Articles tagged with Blood Vessels
Researchers discovered Empa, an FDA-approved diabetes medication, improved blood vessel function and reduced arterial stiffness in aged male mice. The study suggests SGLT2 inhibition may be a therapeutic tool to delay or reverse vascular aging in humans.
A research team discovered that an excessive number of thromboxane A2 receptors in blood vessel cells hinders the formation of new blood vessels, leading to vascular and cardiovascular diseases. The finding offers a promising biomarker for treatment and potential therapeutic benefits from blocking the receptor's action.
Researchers at Massachusetts General Hospital developed two approaches to repair tumor blood vessels, alleviating hypoxia and improving chemotherapy's effectiveness. Combining these approaches may create a more powerful anti-cancer strategy.
A new study suggests that a diet high in protein, zinc, and niacin, and low in saturated fat, can improve blood vessel flexibility. The study found improvements in metabolic and cardiovascular health, including reductions in calorie and saturated fat intake, increases in zinc and niacin, and improvements in blood vessel function.
Scientists found that a single 45-minute session of moderate-intensity exercise enables the growth of new blood vessels in people with type 2 diabetes. The exercise increases levels of ATP7A, a protein carried by exosomes that helps deliver essential copper to endothelial cells, promoting angiogenesis and reducing oxidative stress.
Researchers have discovered how fungus blocks and bursts blood vessels in the brain, allowing microbes to spread and cause meningitis. The study identifies a simple yet effective method that microbes use to escape the immune system and enter the brain.
Research in mice suggests that neutrophil extracellular traps (NETs) can cause further damage to the brain after a stroke by trapping other cells and reducing blood flow. Blocking NETs with a compound called nNIF may protect the brain from this harm, leading to better outcomes for patients.
Researchers at UC Riverside have discovered that curcumin promotes vascular endothelial growth factor (VEGF) secretion, helping to grow engineered blood vessels and tissues. The study uses magnetic hydrogels coated with curcumin-coated nanoparticles, which gradually release the compound without injuring cells.
A new wireless implant has the potential to treat neuropathic pain resistant to medical therapy, offering a minimally invasive alternative to surgery. The device uses bioelectronic therapy to stimulate peripheral nerves from within blood vessels, providing precise placement and predictable outcomes.
Researchers discovered a key protein, c-Maf, required for naive endothelial cells to mature into liver sinusoidal blood vessels. Induced liver sinusoidal endothelial cells (iLSECs) support hepatocytes, promoting healthy function.
A post-hoc subgroup analysis of the AFIRE trial found that reduced kidney function significantly influences bleeding events during antithrombotic therapy. Patients with healthy kidney function have a decreased risk of bleeding over time, while those with reduced kidney function remain at high risk.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
A new study suggests that a high-salt diet can lead to the hyperactivity of brain cells, resulting in increased constriction of blood vessels and worsening of cardiometabolic diseases. The research also found that excessive salt consumption can trigger an unusual response in which neurons become more active despite reduced blood flow.
Researchers from Tel Aviv University found that hyperbaric oxygen therapy (HBOT) relieves PTSD symptoms in treatment-resistant veterans, improving brain function and microstructure. The breakthrough study provides new hope for PTSD sufferers, offering an objective diagnostic tool and potential long-term improvements.
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Researchers found circulating antiphospholipid antibodies and autoantibodies in COVID-19 patients, which may explain mechanisms associated with severe blood clotting. IgG levels were also linked to disease severity, and removing it from samples led to reduced 'blood vessel stickiness',
A new study found that statin intolerance is over-estimated, affecting only 6-10% of patients worldwide. Researchers identified risk factors for statin intolerance, including age, sex, ethnicity, and medical conditions.
Researchers compared two treatment methods for wide-neck aneurysms: microsurgery with clips and coils/stents deployed via catheters. Microsurgery was found to be longer-lasting, but endovascular therapy showed superior clinical outcomes in unruptured aneurysms.
The University of South Florida has received a five-year, $1.35 million NIH institutional grant to train scientists in vascular inflammation and injury research. The grant will support the comprehensive training of pre- and postdoctoral scientists focused on this emerging area of research.
