Articles tagged with Cerebral Cortex
The Hippenmeyer group has developed a stable mouse stem cell line and created a robust and reproducible mouse cortical organoid protocol. By comparing developmental stages of the mouse brain with those of the organoids using single-cell sequencing, they found similar cell populations and molecular programs.
A new study published in Science Advances reveals that neuronal precursor cells divide into two independent lineages, producing distinct types of projection neurons. This challenges previous assumptions about the development of neural stem cells and sheds light on how the cerebral cortex arises.
Researchers identified 17 additional regions of the brain that appear to play a role in language, including parts of the cerebellum and hippocampus. These regions make up about 5 percent of the total volume of the adult brain and contribute to language processing despite being distant from traditional language centers.
A large cohort study found that antenatal opioid exposure was associated with impaired cerebral cortical folding in newborns. The extent of impairment differed based on the opioid type and presence of polysubstance exposure. Longitudinal assessments aim to inform early interventions for vulnerable populations.
Researchers at University of California - Riverside discovered that the primary cilium, a microscopic structure inside nearly every cell, plays a critical role in brain development. The study found that proteins associated with the cilium are directly linked to human developmental disorders and that protein production occurs directly w...
Researchers created a pioneering database to map neocortical development across species using multiomic data from 188 studies. They discovered that humans take longer than mice to reach full molecular maturity, and gene regulation plays a key role in brain disorders.
Researchers at Kyushu University develop a new tissue-clearing reagent, SeeDB-Live, enabling repeated, reversible, and real-time imaging of living brains at greater depth and clarity. This breakthrough allows scientists to visualize neural activity in living mice and brain slices, offering new insights into brain dynamics and function.
Researchers identify nonsense-mediated mRNA decay (NMD) as a central mediator of neuronal migration and cortical lamination. The study reveals that UPF2, a core component of NMD machinery, is essential for proper neuron migration and brain development.
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Researchers from Kyushu University found that the brain forms new, high-density clusters of synapses on specific segments of dendrites during adolescence, challenging the 'adolescent synaptic pruning' hypothesis. This discovery may offer new hope for understanding the biological basis of schizophrenia and other neurodevelopmental condi...
A study among WTC responders with chronic PTSD found measurable physical changes in their brain structure, including cortical changes and imbalance of myelinated to unmyelinated neurons. These changes were most strongly associated with re-experiencing symptoms in individuals with PTSD.
Researchers analyzed rare intracranial EEG data to identify unique computational methods for refining brain cortex mapping. The study offers new insights into early detection of neurodegenerative and sleep disorders, improving diagnosis and prevention of neurological diseases.
Dr. Xuyu Qian's pioneering research using MERFISH technology created an unprecedented developmental atlas of the human cerebral cortex, analyzing over 18 million single cells. His work aims to identify mechanisms disrupted in conditions like malformations and autism spectrum disorder.
Nontraumatic subarachnoid hemorrhage (SAH) is the third most common stroke type, accounting for 5-10% of all strokes. Despite declining age-standardized burden rates, SAH remains a major public health concern globally.
A comprehensive analysis reveals how brains generalize learning from previous experiences to new scenarios, mapping neural pathways from hippocampus to cortex. The study's findings highlight the critical role of the hippocampus and prefrontal cortex in cognitive generalization.
Researchers found that the brain prioritizes more important items, representing them with higher precision and lower resolution for less important ones. The frontal cortex communicates with the visual cortex to decide which item receives more working memory resources.
Researchers have discovered that the thalamus can update its own connections independently of the cortex, a finding relevant to children with neurodevelopmental disorders. This breakthrough suggests that modulating neurotransmitters in the thalamus could alter sensory processing and improve cognitive function.
Researchers at Cornell University have discovered key neurological mechanisms in psilocybin's brain effects, targeting pyramidal tract neurons and serotonin receptors. This could enable pharmaceuticals to deliver mood-altering benefits while suppressing perceptual hallucinations.
Researchers have discovered column-like structures in the visual cortex of mice, where neurons processing stimuli from the same eye form clusters. This finding sheds light on the structural organization of the brain and may help solve the mystery of cortical columns' function.
A new study found that the brain's cerebral cortex acts like a memory machine, encoding new experiences and predicting the near future. Novelty detection is a critical function for humans and animals, allowing them to adapt and improve their predictions of future events.
