. The reduction in microRNA-210 levels impaired blood vessel endothelial cell function and led to increased risk of cardiovascular disease.
Researchers developed a human Intestine Chip to study coronavirus infection and test potential treatments. The chip showed that nafamostat reduced virus presence while remdesivir damaged intestinal tissue, offering insights into underlying causes of GI symptoms and improving understanding of treatment efficacy and toxicity.
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
A team of experts from Tel Aviv University has identified 5 coronavirus proteins responsible for damaging blood vessels. The researchers hope that the identification will lead to the development of targeted drugs that reduce vascular damage in COVID-19 patients.
Metastases in malignant melanoma can use an alternative process to access the circulatory system, where a blood vessel divides into two parallel vessels. This finding challenges traditional research on tumor growth and may lead to new treatment options for metastatic cancer.
Researchers from the University of Queensland found that COVID-19 causes cardiovascular complications due to inflammation in infected airway cells. The study clarifies a key debate about the relationship between the virus and blood vessel linings, suggesting inflammation as the primary cause of damage.
Researchers found that females rely more heavily on aldosterone to regulate blood pressure, whereas males primarily use angiotensin II. This discovery could lead to targeted treatments for female hypertensive patients, improving treatment outcomes and reducing the risk of heart disease and stroke.
A high intake of alpha linolenic acid (ALA), found in nuts, seeds, and plant oils, is associated with a lower risk of death from all causes and diseases of the heart and blood vessels. However, further studies are needed to confirm the association with cancer mortality.
German scientists developed a method to supply oxygen to tadpole brains using photosynthesizing algae injected into their bloodstream. This approach effectively revived neurons in oxygen-deprived tadpoles, showing promise for new therapies for conditions such as stroke and high-altitude environments.
Researchers at WVU will explore how a specific enzyme protects the brain from stroke effects and aging. Their findings may indicate a potential target for medications improving brain blood vessel function after a stroke.
A pre-clinical study by University of Illinois Chicago researchers shows that a drug targeting specific immune pathways can prevent lung damage and death in mice infected with the SARS-CoV-2 virus. The study suggests targeted treatments may be more suitable for COVID-19 patients than broad immune suppressants.
Researchers find PADI4 and HIF-1 proteins work together to deliver oxygen and nutrients to tumors, allowing them to grow. The discovery provides new avenues for anti-cancer therapies targeting blood vessel development.
Researchers at Max-Planck-Gesellschaft engineered synthetic exosomes that regulate cellular signaling during wound closure, leading to faster healing and improved formation of new blood vessels. The study provides a systematic understanding of extracellular vesicle communication and its potential therapeutic application.
Researchers found that e-cigarette use led to increased blood clots and raised heart rate and blood pressure, while also making small blood vessels narrower. Long-term effects could lead to heart attacks and strokes.
A recent study reveals that protein HSP27 plays a crucial role in regulating blood vessel leakage, which is a hallmark of sepsis. By targeting HSP27, researchers hope to develop drugs that can stabilize blood vessel barriers and prevent fluid loss.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
A new study reanalyzes the Sorby vitamin C experiment, a landmark trial that determined the minimum vitamin C requirements for preventing scurvy. The analysis suggests that the recommended daily intake of 45mg may be too low to prevent weak scar strength.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
A new technology has been developed to reduce adverse effects of medical materials in the human body. The material can be loaded with therapeutic cells and deliver them to desired sites, mitigating inflammation and blood clots.
Researchers at King Abdullah University of Science & Technology (KAUST) create a biomaterial that supports the growth of bone marrow precursor cells and forms tubular blood vessels, mimicking natural bone tissue architecture. This breakthrough enables the development of 3D disease models for tissue engineering and biomedical research.
Researchers at University of Queensland develop gene therapy to block scar formation by targeting SOX9 gene, promising benefits for burn patients and others with significant scarring. The study uses siRNA technology to reduce scarring in animal models, paving the way for potential human treatment.
The study identifies novel non-coding RNAs involved in regulating vascular endothelial growth factors (VEGF) expression, which are key regulators of angiogenesis. These findings may lead to new therapeutic approaches for diseases such as atherosclerosis and ischemia.
A new mitochondrial peptide called MOCCI regulates inflammation of blood vessels and immunity after viral infection. Researchers discovered that MOCCI dampens the activity of Complex IV in mitochondria to reduce inflammation.
Scientists have developed a new biomaterial that regrows both blood vessels and bone, potentially providing an alternative to current systems. The biomaterial was inspired by the natural way in which bone defects regenerate and uses a mechanobiology-informed approach to promote both angiogenesis and osteogenesis.
New research reveals sex-specific differences in brain stem cell activity and blood vessel density with age. Female mice show more efficient neurogenesis and better neuron migration compared to male mice, suggesting hormonal or genetic influences may play a role.
During the COVID-19 state of emergency, Kawasaki disease primarily affecting children saw a notable rise in pediatric admissions in Japan. The study investigated transmission modes, revealing a potential link between droplet or contact transmission and disease development.
A new study found that drinking beetroot juice for ten days increased levels of beneficial oral bacteria linked to healthier blood vessels and brain function in older adults. The results also showed a significant drop in systolic blood pressure, suggesting potential benefits for cardiovascular health.