Researchers are developing novel biomaterials to promote new blood vessel and axon formation after a stroke, aiming to improve neurological conditions. The project targets post-stroke immune response and aims to enhance the healing process.
A new study published in Clinical Nutrition found that drinking less than the UK's recommended 14 units of alcohol per week increases the risk of cardiovascular events. Moderate alcohol consumption is associated with a 23% increased risk of suffering a cardiovascular event for every additional 1.5 pints of beer consumed.
Researchers developed an AI system that can analyze retinal scans to identify patients at high risk of a heart attack over the next year. The system uses deep learning techniques and achieves an accuracy of 70-80%, revolutionizing the way patients are screened for signs of heart disease.
Researchers at West Virginia University are investigating the link between chronic stress and Alzheimer's disease using animal models. They aim to understand how xanthine oxidase may sabotage brain blood vessels in Alzheimer's patients, and explore whether a medication can block this pathway to keep the brain healthy.
A recent study published in Stroke found that the Woven Endobridge (WEB) device is safe and effective in treating brain aneurysms, with adequate occlusion occurring in 85.7% of cases. The device also showed low rates of blood clot-related complications and no re-ruptures after treatment.
Researchers found that the fetus uses a signal called IGF2 to control nutrient supply from the placenta. The team discovered that only the paternal copy of the IGF2 gene is active, while the maternal copy inactivates it.
Researchers from Göttingen University and Hannover Medical School have detected changes in heart muscle tissue of people who died from Covid-19. The study used innovative X-ray imaging to visualize the affected tissue in three dimensions, revealing a network of chaotic vessel formations.
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
Researchers found that defibrotide suppresses neutrophil release of NETs and reduces downstream blood-clotting in mice with antiphospholipid syndrome. The treatment neutralizes toxic histones, preventing activation of blood vessel cells.
Microglia, the brain's immune cells, migrate to the retina using blood vessels as pathways and require neurogenesis for colonization. The study provides insights into microglial migration and its implications for neurodegenerative diseases.
Researchers at Skoltech have created an optoacoustic endoscopic probe that can analyze atherosclerotic plaques by forcing molecules to sound their presence. The device uses laser light to make biomarkers oscillate, producing ultrasound signals that can be detected by a sensitive microphone.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
Women with breast cancer are at a higher risk of developing atrial fibrillation and dying from heart-related issues within the first year. The condition was more common in women who did not receive surgery or radiation as their initial treatment.
A study by Karolinska Institutet found that low levels of microRNA-210 in red blood cells cause vascular damage in type 2 diabetes. The reduction in microRNA-210 levels impaired blood vessel endothelial cell function and led to increased risk of cardiovascular disease.
Researchers developed a human Intestine Chip to study coronavirus infection and test potential treatments. The chip showed that nafamostat reduced virus presence while remdesivir damaged intestinal tissue, offering insights into underlying causes of GI symptoms and improving understanding of treatment efficacy and toxicity.
A team of experts from Tel Aviv University has identified 5 coronavirus proteins responsible for damaging blood vessels. The researchers hope that the identification will lead to the development of targeted drugs that reduce vascular damage in COVID-19 patients.
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
Metastases in malignant melanoma can use an alternative process to access the circulatory system, where a blood vessel divides into two parallel vessels. This finding challenges traditional research on tumor growth and may lead to new treatment options for metastatic cancer.
Researchers from the University of Queensland found that COVID-19 causes cardiovascular complications due to inflammation in infected airway cells. The study clarifies a key debate about the relationship between the virus and blood vessel linings, suggesting inflammation as the primary cause of damage.
Researchers found that females rely more heavily on aldosterone to regulate blood pressure, whereas males primarily use angiotensin II. This discovery could lead to targeted treatments for female hypertensive patients, improving treatment outcomes and reducing the risk of heart disease and stroke.
A high intake of alpha linolenic acid (ALA), found in nuts, seeds, and plant oils, is associated with a lower risk of death from all causes and diseases of the heart and blood vessels. However, further studies are needed to confirm the association with cancer mortality.