Researchers used single-cell sequencing to characterize different cell types in brain lesions and identify subpopulations involved in disease progression. The study provides a cellular view of focal cortical dysplasia, a malformation leading to drug-resistant epilepsy.
Researchers used EEG to map brain activity in response to hot and cold temperatures, finding that both invoke similar activity patterns in overlapping brain regions. The study could lead to more objective methods for evaluating thermal comfort and reducing health risks due to ambiguous subjective evaluations.
A new study sheds light on how age-related changes affect financial skills, finding that verbal representations and language processing play a crucial role. Individuals with better language skills and higher household income are more likely to excel in financial tasks.
Researchers at the Salk Institute identified a specific brain circuit responsible for slowing anxious breathing, connecting the frontal cortex to the brainstem. This discovery may offer a scientific explanation for the beneficial effects of practices like yoga and mindfulness on alleviating negative emotions and could lead to the devel...
A study by Northwestern University found that cross-talk between the hippocampus and cortex can predict chronic pain, with higher anxiety levels increasing precision. The researchers suggest targeting anxiety after injury to prevent chronic pain, paving the way for novel treatments.
A new study finds that the FOXG1 gene has a dual function in regulating RNA transcription and translation, essential for proper brain development. The discovery raises questions about the evolution of this complex mechanism and its potential role in neuroplasticity.
Researchers found that conscious thought requires synchronized communication—mediated by brain rhythms in specific frequency bands—between basic sensory and higher-order cognitive regions of the brain. Under anesthesia, communication was lost, highlighting the key role of frontal areas in consciousness.
A new Northwestern Medicine study identifies critical language connector sites in the cerebral cortex that work together to produce language. These sites serve as connectors between subnetworks of people, serving a similar function for language in the brain.
A UW study found that COVID-19 lockdowns accelerated brain maturation in adolescents, particularly in females, leading to increased anxiety, depression, and internalizing problems. The study suggests that social isolation and lack of normal stress release channels may have exacerbated these effects.
A new study published in Nature Communications reveals how propofol sedation alters the connections between brain cells in the thalamus and cortex, shedding light on the neural mechanisms underlying consciousness. The researchers found that disruptions to the matrix cells' activity play a crucial role in the transition to unconsciousness.
Researchers at UC San Diego School of Medicine used intracranial EEG to study co-rippling in the cortex, finding synchronized activity between neurons enables integration of information and conscious thought. This breakthrough has potential implications for understanding neurological and psychiatric disorders and human experience.
Scientists successfully mapped transcriptomes from 1.3 million brain cortex cells to gain molecular insights into Alzheimer's vulnerability and resilience. The resulting atlas holds promise for gene and molecular discovery across pathways affecting brain health.
A University of Maryland study reveals how the brain adapts to different listening situations, with the orbitofrontal cortex playing a central role. The findings may have implications for human health and well-being, particularly in conditions such as autism, dyslexia, or schizophrenia.
By 16 months, toddlers use the left parietal cortex and both sides of the prefrontal cortex more extensively, enabling them to follow simple instructions and control impulses. The study found that brain changes occur despite no improvement in observable skills between 10 and 16 months.
Researchers characterize thalamic and cortical neurons responding to ocular surface stimulation, showing diverse multimodal response profiles. The study provides insights into how sensory stimulus information is integrated from the peripheral nervous system into the brain's cortical networks.
Researchers discover that epigenetic marks, particularly H3K27ac, are crucial for instructing genes to express themselves and generate folds. The Cux2 protein is found to be a master factor that utilizes the epigenetic landscape to regulate gene expression, leading to the formation of folds in the cerebral cortex.
Researchers at OIST used a novel technique to study how activating the brain's serotonin center affects awake animals. They found that serotonin from the dorsal raphe nucleus (DRN) activates brain areas influencing behavior and motivation, including the cerebral cortex and basal ganglia.
A new study found significant differences in brain development between autistic boys and girls, with autistic females showing a thicker cortex at age 3 and faster cortical thinning into middle childhood. The findings highlight the need for longitudinal studies that include both sexes to better understand sex-specific changes in autism.
Researchers at the University of Minnesota have found that the cortex can transform unorganized inputs into highly organized patterns of activity, demonstrating self-organization. This process occurs entirely within the cortex itself, indicating that the brain is able to organize its own function during development.
Engineers at the University of California San Diego used a new technique called MUSIC to map out interactions between chromatin and RNA in individual brain cells. The study found that some brain cells age faster and are more prevalent in individuals with Alzheimer's disease, particularly in women.
