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Pressured to become the organizer

Researchers found that mechanical pressure inside the growing tissue determines the location of signaling centers, crucial for organ formation. These centers send signals to organize surrounding cells, and their correct placement is vital for healthy embryonic development.

SourceTechnische Universität Dresden·JournalNature Cell Biology·DateApr 3, 2024

Scientists extract genetic secrets from 4,000-year-old teeth to illuminate the impact of changing human diets over the centuries

Researchers have recovered ancient microbiomes from 4,000-year-old teeth in Ireland, revealing major changes in oral microenvironments. The study identified bacteria linked to gum disease and provided the first high-quality ancient genome of Streptococcus mutans, a major culprit behind tooth decay.

SourceTrinity College Dublin·JournalMolecular Biology and Evolution·DateMar 27, 2024

Low-cost liquid tames tooth decay

A new study by NYU College of Dentistry shows that silver diamine fluoride (SDF) is an effective alternative to dental sealants for preventing cavities, especially in schools. SDF can increase access to dental care while reducing costs, and its use could keep kids from needing fillings, saving families and the healthcare system money.

SourceNew York University·JournalJAMA Pediatrics·TypeRandomized controlled/clinical trial·DateMar 4, 2024

Study provides insights into diets of early primates

A University of Otago-led study found that early primates primarily consumed soft fruits, as indicated by dental chipping patterns and cavities. The research, published in the American Journal of Biological Anthropology, analyzed fossils from the Fayum Depression in Egypt and compared them to data from living primates.

SourceUniversity of Otago·JournalAmerican Journal of Biological Anthropology·DateDec 17, 2023

Viking dentistry was surprisingly advanced

A study of Viking Age teeth from Varnhem in Sweden found that 49% of the population had one or more caries lesions, with children's milk teeth being entirely caries-free. The Vikings also underwent dental treatment, including filing front teeth and relieving pressure through holes drilled into molars.

SourceUniversity of Gothenburg·JournalPLOS ONE·DateDec 14, 2023

Rice study: AI provides more accurate analysis of prehistoric and modern animals, painting picture of ancient world

A recent study published in Annals of the New York Academy of Sciences found that AI technology can accurately identify prehistoric and modern African antelopes, with an accuracy rate of over 90% compared to humans. This breakthrough sheds light on ancient ecosystems and their impact on human evolution.

SourceRice University·JournalAnnals of the New York Academy of Sciences·TypeData/statistical analysis·DateDec 14, 2023

Vikings in Sweden suffered from tooth decay

A study published in PLOS ONE reveals that Vikings in Sweden had a high prevalence of tooth decay, with many exhibiting severe caries and other dental pathologies. The findings provide insights into the lives of these ancient Scandinavians and their attempts to treat dental issues.

SourcePLOS·JournalPLOS ONE·TypeObservational study·DateDec 13, 2023

ADA Forsyth scientists work to bring tissue regeneration to replace root canal treatment

Researchers at ADA Forsyth have discovered the regenerative properties of Resolvins, specifically RvE1, which promotes pulp regeneration and reduces bacterial invasion in dental pulp. The technology has far-reaching potential for regenerative medicine beyond oral health, including growing bones in other parts of the body.

SourceForsyth Institute·JournalJournal of Dental Research·TypeExperimental study·DateDec 1, 2023

Children's dental health significantly improved using electric toothbrushes

A new study found that electric toothbrushes significantly reduce plaque and gingivitis in young children aged 3-10. The research showed that electric toothbrushes are more effective than manual toothbrushes in reducing these dental issues, with whole mouth plaque reduction increasing by up to 55.7% in younger children.

SourceThe Hebrew University of Jerusalem·JournalInternational Journal of Paediatric Dentistry·TypeRandomized controlled/clinical trial·DateNov 8, 2023

Stem-cell derived organoids secrete tooth enamel proteins

Researchers successfully created stem-cell derived organoids from human stem cells that secrete three essential enamel proteins. These proteins form a matrix that undergoes mineralization to create a hardened enamel structure. The breakthrough offers hope for developing novel treatments to repair and regenerate teeth.

SourceUniversity of Washington School of Medicine/UW Medicine·JournalDevelopmental Cell·TypeExperimental study·DateAug 14, 2023

Smiles all round: clinical trial shows that a toothpaste containing synthetic tooth minerals can prevent cavities as effectively as fluoride

A clinical trial found that hydroxyapatite toothpaste is equally effective in preventing cavities as fluoride toothpaste. The study involved 189 adults who used either hydroxyapatite or fluoride toothpaste for 18 months, with no significant difference in efficacy between the two groups.