German scientists developed a method to supply oxygen to tadpole brains using photosynthesizing algae injected into their bloodstream. This approach effectively revived neurons in oxygen-deprived tadpoles, showing promise for new therapies for conditions such as stroke and high-altitude environments.
Researchers at WVU will explore how a specific enzyme protects the brain from stroke effects and aging. Their findings may indicate a potential target for medications improving brain blood vessel function after a stroke.
A pre-clinical study by University of Illinois Chicago researchers shows that a drug targeting specific immune pathways can prevent lung damage and death in mice infected with the SARS-CoV-2 virus. The study suggests targeted treatments may be more suitable for COVID-19 patients than broad immune suppressants.
Researchers find PADI4 and HIF-1 proteins work together to deliver oxygen and nutrients to tumors, allowing them to grow. The discovery provides new avenues for anti-cancer therapies targeting blood vessel development.
Researchers at Max-Planck-Gesellschaft engineered synthetic exosomes that regulate cellular signaling during wound closure, leading to faster healing and improved formation of new blood vessels. The study provides a systematic understanding of extracellular vesicle communication and its potential therapeutic application.
Researchers found that e-cigarette use led to increased blood clots and raised heart rate and blood pressure, while also making small blood vessels narrower. Long-term effects could lead to heart attacks and strokes.
A recent study reveals that protein HSP27 plays a crucial role in regulating blood vessel leakage, which is a hallmark of sepsis. By targeting HSP27, researchers hope to develop drugs that can stabilize blood vessel barriers and prevent fluid loss.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
A new study reanalyzes the Sorby vitamin C experiment, a landmark trial that determined the minimum vitamin C requirements for preventing scurvy. The analysis suggests that the recommended daily intake of 45mg may be too low to prevent weak scar strength.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
A new technology has been developed to reduce adverse effects of medical materials in the human body. The material can be loaded with therapeutic cells and deliver them to desired sites, mitigating inflammation and blood clots.
Researchers at King Abdullah University of Science & Technology (KAUST) create a biomaterial that supports the growth of bone marrow precursor cells and forms tubular blood vessels, mimicking natural bone tissue architecture. This breakthrough enables the development of 3D disease models for tissue engineering and biomedical research.
Researchers at University of Queensland develop gene therapy to block scar formation by targeting SOX9 gene, promising benefits for burn patients and others with significant scarring. The study uses siRNA technology to reduce scarring in animal models, paving the way for potential human treatment.
The study identifies novel non-coding RNAs involved in regulating vascular endothelial growth factors (VEGF) expression, which are key regulators of angiogenesis. These findings may lead to new therapeutic approaches for diseases such as atherosclerosis and ischemia.
A new mitochondrial peptide called MOCCI regulates inflammation of blood vessels and immunity after viral infection. Researchers discovered that MOCCI dampens the activity of Complex IV in mitochondria to reduce inflammation.
Scientists have developed a new biomaterial that regrows both blood vessels and bone, potentially providing an alternative to current systems. The biomaterial was inspired by the natural way in which bone defects regenerate and uses a mechanobiology-informed approach to promote both angiogenesis and osteogenesis.
New research reveals sex-specific differences in brain stem cell activity and blood vessel density with age. Female mice show more efficient neurogenesis and better neuron migration compared to male mice, suggesting hormonal or genetic influences may play a role.
During the COVID-19 state of emergency, Kawasaki disease primarily affecting children saw a notable rise in pediatric admissions in Japan. The study investigated transmission modes, revealing a potential link between droplet or contact transmission and disease development.
A new study found that drinking beetroot juice for ten days increased levels of beneficial oral bacteria linked to healthier blood vessels and brain function in older adults. The results also showed a significant drop in systolic blood pressure, suggesting potential benefits for cardiovascular health.
A four-year clinical trial from the DRCR Retina Network found that early anti-VEGF injections slowed diabetic retinopathy progression, but did not improve vision at two years. Standard treatment remained effective in preventing further vision loss.