A four-year clinical trial from the DRCR Retina Network found that early anti-VEGF injections slowed diabetic retinopathy progression, but did not improve vision at two years. Standard treatment remained effective in preventing further vision loss.
Researchers have discovered 12 genetic regions linked to lacunar strokes, which can lead to long-term disability and dementia. The study provides new hope for preventing and treating this devastating type of stroke.
COVID-19 survivors may experience blood clots due to a lingering immune response that damages blood vessels. The study found twice as many damaged blood vessel cells in COVID-19 survivors compared to healthy individuals.
A new study published in Lab on a Chip suggests that electrical stimulation can increase blood vessel permeability, potentially speeding up the wound healing process. This increased permeability allows white blood cells and oxygen to reach injuries more efficiently.
A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications.
Remote ischemic conditioning (RIC) treatment may improve recovery from intracerebral hemorrhage, the deadliest type of stroke. RIC reduces inflammation and promotes new blood vessel growth, accelerating functional recovery.
Researchers found that inhibiting RUNX1, a gene linked to retinal neovascularization, presents a promising therapeutic advance for treating age-related macular degeneration. The study showed that a RUNX1 inhibitor alone or in combination with standard treatment reduced CNV lesion size and vascular leakage.
Researchers at WashU Medicine have identified an antibody that removes amyloid plaques from brain tissue and blood vessels, improving vessel function without raising the risk of brain bleeds. This breakthrough discovery offers a potentially safer approach to treating Alzheimer's disease and cerebral amyloid angiopathy.
Scientists at Fralin Biomedical Research Institute have identified a zebrafish model that can help advance glioblastoma multiforme research. The study shows similar observations in zebrafish and highlights the potential of zebrafish as an additional platform for cancer drug discovery.
Researchers discovered that cells use active perception to coordinate action when creating new tissue. They found that filopodia movement helps inform a decision by detecting signals in the environment.
Researchers at Newcastle University are studying the role of genes in congenital heart defects to better understand their formation and development. By examining the pharyngeal endoderm tissue from mice, they hope to identify key genes involved in forming large blood vessels and prevent potential defects.
Researchers discovered myelomonocytic cells that enter the brain too quickly and cause devastating damage, while a slower subset helps repair damaged vessels. Administering treatment within six hours of injury can reduce swelling and improve outcomes.
A study from Scripps Research Institute has identified an enzyme that limits blood vessel growth, providing insights into potential medicines to kill tumors and stop cancer from spreading. The findings also may enable new interventions for healthy blood-vessel development in people with heart disease and other conditions.
Researchers found that consuming cocoa flavanols improved brain oxygenation and cognitive performance in healthy adults, with the greatest benefits seen in complex tasks. The study's findings suggest that flavanols may have a positive impact on cognitive function, particularly during challenging cognitive tasks.
People with diabetes and eye disease are at a higher risk of requiring intubation when hospitalized with COVID-19. Diabetic retinopathy was associated with a five-fold increased risk for intubation in patients hospitalized with severe COVID-19.
A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation. Bone morphogenetic factor 6, BMP6, is shown to regulate blood vessel formation via vascular endothelial growth factor receptor 2 (VEGFR2) and Hippo signalling pathway.
Researchers identified a compound that disables abnormal blood vessels, potentially reversing vision loss in patients with retinopathy of prematurity and diabetic retinopathy. The treatment targets only the abnormal vessels, sparing healthy ones.
A newly developed oxygen-releasing bioink has been shown to enhance the ability of implanted cells to grow and regenerate new tissue. The bioink was tested extensively to optimize its properties, delivering oxygen to cells in tissue constructs for the necessary period for blood vessels to develop fully.
Researchers developed a machine learning approach to examine placentas, decreasing healthcare costs and allowing more women to be informed of their health risks. The algorithm can identify diseased blood vessels indicating preeclampsia risk with high accuracy.
Researchers at Johns Hopkins Kimmel Cancer Center created a 3D blood vessel model to study how cancer cells spread. They found that cancer cells can take over existing blood vessels, causing them to leak or constrict, and release tumor cells into the bloodstream.
Researchers have identified six molecules that can be used as biomarkers to predict how severely ill a patient with COVID-19 will become. Additionally, they discovered a new mechanism causing life-threatening blood clots in COVID-19 patients and potential ways to treat them.
A research team has revealed that Ca2+ activities mediated by mechanosensitive Piezo1 channels regulate the pathfinding of growing brain vessels in larval zebrafish. This process is critical for proper patterning of the vasculature, but its underlying mechanism remained unknown.
A new study published in Science sheds light on a cellular process in diabetic retinopathy, which could lead to the development of a treatment for this serious complication of diabetes. The research reveals that blood vessels apply molecular brakes to stop abnormal vascular proliferation.
Dr. Yuan's research program expands to include COVID-19, exploring tissue-specific biomarkers for diagnosis and treatment. Her microvascular research has significantly advanced understanding of vascular barrier function and inflammation.
Researchers have developed a tiny, flexible scope that can provide high-quality 3D images inside blood vessels, enabling better understanding of heart attack causes and progression. The device's miniaturization could lead to improved treatment and prevention of cardiovascular disease.
Researchers at Universitat Pompeu Fabra discovered that blood vessels communicate with sensory neurons through dynamic protrusions, allowing them to regulate cell growth and maintenance of stem cells. This communication is crucial for the development and regeneration of the peripheral nervous system.