SourceFrontiers·JournalFrontiers in Public Health·TypeRandomized controlled/clinical trial·DateJul 18, 2023

Tiny scales reveal megalodon was not as fast as believed, but it had a mega-appetite explaining its gigantism

A new study reveals that Megalodon, the iconic extinct shark, was not as fast as believed but had a mega-appetite that explained its gigantism. The discovery of tiny scales found in rock pieces surrounding fossil teeth suggests that Megalodon used its warm-bloodedness to promote visceral food processing and absorb nutrients.

SourceTaylor & Francis Group·JournalHistorical Biology·DateJul 11, 2023

How the evolution of tooth enamel tissue unfolded

A recent study by researchers at the University of Zurich found that the Notch signaling pathway plays a crucial role in shaping and varying tooth enamel. The team used genetically modified mouse models to analyze the effects of the Notch-ligands on teeth, revealing that their absence affected tooth morphology and enamel formation.

SourceUniversity of Zurich·JournalCellular and Molecular Life Sciences·TypeComputational simulation/modeling·DateJun 27, 2023

Tooth enamel provides clues to hunter-gatherer lifestyle of Neanderthals

A study using tooth enamel analyzed by laser ablation revealed that Neanderthals in western Europe hunted large animals, such as wild goat and horses, whereas humans consumed smaller creatures like rabbits and fish. The researchers estimated the territory size of both human groups, finding contrasting results.

SourceUniversity of Southampton·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMay 9, 2023

Sugar consumption and early interruption of breastfeeding are risk factors for dental caries in infancy

A Brazilian study found that early sugar consumption and interruption of breastfeeding are key factors contributing to dental caries in infants. Extended breastfeeding was shown to protect babies' teeth as long as they didn't receive sugary food, with the risk declining with falling sugar consumption.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCommunity Dentistry And Oral Epidemiology·DateFeb 7, 2023

Dental service use falls, oral health worsens after people become eligible for Medicare

A recent study found that nearly half of older adults receive no dental care and half lack dental insurance. After becoming eligible for Medicare, the percentage of people receiving restorative dental care decreased by 8.7%, while complete edentulism increased by almost 5 percentage points among those aged 65 and above.

SourceBrigham and Women's Hospital·JournalHealth Affairs·TypeData/statistical analysis·DateFeb 7, 2023

Early humans: Annual cycles in tooth enamel provide insights into life histories

Researchers analyzed ancient teeth from Homo erectus and great apes to reveal annual cycles in tooth enamel, providing insights into their diets and seasonal food supplies. The study shows that humans and great apes had distinct dietary patterns, with humans exhibiting less pronounced peaks and lower Sr/Ca values.

SourceGoethe University Frankfurt·JournalNature Ecology & Evolution·TypeExperimental study·DateJan 16, 2023

Neanderthals appear to have been carnivores

A new study using zinc isotope analysis found that Neanderthals were probable carnivores, contrary to earlier research suggesting a plant-based diet. The analysis of a tooth enamel sample from the Gabasa site in Spain revealed a carnivorous diet without blood consumption.

SourceCNRS·JournalProceedings of the National Academy of Sciences·DateOct 17, 2022

Diego bows to ancestral sabretoothed mammal

A new fossil specimen discovered in California reveals that the first saber-like canines evolved in an early nimravid around 40 million years ago. This finding highlights the quick diversification of carnivorous mammals after the middle Eocene climatic optimum.

SourceKyoto University·JournalBiology Letters·TypeMeta-analysis·DateOct 13, 2022

Microbes that cause cavities can form superorganisms able to ‘crawl’ and spread on teeth

Researchers discovered that cross-kingdom assemblages of bacteria and fungi can form superorganisms that colonize teeth, causing extensive tooth decay. These superorganisms exhibit enhanced surface adhesion, increased mechanical and antimicrobial tolerance, and unique mobility, moving at speeds similar to fibroblasts.

SourceUniversity of Pennsylvania·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateOct 6, 2022

Genetic defects lead to enamel malformations

A study conducted at the University of Zurich has identified a key gene network responsible for severe tooth enamel defects. The researchers found that mutations in the Adam10 molecule lead to disorganization of ameloblasts and severe defects in both structure and mineral composition of enamel.

SourceUniversity of Zurich·JournaliScience·TypeExperimental study·DateSep 26, 2022