Identical odors are processed differently in the brain based on their assigned labels, according to new research. The study found that participants rated odors with different names as more dissimilar than those labeled with the same name.
Researchers used intracortical recordings to study the neural mechanisms behind exogenous attention, identifying three cortical networks activated in sequence as attention was captured by visual stimuli. The findings suggest a continuum of activity in the cortex, with attention emerging as a bridge between perception and action.
Researchers at University of California - San Francisco have developed a precise map of what is happening in the brain’s auditory cortex when someone hears a melody. The study found that some aspects of music are entwined with how we understand speech, while other important aspects stand alone. The brain uses two sets of neurons to ass...
A recent study published in NeuroImage found that physically active individuals experienced less decline in entorhinal cortex thickness over a seven-year period. Cognitive reserve is also boosted through regular mental stimulation, suggesting that brains can be trained like muscles to counteract age-related decline.
A new study from MIT shows that computational models trained on auditory tasks display an internal organization similar to the human auditory cortex. Models trained on diverse tasks and background noise more closely mimic brain activation patterns.
Eating fatty foods during stressful periods can reduce brain oxygenation and cause poorer vascular function in adults. Consuming low-fat food and drinks may help mitigate this effect.
Researchers at the Princess Máxima Center and Hubrecht Institute developed a new cortex organoid that more accurately captures essential features of the human brain. The mini-organs can be used to model pediatric brain tumors, offering potential targets for treatment.
A new USC study reveals that variants of the autism-linked gene SYNGAP1 can disrupt early brain development in the cortex, a region involved in higher-order cognitive functions. The research found that disease-causing variants of SYNGAP1 alter the cells' cytoskeletons and lead to disorganized neural circuits.
Research suggests that consciousness requires synchronized communication across cortical regions; propofol general anesthesia cancels sensory processing by cutting it off. Neural activity in higher-level processing and cognitive regions fails to propagate during anesthesia.
Researchers found that hierarchical cortical organization is impaired in people with schizophrenia, leading to disruptions in processing stimuli from the external world. This disruption affects secondary processing of sensorimotor-visual gradients, explaining behavioral and clinical symptoms of the disease.
A breakthrough technique has been developed by University of Oxford researchers to repair brain injuries using 3D printing. Neural cells can be printed to mimic the architecture of the cerebral cortex, showing structural and functional integration with host tissue.
In Parkinson's disease, the cerebral cortex compensates for lost dopamine cells by taking over tasks, which determines symptom severity. Exercise can stimulate this compensation and slow down disease progression.
Researchers found differential activation patterns of the Default Mode Network nodes, with facial movement inducing an inverted positive BOLD pattern in certain areas. Facial recognition and movement uniquely impact brain activity, highlighting their importance in cognitive and social development.
A new study suggests that transcranial ultrasound stimulation can be used to change specific types of activity within the brain, paving the way for targeted treatments of mental health conditions. The research found that TUS induced significant changes in GABA concentration and altered communication between brain regions.
Scientists at Van Andel Institute have discovered processes that enable the brain to adapt to damage in movement, cognition, and sensory perception circuits. This finding may help optimize current treatments or develop new ones that repair or bypass broken circuits.
A new study published in Nature Genetics has identified over 4,000 genetic variants linked to brain structure, revealing how the brain's organization is shaped by genetics. The research found that different sets of genes contribute to folding and size of the cortex, with some genes linked to larger or smaller head sizes.
Scientists successfully reconstructed recognizable versions of Pink Floyd's 'Another Brick in the Wall, Part 1' using nonlinear modeling to decode brain activity. The study identified a unique region in the Superior Temporal Gyrus (STG) responsible for rhythm perception, with electrodes from this region crucial for accurate reconstruct...
A study published in PLOS Biology reveals that the inferolateral occipitotemporal cortex selectively encodes object shape in both sighted and early blind individuals. This finding suggests that the brain is organized as operators executing a function regardless of input senses.
A three-month mild exercise program improved executive function in middle-aged and older adults by increasing neural efficiency in the prefrontal cortex. The benefits were particularly pronounced in the older adult group, suggesting a positive impact on cognitive function and brain function with minimal physical exertion.
Researchers at Harvard Medical School have identified a specific group of neurons that become active when mice correct mistakes during spatial navigation. The findings bring scientists closer to understanding how navigation works and raise new questions about the role of these cells in other brain regions.